Search Results - "NYCE, J. W"

Antisense to NPY-Y1 Demonstrates that Y1 Receptors in the Hypothalamus Underlie NPY Hypothermia and Feeding in Rats by Lopez-Valpuesta, F. J., Nyce, J. W., Griffin-Biggs, T. A., Ice, J. C., Myers, R. D.

“…Neuropeptide Y (NPY) is a highly potent endogenous peptide which when injected into the medial hypothalamus causes spontaneous eating behaviour and an intense…”
Get full text

Oligonucleotide therapy of allergic asthma by Metzger, W.James, Nyce, Jonathan W.

“…The recent increase in the prevalence of and mortality from asthma has inspired several new molecular techniques to improve treatment. Because asthma is a…”
Get full text

Anorexic action of a new potential neuropeptide Y antagonist [ d-Tyr 27,36, d-Thr 32]-NPY (27–36) infused into the hypothalamus of the rat by Myers, R.D., Wooten, M.H., Ames, C.D., Nyce, J.W.

“…Neuropeptide Y (NPY) produces a vigorous feeding response in several species when it is injected into hypothalamic structures involved in eating behavior. The…”
Get full text

DNA antisense therapy for asthma in an animal model by Nyce, J W, Metzger, W J

“…Asthma is an inflammatory disease characterized by bronchial hyper-responsiveness that can proceed to life-threatening airway obstruction. It is one of the…”
Get full text

Inhibition of protein farnesyltransferase: a possible mechanism of tumor prevention by dehydroepiandrosterone sulfate by Schulz, S, Nyce, J W

“…Dehydroepiandrosterone sulfate (DHEAS) is the most abundant adrenal steroid with apparent anticarcinogenic properties. Given our recent observation of the…”
Get more information

Mechanisms of cell growth inhibition and cell cycle arrest in human colonic adenocarcinoma cells by dehydroepiandrosterone : role of isoprenoid biosynthesis by SCHULZ, S, KLANN, R. C, SCHÖNFELD, S, NYCE, J. W

“…We have previously demonstrated that the chemopreventive agent dehydroepiandrosterone (DHEA) inhibits the isoprenylation of cellular proteins by depletion of…”
Get full text

Differential feeding responses evoked in the rat by NPY and NPY1-27 injected intracerebroventricularly by Paez, X, Nyce, J W, Myers, R D

“…Neuropeptide Y (NPY) given by the intracerebroventricular (ICV) route in the rat evokes hyperphagic-like feeding. To examine the molecular nature of action of…”
Get more information

Insight into adenosine receptor function using antisense and gene- knockout approaches by Nyce, Jonathan W

“…The extensive role of adenosine in discriminating input from the extracellular environment is effected through a series of cell membrane-spanning proteins –…”
Get full text

Induction of peroxisomal enzymes in rat liver by dehydroepiandrosterone sulfate by Khan, Seher A., Nyce, Jonathan W.

“…Male F-344 rats, when treated with either 150 mg/kg or 300 mg/kg body weight of DHEAS for 14 days, produced a dose-dependent increase in liver weight and…”
Get full text

Chemotherapy of murine colorectal carcinoma with cisplatin and cisplatin plus 3'-deoxy-3'-azidothymidine by Klann, R C, Holbrook, C T, Nyce, J W

“…In light of the discouraging results obtained with conventional chemotherapy of human colon cancer using 5-fluorouracil, we examined the effects of…”
Get more information

Dehydroepiandrosterone and structural analogs: a new class of cancer chemopreventive agents by Schwartz, A G, Whitcomb, J M, Nyce, J W, Lewbart, M L, Pashko, L L

Get more information

Respirable antisense oligonucleotides: a new drug class for respiratory disease by Tanaka, M, Nyce, J W

“…Respirable antisense oligonucleotides (RASONs), which attenuate specific disease-associated mRNAs, represent a new class of respiratory therapeutics with…”
Get full text

Quantitation of 5-methylcytosine by one-dimensional high-performance thin-layer chromatography by Leonard, S A, Wong, S C, Nyce, J W

“…A method for the quantitative analysis of DNA 5-methylcytosine by one-dimensional high-performance thin-layer chromatography using alkylamino modified silica…”
Get more information

Inhibition of 1,2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by dehydroepiandrosterone by Nyce, J W, Magee, P N, Hard, G C, Schwartz, A G

“…Long-term administration of dehydroepiandrosterone (DHEA) to Balb/c mice significantly inhibits the rate of appearance of 1,2-dimethylhydrazine (DMH)-induced…”
Get more information

Absorption, distribution, metabolism, and excretion of a respirable antisense oligonucleotide for asthma by ALI, Shahid, LEONARD, Sherry A, KUKOLY, Cindy A, METZGER, W. James, WOOLES, Wallace R, MCGINTY, Jacqueline F, TANAKA, Makoto, SANDRASAGRA, Anthony, NYCE, Jonathan W

“…EPI-2010 is a respirable antisense oligonucleotide (RASON), which selectively attenuates discordantly overexpressed adenosine A(1) receptors in allergic lung…”
Get full text

Drug-induced DNA hypermethylation: A potential mediator of acquired drug resistance during cancer chemotherapy by Nyce, Jonathan W

Get full text

Intrastriatal adenosine A1 receptor antisense oligodeoxynucleotide blocks ethanol-induced motor incoordination by TU ANH PHAN, GRAY, A. M, NYCE, J. W

“…Intrastriatal administration of a 21-mer phosphorothioate antisense oligodeoxynucleotide targeting the adenosine A1 receptor blocked ethanol-induced motor…”
Get full text

NPY-Y1 receptor antisense injected centrally in rats causes hyperthermia and feeding by Lopez-Valpuesta, F J, Nyce, J W, Myers, R D

“…The central actions of neuropeptide Y antisense oligodeoxynucleotide (aNPY) and NPY-Y1 receptor antisense (aNPY-Y1) on body temperature (Tb), feeding and body…”
Get more information

RASONs: a novel antisense oligonucleotide therapeutic approach for asthma by Sandrasagra, A, Tang, L, Leonard, S A, Teng, K, Li, Y, Mannion, J C, Nyce, J W

“…Inhalation based approaches enable the local delivery of antisense oligonucleotides (ASONs) to the respiratory tract and thus facilitate the ability of ASONs…”
Get more information

Inhibition of protein isoprenylation and p21ras membrane association by dehydroepiandrosterone in human colonic adenocarcinoma cells in vitro by SCHULZ, S, NYCE, J. W

“…Treatment of mice and rats with the adrenal steroid, dehydroepiandrosterone (DHEA), protects against spontaneous and chemically induced tumors. The mechanism…”
Get full text