Probiotic yogurt improves body mass index and fasting insulin levels without affecting serum leptin and adiponectin levels in non-alcoholic fatty liver disease (NAFLD)

Probiotic yogurt improves body mass index and fasting insulin levels without affecting serum leptin and adiponectin levels in non-alcoholic fatty liver disease (NAFLD)

•Effects of probiotic yogurt were investigated in NAFLD.•Probiotic yogurt consumption improved body mass index and insulin levels.•Probiotic yogurt consumption had no marked effect on serum leptin and adiponectin. There is evidence of possible beneficial effects of probiotic products in non-alcoholi...

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Bibliographic Details
Published in:Journal of functional foods Vol. 18; pp. 684 - 691
Main Authors: Nabavi, Safoora, Rafraf, Maryam, Somi, Mohammad-hossein, Homayouni-Rad, Aziz, Asghari-Jafarabadi, Mohammad
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-10-2015
Elsevier
Subjects:
Adiponectin
Insulin
Leptin
Non-alcoholic fatty liver disease
Obesity values
Probiotic yogurt
NAFLD
PUFA
MUFA
IR
WC
Probiotic yogurt
SCFA
Insulin
PPARγ
SFA
Adiponectin
cfu
Leptin
HOMA
ANGPTL4
Non-alcoholic fatty liver disease
Obesity values
BMI
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Summary:•Effects of probiotic yogurt were investigated in NAFLD.•Probiotic yogurt consumption improved body mass index and insulin levels.•Probiotic yogurt consumption had no marked effect on serum leptin and adiponectin. There is evidence of possible beneficial effects of probiotic products in non-alcoholic fatty liver disease (NAFLD). Here the effects of probiotic yogurt consumption on obesity values, fasting insulin, insulin resistance, and serum leptin and adiponectin levels in NAFLD patients were investigated by a randomized double-blind controlled clinical trial. Seventy-two subjects, aged between 23 and 63 years, were divided into two groups. Subjects consumed either 300 g/day of probiotic yogurt or 300 g/day of conventional yogurt for 8 weeks. Probiotic yogurt consumption resulted in a significant reduction in weight, body mass index, and serum levels of fasting insulin as compared with that in the control group. No significant changes were observed in waist circumference, homeostasis model assessment insulin resistance, serum leptin, adiponectin, and leptin to adiponectin ratio in both groups. Our study suggests that probiotic yogurt consumption improved body mass index and insulin levels and may be applicable in reducing risk factors of NAFLD.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2015.08.031