Search Results - "NUNOMURA, AKIHIKO"

RNA and Oxidative Stress in Alzheimer’s Disease: Focus on microRNAs by Nunomura, Akihiko, Perry, George

“…Oxidative stress (OS) is one of the major pathomechanisms of Alzheimer’s disease (AD), which is closely associated with other key events in neurodegeneration…”
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Idiopathic basal ganglia calcification (Fahr's disease) and dementia by Nunomura, Akihiko

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Consequences of RNA oxidation on protein synthesis rate and fidelity: implications for the pathophysiology of neuropsychiatric disorders by Nunomura, Akihiko, Lee, Hyoung-Gon, Zhu, Xiongwei, Perry, George

“…Unlike DNA, oxidative damage to RNA has received little attention presumably due to the assumed transient nature of RNA. However, RNAs including mRNA can…”
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Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease by Santos, Renato X, Correia, Sónia C, Zhu, Xiongwei, Smith, Mark A, Moreira, Paula I, Castellani, Rudy J, Nunomura, Akihiko, Perry, George

“…Mitochondria are fundamental to the life and proper functioning of cells. These organelles play a key role in energy production, in maintaining homeostatic…”
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Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment by Smith, Mark A, Zhu, Xiongwei, Tabaton, Massimo, Liu, Gang, McKeel, Jr, Daniel W, Cohen, Mark L, Wang, Xinglong, Siedlak, Sandra L, Dwyer, Barney E, Hayashi, Takaaki, Nakamura, Masao, Nunomura, Akihiko, Perry, George

“…It is now established that oxidative stress is one of the earliest, if not the earliest, change that occurs in the pathogenesis of Alzheimer's disease (AD)…”
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Oxidative Damage to RNA in Aging and Neurodegenerative Disorders by Nunomura, Akihiko, Moreira, Paula I., Castellani, Rudy J., Lee, Hyoung-gon, Zhu, Xiongwei, Smith, Mark A., Perry, George

“…An age-associated increase in oxidative damage to nucleic acids, predominantly to RNA, has been recently demonstrated in neurons of human and rodent brains,…”
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Modulation of Parkinson's Disease Associated Protein Rescues Alzheimer's Disease Degeneration by Nunomura, Akihiko, Zhu, Xiongwei, Perry, George

“…DJ-1, a causative gene product of an autosomal recessive familial form of Parkinson's disease (PD), plays roles in reducing oxidative stress and…”
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RNA oxidation in Alzheimer disease and related neurodegenerative disorders by Nunomura, Akihiko, Hofer, Tim, Moreira, Paula I., Castellani, Rudy J., Smith, Mark A., Perry, George

“…RNA oxidation and its biological effects are less well studied compared to DNA oxidation. However, RNA may be more susceptible to oxidative insults than DNA,…”
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The Earliest Stage of Cognitive Impairment in Transition From Normal Aging to Alzheimer Disease Is Marked by Prominent RNA Oxidation in Vulnerable Neurons by Nunomura, Akihiko, Tamaoki, Toshio, Motohashi, Nobutaka, Nakamura, Masao, McKeel, Daniel W, Tabaton, Massimo, Lee, Hyoung-gon, Smith, Mark A, Perry, George, Zhu, Xiongwei

“…ABSTRACTAlthough neuronal RNA oxidation is a prominent and established feature in age-associated neurodegenerative disorders such as Alzheimer disease (AD),…”
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Automated Volumetry of Medial Temporal Lobe Subregions in Mild Cognitive Impairment and Alzheimer Disease by Hata, Kaori, Nakamoto, Kazunori, Nunomura, Akihiko, Sone, Daichi, Maikusa, Norihide, Ogawa, Masayo, Sato, Noriko, Matsuda, Hiroshi

“…PURPOSE:Hippocampal subfield volumetry should be more useful than whole hippocampal (WH) volumetry for diagnosing Alzheimer disease (AD). This study sought to…”
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Oxidative stress hypothesis for Alzheimer's disease and its potential therapeutic implications by Nunomura, Akihiko

“…Significantly increased levels of oxidized nucleic acids, proteins, and lipids have been described in the brains of subjects with Alzheimer disease (AD) and…”
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Repetitive transcranial magnetic stimulation for treatment‐resistant depression in an elderly patient with an unruptured intracranial aneurysm: a case report by Matsuda, Yuki, Terada, Rema, Yamada, Kodai, Yamazaki, Ryuichi, Nunomura, Akihiko, Shigeta, Masahiro, Kito, Shinsuke

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A case presenting with persecutory delusions as an initial symptom of elderly bipolar disorder by Katayama, Nagisa, Inamura, Keisuke, Yamazaki, Ryuichi, Matsuda, Yuki, Nunomura, Akihiko, Shigeta, Masahiro

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Repetitive transcranial magnetic stimulation for residual depressive symptoms after electroconvulsive therapy in an elderly patient with treatment‐resistant depression by Matsuda, Yuki, Terada, Rema, Yamada, Kodai, Yamazaki, Ryuichi, Nunomura, Akihiko, Shigeta, Masahiro, Kito, Shinsuke

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Mirtazapine‐induced long QT syndrome in an elderly patient: a case report by Matsuda, Yuki, Furukawa, Yujiro, Yamazaki, Ryuichi, Inamura, Keisuke, Kito, Shinsuke, Nunomura, Akihiko, Shigeta, Masahiro

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Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease by Nunomura, Akihiko, Tamaoki, Toshio, Tanaka, Koich, Motohashi, Nobutaka, Nakamura, Masao, Hayashi, Takaaki, Yamaguchi, Haruyasu, Shimohama, Shun, Lee, Hyoung-gon, Zhu, Xiongwei, Smith, Mark A, Perry, George

“…Abstract In an analysis of amyloid pathology in Alzheimer disease, we used an in situ approach to identify amyloid-β (Aβ) accumulation and oxidative damage to…”
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Oxidative Damage Is the Earliest Event in Alzheimer Disease by NUNOMURA, AKIHIKO, PERRY, GEORGE, ALIEV, GJUMRAKCH, HIRAI, KEISUKE, TAKEDA, ATSUSHI, BALRAJ, ELIZABETH K, JONES, PAUL K, GHANBARI, HOSSEIN, WATAYA, TAKAFUMI, SHIMOHAMA, SHUN, CHIBA, SHIGERU, ATWOOD, CRAIG S, PETERSEN, ROBERT B, SMITH, MARK A

“…Recently, we demonstrated a significant increase of an oxidized nucleoside derived from RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid,…”
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Antioxidant therapy in Alzheimer's disease: theory and practice by Aliev, Gjumrakch, Obrenovich, Mark E, Reddy, V Prakash, Shenk, Justin C, Moreira, Paula I, Nunomura, Akihiko, Zhu, Xiongwei, Smith, Mark A, Perry, George

“…Alzheimer disease treatment has yet to yield a successful therapy that addresses the source of the damage found in brains. Of the varied proposed theories of…”
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Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron by Honda, Kazuhiro, Smith, Mark A., Zhu, Xiongwei, Baus, Diane, Merrick, William C., Tartakoff, Alan M., Hattier, Thomas, Harris, Peggy L., Siedlak, Sandra L., Fujioka, Hisashi, Liu, Quan, Moreira, Paula I., Miller, Frank P., Nunomura, Akihiko, Shimohama, Shun, Perry, George

“…Oxidative modification of cytoplasmic RNA in vulnerable neurons is an important, well documented feature of the pathophysiology of Alzheimer disease. Here we…”
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Alzheimer disease and the role of free radicals in the pathogenesis of the disease by Moreira, Paula I, Santos, Maria S, Oliveira, Catarina R, Shenk, Justin C, Nunomura, Akihiko, Smith, Mark A, Zhu, Xiongwei, Perry, George

“…Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary…”
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