Search Results - "NYE, J. S"

Safety and efficacy of galantamine in subjects with mild cognitive impairment by WINBLAD, B, GAUTHIER, S, SCINTO, L, FELDMAN, H, WILCOCK, G. K, TRUYEN, L, MAYORGA, A. J, WANG, D, BRASHEAR, H. R, NYE, J. S

“…To assess the safety of galantamine in subjects with mild cognitive impairment (MCI), the ability of galantamine to benefit cognition and global functioning in…”
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Randomized trial of adjunctive topiramate therapy in infants with refractory partial seizures by NOVOTNY, E, RENFROE, B, VENKATRAMAN, L, NYE, J. S, FORD, L, YARDI, N, NORDLI, D, NESS, S, WANG, S, WEBER, T, KURLAND, C. L, YUEN, E, EERDEKENS, M

“…To evaluate the efficacy and safety of adjunctive topiramate (sprinkle capsules or oral liquid) in reducing daily rates of partial-onset seizures (POS) in…”
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Signal Transduction by Activated mNotch: Importance of Proteolytic Processing and its Regulation by the Extracellular Domain by Kopan, Raphael, Schroeter, Eric H., Weintraub, Harold, Nye, Jeffrey S.

“…Previous studies imply that the intracellular domain of Notch 1 must translocate to the nucleus for its activity. In this study, we demonstrate that a mNotch 1…”
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Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors by Chambers, C B, Peng, Y, Nguyen, H, Gaiano, N, Fishell, G, Nye, J S

“…The olfactory bulb, neocortex and archicortex arise from a common pool of progenitors in the dorsal telencephalon. We studied the consequences of supplying…”
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The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD by KOPAN, R, NYE, J. S, WEINTRAUB, H

“…We show that Myf-5 and mNotch mRNA are both present in the presomitic mesoderm before muscle cell commitment and before muscle structural gene activation. The…”
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Whole genomewide linkage screen for neural tube defects reveals regions of interest on chromosomes 7 and 10 by Rampersaud, E, Bassuk, A G, Enterline, D S, George, T M, Siegel, D G, Melvin, E C, Aben, J, Allen, J, Aylsworth, A, Brei, T, Bodurtha, J, Buran, C, Floyd, L E, Hammock, P, Iskandar, B, Ito, J, Kessler, J A, Lasarsky, N, Mack, P, Mackey, J, McLone, D, Meeropol, E, Mehltretter, L, Mitchell, L E, Oakes, W J, Nye, J S, Powell, C, Sawin, K, Stevenson, R, Walker, M, West, S G, Worley, G, Gilbert, J R, Speer, M C

“…Neural tube defects (NTDs) are the second most common birth defects (1 in 1000 live births) in the world. Periconceptional maternal folate supplementation…”
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An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells by NYE, J. S, KOPLAN, R, AXEL, R

“…P19 cells, a mouse embryonal carcinoma line, can be induced to differentiate into neurons. After induction, however, only a small subpopulation of cells…”
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Innovative solutions to novel drug development in mental health by Insel, T R, Voon, V, Nye, J S, Brown, V J, Altevogt, B M, Bullmore, E T, Goodwin, G M, Howard, R J, Kupfer, D J, Malloch, G, Marston, H M, Nutt, D J, Robbins, T W, Stahl, S M, Tricklebank, M D, Williams, J H, Sahakian, B J

“…There are many new advances in neuroscience and mental health which should lead to a greater understanding of the neurobiological dysfunction in…”
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Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1 by Franklin, J.L, Berechid, B.E, Cutting, F.B, Presente, A, Chambers, C.B, Foltz, D.R, Ferreira, A, Nye, J.S

“…Background: On the basis of experiments suggesting that Notch and Delta have a role in axonal development in Drosophila neurons, we studied the ability of…”
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Effects of galantamine in a 2-year, randomized, placebo-controlled study in Alzheimer's disease [Corrigendum] by Baseman, Alan, Hager, Klaus, Nye, Jeffrey S., Brashear, Robert, Han, John, Sano, Mary, Davis, Bonnie, Richards, Henry

“…Hager K, Baseman AS, Nye JS, Brashear HR, Han J, Sano M, Davis B, Richards HM. Neuropsychiatr Dis Trea. 2014;10:391-401. On page 393, Figure 1, "Maintenance…”
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Updated investigations of the role of methylenetetrahydrofolate reductase in human neural tube defects by Rampersaud, E, Melvin, EC, Siegel, D, Mehltretter, L, Dickerson, ME, George, TM, Enterline, D, Nye, JS, Speer, MC

“…Folate supplementation appears to reduce the risk for neural tube defects (NTDs). Methylenetetrahydrofolate reductase (MTHFR) is a candidate gene in the folate…”
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Porphyrins are Endogenous Ligands for the Mitochondrial (Peripheral-Type) Benzodiazepine Receptor by Verma, Ajay, Nye, Jeffrey S., Snyder, Solomon H.

“…``Peripheral-type'' benzodiazepine receptors are localized to the outer mitochondrial membrane. We have identified potent competitive inhibitors of these…”
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Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain by Gaiano, Nicholas, Nye, Jeffrey S., Fishell, Gord

“…In vertebrates, Notch signaling is generally thought to inhibit neural differentiation. However, whether Notch can also promote specific early cell fates in…”
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Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells by Hitoshi, Seiji, Alexson, Tania, Tropepe, Vincent, Donoviel, Dorit, Elia, Andrew J, Nye, Jeffrey S, Conlon, Ronald A, Mak, Tak W, Bernstein, Alan, van der Kooy, Derek

“…Neural stem cells, which exhibit self-renewal and multipotentiality, are generated in early embryonic brains and maintained throughout the lifespan. The…”
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Glycogen Synthase Kinase-3β Modulates Notch Signaling and Stability by Foltz, Daniel R., Santiago, Michelle C., Berechid, Bridget E., Nye, Jeffrey S.

“…Notch receptors modulate transcriptional targets following the proteolytic release of the Notch intracellular domain (NotchIC). Phosphorylated forms of NotchIC…”
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Lack of requirement for Presenilin1 in Notch1 signaling by Berechid, B.E, Thinakaran, G, Wong, P.C, Sisodia, S.S., Nye, J.S.

“…Studies in invertebrates have indicated a functional requirement for presenilin (PS) genes in the Notch pathway [1–5]. One model of Notch signal transduction…”
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A case of anaphylaxis to alemtuzumab by Nye, Charles J. S., Wagner, Annette, Kousin-Ezewu, Onajite, Jones, Joanne L., Coles, Alasdair J.

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The Notch proteins by Nye, Jeffrey S

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Drug solubilizers to aid pharmacologists: amorphous cyclodextrin derivatives by Pitha, J, Irie, T, Sklar, P B, Nye, J S

“…Conversion of crystalline alpha-, beta-, or gamma-cyclodextrins into amorphous mixtures of water soluble derivatives yields non-toxic solubilizers which…”
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Human cerebral cortical cell lines from patients with unilateral megalencephaly and Rasmussen's encephalitis by Ronnett, G V, Hester, L D, Nye, J S, Snyder, S H

“…Continuous cerebral cortical cell lines have been developed from two patients, an 11-month-old with unilateral megalencephaly and a seven-year-old with…”
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