Search Results - "NYGREN, Peter"

Aminopeptidase N (CD13) as a target for cancer chemotherapy by Wickström, Malin, Larsson, Rolf, Nygren, Peter, Gullbo, Joachim

“…The enzyme aminopeptidase N (APN, also known as CD13) is a Zn2+ dependent membrane‐bound ectopeptidase that degrades preferentially proteins and peptides with…”
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Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system by Karlsson, Henning, Fryknäs, Mårten, Larsson, Rolf, Nygren, Peter

“…Clinically relevant in vitro methods are needed to identify new cancer drugs for solid tumors. We report on a new 3-D spheroid cell culture system aimed to…”
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The fluorometric microculture cytotoxicity assay by Lindhagen, Elin, Nygren, Peter, Larsson, Rolf

“…The fluorometric microculture cytotoxicity assay (FMCA) is a nonclonogenic microplate-based cell viability assay used for measurement of the cytotoxic and/or…”
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Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer by Senkowski, Wojciech, Zhang, Xiaonan, Olofsson, Maria Hägg, Isacson, Ruben, Höglund, Urban, Gustafsson, Mats, Nygren, Peter, Linder, Stig, Larsson, Rolf, Fryknäs, Mårten

“…Because dormant cancer cells in hypoxic and nutrient-deprived regions of solid tumors provide a major obstacle to treatment, compounds targeting those cells…”
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Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death by Selvin, Tove, Berglund, Malin, Lenhammar, Lena, Jarvius, Malin, Nygren, Peter, Fryknäs, Mårten, Larsson, Rolf, Andersson, Claes R

“…High-throughput screening (HTS) of small molecule drug libraries has greatly facilitated the discovery of new cancer drugs. However, most phenotypic screening…”
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Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data by von Heideman, Anne, Berglund, Åke, Larsson, Rolf, Nygren, Peter

“…Purpose Depletion of cellular nicotinamide adenine dinucleotide (NAD) by inhibition of its synthesis is a new pharmacological principle for cancer treatment…”
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Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma by Ek, Frida, Blom, Kristin, Selvin, Tove, Rudfeldt, Jakob, Andersson, Claes, Senkowski, Wojciech, Brechot, Christian, Nygren, Peter, Larsson, Rolf, Jarvius, Malin, Fryknäs, Mårten

“…Quiescent cancer cells in malignant tumors can withstand cell-cycle active treatment and cause cancer spread and recurrence. Three-dimensional (3D) cancer cell…”
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Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids by Senkowski, Wojciech, Jarvius, Malin, Rubin, Jenny, Lengqvist, Johan, Gustafsson, Mats G, Nygren, Peter, Kultima, Kim, Larsson, Rolf, Fryknäs, Mårten

“…Cancer cell lines grown as two-dimensional (2D) cultures have been an essential model for studying cancer biology and anticancer drug discovery. However, 2D…”
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Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy by Rendo, Veronica, Stoimenov, Ivaylo, Mateus, André, Sjöberg, Elin, Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Ng, Adrian, OʼBrien, Casey, Giannakis, Marios, Artursson, Per, Nygren, Peter, Cheong, Ian, Sjöblom, Tobias

“…Cancer chemotherapy targeting frequent loss of heterozygosity events is an attractive concept, since tumor cells may lack enzymatic activities present in…”
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Novel activity of acriflavine against colorectal cancer tumor cells by Hassan, Saadia, Laryea, Daniel, Mahteme, Haile, Felth, Jenny, Fryknäs, Mårten, Fayad, Walid, Linder, Stig, Rickardson, Linda, Gullbo, Joachim, Graf, Wilhelm, Påhlman, Lars, Glimelius, Bengt, Larsson, Rolf, Nygren, Peter

“…A high‐throughput screen of the cytotoxic activity of 2000 molecules from a commercial library in three human colon cancer cell lines and two normal cell types…”
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Prognostic factors in patients with loco-regionally advanced gastric cancer by Hultman, Bo, Gunnarsson, Ulf, Nygren, Peter, Sundbom, Magnus, Glimelius, Bengt, Mahteme, Haile

“…The aim of this study was to investigate epidemiologic and prognostic factors relevant to the treatment of loco-regionally advanced gastric cancer (GC). Two…”
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Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition by Blom, Kristin, Rubin, Jenny, Berglund, Malin, Jarvius, Malin, Lenhammar, Lena, Parrow, Vendela, Andersson, Claes, Loskog, Angelica, Fryknäs, Mårten, Nygren, Peter, Larsson, Rolf

“…We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity by inducing a M2 to M1 phenotype switch in…”
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Drug Sensitivity Testing in Cytoreductive Surgery and Intraperitoneal Chemotherapy of Pseudomyxoma Peritonei by Bjersand, Kathrine, Mahteme, Haile, Sundström Poromaa, Inger, Andréasson, Håkan, Graf, Wilhelm, Larsson, Rolf, Nygren, Peter

“…Background Cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) is an established therapy for pseudomyxoma peritonei (PMP). However, the role of…”
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Inhibition of proteasome activity, nuclear factor‐KB translocation and cell survival by the antialcoholism drug disulfiram by Lövborg, Henrik, Öberg, Fredrik, Rickardson, Linda, Gullbo, Joachim, Nygren, Peter, Larsson, Rolf

“…The proteasome pathway is an important target for anticancer drug development. Here, we identify the antialcoholism drug disulfiram and its analogue…”
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Multiparametric evaluation of apoptosis: Effects of standard cytotoxic agents and the cyanoguanidine CHS 828 by Lövborg, Henrik, Nygren, Peter, Larsson, Rolf

“…A multiparametric high-content screening assay for measurement of apoptosis was developed. HeLa cells and lymphoma U-937 cells were exposed to cytotoxic drugs…”
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Drug repositioning from bench to bedside: tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer by Nygren, Peter, Larsson, Rolf

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Lack of effect of aprepitant on the pharmacokinetics of docetaxel in cancer patients by NYGREN, Peter, HANDE, Kenneth, GOTTESDIENER, Keith M, COCQUYT, Veronique, VAN BELLE, Simon, PETTY, Kevin J, FEDGCHIN, Margaret, VAN DYCK, Kristien, MAJUMDAR, Anup, PANEBIANCO, Debbie, DE SMET, Marina, AHMED, Tuli, MURPHY, M. Gail

“…Aprepitant is a selective neurokinin-1 receptor antagonist that is effective for the prevention of nausea and vomiting caused by highly emetogenic…”
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A systematic overview of chemotherapy effects in ovarian cancer by Högberg, T, Glimelius, B, Nygren, P

“…A systematic review of chemotherapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The…”
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Always look at the bright side of drugs? by Nygren, Peter

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A systematic overview of chemotherapy effects in non-small cell lung cancer by Sörenson, S, Glimelius, B, Nygren, P

“…A systematic review of chemotherapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The…”
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