Search Results - "NYKÄNEN, Antti I"

Creating superior lungs for transplantation with next-generation gene therapy during ex vivo lung perfusion by Nykänen, Antti I., Keshavjee, Shaf, Liu, Mingyao

“…Engineering donor organs to better tolerate the harmful non-immunological and immunological responses inherently related to solid organ transplantation would…”
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Donor Simvastatin Treatment in Liver Transplantation: Post Hoc Analysis of a Randomized Placebo-controlled Trial With Long-term Follow-up by Åberg, Fredrik, Nykänen, Antti I., Helanterä, Ilkka, Lemström, Karl

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Targeting Lymphatic Vessel Activation and CCL21 Production by Vascular Endothelial Growth Factor Receptor-3 Inhibition Has Novel Immunomodulatory and Antiarteriosclerotic Effects in Cardiac Allografts by NYKÄNEN, Antti I, SANDELIN, Henrik, ALITALO, Kari, LEMSTRÖM, Karl B, KREBS, Rainer, KERÄNEN, Mikko A. I, TUUMINEN, Raimo, KÄRPÄNEN, Terhi, YAN WU, PYTOWSKI, Bronislaw, KOSKINEN, Petri K, YLÄ-HERTTUALA, Seppo

“…Lymphatic network and chemokine-mediated signals are essential for leukocyte traffic during the proximal steps of alloimmune response. We aimed to determine…”
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Mesenchymal Stromal Cell Therapy in Lung Transplantation by Nykänen, Antti I, Liu, Mingyao, Keshavjee, Shaf

“…Lung transplantation is often the only viable treatment option for a patient with end-stage lung disease. Lung transplant results have improved substantially…”
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Donor Simvastatin Treatment Abolishes Rat Cardiac Allograft Ischemia/Reperfusion Injury and Chronic Rejection Through Microvascular Protection by TUUMINEN, Raimo, SYRJALA, Simo, KREBS, Rainer, KERÄNEN, Mikko A. I, KOLI, Katri, ABO-RAMADAN, Usama, NEUVONEN, Pertti J, TIKKANEN, Jussi M, NYKANEN, Antti I, LEMSTRÖM, Karl B

“…Ischemia/reperfusion injury may have deleterious short- and long-term consequences for cardiac allografts. The underlying mechanisms involve microvascular…”
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Upregulation of Coagulation Factor VIII and Fibrinogen After Pulmonary Endarterectomy in Patients with Chronic Thromboembolic Pulmonary Hypertension by Myllylahti, Lasse, Ropponen, Jussi, Lax, Mikko, Lassila, Riitta, Nykänen, Antti I.

“…Objectives Chronic thromboembolic pulmonary hypertension (CTEPH) is associated with thrombotic states including elevated coagulation factor VIII (FVIII)…”
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VEGF Pathways in the Lymphatics of Healthy and Diseased Heart by Dashkevich, Alexey, Hagl, Christian, Beyersdorf, Friedhelm, Nykänen, Antti I., Lemström, Karl B.

“…Cardiac lymphatic system is a rare focus of the modern cardiovascular research. Nevertheless, the growing body of evidence is depicting lymphatic endothelium…”
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Transcriptomic Landscape of Circulating Extracellular Vesicles in Heart Transplant Ischemia-Reperfusion by Joo, SeoJeong, Dhaygude, Kishor, Westerberg, Sofie, Krebs, Rainer, Puhka, Maija, Holmström, Emil, Syrjälä, Simo, Nykänen, Antti I, Lemström, Karl

“…Ischemia-reperfusion injury (IRI) is an inevitable event during heart transplantation, which is known to exacerbate damage to the allograft. However, the…”
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Critical Role of VEGF-C/VEGFR-3 Signaling in Innate and Adaptive Immune Responses in Experimental Obliterative Bronchiolitis by Krebs, Rainer, Tikkanen, Jussi M, Ropponen, Jussi O, Jeltsch, Michael, Jokinen, Janne J, Ylä-Herttuala, Seppo, Nykänen, Antti I, Lemström, Karl B

“…Chronic inflammation, a hallmark of obliterative bronchiolitis, is known to induce lymphangiogenesis. We therefore studied the role of lymphangiogenic vascular…”
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Lung Transplant Immunomodulation with Genetically Engineered Mesenchymal Stromal Cells-Therapeutic Window for Interleukin-10 by Nykänen, Antti I, Mariscal, Andrea, Duong, Allen, Ali, Aadil, Takahagi, Akihiro, Bai, Xiaohui, Zehong, Guan, Joe, Betty, Takahashi, Mamoru, Chen, Manyin, Gokhale, Hemant, Shan, Hongchao, Hwang, David M, Estrada, Catalina, Yeung, Jonathan, Waddell, Tom, Martinu, Tereza, Juvet, Stephen, Cypel, Marcelo, Liu, Mingyao, Davies, John E, Keshavjee, Shaf

“…Lung transplantation results are compromised by ischemia-reperfusion injury and alloimmune responses. Ex vivo lung perfusion (EVLP) is used to assess marginal…”
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Engineered mesenchymal stromal cell therapy during human lung ex vivo lung perfusion is compromised by acidic lung microenvironment by Nykänen, Antti I., Mariscal, Andrea, Duong, Allen, Estrada, Catalina, Ali, Aadil, Hough, Olivia, Sage, Andrew, Chao, Bonnie T., Chen, Manyin, Gokhale, Hemant, Shan, Hongchao, Bai, Xiaohui, Zehong, Guan, Yeung, Jonathan, Waddell, Tom, Martinu, Tereza, Juvet, Stephen, Cypel, Marcelo, Liu, Mingyao, Davies, John E., Keshavjee, Shaf

“…Ex vivo lung perfusion (EVLP) is an excellent platform to apply novel therapeutics, such as gene and cell therapies, before lung transplantation. We…”
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Platelet-derived Growth Factor-B Protects Rat Cardiac Allografts From Ischemia-reperfusion Injury by Tuuminen, Raimo, Dashkevich, Alexey, Keränen, Mikko A I, Raissadati, Alireza, Krebs, Rainer, Jokinen, Janne J, Arnaudova, Ralica, Rouvinen, Eeva, Ylä-Herttuala, Seppo, Nykänen, Antti I, Lemström, Karl B

“…BACKGROUNDMicrovascular dysfunction and cardiomyocyte injury are hallmarks of ischemia-reperfusion injury (IRI) after heart transplantation. Platelet-derived…”
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Effect of Triclosan-Coated Sutures on the Incidence of Surgical Wound Infection After Lower Limb Revascularization Surgery: A Randomized Controlled Trial by Turtiainen, Johanna, Saimanen, Eija I. T., Mäkinen, Kimmo T., Nykänen, Antti I., Venermo, Maarit A., Uurto, Ilkka T., Hakala, Tapio

“…Background Surgical wound infection (SWI) is a common complication after peripheral vascular surgery. In a prospective study, triclosan-coated sutures were…”
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PDGF-A, -C, and -D but not PDGF-B Increase TGF-β1 and Chronic Rejection in Rat Cardiac Allografts by TUUMINEN, Raimo, NYKÄNEN, Antti I, KREBS, Rainer, SORONEN, Jarkko, PAJUSOLA, Katri, KERÄNEN, Mikko A. I, KOSKINEN, Petri K, ALITALO, Kari, LEMSTRÖM, Karl B

“…Objective— Chronic rejection is the main reason for the poor long-term survival of heart transplant recipients and is characterized by cardiac allograft…”
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Systemic overexpression of matricellular protein CCN1 exacerbates obliterative bronchiolitis in mouse tracheal allografts by Raissadati, Alireza, Nykänen, Antti I, Tuuminen, Raimo, Syrjälä, Simo O, Krebs, Rainer, Arnaudova, Ralica, Rouvinen, Eeva, Wang, Xiaomin, Poller, Wolfgang, Lemström, Karl B

“…Obliterative bronchiolitis (OB) involves airway epithelial detachment, fibroproliferation, and inflammation, resulting in chronic rejection and transplant…”
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Increased myeloid cell hypoxia-inducible factor-1 delays obliterative airway disease in the mouse by Ropponen, Jussi O., MD, Keränen, Mikko A., MD, PhD, Raissadati, Alireza, MD, Nykänen, Antti I., MD, PhD, Krebs, Rainer, MSc, PhD, Lemström, Karl B., MD, PhD, Tikkanen, Jussi M., MD, PhD

“…Background Obliterative bronchiolitis after lung transplantation is characterized by chronic airway inflammation leading to the obliteration of small airways…”
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Donor simvastatin treatment and cardiac allograft ischemia/reperfusion injury by Nykänen, Antti I, Tuuminen, Raimo, Lemström, Karl B

“…Abstract Ischemia/reperfusion injury of a transplanted heart may result in serious early and late adverse effects such as primary graft dysfunction, increased…”
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Reconstruction of Donor Anomalous Pulmonary Vein During Lung Transplantation by Nykänen, Antti I., Raivio, Peter

“…Pulmonary vein anomalies are rare but can complicate lung transplantation especially if unrecognized during the lung procurement operation. We describe a case…”
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Combined Donor Simvastatin and Methylprednisolone Treatment Prevents Ischemia-Reperfusion Injury in Rat Cardiac Allografts Through Vasculoprotection and Immunomodulation by Tuuminen, Raimo, Syrjälä, Simo, Krebs, Rainer, Arnaudova, Ralica, Rouvinen, Eeva, Nykänen, Antti I, Lemström, Karl B

“…BACKGROUNDIschemia-reperfusion injury (IRI) and allograft dysfunction remain as two of the major clinical challenges after heart transplantation. Here, we…”
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Access site complications in thoracic endovascular aortic repair by Dahlbacka, Sebastian, Nykänen, Antti I., Juvonen, Tatu, Jormalainen, Mikko

“…Percutaneous access and use of vascular closure devices facilitate thoracic endovascular aortic repair (TEVAR) procedures during local anesthesia and allow…”
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