Search Results - "NOVOTNY, W. F"

Purification and characterization of the lipoprotein-associated coagulation inhibitor from human plasma by Novotny, W F, Girard, T J, Miletich, J P, Broze, G J

“…The lipoprotein-associated coagulation inhibitor (LACI) has been isolated from human plasma using a combination of hydrophobic, ion-exchange, and affinity…”
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Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat by Lortie, M J, Novotny, W F, Peterson, O W, Vallon, V, Malvey, K, Mendonca, M, Satriano, J, Insel, P, Thomson, S C, Blantz, R C

“…Until recently, conversion of arginine to agmatine by arginine decarboxylase (ADC) was considered important only in plants and bacteria. In the following, we…”
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Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues by NOVOTNY, W. F, CHASSANDE, O, BAKER, M, LAZDUNSKI, M, BARBRY, P

“…Diamine oxidase (histaminase), an enzyme that oxidatively deaminates putrescine and histamine, was purified from human placenta and from pig kidney. Both…”
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Regulation of coagulation by a multivalent Kunitz-type inhibitor by Broze, George J, Girard, Thomas J, Novotny, William F

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Purification and Properties of Heparin-Releasable Lipoprotein-Associated Coagulation Inhibitor by Novotny, William F., Palmier, Mark, Wun, Tze-Chein, Broze, George J., Miletich, Joseph P.

“…The lipoprotein-associated coagulation inhibitor (LACI) is present in vivo in at least three different pools: sequestered in platelets, associated with plasma…”
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Platelets Secrete a Coagulation Inhibitor Functionally and Antigenically Similar to the Lipoprotein Associated Coagulation Inhibitor by Novotny, William F., Girard, Thomas J., Miletich, Joseph P., Broze, George J.

“…Stimulation with thrombin or the calcium ionophore, A23187 caused human platelets to release a coagulation inhibitor similar to the Lipoprotein Associated…”
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Plasma Antigen Levels of the Lipoprotein-Associated Coagulation Inhibitor in Patient Samples by Novotny, William F., Brown, Susan G., Miletich, Joseph P., Rader, Daniel J., Broze, George J.

“…Human plasma contains an inhibitor of tissue factor-initiated coagulation known as the lipoprotein-associated coagulation inhibitor (LACI) or also known as the…”
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First-line, single-agent Herceptin(trastuzumab) in metastatic breast cancer: a preliminary report by Vogel, C, Cobleigh, M A, Tripathy, D, Gutheil, J C, Harris, L N, Fehrenbacher, L, Slamon, D J, Murphy, M, Novotny, W F, Burchmore, M, Shak, S, Stewart, S J

“…Following confirmation of the appropriate dosage, safety and potential efficacy of Herceptin(trastuzumab) in small-scale phase I and II trials involving…”
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Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor by Girard, Thomas J, Warren, Louise A, Novotny, William F, Likert, Karen M, Brown, Susan G, Miletich, Joseph P, Broze, George J

“…Blood coagulation can be initiated when factor VII or VIIa, a plasma protease, binds to its essential cofactor, tissue factor (TF), and proteolytically…”
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The Lipoprotein-Associated Coagulation Inhibitor That Inhibits the Factor VII-Tissue Factor Complex Also Inhibits Factor Xa: Insight Into Its Possible Mechanism of Action by Broze, George J., Warren, Louise A., Novotny, William F., Higuchi, Darryl A., Girard, James J., Miletich, Joseph P.

“…Blood coagulation is initiated when plasma factor Vll(a) binds to its essential cofactor tissue factor (TF) and proteo-lytically activates factors X and IX…”
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Platelets secrete a coagulation inhibitor functionally and antigenically similar to the lipoprotein associated coagulation inhibitor by Novotny, WF, Girard, TJ, Miletich, JP, Broze, GJ Jr

“…Stimulation with thrombin or the calcium ionophore, A23187 caused human platelets to release a coagulation inhibitor similar to the Lipoprotein Associated…”
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Tissue factor pathway inhibitor by Novotny, W F

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Platelet activation in patients after an acute coronary syndrome: results from the TIMI-12 trial by Ault, Kenneth A, Cannon, Christopher P, Mitchell, Jane, McCahan, John, Tracy, Russell P, Novotny, William F, Reimann, James D, Braunwald, Eugene

“…OBJECTIVES This study was designed to determine the magnitude and time course of platelet activation during therapy of acute coronary syndromes with an oral…”
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Identification of novel heparin-releasable proteins, as well as the cytokines midkine and pleiotrophin, in human postheparin plasma by NOVOTNY, W. F, MAFFI, T, MEHTA, R. L, MILNER, P. G

“…The heparin-releasable proteins are a group of proteins that are targeted to the endothelial surface by attachment to glycosaminoglycans and may have functions…”
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First-line Herceptin monotherapy in metastatic breast cancer by Vogel, C L, Cobleigh, M A, Tripathy, D, Gutheil, J C, Harris, L N, Fehrenbacher, L, Slamon, D J, Murphy, M, Novotny, W F, Burchmore, M, Shak, S, Stewart, S J

“…The pivotal phase II and III Herceptin trials proved the efficacy and safety of second- or third-line single-agent Herceptin and first-line Herceptin in…”
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Pregnancies in a patient with congenital absence of prothrombin activity: case report by Catanzarite, V A, Novotny, W F, Cousins, L M, Schneider, J M

“…Congenital hypoprothrombinemias are very rare, inherited disorders in which factor II (prothrombin) levels and/or activity are extremely low or absent. We…”
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Endogenous phosphorylation of the lipoprotein-associated coagulation inhibitor at serine-2 by GIRARD, T. J, MCCOURT, D, NOVOTNY, W. F, MACPHAIL, L. A, LIKERT, K. M, BROZE, G. J

“…Lipoprotein-associated coagulation inhibitor (LACI) inhibits activated Factor X (Xa) directly and, in an Xa-dependent fashion, inhibits Factor VIIa-tissue…”
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Lipoprotein associated coagulation inhibitor, factor VII, antithrombin III, and monocyte tissue factor following surgery by Carson, S D, Haire, W D, Broze, Jr, G J, Novotny, W F, Pirrucello, S J, Duggan, M J

“…Fifteen patients undergoing major surgical procedures were evaluated for lipoprotein associated coagulation inhibitor (LACI) antigen, factor VII (F VII),…”
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Randomized trial of an oral platelet glycoprotein IIb/IIIa antagonist, sibrafiban, in patients after an acute coronary syndrome results of the TIMI 12 trial by CANNON, C. P, MCCABE, C. H, ROTHMAN, J. M, NOVOTNY, W. F, BRAUNWALD, E, BORZAK, S, HENRY, T. D, TISCHLER, M. D, MUELLER, H. S, FELDMAN, R, PALMERI, S. T, AULT, K, HAMILTON, S. A

“…Background —Inhibitors of the platelet glycoprotein IIb/IIIa receptor given intravenously have been shown to be effective in reducing ischemic complications…”
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Effect of lipoprotein-associated coagulation inhibitor (LACI) on thromboplastin-induced coagulation of normal and hemophiliac plasmas by Welsch, D J, Novotny, W F, Wun, T C

“…Lipoprotein-associated coagulation inhibitor (LACI) is a plasma-derived protein that inhibits the tissue factor/factor VIIa/calcium/phospholipid complex in a…”
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