Search Results - "Nabeshima, Yo‐ichi"

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men by Irie, Junichiro, Inagaki, Emi, Fujita, Masataka, Nakaya, Hideaki, Mitsuishi, Masanori, Yamaguchi, Shintaro, Yamashita, Kazuya, Shigaki, Shuhei, Ono, Takashi, Yukioka, Hideo, Okano, Hideyuki, Nabeshima, Yo-ichi, Imai, Shin-ichiro, Yasui, Masato, Tsubota, Kazuo, Itoh, Hiroshi

“…Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches…”
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Vasculature-Associated Niche for Undifferentiated Spermatogonia in the Mouse Testis by Yoshida, Shosei, Sukeno, Mamiko, Nabeshima, Yo-ichi

“…Mammalian spermatogenesis produces numerous sperm for a long period based on a highly potent stem cell system, which relies on a special microenvironment, or…”
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Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis by Yanagihashi, Yuichi, Segawa, Katsumori, Maeda, Ryota, Nabeshima, Yo-ichi, Nagata, Shigekazu

“…Protein S (ProS) and growth arrest-specific 6 (Gas6) bind to phosphatidylserine (PtdSer) and induce efferocytosis upon binding TAM-family receptors (Tyro3,…”
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Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment by Nakagawa, Toshinori, Sharma, Manju, Nabeshima, Yo-ichi, Braun, Robert E, Yoshida, Shosei

“…Stem cells support tissue maintenance by balancing self-renewal and differentiation. In mice, it is believed that a homogeneous stem cell population of single…”
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Functional Identification of the Actual and Potential Stem Cell Compartments in Mouse Spermatogenesis by Nakagawa, Toshinori, Nabeshima, Yo-ichi, Yoshida, Shosei

“…To clarify the mechanisms that support the continuity of actively cycling tissues of long-lived organisms, we investigated the composition of a mouse…”
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Rab21 regulates caveolin‐1‐mediated endocytic trafficking to promote immature neurite pruning by Shikanai, Mima, Ito, Shiho, Nishimura, Yoshiaki V, Akagawa, Remi, Fukuda, Mitsunori, Yuzaki, Michisuke, Nabeshima, Yo‐ichi, Kawauchi, Takeshi

“…Transmembrane proteins are internalized by clathrin‐ and caveolin‐dependent endocytosis. Both pathways converge on early endosomes and are thought to share the…”
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NRF2 pathway activation attenuates ageing-related renal phenotypes due to α-klotho deficiency by Zhao, Mingyue, Murakami, Shohei, Matsumaru, Daisuke, Kawauchi, Takeshi, Nabeshima, Yo-ichi, Motohashi, Hozumi

“…Abstract Oxidative stress is one of the major causes of the age-related functional decline in cells and tissues. The KEAP1–NRF2 system plays a central role in…”
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Unique multipotent cells in adult human mesenchymal cell populations by Kuroda, Yasumasa, Kitada, Masaaki, Wakao, Shohei, Nishikawa, Kouki, Tanimura, Yukihiro, Makinoshima, Hideki, Goda, Makoto, Akashi, Hideo, Inutsuka, Ayumu, Niwa, Akira, Shigemoto, Taeko, Nabeshima, Yoko, Nakahata, Tatsutoshi, Nabeshima, Yo-ichi, Fujiyoshi, Yoshinori, Dezawa, Mari

“…We found adult human stem cells that can generate, from a single cell, cells with the characteristics of the three germ layers. The cells are stress-tolerant…”
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Rab GTPases-Dependent Endocytic Pathways Regulate Neuronal Migration and Maturation through N-Cadherin Trafficking by Kawauchi, Takeshi, Sekine, Katsutoshi, Shikanai, Mima, Chihama, Kaori, Tomita, Kenji, Kubo, Ken-ichiro, Nakajima, Kazunori, Nabeshima, Yo-ichi, Hoshino, Mikio

“…Although membrane trafficking pathways are involved in basic cellular functions, the evolutionally expanded number of their related family proteins suggests…”
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Reduced renal α-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism by Sakan, Hirokazu, Nakatani, Kimihiko, Asai, Osamu, Imura, Akihiro, Tanaka, Tomohiro, Yoshimoto, Shuhei, Iwamoto, Noriyuki, Kurumatani, Norio, Iwano, Masayuki, Nabeshima, Yo-Ichi, Konishi, Noboru, Saito, Yoshihiko

“…Renal α-Klotho (α-KL) plays a fundamental role as a co-receptor for fibroblast growth factor 23 (FGF23), a phosphaturic hormone and regulator of 1,25(OH)2…”
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Simple method for large-scale production of macrophage activating factor GcMAF by Nabeshima, Yoko, Abe, Chiaki, Kawauchi, Takeshi, Hiroi, Tomoko, Uto, Yoshihiro, Nabeshima, Yo-ichi

“…Human group-specific component protein (Gc protein) is a multifunctional serum protein which has three common allelic variants, Gc1F, Gc1S and Gc2 in humans…”
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Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects by Yamazaki, Yuji, Imura, Akihiro, Urakawa, Itaru, Shimada, Takashi, Murakami, Junko, Aono, Yukiko, Hasegawa, Hisashi, Yamashita, Takeyoshi, Nakatani, Kimihiko, Saito, Yoshihiko, Okamoto, Nozomi, Kurumatani, Norio, Namba, Noriyuki, Kitaoka, Taichi, Ozono, Keiichi, Sakai, Tomoyuki, Hataya, Hiroshi, Ichikawa, Shoji, Imel, Erik A., Econs, Michael J., Nabeshima, Yo-ichi

“…► We established a detection system to measure human serum soluble α-Klotho (sαKl). ► We found that Age influences serum sαKl levels in a normal population. ►…”
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Establishment of a highly sensitive sandwich ELISA for the N-terminal fragment of titin in urine by Maruyama, Nobuhiro, Asai, Tsuyoshi, Abe, Chiaki, Inada, Akari, Kawauchi, Takeshi, Miyashita, Kazuya, Maeda, Masahiro, Matsuo, Masafumi, Nabeshima, Yo-ichi

“…Muscle damage and loss of muscle mass are triggered by immobilization, loss of appetite, dystrophies and chronic wasting diseases. In addition, physical…”
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Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly by Ohnishi, Takayuki, Yanazawa, Masako, Sasahara, Tomoya, Kitamura, Yasuki, Hiroaki, Hidekazu, Fukazawa, Yugo, Kii, Isao, Nishiyama, Takashi, Kakita, Akiyoshi, Takeda, Hiroyuki, Takeuchi, Akihide, Arai, Yoshie, Ito, Akane, Komura, Hitomi, Hirao, Hajime, Satomura, Kaori, Inoue, Masafumi, Muramatsu, Shin-ichi, Matsui, Ko, Tada, Mari, Sato, Michio, Saijo, Eri, Shigemitsu, Yoshiki, Sakai, Satoko, Umetsu, Yoshitaka, Goda, Natsuko, Takino, Naomi, Takahashi, Hitoshi, Hagiwara, Masatoshi, Sawasaki, Tatsuya, Iwasaki, Genji, Nakamura, Yu, Nabeshima, Yo-ichi, Teplow, David B., Hoshi, Minako

“…Neurodegeneration correlates with Alzheimer’s disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their…”
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Diagnostic and clinical significance of the titin fragment in urine of Duchenne muscular dystrophy patients by Awano, Hiroyuki, Matsumoto, Masaaki, Nagai, Masashi, Shirakawa, Taku, Maruyama, Nobuhiro, Iijima, Kazumoto, Nabeshima, Yo-ichi, Matsuo, Masafumi

“…Duchenne muscular dystrophy (DMD) is a fatal progressive muscle wasting disease of childhood. Titin in sarcomere is digested by calcium dependent protease. To…”
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Specification of spatial identities of cerebellar neuron progenitors by ptf1a and atoh1 for proper production of GABAergic and glutamatergic neurons by Yamada, Mayumi, Seto, Yusuke, Taya, Shinichiro, Owa, Tomoo, Inoue, Yukiko U, Inoue, Takayoshi, Kawaguchi, Yoshiya, Nabeshima, Yo-Ichi, Hoshino, Mikio

“…In the cerebellum, the bHLH transcription factors Ptf1a and Atoh1 are expressed in distinct neuroepithelial regions, the ventricular zone (VZ) and the rhombic…”
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translocation causing increased α-Klotho level results in hypophosphatemic rickets and hyperparathyroidism by Brownstein, Catherine A, Adler, Felix, Nelson-Williams, Carol, Iijima, Junko, Li, Peining, Imura, Akihiro, Nabeshima, Yo-ichi, Reyes-Mugica, Miguel, Carpenter, Thomas O, Lifton, Richard P

“…Phosphate homeostasis is central to diverse physiologic processes including energy homeostasis, formation of lipid bilayers, and bone formation. Reduced…”
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Relevant use of Klotho in FGF19 subfamily signaling system in vivo by Tomiyama, Ken-ichi, Maeda, Ryota, Urakawa, Itaru, Yamazaki, Yuji, Tanaka, Tomohiro, Ito, Shinji, Nabeshima, Yoko, Tomita, Tsutomu, Odori, Shinji, Hosoda, Kiminori, Nakao, Kazuwa, Imura, Akihiro, Nabeshima, Yo-ichi

“…α-Klotho (α-Kl) and its homolog, β-Klotho (β-Kl) are key regulators of mineral homeostasis and bile acid/cholesterol metabolism, respectively. FGF15/…”
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Clinical effects of wasabi extract containing 6-MSITC on myalgic encephalomyelitis/chronic fatigue syndrome: an open-label trial by Oka, Takakazu, Yamada, Yu, Lkhagvasuren, Battuvshin, Nakao, Mutsuhiro, Nakajima, Ryota, Kanou, Masanobu, Hiramatsu, Ryuji, Nabeshima, Yo-Ichi

“…Wasabi (Eutrema japonicum) is a common pungent spice used in Japan. 6-Methylsulfinylhexyl isothiocyanate (6-MSITC) found in the rhizome of wasabi has been…”
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The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage by Yoshida, Shosei, Sukeno, Mamiko, Nakagawa, Toshinori, Ohbo, Kazuyuki, Nagamatsu, Go, Suda, Toshio, Nabeshima, Yo-ichi

“…Mammalian spermatogenesis is maintained by a continuous supply of differentiating cells from self-renewing stem cells. The stem cell activity resides in a…”
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