Search Results - "Nacarelli, Timothy"

NAD+ metabolism governs the proinflammatory senescence-associated secretome by Nacarelli, Timothy, Lau, Lena, Fukumoto, Takeshi, Zundell, Joseph, Fatkhutdinov, Nail, Wu, Shuai, Aird, Katherine M., Iwasaki, Osamu, Kossenkov, Andrew V., Schultz, David, Noma, Ken-ichi, Baur, Joseph A., Schug, Zachary, Tang, Hsin-Yao, Speicher, David W., David, Gregory, Zhang, Rugang

“…Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. Senescent cells are characterized by an upregulation of…”
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Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence by Zhao, Bo, Liu, Pingyu, Fukumoto, Takeshi, Nacarelli, Timothy, Fatkhutdinov, Nail, Wu, Shuai, Lin, Jianhuang, Aird, Katherine M., Tang, Hsin-Yao, Liu, Qin, Speicher, David W., Zhang, Rugang

“…Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that is essential for cellular senescence. cGAS promotes inflammatory…”
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Epigenetic Basis of Cellular Senescence and Its Implications in Aging by Nacarelli, Timothy, Liu, Pingyu, Zhang, Rugang

“…Cellular senescence is a tumor suppressive response that has become recognized as a major contributor of tissue aging. Senescent cells undergo a stable…”
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Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization by Iwasaki, Osamu, Tanizawa, Hideki, Kim, Kyoung-Dong, Kossenkov, Andrew, Nacarelli, Timothy, Tashiro, Sanki, Majumdar, Sonali, Showe, Louise C., Zhang, Rugang, Noma, Ken-ichi

“…Senescence is induced by various stimuli such as oncogene expression and telomere shortening, referred to as oncogene-induced senescence (OIS) and replicative…”
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Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts by Lerner, Chad, Bitto, Alessandro, Pulliam, Daniel, Nacarelli, Timothy, Konigsberg, Mina, Remmen, Holly, Torres, Claudio, Sell, Christian

“…Summary Coordinated expression of mitochondrial and nuclear genes is required to maintain proper mitochondrial function. However, the precise mechanisms that…”
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p62/SQSTM1 at the interface of aging, autophagy, and disease by Bitto, Alessandro, Lerner, Chad A., Nacarelli, Timothy, Crowe, Elizabeth, Torres, Claudio, Sell, Christian

“…Advanced age is characterized by increased incidence of many chronic, noninfectious diseases that impair the quality of living of the elderly and pose a major…”
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m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype by Liu, Pingyu, Li, Fuming, Lin, Jianhuang, Fukumoto, Takeshi, Nacarelli, Timothy, Hao, Xue, Kossenkov, Andrew V., Simon, M. Celeste, Zhang, Rugang

“…Methyltransferase-like 3 (METTL3) and 14 (METTL14) are core subunits of the methyltransferase complex that catalyses messenger RNA N 6 -methyladenosine (m 6 A)…”
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NAD+ metabolism controls inflammation during senescence by Nacarelli, Timothy, Zhang, Rugang

“…We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during…”
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Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma by Wu, Shuai, Fukumoto, Takeshi, Lin, Jianhuang, Nacarelli, Timothy, Wang, Yemin, Ong, Dionzie, Liu, Heng, Fatkhutdinov, Nail, Zundell, Joseph A, Karakashev, Sergey, Zhou, Wei, Schwartz, Lauren E, Tang, Hsin-Yao, Drapkin, Ronny, Liu, Qin, Huntsman, David G, Kossenkov, Andrew V, Speicher, David W, Schug, Zachary T, Van Dang, Chi, Zhang, Rugang

“…Alterations in components of the SWI/SNF chromatin-remodeling complex occur in ~20% of all human cancers. For example, is mutated in up to 62% of clear cell…”
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N6-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance by Fukumoto, Takeshi, Zhu, Hengrui, Nacarelli, Timothy, Karakashev, Sergey, Fatkhutdinov, Nail, Wu, Shuai, Liu, Pingyu, Kossenkov, Andrew V., Showe, Louise C., Jean, Stephanie, Zhang, Lin, Zhang, Rugang

“…Abstract Despite the high initial response rates to PARP inhibitors (PARPi) in BRCA-mutated epithelial ovarian cancers (EOC), PARPi resistance remains a major…”
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ARID1A mutation and genomic stability by Nacarelli, Timothy, Zhao, Bo, Hao, Xue, Zhang, Rugang

“…We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit…”
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Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer by Fukumoto, Takeshi, Park, Pyoung Hwa, Wu, Shuai, Fatkhutdinov, Nail, Karakashev, Sergey, Nacarelli, Timothy, Kossenkov, Andrew V., Speicher, David W., Jean, Stephanie, Zhang, Lin, Wang, Tian-Li, Shih, Ie-Ming, Conejo-Garcia, Jose R., Bitler, Benjamin G., Zhang, Rugang

“…ARID1A, a subunit of the SWI/SNF complex, is among the most frequently mutated genes across cancer types. ARID1A is mutated in more than 50% of ovarian clear…”
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m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype by Liu, Pingyu, Li, Fuming, Lin, Jianhuang, Fukumoto, Takeshi, Nacarelli, Timothy, Hao, Xue, Kossenkov, Andrew V., Simon, M. Celeste, Zhang, Rugang

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Targeting metabolism in cellular senescence, a role for intervention by Nacarelli, Timothy, Sell, Christian

“…Cellular senescence has gained much attention as a contributor to aging and susceptibility to disease. Senescent cells undergo a stable cell cycle arrest and…”
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Aberrant mTOR activation in senescence and aging: A mitochondrial stress response? by Nacarelli, Timothy, Azar, Ashley, Sell, Christian

“…Unexpected activation of mTOR signaling, measured by ribosomal S6 phosphorylation or ribosomal S6 kinase (p70S6K) activity, has been reported in aging-related…”
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Mitochondrial stress induces cellular senescence in an mTORC1-dependent manner by Nacarelli, Timothy, Azar, Ashley, Sell, Christian

“…Although mitochondrial stress is a key determinant of cellular homeostasis, the intracellular mechanisms by which this stress is communicated to the nucleus…”
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Metabolic stress as a trigger for cellular senescence by Nacarelli, Timothy, Sell, Christian

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NAMPT Inhibition Suppresses Cancer Stem-like Cells Associated with Therapy-Induced Senescence in Ovarian Cancer by Nacarelli, Timothy, Fukumoto, Takeshi, Zundell, Joseph A, Fatkhutdinov, Nail, Jean, Stephanie, Cadungog, Mark G, Borowsky, Mark E, Zhang, Rugang

“…Epithelial ovarian cancer (EOC) is the most lethal of gynecologic malignancies. The standard-of-care treatment for EOC is platinum-based chemotherapy such as…”
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N 6 -Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance by Fukumoto, Takeshi, Zhu, Hengrui, Nacarelli, Timothy, Karakashev, Sergey, Fatkhutdinov, Nail, Wu, Shuai, Liu, Pingyu, Kossenkov, Andrew V, Showe, Louise C, Jean, Stephanie, Zhang, Lin, Zhang, Rugang

“…Despite the high initial response rates to PARP inhibitors (PARPi) in -mutated epithelial ovarian cancers (EOC), PARPi resistance remains a major challenge…”
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Mitochondrial dysfunction influences mTORC1 and triggers premature senescence by Nacarelli, Timothy, Sell, Christian

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