Search Results - "NOWAK, P."

Targeted protein degradation as a powerful research tool in basic biology and drug target discovery by Wu, Tao, Yoon, Hojong, Xiong, Yuan, Dixon-Clarke, Sarah E., Nowak, Radosław P., Fischer, Eric S.

“…Controlled perturbation of protein activity is essential to study protein function in cells and living organisms. Small molecules that hijack the cellular…”
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Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome by Donovan, Katherine A, An, Jian, Nowak, Radosław P, Yuan, Jingting C, Fink, Emma C, Berry, Bethany C, Ebert, Benjamin L, Fischer, Eric S

“…In historical attempts to treat morning sickness, use of the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite…”
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Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance by Zhou, Wen, Whiteley, Aaron T., de Oliveira Mann, Carina C., Morehouse, Benjamin R., Nowak, Radosław P., Fischer, Eric S., Gray, Nathanael S., Mekalanos, John J., Kranzusch, Philip J.

“…Cyclic GMP–AMP synthase (cGAS) recognition of cytosolic DNA is critical for immune responses to pathogen replication, cellular stress, and cancer. Existing…”
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A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density by Pearce, Nicholas M., Krojer, Tobias, Bradley, Anthony R., Collins, Patrick, Nowak, Radosław P., Talon, Romain, Marsden, Brian D., Kelm, Sebastian, Shi, Jiye, Deane, Charlotte M., von Delft, Frank

“…In macromolecular crystallography, the rigorous detection of changed states (for example, ligand binding) is difficult unless signal is strong. Ambiguous…”
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Plasticity in binding confers selectivity in ligand-induced protein degradation by Nowak, Radosław P., DeAngelo, Stephen L., Buckley, Dennis, He, Zhixiang, Donovan, Katherine A., An, Jian, Safaee, Nozhat, Jedrychowski, Mark P., Ponthier, Charles M., Ishoey, Mette, Zhang, Tinghu, Mancias, Joseph D., Gray, Nathanael S., Bradner, James E., Fischer, Eric S.

“…Heterobifunctional small-molecule degraders that induce protein degradation through ligase-mediated ubiquitination have shown considerable promise as a new…”
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Ballistic superconductivity in semiconductor nanowires by Zhang, Hao, Gül, Önder, Conesa-Boj, Sonia, Nowak, Michał P., Wimmer, Michael, Zuo, Kun, Mourik, Vincent, de Vries, Folkert K., van Veen, Jasper, de Moor, Michiel W. A., Bommer, Jouri D. S., van Woerkom, David J., Car, Diana, Plissard, Sébastien R, Bakkers, Erik P.A.M., Quintero-Pérez, Marina, Cassidy, Maja C., Koelling, Sebastian, Goswami, Srijit, Watanabe, Kenji, Taniguchi, Takashi, Kouwenhoven, Leo P.

“…Semiconductor nanowires have opened new research avenues in quantum transport owing to their confined geometry and electrostatic tunability. They have offered…”
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Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 by Faust, Tyler B., Yoon, Hojong, Nowak, Radosław P., Donovan, Katherine A., Li, Zhengnian, Cai, Quan, Eleuteri, Nicholas A., Zhang, Tinghu, Gray, Nathanael S., Fischer, Eric S.

“…The investigational drugs E7820, indisulam and tasisulam (aryl-sulfonamides) promote the degradation of the splicing factor RBM39 in a proteasome-dependent…”
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Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML by Brand, Matthias, Jiang, Baishan, Bauer, Sophie, Donovan, Katherine A, Liang, Yanke, Wang, Eric S, Nowak, Radosław P, Yuan, Jingting C, Zhang, Tinghu, Kwiatkowski, Nicholas, Müller, André C, Fischer, Eric S, Gray, Nathanael S, Winter, Georg E

“…The design of selective small molecules is often stymied by similar ligand binding pockets. Here, we report BSJ-03-123, a phthalimide-based degrader that…”
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Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations by de Wispelaere, Mélissanne, Du, Guangyan, Donovan, Katherine A., Zhang, Tinghu, Eleuteri, Nicholas A., Yuan, Jingting C., Kalabathula, Joann, Nowak, Radosław P., Fischer, Eric S., Gray, Nathanael S., Yang, Priscilla L.

“…Targeted protein degradation is a promising drug development paradigm. Here we leverage this strategy to develop a new class of small molecule antivirals that…”
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Small-molecule-induced polymerization triggers degradation of BCL6 by Słabicki, Mikołaj, Yoon, Hojong, Koeppel, Jonas, Nitsch, Lena, Roy Burman, Shourya S., Di Genua, Cristina, Donovan, Katherine A., Sperling, Adam S., Hunkeler, Moritz, Tsai, Jonathan M., Sharma, Rohan, Guirguis, Andrew, Zou, Charles, Chudasama, Priya, Gasser, Jessica A., Miller, Peter G., Scholl, Claudia, Fröhling, Stefan, Nowak, Radosław P., Fischer, Eric S., Ebert, Benjamin L.

“…Effective and sustained inhibition of non-enzymatic oncogenic driver proteins is a major pharmacological challenge. The clinical success of thalidomide…”
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Bruton tyrosine kinase degradation as a therapeutic strategy for cancer by Dobrovolsky, Dennis, Wang, Eric S., Morrow, Sara, Leahy, Catharine, Faust, Tyler, Nowak, Radosław P., Donovan, Katherine A., Yang, Guang, Li, Zhengnian, Fischer, Eric S., Treon, Steven P., Weinstock, David M., Gray, Nathanael S.

“…The covalent Bruton tyrosine kinase (BTK) inhibitor ibrutinib is highly efficacious against multiple B-cell malignancies. However, it is not selective for BTK,…”
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Chemo-proteomics exploration of HDAC degradability by small molecule degraders by Xiong, Yuan, Donovan, Katherine A, Eleuteri, Nicholas A, Kirmani, Nadia, Yue, Hong, Razov, Anthony, Krupnick, Noah M, Nowak, Radosław P, Fischer, Eric S

“…Targeted protein degradation refers to the use of small molecules that recruit a ubiquitin ligase to a target protein for ubiquitination and subsequent…”
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Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK) by Powell, Chelsea E, Gao, Yang, Tan, Li, Donovan, Katherine A, Nowak, Radosław P, Loehr, Amanda, Bahcall, Magda, Fischer, Eric S, Jänne, Pasi A, George, Rani E, Gray, Nathanael S

“…We present the development of the first small molecule degraders that can induce anaplastic lymphoma kinase (ALK) degradation, including in non-small-cell lung…”
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Targeted protein degradation: from mechanisms to clinic by Tsai, Jonathan M., Nowak, Radosław P., Ebert, Benjamin L., Fischer, Eric S.

“…Targeted protein degradation refers to the use of small molecules to induce the selective degradation of proteins. In its most common form, this degradation is…”
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A double whammy for KEAP1 by Gerhartz, Jan, Nowak, Radosław P

“…In this issue of Cell Chemical Biology, Lu et al. report the discovery of a bivalent KEAP1 inhibitor (biKEAP1), which more rapidly activates NRF2 compared to…”
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Shadow-wall lithography of ballistic superconductor–semiconductor quantum devices by Heedt, Sebastian, Quintero-Pérez, Marina, Borsoi, Francesco, Fursina, Alexandra, van Loo, Nick, Mazur, Grzegorz P., Nowak, Michał P., Ammerlaan, Mark, Li, Kongyi, Korneychuk, Svetlana, Shen, Jie, van de Poll, May An Y., Badawy, Ghada, Gazibegovic, Sasa, de Jong, Nick, Aseev, Pavel, van Hoogdalem, Kevin, Bakkers, Erik P. A. M., Kouwenhoven, Leo P.

“…The realization of hybrid superconductor–semiconductor quantum devices, in particular a topological qubit, calls for advanced techniques to readily and…”
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Mutant‐Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug‐Resistant Mutations by Jang, Jaebong, To, Ciric, De Clercq, Dries J. H., Park, Eunyoung, Ponthier, Charles M., Shin, Bo Hee, Mushajiang, Mierzhati, Nowak, Radosław P., Fischer, Eric S., Eck, Michael J., Jänne, Pasi A., Gray, Nathanael S.

“…Targeting epidermal growth factor receptor (EGFR) through an allosteric mechanism provides a potential therapeutic strategy to overcome drug‐resistant EGFR…”
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Hard Superconducting Gap in InSb Nanowires by Gül, Önder, Zhang, Hao, de Vries, Folkert K, van Veen, Jasper, Zuo, Kun, Mourik, Vincent, Conesa-Boj, Sonia, Nowak, Michał P, van Woerkom, David J, Quintero-Pérez, Marina, Cassidy, Maja C, Geresdi, Attila, Koelling, Sebastian, Car, Diana, Plissard, Sébastien R, Bakkers, Erik P. A. M, Kouwenhoven, Leo P

“…Topological superconductivity is a state of matter that can host Majorana modes, the building blocks of a topological quantum computer. Many experimental…”
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Quantized conductance doubling and hard gap in a two-dimensional semiconductor–superconductor heterostructure by Kjaergaard, M., Nichele, F., Suominen, H. J., Nowak, M. P., Wimmer, M., Akhmerov, A. R., Folk, J. A., Flensberg, K., Shabani, J., Palmstrøm, C. J., Marcus, C. M.

“…Coupling a two-dimensional (2D) semiconductor heterostructure to a superconductor opens new research and technology opportunities, including fundamental…”
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Structural basis of regulated m7G tRNA modification by METTL1–WDR4 by Li, Jiazhi, Wang, Longfei, Hahn, Quentin, Nowak, Radosław P., Viennet, Thibault, Orellana, Esteban A., Roy Burman, Shourya S., Yue, Hong, Hunkeler, Moritz, Fontana, Pietro, Wu, Hao, Arthanari, Haribabu, Fischer, Eric S., Gregory, Richard I.

“…Chemical modifications of RNA have key roles in many biological processes 1 – 3 . N 7 -methylguanosine (m 7 G) is required for integrity and stability of a…”
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