Search Results - "NUPPONEN, N"

Parkinsonism, premature menopause, and mitochondrial DNA polymerase γ mutations: clinical and molecular genetic study by Luoma, Petri, Melberg, Atle, Rinne, Juha O, Kaukonen, Jyrki A, Nupponen, Nina N, Chalmers, Richard M, Oldfors, Anders, Rautakorpi, Ilkka, Peltonen, Leena, Majamaa, Kari, Somer, Hannu, Suomalainen, Anu

“…Mutations in the gene encoding mitochondrial DNA polymerase γ ( POLG), the enzyme that synthesises mitochondrial DNA (mtDNA), have been associated with a…”
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Genetic Alterations in Hormone-Refractory Recurrent Prostate Carcinomas by Nupponen, Nina N., Kakkola, Laura, Koivisto, Pasi, Visakorpi, Tapio

“…To study the genetic basis of tumor progression, we have screened 37 hormone-refractory prostate carcinomas for genetic changes by comparative genomic…”
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KIT and Platelet-Derived Growth Factor Receptor Alpha Tyrosine Kinase Gene Mutations and KIT Amplifications in Human Solid Tumors by Sihto, Harri, Sarlomo-Rikala, Maarit, Tynninen, Olli, Tanner, Minna, Andersson, Leif C, Franssila, Kaarle, Nupponen, Nina N, Joensuu, Heikki

“…Mutated KIT and platelet-derived growth factor receptor alpha (PDGFRalpha) tyrosine kinases are the principal targets for imatinib mesylate in the treatment of…”
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Early-Onset Renal Cell Carcinoma as a Novel Extraparaganglial Component of SDHB-Associated Heritable Paraganglioma by Vanharanta, Sakari, Buchta, Mary, McWhinney, Sarah R., Virta, Sanna K., Peçzkowska, Mariola, Morrison, Carl D., Lehtonen, Rainer, Januszewicz, Andrzej, Järvinen, Heikki, Juhola, Matti, Mecklin, Jukka-Pekka, Pukkala, Eero, Herva, Riitta, Kiuru, Maija, Nupponen, Nina N., Aaltonen, Lauri A., Neumann, Hartmut P.H., Eng, Charis

“…Hereditary paraganglioma syndrome has recently been shown to be caused by germline heterozygous mutations in three ( SDHB, SDHC, and SDHD) of the four genes…”
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Phase II study of sunitinib malate in patients with recurrent high-grade glioma by Neyns, B., Sadones, J., Chaskis, C., Dujardin, M., Everaert, H., Lv, S., Duerinck, J., Tynninen, O., Nupponen, N., Michotte, A., De Greve, J.

“…Receptor tyrosine kinase signaling causes profound neo-angiogenesis in high-grade gliomas (HGG). The KIT , PDGFR-α , and VEGFR2 genes are frequently amplified…”
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Consensus meeting for the management of gastrointestinal stromal tumors Report of the GIST Consensus Conference of 20–21 March 2004, under the auspices of ESMO by Blay, J.-Y., Bonvalot, S., Casali, P., Choi, H., Debiec-Richter, M., Dei Tos, A. P., Emile, J.-F., Gronchi, A., Hogendoorn, P. C. W., Joensuu, H., Le Cesne, A., Mac Clure, J., Maurel, J., Nupponen, N., Ray-Coquard, I., Reichardt, P., Sciot, R., Stroobants, S., van Glabbeke, M., van Oosterom, A., Demetri, G. D.

“…Background: The management of gastrointestinal stromal tumors (GIST) has evolved very rapidly in the last 4 years. The objectives of this international…”
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Amplification of KIT, PDGFRA, VEGFR2, and EGFR in Gliomas by Puputti, Marjut, Tynninen, Olli, Sihto, Harri, Blom, Tea, Mäenpää, Hanna, Isola, Jorma, Paetau, Anders, Joensuu, Heikki, Nupponen, Nina N

“…Receptor tyrosine kinase aberrations are implicated in the genesis of gliomas. We investigated expression and amplification of KIT, PDGFRA, VEGFR2 , and EGFR…”
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NF1-associated gastrointestinal stromal tumors have unique clinical, phenotypic, and genotypic characteristics by ANDERSSON, Johanna, SIHTO, Harri, MEIS-KINDBLOM, Jeanne M, JOENSUU, Heikki, NUPPONEN, Nina, KINDBLOM, Lars-Gunnar

“…Gastrointestinal stromal tumors (GIST) have been reported to occasionally occur in patients with neurofibromatosis type 1 (NF1). This study aims to describe…”
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Amplification of genes encoding KIT, PDGFRα and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme by Joensuu, Heikki, Puputti, Marjut, Sihto, Harri, Tynninen, Olli, Nupponen, Nina N

“…KIT, platelet‐derived growth factor receptors (PDGFRs) and vascular endothelial growth factor receptors (VEGFRs) are important clinical targets for tyrosine…”
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Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma by LASSUS, Heini, SIHTO, Harri, LEMINEN, Arto, JOENSUU, Heikki, ISOLA, Jorma, NUPPONEN, Nina N, BUTZOW, Ralf

“…EGFR and erbB-2 are targets for specific cancer therapy. The purpose of this study was to examine the frequency and clinicopathological correlations of gene…”
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P874: DECIPHERING PLASMA CELL HETEROGENEITY AND TUMOR MICROENVIRONMENT IN LIGHT‐CHAIN AMYLOIDOSIS USING SINGLE CELL RNA‐SEQUENCING by Srivastava, A., Kumari, R., Adhikari, S., Sergeev, P., Miettinen, J. J., Suvela, M. H., Flanagan, K., Slipicevic, A., Nupponen, N. N., Lehmann, F., Heckman, C.

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Genetic alterations and protein expression of KIT and PDGFRA in serous ovarian carcinoma by LASSUS, H, SIHTO, H, LEMINEN, A, NORDLING, S, JOENSUU, H, NUPPONEN, N. N, BUTZOW, R

“…KIT and PDGFRA are receptor tyrosine kinases that can be specifically inactivated by small-molecule tyrosine kinase inhibitors, notably imatinib mesylate. In…”
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Growth Response and Differentiation of Bone Marrow-Derived Mesenchymal Stem/Stromal Cells in the Presence of Novel Multiple Myeloma Drug Melflufen by Gebraad, Arjen, Ohlsbom, Roope, Miettinen, Juho J, Emeh, Promise, Pakarinen, Toni-Karri, Manninen, Mikko, Eskelinen, Antti, Kuismanen, Kirsi, Slipicevic, Ana, Lehmann, Fredrik, Nupponen, Nina N, Heckman, Caroline A, Miettinen, Susanna

“…Mesenchymal stem/stromal cells (MSCs) are self-renewing and multipotent progenitors, which constitute the main cellular compartment of the bone marrow stroma…”
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Biallelic Inactivation of Fumarate Hydratase ( FH) Occurs in Nonsyndromic Uterine Leiomyomas but Is Rare in Other Tumors by Lehtonen, Rainer, Kiuru, Maija, Vanharanta, Sakari, Sjöberg, Jari, Aaltonen, Leena-Maija, Aittomäki, Kristiina, Arola, Johanna, Butzow, Ralf, Eng, Charis, Husgafvel-Pursiainen, Kirsti, Isola, Jorma, Järvinen, Heikki, Koivisto, Pasi, Mecklin, Jukka-Pekka, Peltomäki, Päivi, Salovaara, Reijo, Wasenius, Veli-Matti, Karhu, Auli, Launonen, Virpi, Nupponen, Nina N., Aaltonen, Lauri A.

“…Germline mutations in the fumarate hydratase ( FH ) gene at 1q43 predispose to dominantly inherited cutaneous and uterine leiomyomas, uterine leiomyosarcoma,…”
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Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours by Häyry, V., Tynninen, O., Haapasalo, H. K., Wölfer, J., Paulus, W., Hasselblatt, M., Sariola, H., Paetau, A., Sarna, S., Niemelä, M., Wartiovaara, K., Nupponen, N. N.

“…Aims: The polycomb factor BMI‐1 has recently been implicated in tumorigenesis of the central nervous system in several experimental animal models. However, the…”
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The Peptide–Drug Conjugate Melflufen Modulates the Unfolded Protein Response of Multiple Myeloma and Amyloidogenic Plasma Cells and Induces Cell Death by Flanagan, Ken, Kumari, Romika, Miettinen, Juho J., Haney, Staci L., Varney, Michelle L., Williams, Jacob T., Majumder, Muntasir M., Suvela, Minna, Slipicevic, Ana, Lehmann, Fredrik, Nupponen, Nina N., Holstein, Sarah A., Heckman, Caroline A.

“…Immunoglobulin light‐chain (AL) amyloidosis is a rare disease caused by clonal plasma cell secretion of misfolded light chains that assemble as toxic amyloid…”
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Prognostic but not predictive role of platelet‐derived growth factor receptors in patients with recurrent glioblastoma by Paulsson, Janna, Lindh, Maja Bradic, Jarvius, Malin, Puputti, Marjut, Nistér, Monica, Nupponen, Nina N., Paulus, Werner, Söderberg, Ola, Dresemann, Gregor, von Deimling, Andreas, Joensuu, Heikki, Östman, Arne, Hasselblatt, Martin

“…Platelet‐derived growth factor receptor (PDGFR) signaling has been implicated in the pathogenesis of glioblastomas and represents a target for the tyrosine…”
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Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile by ALLANDER, Susanne V, NUPPONEN, Nina N, RINGNER, Markus, HOSTETTER, Galen, MAHER, Greg W, GOLDBERGER, Natalie, YIDONG CHEN, CARPTEN, John, ELKAHLOUN, Abdel G, MELTZER, Paul S

“…Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the digestive tract, are believed to arise from the interstitial cells of Cajal…”
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Germline mutations in the ribonuclease L gene in families showing linkage with HPC1 by Trent, J, Carpten, J, Nupponen, N, Isaacs, S, Sood, R, Robbins, C, Xu, J, Faruque, M, Moses, T, Ewing, C, Gillanders, E, Hu, P, Bujnovszky, P, Makalowska, I, Baffoe-Bonnie, A, Faith, D, Smith, J, Stephan, D, Wiley, K, Brownstein, M, Gildea, D, Kelly, B, Jenkins, R, Hostetter, G, Matikainen, M, Schleutker, J, Klinger, K, Connors, T, Xiang, Y, Wang, Z, De Marzo, A, Papadopoulos, N, Kallioniemi, O.-P, Burk, R, Meyers, D, Grönberg, H, Meltzer, P, Silverman, R, Bailey-Wilson, J, Walsh, P, Isaacs, W

“…Although prostate cancer is the most common non-cutaneous malignancy diagnosed in men in the United States, little is known about inherited factors that…”
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Amplification of EIF3S3 Gene Is Associated with Advanced Stage in Prostate Cancer by Saramäki, Outi, Willi, Niels, Bratt, Ola, Gasser, Thomas C., Koivisto, Pasi, Nupponen, Nina N., Bubendorf, Lukas, Visakorpi, Tapio

“…Gain of the long arm of chromosome 8 (8q) is one of the most common gains found in the advanced prostate cancer by comparative genomic hybridization. We have…”
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