Search Results - "NUTLAND, S."

Complotype affects the extent of down‐regulation by Factor I of the C3b feedback cycle in vitro by Lay, E., Nutland, S., Smith, J. E., Hiles, I., Smith, R. A. G., Seilly, D. J., Buchberger, A., Schwaeble, W., Lachmann, P. J.

“…Summary Sera from a large panel of normal subjects were typed for three common polymorphisms, one in C3 (R102G) and two in Factor H (V62I and Y402H), that…”
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type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene by Howson, J. M. M, Dunger, D. B, Nutland, S, Stevens, H, Wicker, L. S, Todd, J. A

“…Aims/hypothesis HLA haplotypes DRB1*03_DQB1*02 and DRB1*04_DQB1*0302, and allelic variation of the T cell regulatory gene cytotoxic T-lymphocyte-associated…”
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Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design by BARRATT, B. J., PAYNE, F., RANCE, H. E., NUTLAND, S., TODD, J. A., CLAYTON, D. G.

“…Genotyping costs still preclude analysis of a comprehensive SNP map in thousands of individual subjects in the search for disease susceptibility loci. Allele…”
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Type 1 diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania by Guja, C., Guja, L., Nutland, S., Rance, H., Sebastien, M., Todd, J. A., Ionescu‐Tirgoviste, C.

“…Most cases of type 1 diabetes (T1DM) are due to an immune‐mediated destruction of the pancreatic beta cells, a process that is conditioned by multiple genes…”
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Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene by MAIER, L. M, TWELLS, R. C. J, WALKER, N. M, BURREN, O. S, NUTLAND, S, RANCE, H, TUOMILEHTO-WOLF, E, TUOMILEHTO, J, GUJA, C, IONESCU-TIRGOVISTE, C, UNDLIEN, D. E, RØNNINGEN, K. S, HOWSON, J. M. M, CUCCA, F, TODD, J. A, LAM, A. C, CLAYTON, D. G, SMYTH, D. J, SAVAGE, D, CARSON, D, PATTERSON, C. C, SMINK, L. J

“…Variations in the interleukin 4 receptor A (IL4RA) gene have been reported to be associated with atopy, asthma, and allergy, which may occur less frequently in…”
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Rheumatoid arthritis association at 6q23 by Worthington, Jane, Thomson, Wendy, Barton, Anne, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Donn, Rachelle, Symmons, Deborah, Hider, Samantha, Bruce, Ian N, Wilson, Anthony G, Marinou, Ioanna, Morgan, Ann, Emery, Paul, Carter, Angela, Steer, Sophia, Hocking, Lynne, Reid, David M, Wordsworth, Paul, Harrison, Pille, Strachan, David

“…The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 × 10−5 − 5 × 10−7 in a…”
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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease by Wicker, Linda S, Todd, John A, Ueda, Hironori, Howson, Joanna M. M, Esposito, Laura, Heward, Joanne, Snook, Chamberlain, Giselle, Rainbow, Daniel B, Hunter, Kara M. D, Smith, Annabel N, Di Genova, Gianfranco, Herr, Mathias H, Dahlman, Ingrid, Payne, Felicity, Smyth, Deborah, Lowe, Christopher, Twells, Rebecca C. J, Howlett, Sarah, Healy, Barry, Nutland, Sarah, Rance, Helen E, Everett, Vin, Smink, Luc J, Lam, Alex C, Cordell, Heather J, Walker, Neil M, Bordin, Cristina, Hulme, John, Motzo, Costantino, Cucca, Francesco, Hess, J. Fred, Metzker, Michael L, Rogers, Jane, Gregory, Simon, Allahabadia, Amit, Nithiyananthan, Ratnasingam, Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Bingley, Polly, Gillespie, Kathleen M, Undlien, Dag E, Rønningen, Kjersti S, Guja, Cristian, Ionescu-Tîrgovi te, Constantin, Savage, David A, Maxwell, A. Peter, Carson, Dennis J, Patterson, Chris C, Franklyn, Jayne A, Clayton, David G, Peterson, Laurence B, Gough, Stephen C. L

“…Genes and mechanisms involved in common complex diseases, such as the autoimmune disorders that affect approximately 5% of the population, remain obscure. Here…”
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Population structure, differential bias and genomic control in a large-scale, case-control association study by Clayton, David G, Todd, John A, Walker, Neil M, Smyth, Deborah J, Pask, Rebecca, Cooper, Jason D, Maier, Lisa M, Smink, Luc J, Lam, Alex C, Ovington, Nigel R, Stevens, Helen E, Nutland, Sarah, Howson, Joanna M M, Faham, Malek, Moorhead, Martin, Jones, Hywel B, Falkowski, Matthew, Hardenbol, Paul, Willis, Thomas D

“…The main problems in drawing causal inferences from epidemiological case-control studies are confounding by unmeasured extraneous factors, selection bias and…”
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Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design by BARRATT, B. J., PAYNE, F., RANCE, H. E., NUTLAND, S., TODD, J. A., CLAYTON, D. G.

“…Genotyping costs still preclude analysis of a comprehensive SNP map in thousands of individual subjects in the search for disease susceptibility loci. Allele…”
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Localization of a Type 1 Diabetes Locus in the IL2RA/CD25 Region by Use of Tag Single-Nucleotide Polymorphisms by Vella, Adrian, Cooper, Jason D., Lowe, Christopher E., Walker, Neil, Nutland, Sarah, Widmer, Barry, Jones, Richard, Ring, Susan M., McArdle, Wendy, Pembrey, Marcus E., Strachan, David P., Dunger, David B., Rebecca Twells, C.J., Clayton, David G., Todd, John A.

“…As part of an ongoing search for genes associated with type 1 diabetes (T1D), a common autoimmune disease, we tested the biological candidate gene IL2RA (…”
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Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus by SMYTH, Deborah, COOPER, Jason D, BARRATT, Bryan J, GUJA, Cristian, IONESCU-TIRGOVISTE, Constantin, SAVAGE, David A, DUNGER, David B, WIDMER, Barry, STRACHAN, David P, RING, Susan M, WALKER, Neil, CLAYTON, David G, COLLINS, Joanne E, TWELLS, Rebecca C. J, GOUGH, Stephen C. L, TODD, John A, HEWARD, Joanne M, FRANKLYN, Jayne A, HOWSON, Joanna M. M, VELLA, Adrian, NUTLAND, Sarah, RANCE, Helen E, MAIER, Lisa

“…Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus ( LYP/PTPN22 ) With Type 1 Diabetes, and Evidence for Its Role as a General…”
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Haplotype tagging for the identification of common disease genes by Todd, John A, Johnson, Gillian C.L, Esposito, Laura, Barratt, Bryan J, Smith, Annabel N, Heward, Joanne, Di Genova, Gianfranco, Ueda, Hironori, Cordell, Heather J, Eaves, Iain A, Dudbridge, Frank, Twells, Rebecca C.J, Payne, Felicity, Hughes, Wil, Nutland, Sarah, Stevens, Helen, Carr, Phillipa, Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Gough, Stephen C.L, Clayton, David G

“…Genome-wide linkage disequilibrium (LD) mapping of common disease genes could be more powerful than linkage analysis if the appropriate density of polymorphic…”
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Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene by Nejentsev, Sergey, Godfrey, Lisa, Snook, Hywel, Rance, Helen, Nutland, Sarah, Walker, Neil M., Lam, Alex C., Guja, Cristian, Ionescu-Tirgoviste, Constantin, Undlien, Dag E., Rønningen, Kjersti S., Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Newport, Melanie J., Clayton, David G., Todd, John A.

“…A genome-wide map of single nucleotide polymorphisms (SNP) and a pattern of linkage disequilibrium (LD) between their alleles are being established in three…”
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A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins by CUCCA, Francesco, LAMPIS, Rosannna, CONGIA, Mauro, ANGIUS, Efisio, NUTLAND, Sarah, BAIN, Stephen C, BARNETT, Anthony H, TODD, John A

“…In human type 1 diabetes (T1D) and in its murine model, the major histocompatibility complex (MHC) class II molecules, human leukocyte antigens (HLA)-DQ and…”
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Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation by Mein, C A, Barratt, B J, Dunn, M G, Siegmund, T, Smith, A N, Esposito, L, Nutland, S, Stevens, H E, Wilson, A J, Phillips, M S, Jarvis, N, Law, S, de Arruda, M, Todd, J A

“…Large-scale pharmacogenetics and complex disease association studies will require typing of thousands of single-nucleotide polymorphisms (SNPs) in thousands of…”
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The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes by Todd, John A, Eaves, Iain A, Merriman, Tony R, Barber, Rachael A, Nutland, Sarah, Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Cucca, Francesco

“…The choice of which population to study in the mapping of common disease genes may be critical. Isolated founder populations, such as that found in Finland,…”
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Analysis of the Vitamin D Receptor Gene Sequence Variants in Type 1 Diabetes by NEJENTSEV, Sergey, COOPER, Jason D, UNDLIEN, Dag E, RØNNINGEN, Kjersti S, TUOMILEHTO-WOLF, Eva, TUOMILEHTO, Jaakko, GILLESPIE, Kathleen M, RING, Susan M, STRACHAN, David P, WIDMER, Barry, DUNGER, David, TODDL, John A, GODFREY, Lisa, HOWSON, Joanna M. M, RANCE, Helen, NUTLAND, Sarah, WALKER, Neil M, GUJA, Cristian, IONESCU-TIRGOVISTE, Constantin, SAVAGE, David A

“…Analysis of the Vitamin D Receptor Gene Sequence Variants in Type 1 Diabetes Sergey Nejentsev , Jason D. Cooper 1 , Lisa Godfrey 1 , Joanna M.M. Howson 1 ,…”
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Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes by Smyth, Deborah J, Howson, Joanna M M, Lowe, Christopher E, Walker, Neil M, Lam, Alex C, Nutland, Sarah, Hutchings, Jayne, Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Guja, Cristian, Ionescu-Tîrgoviste, Constantin, Undlien, Dag E, Rønningen, Kjersti S, Savage, David, Dunger, David B, Twells, Rebecca C J, McArdle, Wendy L, Strachan, David P, Todd, John A

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Parameters for reliable results in genetic association studies in common disease by Todd, John A, Dahlman, Ingrid, Eaves, Iain A, Kosoy, Roman, Morrison, V. Anne, Heward, Joanne, Gough, Stephen C.L, Allahabadia, Amit, Franklyn, Jayne A, Tuomilehto, Jaakko, Tuomilehto-Wolf, Eva, Cucca, Francesco, Guja, Cristian, Ionescu-Tirgoviste, Constantin, Stevens, Helen, Carr, Philippa, Nutland, Sarah, McKinney, Patricia, Shield, Julian P, Wang, William, Cordell, Heather J, Walker, Neil, Concannon, Patrick

“…It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands…”
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Cell-specific CD25 Expression is Determined by Type 1 Diabetes Associated IL2RA Haplotypes by Dendrou, C, Plagnol, V, Fung, E, Downes, K, Cooper, J, Nutland, S, Coleman, G, Himsworth, M, Hardy, M, Burren, O, Healy, B, Walker, N, Koch, K, Ouwehand, W, Bradley, J, Wareham, N, Todd, J, Wicker, L

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