Search Results - "Nacci, Carmela"

Activation of AMPK/SIRT1 axis is required for adiponectin-mediated preconditioning on myocardial ischemia-reperfusion (I/R) injury in rats by Potenza, Maria Assunta, Sgarra, Luca, Nacci, Carmela, Leo, Valentina, De Salvia, Maria Antonietta, Montagnani, Monica

“…Adiponectin (AD) cardioprotective activities are mediated by AMPK, a fuel-sensing molecule sharing common targets and cellular activities with SIRT-1. Whether…”
Get full text

Endothelial dysfunction in diabetes: from mechanisms to therapeutic targets by Potenza, Maria Assunta, Gagliardi, Sara, Nacci, Carmela, Carratu', Maria Rosaria, Montagnani, Monica

“…Micro- and macrovascular complications are major causes of disability and death in patients with diabetes mellitus. Functional impairment of endothelial…”
Get more information

Diabetes and Alzheimer’s Disease: Might Mitochondrial Dysfunction Help Deciphering the Common Path? by Potenza, Maria Assunta, Sgarra, Luca, Desantis, Vanessa, Nacci, Carmela, Montagnani, Monica

“…A growing number of clinical and epidemiological studies support the hypothesis of a tight correlation between type 2 diabetes mellitus (T2DM) and the…”
Get full text

microRNAs as Biomarkers of Endothelial Dysfunction and Therapeutic Target in the Pathogenesis of Atrial Fibrillation by Desantis, Vanessa, Potenza, Maria Assunta, Sgarra, Luca, Nacci, Carmela, Scaringella, Antonietta, Cicco, Sebastiano, Solimando, Antonio Giovanni, Vacca, Angelo, Montagnani, Monica

“…The pathophysiology of atrial fibrillation (AF) may involve atrial fibrosis/remodeling and dysfunctional endothelial activities. Despite the currently…”
Get full text

Can Epigenetics of Endothelial Dysfunction Represent the Key to Precision Medicine in Type 2 Diabetes Mellitus? by Coco, Celeste, Sgarra, Luca, Potenza, Maria Assunta, Nacci, Carmela, Pasculli, Barbara, Barbano, Raffaela, Parrella, Paola, Montagnani, Monica

“…In both developing and industrialized Countries, the growing prevalence of Type 2 Diabetes Mellitus (T2DM) and the severity of its related complications make…”
Get full text

Endothelial and Metabolic Function Interactions in Overweight/Obese Children: The Role of High-Molecular Weight Adiponectin by Ciccone, Marco Matteo, Faienza, Maria Felicia, Altomare, Maria, Nacci, Carmela, Montagnani, Monica, Valente, Federica, Cortese, Francesca, Gesualdo, Michele, Zito, Annapaola, Mancarella, Rossana, Leogrande, Domenico, Viola, Domenico, Scicchitano, Pietro, Giordano, Paola

“…Aim: Although the underlined mechanisms are still unknown, metabolic/coagulation alterations related to childhood obesity can induce vascular impairments. The…”
Get full text

Carbon monoxide contributes to the constipating effects of granisetron in rat colon by Nacci, Carmela, Fanelli, Margherita, Potenza, Maria Assunta, Leo, Valentina, Montagnani, Monica, De Salvia, Maria Antonietta

“…AIM To investigate the mechanisms underlying the potential contribution of the heme oxygenase/carbon monoxide(HO/CO) pathway in the constipating effects of…”
Get full text

Endothelial Dysfunction May Link Interatrial Septal Abnormalities and MTHFR-Inherited Defects to Cryptogenic Stroke Predisposition by Sgarra, Luca, Bortone, Alessandro Santo, Potenza, Maria Assunta, Nacci, Carmela, De Salvia, Maria Antonietta, Acquaviva, Tommaso, De Cillis, Emanuela, Ciccone, Marco Matteo, Grimaldi, Massimo, Montagnani, Monica

“…We explored the significance of the L-Arginine/asymmetric dimethylarginine (L-Arg/ADMA) ratio as a biomarker of endothelial dysfunction in stroke patients. To…”
Get full text

Chronic treatment with epigallocatechin gallate reduces motor hyperactivity and affects in vitro tested intestinal motility of spontaneously hypertensive rats by Potenza, Maria Assunta, Montagnani, Monica, Nacci, Carmela, Salvia, Maria Antonietta De

“…Green tea catechins seem to contribute toward reducing body weight and fat. We aimed to investigate whether chronic administration of…”
Get full text

Endothelial and Metabolic Function Interactions in Overweight/Obese Children by Ciccone, Marco Matteo, Faienza, Maria Felicia, Altomare, Maria, Nacci, Carmela, Montagnani, Monica, Valente, Federica, Cortese, Francesca, Gesualdo, Michele, Zito, Annapaola, Mancarella, Rossana, Leogrande, Domenico, Viola, Domenico, Scicchitano, Pietro, Giordano, Paola

“…Although the underlined mechanisms are still unknown, metabolic/coagulation alterations related to childhood obesity can induce vascular impairments. The aim…”
Get full text

ROLE OF CIRCULATING ENDOTHELIAL PROGENITOR CELLS AND CORRELATION WITH VASCULAR STIFFNESS AND ORGAN DAMAGE by Desantis, Vanessa, Marozzi, Marialuisa Sveva, Giliberti, Lucia, Corvasce, Francesco, Scaringella, Antonella, Potenza, Maria Assunta, Nacci, Carmela, Montagnani, Monica, Vacca, Angelo, Nazzaro, Pietro, Cicco, Sebastiano

“…Objective: Atherosclerosis is a chronic cardiovascular disease. High plasma concentration of LDL is the main risk factor but the role of inflammation in all…”
Get full text

Targeting endothelial metaflammation to counteract diabesity cardiovascular risk: Current and perspective therapeutic options by Potenza, Maria Assunta, Nacci, Carmela, De Salvia, Maria Antonietta, Sgarra, Luca, Collino, Massimo, Montagnani, Monica

“…[Display omitted] The association of obesity and diabetes, termed “diabesity”, defines a combination of primarily metabolic disorders with insulin resistance…”
Get full text

Activation of AMPK/SIRT1 axis is required for adiponectin-mediated preconditioning on myocardial ischemia-reperfusion by Potenza, Maria Assunta, Sgarra, Luca, Nacci, Carmela, Leo, Valentina, De Salvia, Maria Antonietta, Montagnani, Monica

“…Background Adiponectin (AD) cardioprotective activities are mediated by AMPK, a fuel-sensing molecule sharing common targets and cellular activities with…”
Get full text

Infliximab therapy restores adiponectin expression in perivascular adipose tissue and improves endothelial nitric oxide-mediated vasodilation in mice with type 1 diabetes by Nacci, Carmela, Leo, Valentina, De Benedictis, Leonarda, Potenza, Maria A, Sgarra, Luca, De Salvia, Maria A, Quon, Michael J, Montagnani, Monica

“…Abstract Increased TNFα-mediated JNK signaling in the perivascular adipose tissue (PVAT) may contribute to the pathogenesis of vascular complications in T1DM…”
Get full text

Globular adiponectin counteracts VCAM-1-mediated monocyte adhesion via AdipoR1/NF-κB/COX-2 signaling in human aortic endothelial cells by Addabbo, Francesco, Nacci, Carmela, De Benedictis, Leonarda, Leo, Valentina, Tarquinio, Mariela, Quon, Michael J, Montagnani, Monica

“…Adiponectin (Ad) is an insulin-sensitizing adipocytokine with anti-inflammatory and vasoprotective properties. Cleavage of native full-length Ad (fAd) by…”
Get more information

Elevated Endothelin-1 (ET-1) Levels May Contribute to Hypoadiponectinemia in Childhood Obesity by Nacci, Carmela, Leo, Valentina, De Benedictis, Leonarda, Carratù, Maria Rosaria, Bartolomeo, Nicola, Altomare, Maria, Giordano, Paola, Faienza, Maria Felicia, Montagnani, Monica

“…Context: Pediatric obesity is associated with endothelial dysfunction and hypoadiponectinemia, but the relationship between these two conditions remains to be…”
Get full text

Molecular and clinical aspects of endothelial dysfunction in diabetes by Nacci, Carmela, Tarquinio, Mariela, Montagnani, Monica

“…Diabetic patients have an increased risk for cardiovascular complications with respect to the general population. Micro- and macrovascular complications such…”
Get full text

The Leading Role of the Immune Microenvironment in Multiple Myeloma: A New Target with a Great Prognostic and Clinical Value by Desantis, Vanessa, Savino, Francesco Domenico, Scaringella, Antonietta, Potenza, Maria Assunta, Nacci, Carmela, Frassanito, Maria Antonia, Vacca, Angelo, Montagnani, Monica

“…Multiple myeloma (MM) is a plasma cell (PC) malignancy whose development flourishes in the bone marrow microenvironment (BMME). The BMME components'…”
Get full text

Galloyl benzamide-based compounds modulating tumour necrosis factor [alpha]-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways by Leo, Valentina, Stefanachi, Angela, Nacci, Carmela, Leonetti, Francesco, Candia, Modesto, Carotti, Angelo, Altomare, Cosimo D, Montagnani, Monica, Cellamare, Saverio

“…Objectives The aim of this work is to investigate whether and how two newly synthesized 3,4,5-trimethoxygalloyl-containing compounds 1 and 3 interfere with the…”
Get full text

Endothelial Dysfunction in Mice with Streptozotocin-induced Type 1 Diabetes Is Opposed by Compensatory Overexpression of Cyclooxygenase-2 in the Vasculature by Nacci, Carmela, Tarquinio, Mariela, De Benedictis, Leonarda, Mauro, Annamaria, Zigrino, Addolorata, Carratù, Maria Rosaria, Quon, Michael J, Montagnani, Monica

“…Cardiovascular complications of diabetes result from endothelial dysfunction secondary to persistent hyperglycemia. We investigated potential compensatory…”
Get full text