Search Results - "Naasani, Imad"

In vivo biodistribution studies and ex vivo lymph node imaging using heavy metal-free quantum dots by Yaghini, Elnaz, Turner, Helen D, Le Marois, Alix M, Suhling, Klaus, Naasani, Imad, MacRobert, Alexander J

“…Abstract Quantum dots (QDs) are attractive photoluminescence probes for biomedical imaging due to their unique photophysical properties. However, the potential…”
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Establishing the Pharmacokinetics of Genetic Vaccines is Essential for Maximising their Safety and Efficacy by Naasani, Imad

“…In a typical course of drug development, thorough pharmacokinetic (PK) studies are essential for the determination of drug biodistribution, dosage and efficacy…”
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Telomerase Inhibition, Telomere Shortening, and Senescence of Cancer Cells by Tea Catechins by Naasani, Imad, Seimiya, Hiroyuki, Tsuruo, Takashi

“…Animalin vivostudies and human epidemiological observations indicated potent anticancer effects for tea. Here we demonstrate that epigallocatechin gallate…”
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COMPARE Analysis, a Bioinformatic Approach to Accelerate Drug Repurposing against Covid-19 and Other Emerging Epidemics by Naasani, Imad

“…A novel bioinformatic approach for drug repurposing against emerging viral epidemics like Covid-19 is described. It exploits the COMPARE algorithm, a public…”
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Hypoxia Up-Regulates Telomerase Activity via Mitogen-Activated Protein Kinase Signaling in Human Solid Tumor Cells by Seimiya, Hiroyuki, Tanji, Masanori, Oh-hara, Tomoko, Tomida, Akihiro, Naasani, Imad, Tsuruo, Takashi

“…Solid tumor cells are often exposed to hypoxia in vivo, which has been suggested to promote genetic instability in those cells. Telomere elongation by…”
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In vivo biodistribution and toxicology studies of cadmium-free indium-based quantum dot nanoparticles in a rat model by Yaghini, Elnaz, Turner, Helen, Pilling, Andrew, Naasani, Imad, MacRobert, Alexander J.

“…Quantum dot (QD) nanoparticles are highly promising contrast agents and probes for biomedical applications owing to their excellent photophysical properties…”
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Photoactivable Polymers Embedded with Cadmium-Free Quantum Dots and Crystal Violet: Efficient Bactericidal Activity against Clinical Strains of Antibiotic-Resistant Bacteria by Owusu, Ethel G. A, MacRobert, Alexander J, Naasani, Imad, Parkin, Ivan P, Allan, Elaine, Yaghini, Elnaz

“…The rising incidence of antibiotic-resistant infections from contaminated surfaces in hospitals or implanted medical devices has led to increasing interest in…”
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Population pharmacokinetic modelling of indium-based quantum dot nanoparticles: preclinical in vivo studies by Yaghini, Elnaz, Tacconi, Elisa, Pilling, Andrew, Rahman, Paula, Broughton, Joe, Naasani, Imad, Keshtgar, Mohammed R.S., MacRobert, Alexander J., Della Pasqua, Oscar

“…There is considerable interest in biomedical applications of quantum dot (QD) nanoparticles, in particular their use as imaging agents for diagnostic…”
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Synergistic interactions of cadmium-free quantum dots embedded in a photosensitised polymer surface: efficient killing of multidrug-resistant strains at low ambient light levels by Owusu, Ethel G A, Yaghini, Elnaz, Naasani, Imad, Parkin, Ivan P, Allan, Elaine, MacRobert, Alexander J

“…Cadmium-free quantum dots (QD) were combined with crystal violet photosensitising dye and incorporated into medical grade polyurethane via a non-covalent…”
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Improving the Oral Bioavailability of Sulpiride by a Gastric-retained Form in Rabbits by KOHRI, NAONORI, NAASANI, IMAD, ISEKI, KEN, MIYAZAKI, KATSUMI

“…To improve the limited oral bioavailability of sulpiride, a gastric‐retained form was developed and evaluated using gastric‐emptying‐controlled rabbits. The…”
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Recommendations for clinical translation of nanoparticle-enhanced radiotherapy by Ricketts, Kate, Ahmad, Reem, Beaton, Laura, Cousins, Brian, Critchley, Kevin, Davies, Mark, Evans, Stephen, Fenuyi, Ifeyemi, Gavriilidis, Asterios, Harmer, Quentin J, Jayne, David, Jefford, Monica, Loizidou, Marilena, Macrobert, Alexander, Moorcroft, Sam, Naasani, Imad, Ong, Zhan Yuin, Prise, Kevin M, Rannard, Steve, Richards, Thomas, Schettino, Giuseppe, Sharma, Ricky A, Tillement, Olivier, Wakefield, Gareth, Williams, Norman R, Yaghini, Elnaz, Royle, Gary

“…A multi-disciplinary cooperative for nanoparticle-enhanced radiotherapy (NERT) has been formed to review the current status of the field and identify key…”
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Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo by NAASANI, Imad, OH-HASHI, Fujiko, OH-HARA, Tomoko, WAN YONG FENG, JOHNSTON, Jeffrey, CHAN, Kenneth, TSURUO, Takashi

“…Animal and epidemiological studies reveal that consuming food and beverages rich in polyphenols (e.g., catechins, flavones, and antocyanines) is associated…”
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Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991 by Seimiya, Hiroyuki, Oh-hara, Tomoko, Suzuki, Tsuneji, Naasani, Imad, Shimazaki, Toshiyuki, Tsuchiya, Katsutoshi, Tsuruo, Takashi

“…Epidemiological studies suggest potent anticancer effects of tea catechins. Previously, we have reported (I. Naasani et aL, Biochem. Biophys. Res. Commun.,…”
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Transport mechanisms of nucleosides and the derivative, 6-mercaptopurine riboside across rat intestinal brush-border membranes by Iseki, Ken, Sugawara, Mitsuru, Fujiwara, Toshie, Naasani, Imad, Kobayashi, Michiya, Miyazaki, Katsumi

“…Na +-driven nucleoside transport processes across rat intestinal brush-border membrane vesicles were investigated. 6-Mercaptopurine riboside (6-MPR), an…”
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Improving the oral bioavailability of sulpiride by sodium oleate in rabbits by Naasani, I, Kohri, N, Iseki, K, Miyazaki, K

“…To improve the limited oral bioavailability of sulpiride, a dosage form containing sodium oleate as an absorption enhancer was developed and evaluated using…”
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FJ5002 : A potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis by NAASANI, I, SEIMIYA, H, YAMORI, T, TSURUO, T

“…To facilitate the search for candidate telomerase inhibitors, we exploited the database of the disease-oriented screening program (DOS) available in our…”
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Screening with COMPARE analysis for telomerase inhibitors by Naasani, Imad, Yamori, Takao, Tsuruo, Takashi

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Telomere Shortening and Growth Inhibition of Human Cancer Cells by Novel Synthetic Telomerase Inhibitors MST-312, MST-295, and MST-199 1 Supported in part by a Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science and Technology, Japan. 1 by Hiroyuki Seimiya, Tomoko Oh-hara, Tsuneji Suzuki, Imad Naasani, Toshiyuki Shimazaki, Katsutoshi Tsuchiya, Takashi Tsuruo

“…Epidemiological studies suggest potent anticancer effects of tea catechins. Previously, we have reported (I. Naasani et al., Biochem. Biophys. Res. Commun.,…”
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Multiplicity of the H+-dependent transport mechanism of dipeptide and anionic beta-lactam antibiotic ceftibuten in rat intestinal brush-border membrane by Iseki, K, Sugawara, M, Sato, K, Naasani, I, Hayakawa, T, Kobayashi, M, Miyazaki, K

“…To elucidate the transport characteristics of the H+/dipeptide carrier that recognizes the orally active beta-lactam antibiotic ceftibuten, the uptake…”
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Comparison of the transport characteristics of ceftibuten in rat renal and intestinal brush-border membranes by Naasani, Imad, Sato, Kaori, Iseki, Ken, Sugawara, Mitsuru, Kobayashi, Michiya, Miyazaki, Katsumi

“…The transport characteristics of ceftibuten, a dianionic cephem antibiotic, in rat renal and intestinal brush-border membranes were compared. Ceftibuten…”
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