Search Results - "NUPPONEN, Nina N"

Amplification of KIT, PDGFRA, VEGFR2, and EGFR in Gliomas by Puputti, Marjut, Tynninen, Olli, Sihto, Harri, Blom, Tea, Mäenpää, Hanna, Isola, Jorma, Paetau, Anders, Joensuu, Heikki, Nupponen, Nina N

“…Receptor tyrosine kinase aberrations are implicated in the genesis of gliomas. We investigated expression and amplification of KIT, PDGFRA, VEGFR2 , and EGFR…”
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KIT and Platelet-Derived Growth Factor Receptor Alpha Tyrosine Kinase Gene Mutations and KIT Amplifications in Human Solid Tumors by Sihto, Harri, Sarlomo-Rikala, Maarit, Tynninen, Olli, Tanner, Minna, Andersson, Leif C, Franssila, Kaarle, Nupponen, Nina N, Joensuu, Heikki

“…Mutated KIT and platelet-derived growth factor receptor alpha (PDGFRalpha) tyrosine kinases are the principal targets for imatinib mesylate in the treatment of…”
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Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma by LASSUS, Heini, SIHTO, Harri, LEMINEN, Arto, JOENSUU, Heikki, ISOLA, Jorma, NUPPONEN, Nina N, BUTZOW, Ralf

“…EGFR and erbB-2 are targets for specific cancer therapy. The purpose of this study was to examine the frequency and clinicopathological correlations of gene…”
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Early-Onset Renal Cell Carcinoma as a Novel Extraparaganglial Component of SDHB-Associated Heritable Paraganglioma by Vanharanta, Sakari, Buchta, Mary, McWhinney, Sarah R., Virta, Sanna K., Peçzkowska, Mariola, Morrison, Carl D., Lehtonen, Rainer, Januszewicz, Andrzej, Järvinen, Heikki, Juhola, Matti, Mecklin, Jukka-Pekka, Pukkala, Eero, Herva, Riitta, Kiuru, Maija, Nupponen, Nina N., Aaltonen, Lauri A., Neumann, Hartmut P.H., Eng, Charis

“…Hereditary paraganglioma syndrome has recently been shown to be caused by germline heterozygous mutations in three ( SDHB, SDHC, and SDHD) of the four genes…”
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Growth Response and Differentiation of Bone Marrow-Derived Mesenchymal Stem/Stromal Cells in the Presence of Novel Multiple Myeloma Drug Melflufen by Gebraad, Arjen, Ohlsbom, Roope, Miettinen, Juho J, Emeh, Promise, Pakarinen, Toni-Karri, Manninen, Mikko, Eskelinen, Antti, Kuismanen, Kirsi, Slipicevic, Ana, Lehmann, Fredrik, Nupponen, Nina N, Heckman, Caroline A, Miettinen, Susanna

“…Mesenchymal stem/stromal cells (MSCs) are self-renewing and multipotent progenitors, which constitute the main cellular compartment of the bone marrow stroma…”
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The Peptide–Drug Conjugate Melflufen Modulates the Unfolded Protein Response of Multiple Myeloma and Amyloidogenic Plasma Cells and Induces Cell Death by Flanagan, Ken, Kumari, Romika, Miettinen, Juho J., Haney, Staci L., Varney, Michelle L., Williams, Jacob T., Majumder, Muntasir M., Suvela, Minna, Slipicevic, Ana, Lehmann, Fredrik, Nupponen, Nina N., Holstein, Sarah A., Heckman, Caroline A.

“…Immunoglobulin light‐chain (AL) amyloidosis is a rare disease caused by clonal plasma cell secretion of misfolded light chains that assemble as toxic amyloid…”
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Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma by Ollikainen, Miina, Gylling, Annette, Puputti, Marjut, Nupponen, Nina N., Abdel‐Rahman, Wael M., Butzow, Ralf, Peltomäki, Päivi

“…While the phosphatidylinositol 3‐kinase (PI3K)/AKT signaling pathway is known to be activated in multiple sporadic cancers, the role of this pathway in…”
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Genetic Alterations in Hormone-Refractory Recurrent Prostate Carcinomas by Nupponen, Nina N., Kakkola, Laura, Koivisto, Pasi, Visakorpi, Tapio

“…To study the genetic basis of tumor progression, we have screened 37 hormone-refractory prostate carcinomas for genetic changes by comparative genomic…”
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Biallelic Inactivation of Fumarate Hydratase ( FH) Occurs in Nonsyndromic Uterine Leiomyomas but Is Rare in Other Tumors by Lehtonen, Rainer, Kiuru, Maija, Vanharanta, Sakari, Sjöberg, Jari, Aaltonen, Leena-Maija, Aittomäki, Kristiina, Arola, Johanna, Butzow, Ralf, Eng, Charis, Husgafvel-Pursiainen, Kirsti, Isola, Jorma, Järvinen, Heikki, Koivisto, Pasi, Mecklin, Jukka-Pekka, Peltomäki, Päivi, Salovaara, Reijo, Wasenius, Veli-Matti, Karhu, Auli, Launonen, Virpi, Nupponen, Nina N., Aaltonen, Lauri A.

“…Germline mutations in the fumarate hydratase ( FH ) gene at 1q43 predispose to dominantly inherited cutaneous and uterine leiomyomas, uterine leiomyosarcoma,…”
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Amplification and overexpression of KIT, PDGFRA, and VEGFR2 in medulloblastomas and primitive neuroectodermal tumors by Blom, Tea, Roselli, Annariikka, Häyry, Valtteri, Tynninen, Olli, Wartiovaara, Kirmo, Korja, Miikka, Nordfors, Kristiina, Haapasalo, Hannu, Nupponen, Nina N.

“…Medulloblastomas (MB) and primitive neuroectodermal tumors (PNET) are the most common malignant brain tumors in children. These two tumor types are…”
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Prognostic significance of esterase gene expression in multiple myeloma by Kumari, Romika, Majumder, Muntasir Mamun, Lievonen, Juha, Silvennoinen, Raija, Anttila, Pekka, Nupponen, Nina N., Lehmann, Fredrik, Heckman, Caroline A.

“…Background Esterase enzymes differ in substrate specificity and biological function and may display dysregulated expression in cancer. This study evaluated the…”
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Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas by Nupponen, Nina N, Paulsson, Janna, Jeibmann, Astrid, Wrede, Brigitte, Tanner, Minna, Wolff, Johannes E A, Paulus, Werner, Östman, Arne, Hasselblatt, Martin

“…Platelet-derived growth factor (PDGF) receptor signaling has been implicated in the development of glial tumors, but not yet been examined in choroid plexus…”
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Aminopeptidase Expression in Multiple Myeloma Associates with Disease Progression and Sensitivity to Melflufen by Miettinen, Juho J, Kumari, Romika, Traustadottir, Gunnhildur Asta, Huppunen, Maiju-Emilia, Sergeev, Philipp, Majumder, Muntasir M, Schepsky, Alexander, Gudjonsson, Thorarinn, Lievonen, Juha, Bazou, Despina, Dowling, Paul, O Gorman, Peter, Slipicevic, Ana, Anttila, Pekka, Silvennoinen, Raija, Nupponen, Nina N, Lehmann, Fredrik, Heckman, Caroline A

“…Multiple myeloma (MM) is characterized by extensive immunoglobulin production leading to an excessive load on protein homeostasis in tumor cells…”
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Parkinsonism, premature menopause, and mitochondrial DNA polymerase γ mutations: clinical and molecular genetic study by Luoma, Petri, Melberg, Atle, Rinne, Juha O, Kaukonen, Jyrki A, Nupponen, Nina N, Chalmers, Richard M, Oldfors, Anders, Rautakorpi, Ilkka, Peltonen, Leena, Majamaa, Kari, Somer, Hannu, Suomalainen, Anu

“…Mutations in the gene encoding mitochondrial DNA polymerase γ ( POLG), the enzyme that synthesises mitochondrial DNA (mtDNA), have been associated with a…”
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Amplification of genes encoding KIT, PDGFRα and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme by Joensuu, Heikki, Puputti, Marjut, Sihto, Harri, Tynninen, Olli, Nupponen, Nina N

“…KIT, platelet‐derived growth factor receptors (PDGFRs) and vascular endothelial growth factor receptors (VEGFRs) are important clinical targets for tyrosine…”
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Epidermal growth factor receptor domain II, IV, and kinase domain mutations in human solid tumors by SIHTO, Harri, PUPUTTI, Marjut, KNUUTTILA, Aija, NUPPONEN, Nina N, JOENSUU, Heikki, PULLI, Laura, TYNNINEN, Olli, KOSKINEN, Walter, AALTONEN, Leena-Maija, TANNER, Minna, BÖHLING, Tom, VISAKORPI, Tapio, BIITZOW, Ralf

“…Mutations that may predict response to adenosine 5'-triphosphate (ATP)-mimetic epidermal growth factor receptor (EGFR) inhibitors occur in the EGFR kinase…”
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Prognostic but not predictive role of platelet‐derived growth factor receptors in patients with recurrent glioblastoma by Paulsson, Janna, Lindh, Maja Bradic, Jarvius, Malin, Puputti, Marjut, Nistér, Monica, Nupponen, Nina N., Paulus, Werner, Söderberg, Ola, Dresemann, Gregor, von Deimling, Andreas, Joensuu, Heikki, Östman, Arne, Hasselblatt, Martin

“…Platelet‐derived growth factor receptor (PDGFR) signaling has been implicated in the pathogenesis of glioblastomas and represents a target for the tyrosine…”
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The tyrosine kinase c‐Abl promotes proliferation and is expressed in atypical teratoid and malignant rhabdoid tumors by Koos, Björn, Jeibmann, Astrid, Lünenbürger, Henning, Mertsch, Sonja, Nupponen, Nina N., Roselli, Annariikka, Leuschner, Ivo, Paulus, Werner, Frühwald, Michael C., Hasselblatt, Martin

“…BACKGROUND: Atypical teratoid/rhaboid tumors (AT/RTs) and extracranial malignant rhabdoid tumors are highly malignant neoplasms with a dismal prognosis. These…”
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Copy number alterations of the polycomb gene BMI1 in gliomas by Häyry, Valtteri, Tanner, Minna, Blom, Tea, Tynninen, Olli, Roselli, Annariikka, Ollikainen, Miina, Sariola, Hannu, Wartiovaara, Kirmo, Nupponen, Nina N.

“…Gliomas are heterogeneous tumours that grow in an uninhibited fashion, and these brain tumour cells share numerous characteristics with neural stem cells. The…”
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Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile by ALLANDER, Susanne V, NUPPONEN, Nina N, RINGNER, Markus, HOSTETTER, Galen, MAHER, Greg W, GOLDBERGER, Natalie, YIDONG CHEN, CARPTEN, John, ELKAHLOUN, Abdel G, MELTZER, Paul S

“…Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the digestive tract, are believed to arise from the interstitial cells of Cajal…”
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