Search Results - "Nabel, Christopher S."

International, evidence-based consensus diagnostic criteria for HHV-8–negative/idiopathic multicentric Castleman disease by Fajgenbaum, David C., Uldrick, Thomas S., Bagg, Adam, Frank, Dale, Wu, David, Srkalovic, Gordan, Simpson, David, Liu, Amy Y., Menke, David, Chandrakasan, Shanmuganathan, Lechowicz, Mary Jo, Wong, Raymond S.M., Pierson, Sheila, Paessler, Michele, Rossi, Jean-François, Ide, Makoto, Ruth, Jason, Croglio, Michael, Suarez, Alexander, Krymskaya, Vera, Chadburn, Amy, Colleoni, Gisele, Nasta, Sunita, Jayanthan, Raj, Nabel, Christopher S., Casper, Corey, Dispenzieri, Angela, Fosså, Alexander, Kelleher, Dermot, Kurzrock, Razelle, Voorhees, Peter, Dogan, Ahmet, Yoshizaki, Kazuyuki, van Rhee, Frits, Oksenhendler, Eric, Jaffe, Elaine S., Elenitoba-Johnson, Kojo S.J., Lim, Megan S.

“…Human herpesvirus-8 (HHV-8)–negative, idiopathic multicentric Castleman disease (iMCD) is a rare and life-threatening disorder involving systemic inflammatory…”
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Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor by Sun, Zheng, Feng, Dan, Fang, Bin, Mullican, Shannon E., You, Seo-Hee, Lim, Hee-Woong, Everett, Logan J., Nabel, Christopher S., Li, Yun, Selvakumaran, Vignesh, Won, Kyoung-Jae, Lazar, Mitchell A.

“…Histone deacetylases (HDACs) are believed to regulate gene transcription by catalyzing deacetylation reactions. HDAC3 depletion in mouse liver upregulates…”
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Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease by Fajgenbaum, David C, Langan, Ruth-Anne, Japp, Alberto Sada, Partridge, Helen L, Pierson, Sheila K, Singh, Amrit, Arenas, Daniel J, Ruth, Jason R, Nabel, Christopher S, Stone, Katie, Okumura, Mariko, Schwarer, Anthony, Jose, Fábio Freire, Hamerschlak, Nelson, Wertheim, Gerald B, Jordan, Michael B, Cohen, Adam D, Krymskaya, Vera, Rubenstein, Arthur, Betts, Michael R, Kambayashi, Taku, van Rhee, Frits, Uldrick, Thomas S

“…Idiopathic multicentric Castleman disease (iMCD) is a hematologic illness involving cytokine-induced lymphoproliferation, systemic inflammation, cytopenias,…”
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Identification of DHODH as a therapeutic target in small cell lung cancer by Li, Leanne, Ng, Sheng Rong, Colón, Caterina I, Drapkin, Benjamin J, Hsu, Peggy P, Li, Zhaoqi, Nabel, Christopher S, Lewis, Caroline A, Romero, Rodrigo, Mercer, Kim L, Bhutkar, Arjun, Phat, Sarah, Myers, David T, Muzumdar, Mandar Deepak, Westcott, Peter M K, Beytagh, Mary Clare, Farago, Anna F, Vander Heiden, Matthew G, Dyson, Nicholas J, Jacks, Tyler

“…Small cell lung cancer (SCLC) is an aggressive lung cancer subtype with extremely poor prognosis. No targetable genetic driver events have been identified, and…”
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Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV‐8‐negative multicentric Castleman disease by Iwaki, Noriko, Fajgenbaum, David C., Nabel, Christopher S., Gion, Yuka, Kondo, Eisei, Kawano, Mitsuhiro, Masunari, Taro, Yoshida, Isao, Moro, Hiroshi, Nikkuni, Koji, Takai, Kazue, Matsue, Kosei, Kurosawa, Mitsutoshi, Hagihara, Masao, Saito, Akio, Okamoto, Masataka, Yokota, Kenji, Hiraiwa, Shinichiro, Nakamura, Naoya, Nakao, Shinji, Yoshino, Tadashi, Sato, Yasuharu

“…Multicentric Castleman disease (MCD) describes a heterogeneous group of disorders involving systemic inflammation, characteristic lymph node histopathology,…”
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The Curious Chemical Biology of Cytosine: Deamination, Methylation,and Oxidation as Modulators of Genomic Potential by Nabel, Christopher S., Manning, Sara A., Kohli, Rahul M.

“…A multitude of functions have evolved around cytosine within DNA, endowing the base with physiological significance beyond simple information storage. This…”
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Idiopathic multicentric Castleman's disease: a systematic literature review by Liu, Amy Y, Nabel, Christopher S, MD, Finkelman, Brian S, PhD, Ruth, Jason R, PhD, Kurzrock, Razelle, Prof, van Rhee, Frits, Prof, Krymskaya, Vera P, Prof, Kelleher, Dermot, Prof, Rubenstein, Arthur H, Prof, Fajgenbaum, David C, Dr

“…Summary Background Multicentric Castleman's disease describes a group of poorly understood lymphoproliferative disorders driven by proinflammatory…”
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Plasma proteomics identifies a ‘chemokine storm’ in idiopathic multicentric Castleman disease by Pierson, Sheila K., Stonestrom, Aaron J., Shilling, Dustin, Ruth, Jason, Nabel, Christopher S., Singh, Amrit, Ren, Yue, Stone, Katie, Li, Hongzhe, van Rhee, Frits, Fajgenbaum, David C.

“…Human Herpesvirus‐8 (HHV‐8)‐negative/idiopathic multicentric Castleman disease (iMCD) is a poorly understood disease involving polyclonal lymphoproliferation…”
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Ebolavirus Proteins Suppress the Effects of Small Interfering RNA by Direct Interaction with the Mammalian RNA Interference Pathway by FABOZZI, Giulia, NABEL, Christopher S, DOLAN, Michael A, SULLIVAN, Nancy J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Tet2 Catalyzes Stepwise 5‑Methylcytosine Oxidation by an Iterative and de novo Mechanism by Crawford, Daniel J, Liu, Monica Yun, Nabel, Christopher S, Cao, Xing-Jun, Garcia, Benjamin A, Kohli, Rahul M

“…Modification of cytosine-guanine dinucleotides (CpGs) is a key part of mammalian epigenetic regulation and helps shape cellular identity. Tet enzymes catalyze…”
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Virome capture sequencing does not identify active viral infection in unicentric and idiopathic multicentric Castleman disease by Nabel, Christopher S, Sameroff, Stephen, Shilling, Dustin, Alapat, Daisy, Ruth, Jason R, Kawano, Mitsuhiro, Sato, Yasuharu, Stone, Katie, Spetalen, Signe, Valdivieso, Federico, Feldman, Michael D, Chadburn, Amy, Fosså, Alexander, van Rhee, Frits, Lipkin, W Ian, Fajgenbaum, David C

“…Castleman disease (CD) describes a spectrum of heterogeneous disorders defined by characteristic lymph node histopathology. Enlarged lymph nodes demonstrating…”
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Anti‐PD‐1 Immunotherapy‐Induced Flare of a Known Underlying Relapsing Vasculitis Mimicking Recurrent Cancer by Nabel, Christopher S., Severgnini, Mariano, Hung, Yin P., Cunningham‐Bussel, Amy, Gjini, Evisa, Kleinsteuber, Katja, Seymour, Lake J., Holland, Martha K., Cunningham, Rachel, Felt, Kristin D., Vivero, Marina, Rodig, Scott J., Massarotti, Elena M., Rahma, Osama E., Harshman, Lauren C.

“…Safe use of immune checkpoint blockade in patients with cancer and autoimmune disorders requires a better understanding of the pathophysiology of immunologic…”
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Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase by Nabel, Christopher S., Lee, Jae W., Wang, Laura C., Kohli, Rahul M.

“…Activation-induced deaminase (AID), a member of the larger AID/APOBEC family, is the key catalyst in initiating antibody somatic hypermutation and class-switch…”
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Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability by Abbott, Keene L, Ali, Ahmed, Reinfeld, Bradley I, Deik, Amy, Subudhi, Sonu, Landis, Madelyn D, Hongo, Rachel A, Young, Kirsten L, Kunchok, Tenzin, Nabel, Christopher S, Crowder, Kayla D, Kent, Johnathan R, Madariaga, Maria Lucia L, Jain, Rakesh K, Beckermann, Kathryn E, Lewis, Caroline A, Clish, Clary B, Muir, Alexander, Rathmell, W Kimryn, Rathmell, Jeffrey, Vander Heiden, Matthew G

“…The tumor microenvironment is a determinant of cancer progression and therapeutic efficacy, with nutrient availability playing an important role. Although it…”
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AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation by Nabel, Christopher S, Jia, Huijue, Ye, Yu, Shen, Li, Goldschmidt, Hana L, Stivers, James T, Zhang, Yi, Kohli, Rahul M

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HHV-8-negative, idiopathic multicentric Castleman disease: novel insights into biology, pathogenesis, and therapy by Fajgenbaum, David C., van Rhee, Frits, Nabel, Christopher S.

“…Multicentric Castleman's disease (MCD) describes a heterogeneous group of disorders involving proliferation of morphologically benign lymphocytes due to…”
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Macrophages dig into the obesity paradox in cancer by Nabel, Christopher S, Gourgue, Florian, Vander Heiden, Matthew G

“…Response to immune checkpoint blockade is increased in obesity-related cancers, but the mechanisms remain unclear. In a recent issue of Nature, Bader et al…”
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Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase by Schutsky, Emily K, DeNizio, Jamie E, Hu, Peng, Liu, Monica Yun, Nabel, Christopher S, Fabyanic, Emily B, Hwang, Young, Bushman, Frederic D, Wu, Hao, Kohli, Rahul M

“…A bisulfite-free sequencing method yields high-confidence 5hmC profiles in low-input samples. Here we present APOBEC-coupled epigenetic sequencing (ACE-seq), a…”
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Nucleotide imbalance decouples cell growth from cell proliferation by Diehl, Frances F., Miettinen, Teemu P., Elbashir, Ryan, Nabel, Christopher S., Darnell, Alicia M., Do, Brian T., Manalis, Scott R., Lewis, Caroline A., Vander Heiden, Matthew G.

“…Nucleotide metabolism supports RNA synthesis and DNA replication to enable cell growth and division. Nucleotide depletion can inhibit cell growth and…”
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AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation by Nabel, Christopher S, Jia, Huijue, Ye, Yu, Shen, Li, Goldschmidt, Hana L, Stivers, James T, Zhang, Yi, Kohli, Rahul M

“…AID/APOBEC deaminases, which convert cytosine bases to uracils in DNA and RNA, have recently been assigned a role in epigenetic regulation as components of DNA…”
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