Search Results - "Nabakooza, Grace"
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Phylogeography and reassortment patterns of human influenza A viruses in sub-Saharan Africa
Published in Scientific reports (16-08-2024)“…The role of sub-Saharan Africa in the global spread of influenza viruses remains unclear due to insufficient spatiotemporal sequence data. Here, we analyzed…”
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Sequence-matching adapter trimmers generate consistent quality and assembly metrics for Illumina sequencing of RNA viruses
Published in BMC research notes (14-10-2024)“…Trimming adapters and low-quality bases from next-generation sequencing (NGS) data is crucial for optimal analysis. We evaluated six trimming programs,…”
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Employing phylogenetic tree shape statistics to resolve the underlying host population structure
Published in BMC bioinformatics (10-11-2021)“…Host population structure is a key determinant of pathogen and infectious disease transmission patterns. Pathogen phylogenetic trees are useful tools to reveal…”
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Phylogenomic analysis uncovers a 9-year variation of Uganda influenza type-A strains from the WHO-recommended vaccines and other Africa strains
Published in Scientific reports (04-04-2023)“…Genetic characterisation of circulating influenza viruses directs annual vaccine strain selection and mitigation of infection spread. We used next-generation…”
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Immune Responses Following BCG Immunization of Infants in Uganda and United Kingdom Are Similar for Purified Protein Derivative but Differ for Secretory Proteins of Mycobacterium tuberculosis
Published in Frontiers in immunology (19-03-2021)“…The immunogenicity of BCG vaccination in infants differs between populations. We hypothesized that prenatal exposure to mycobacterial antigens might explain…”
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Maternal Latent Mycobacterium tuberculosis Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda
Published in Frontiers in immunology (14-05-2020)“…BCG has low efficacy in tropical countries. We hypothesized that maternal latent infection (LTBI) results in fetal tolerance to mycobacterial antigens and…”
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Whole-genome analysis to determine the rate and patterns of intra-subtype reassortment among influenza type-A viruses in Africa
Published in Virus evolution (2022)“…Abstract Influenza type-A viruses (IAVs) present a global burden of human respiratory infections and mortality. Genome reassortment is an important mechanism…”
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Molecular Epidemiology and Evolutionary Dynamics of Human Influenza Type-A Viruses in Africa: A Systematic Review
Published in Microorganisms (Basel) (25-04-2022)“…Genomic characterization of circulating influenza type-A viruses (IAVs) directs the selection of appropriate vaccine formulations and early detection of…”
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BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial
Published in The Lancet infectious diseases (01-07-2021)“…Trials done in infants with low birthweight in west Africa suggest that BCG vaccination reduces all-cause mortality in the neonatal period, probably because of…”
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Continuous research monitoring improves the quality of research conduct and compliance among research trainees: internal evaluation of a monitoring programme
Published in AAS open research (2020)“…Research site monitoring (RSM) is an effective way to ensure compliance with Good Clinical Practice (GCP). However, RSM is not offered to trainees…”
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