Search Results - "NOWAK, Norma"

Role of alcohol metabolism in non-alcoholic steatohepatitis by Baker, Susan S, Baker, Robert D, Liu, Wensheng, Nowak, Norma J, Zhu, Lixin

“…Non-alcoholic steatohepatitis (NASH) is a serious form of non-alcoholic fatty liver disease (NAFLD), associated with obesity and insulin resistance. Previous…”
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Upregulation of hemoglobin expression by oxidative stress in hepatocytes and its implication in nonalcoholic steatohepatitis by Liu, Wensheng, Baker, Susan S, Baker, Robert D, Nowak, Norma J, Zhu, Lixin

“…Recent studies revealed that hemoglobin is expressed in some non-erythrocytes and it suppresses oxidative stress when overexpressed. Oxidative stress plays a…”
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Reactivation of super-enhancers by KLF4 in human Head and Neck Squamous Cell Carcinoma by Tsompana, Maria, Gluck, Christian, Sethi, Isha, Joshi, Ishita, Bard, Jonathan, Nowak, Norma J., Sinha, Satrajit, Buck, Michael J.

“…Head and neck squamous cell carcinoma (HNSCC) is a disease of significant morbidity and mortality and rarely diagnosed in early stages. Despite extensive…”
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Computational approach for deriving cancer progression roadmaps from static sample data by Sun, Yijun, Yao, Jin, Yang, Le, Chen, Runpu, Nowak, Norma J, Goodison, Steve

“…As with any biological process, cancer development is inherently dynamic. While major efforts continue to catalog the genomic events associated with human…”
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A gene expression atlas of the central nervous system based on bacterial artificial chromosomes by Hatten, Mary E, Heintz, Nathaniel, Gong, Shiaoching, Zheng, Chen, Doughty, Martin L, Losos, Kasia, Didkovsky, Nicholas, Schambra, Uta B, Nowak, Norma J, Joyner, Alexandra, Leblanc, Gabrielle

“…The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate…”
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Genomic profiling and spatial SEIR modeling of COVID-19 transmission in Western New York by Bard, Jonathan E, Jiang, Na, Emerson, Jamaal, Bartz, Madeleine, Lamb, Natalie A, Marzullo, Brandon J, Pohlman, Alyssa, Boccolucci, Amanda, Nowak, Norma J, Yergeau, Donald A, Crooks, Andrew T, Surtees, Jennifer A

“…The COVID-19 pandemic has prompted an unprecedented global effort to understand and mitigate the spread of the SARS-CoV-2 virus. In this study, we present a…”
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Novel Submicroscopic Chromosomal Abnormalities Detected in Autism Spectrum Disorder by Christian, Susan L, Brune, Camille W, Sudi, Jyotsna, Kumar, Ravinesh A, Liu, Shaung, Karamohamed, Samer, Badner, Judith A, Matsui, Seiichi, Conroy, Jeffrey, McQuaid, Devin, Gergel, James, Hatchwell, Eli, Gilliam, T. Conrad, Gershon, Elliot S, Nowak, Norma J, Dobyns, William B, Cook, Edwin H

“…Background One genetic mechanism known to be associated with autism spectrum disorders (ASD) is chromosomal abnormalities. The identification of copy number…”
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A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions by Yu, Tao, Li, Zhongyou, Jia, Zhengping, Clapcote, Steven J., Liu, Chunhong, Li, Shaomin, Asrar, Suhail, Pao, Annie, Chen, Rongqing, Fan, Ni, Carattini-Rivera, Sandra, Bechard, Allison R., Spring, Shoshana, Henkelman, R. Mark, Stoica, George, Matsui, Sei-Ichi, Nowak, Norma J., Roder, John C., Chen, Chu, Bradley, Allan, Yu, Y. Eugene

“…Down syndrome (DS) is caused by the presence of an extra copy of human chromosome 21 (Hsa21) and is the most common genetic cause for developmental cognitive…”
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Recurrent 16p11.2 microdeletions in autism by Kumar, Ravinesh A., KaraMohamed, Samer, Sudi, Jyotsna, Conrad, Donald F., Brune, Camille, Badner, Judith A., Gilliam, T. Conrad, Nowak, Norma J., Cook, Edwin H., Dobyns, William B., Christian, Susan L.

“…Autism is a childhood neurodevelopmental disorder with a strong genetic component, yet the identification of autism susceptibility loci remains elusive. We…”
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Multimodal Dimension Reduction and Subtype Classification of Head and Neck Squamous Cell Tumors by Bard, Jonathan E, Nowak, Norma J, Buck, Michael J, Sinha, Satrajit

“…Traditional analysis of genomic data from bulk sequencing experiments seek to group and compare sample cohorts into biologically meaningful groups. To…”
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Targeting TAZ-Driven Human Breast Cancer by Inhibiting a SKP2-p27 Signaling Axis by Shen, He, Yang, Nuo, Truskinovsky, Alexander, Chen, Yanmin, Mussell, Ashley L, Nowak, Norma J, Kobzik, Lester, Frangou, Costa, Zhang, Jianmin

“…Deregulated expression of the transcriptional coactivator with PDZ-binding motif (WWTR1/TAZ) is a common feature of basal-like breast cancer (BLBC). Yet, how…”
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Molecular dissection of the oncogenic role of ETS1 in the mesenchymal subtypes of head and neck squamous cell carcinoma by Gluck, Christian, Glathar, Alexandra, Tsompana, Maria, Nowak, Norma, Garrett-Sinha, Lee Ann, Buck, Michael J, Sinha, Satrajit

“…Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous disease of significant mortality and with limited treatment options. Recent genomic analysis…”
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Lipid in the livers of adolescents with nonalcoholic steatohepatitis: combined effects of pathways on steatosis by Zhu, Lixin, Baker, Susan S, Liu, Wensheng, Tao, Meng-Hua, Patel, Raza, Nowak, Norma J, Baker, Robert D

“…Abstract Fatty liver is a prerequisite for the development of nonalcoholic steatohepatitis (NASH). The homeostasis of hepatic lipid is determined by the…”
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Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities by Li, Zhongyou, Yu, Tao, Morishima, Masae, Pao, Annie, LaDuca, Jeffrey, Conroy, Jeffrey, Nowak, Norma, Matsui, Sei-Ichi, Shiraishi, Isao, Yu, Y. Eugene

“…Down syndrome is caused by a genomic imbalance of human chromosome 21 which is mainly observed as trisomy 21. The regions on human chromosome 21 are…”
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Molecular Study of Malignant Gliomas Treated with Epidermal Growth Factor Receptor Inhibitors: Tissue Analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01 by LASSMAN, Andrew B, ROSSI, Michael R, WILSON, Richard, NOWAK, Norma J, COWELL, John K, DEANGELIS, Lisa M, WEN, Patrick, GILBERT, Mark R, CHANG, Susan, YUNG, W. A, PRADOS, Michael, HOLLAND, Eric C, RAZIER, Jeffrey R, ABREY, Lauren E, LIEBERMAN, Frank S, GREFE, Chelsea N, LAMBORN, Kathleen, PAO, William, SHIH, Alan H, KUHN, John G

“…Purpose: We investigated the molecular effect of the epidermal growth factor receptor (EGFR) inhibitors erlotinib and gefitinib in vivo on all available tumors…”
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Molecular Karyotypes of Hodgkin and Reed―Sternberg Cells at Disease Onset Reveal Distinct Copy Number Alterations in Chemosensitive versus Refractory Hodgkin Lymphoma by SLOVAK, Marilyn L, BEDELL, Victoria, HSU, Ya-Hsuan, ESTRINE, Dolores B, NOWAK, Norma J, DELIOUKINA, Maria L, WEISS, Lawrence M, SMITH, David D, FORMAN, Stephen J

“…To determine the recurring DNA copy number alterations (CNA) in classical Hodgkin lymphoma (HL) by microarray-based comparative genomic hybridization (aCGH)…”
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Differential copy number aberrations in novel candidate genes associated with progression from in situ to invasive ductal carcinoma of the breast by Liao, Shaoxi, Desouki, Mohamed M., Gaile, Daniel P., Shepherd, Lori, Nowak, Norma J., Conroy, Jeffrey, Barry, William T., Geradts, Joseph

“…Only a minority of intraductal carcinomas of the breast give rise to stromally invasive disease. We microdissected 206 paraffin blocks representing 116…”
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Robust Performance of SARS-CoV‑2 Whole-Genome Sequencing from Wastewater with a Nonselective Virus Concentration Method by Segelhurst, Emily, Bard, Jonathan E., Pillsbury, Annemarie N., Alam, Md Mahbubul, Lamb, Natalie A., Zhu, Chonglin, Pohlman, Alyssa, Boccolucci, Amanda, Emerson, Jamaal, Marzullo, Brandon J., Yergeau, Donald A., Nowak, Norma J., Bradley, Ian M., Surtees, Jennifer A., Ye, Yinyin

“…The sequencing of human virus genomes from wastewater samples is an efficient method for tracking viral transmission and evolution at the community level…”
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Epigenetic Silencing of CYP24 in Tumor-derived Endothelial Cells Contributes to Selective Growth Inhibition by Calcitriol by Chung, Ivy, Karpf, Adam R., Muindi, Josephia R., Conroy, Jeffrey M., Nowak, Norma J., Johnson, Candace S., Trump, Donald L.

“…Calcitriol (1,25-dihydroxycholecalciferol), the most active form of vitamin D, has selective anti-proliferative effects on tumor-derived endothelial cells…”
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Molecular profiling and computational network analysis of TAZ-mediated mammary tumorigenesis identifies actionable therapeutic targets by Frangou, Costa, Li, Ying-Wei, Shen, He, Yang, Nuo, Wilson, Kayla E, Blijlevens, Maxime, Guo, Jin, Nowak, Norma J, Zhang, Jianmin

“…Triple-negative breast cancer (TNBC) accounts for approximately 15-20% of all breast cancer (BC) cases and contributes disproportionately to BC mortality. TAZ,…”
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