Search Results - "NZILA, A. M"

Towards an Understanding of the Mechanism of Pyrimethamine-Sulfadoxine Resistance in Plasmodium falciparum: Genotyping of Dihydrofolate Reductase and Dihydropteroate Synthase of Kenyan Parasites by NZILA, A. M, MBERU, E. K, SULO, J, DAYO, H, WINSTANLEY, P. A, SIBLEY, C. H, WATKINS, W. M

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The role of sequential administration of sulphadoxine/pyrimethamine following quinine in the treatment of severe falciparum malaria in children by Ogutu, B. R., Nzila, A. M., Ochong, E., Mithwani, S., Wamola, B., Olola, C. H. O., Lowe, B., Kokwaro, G. O., Marsh, K., Newton, C. R. J. C.

“…Summary Sulphadoxine/pyrimethamine (SP) is often administered with quinine in the treatment of severe falciparum malaria to shorten the course of quinine. The…”
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Genetic diversity of Plasmodium falciparum parasites from Kenya is not affected by antifolate drug selection by Nzila, A.M, Mberu, E.K, Nduati, E, Ross, A, Watkins, W.M, Sibley, C.H

“…The genotypes of merozoite surface protein-1, merozoite surface protein-2 and glutamine rich protein are frequently used to distinguish recrudescence from…”
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The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya by Mberu, E K, Mosobo, M K, Nzila, A M, Kokwaro, G O, Sibley, C H, Watkins, W M

“…Two clinical trials that used Falcidin (Cosmos Ltd., Nairobi, Kenya), the antifolate combination of pyrimethamine/sulfadoxine (PM/SD), as treatment for…”
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Pyrimethamine–sulfadoxine resistance in Plasmodium falciparum: what next? by Sibley, Carol Hopkins, Hyde, John E, Sims, Paul F.G, Plowe, Christopher V, Kublin, James G, Mberu, Edward K, Cowman, Alan F, Winstanley, Peter A, Watkins, William M, Nzila, Alexis M

“…Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where >90% of the world's burden of malaria mortality and…”
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Characteristics of Plasmodium falciparum dhfr Haplotypes That Confer Pyrimethamine Resistance, Kilifi, Kenya, 1987–2006 by Certain, Laura K., Briceño, Marnie, Kiara, Steven M., Nzila, Alexis M., Watkins, William M., Sibley, Carol Hopkins

“…Resistance to the antimalarial drug sulfadoxine-pyrimethamine (SP) emerged in Plasmodium falciparum from Asia in the 1960s and subsequently spread to Africa…”
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Molecular Evidence of Greater Selective Pressure for Drug Resistance Exerted by the Long-Acting Antifolate Pyrimethamine/Sulfadoxine Compared with the Shorter-Acting Chlorproguanil/Dapsone on Kenyan Plasmodium falciparum by Nzila, Alexis M., Nduati, Eunice, Mberu, Edward K., Hopkins Sibley, Carol, Monks, Stephanie A., Winstanley, Peter A., Watkins, William M.

“…Pyrimethamine (PM) plus sulfadoxine (SD) is the last remaining affordable drug for treating uncomplicated malaria in Africa. The selective pressure exerted by…”
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Sulfa drugs strike more than once by Patel, Onisha G., Mberu, Eddy K., Nzila, Alexis M., Macreadie, Ian G.

“…Sulfa drugs are well known blockers of folate synthesis, acting as competitive inhibitors of p-aminobenzoate (pABA). Their mimicry of pABA is so complete that…”
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Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate pyrimethamine/sulfadoxine compared with the shorter-acting chlorproguanilldapsone on Kenyan Plasmodium falciparum by NZILA, A. M, NDUATI, E, MBERU, E. K, SIBLEY, C. H, MONKS, S. A, WINSTANLEY, P. A, WATKINS, W. M

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Therapeutic potential of folate uptake inhibition in Plasmodium falciparum by Nzila, Alexis M., Kokwaro, Gilbert, Winstanley, Peter A., Marsh, Kevin, Ward, Steve A.

“…Plasmodium falciparum parasites resistant to the combination sulfadoxine–pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter…”
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Plasmodium falciparum: in vitro activity of sulfadoxine and dapsone in field isolates from Kenya: point mutations in dihydropteroate synthase may not be the only determinants in sulfa resistance by Mberu, Edward K, Nzila, Alexis M, Nduati, Eunice, Ross, Amanda, Monks, Stephanie M, Kokwaro, Gilbert O, Watkins, William M, Hopkins Sibley, Carol

“…We have determined the relationship between point mutations in the gene that encodes the sulfa target, dihydropteroate synthase (DHPS) and the chemosensitivity…”
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