Search Results - "NOVO, Erica"

ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis by Foglia, Beatrice, Cannito, Stefania, Bocca, Claudia, Parola, Maurizio, Novo, Erica

“…Fibrogenic progression of chronic liver disease, whatever the etiology, is characterized by persistent chronic parenchymal injury, chronic activation of…”
Get full text

Redox mechanisms in hepatic chronic wound healing and fibrogenesis by Novo, Erica, Parola, Maurizio

“…Reactive oxygen species (ROS) generated within cells or, more generally, in a tissue environment, may easily turn into a source of cell and tissue injury…”
Get full text

Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis by Foglia, Beatrice, Novo, Erica, Protopapa, Francesca, Maggiora, Marina, Bocca, Claudia, Cannito, Stefania, Parola, Maurizio

“…Liver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as…”
Get full text

Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and disease by Cannito, Stefania, Novo, Erica, di Bonzo, Lorenzo Valfrè, Busletta, Chiara, Colombatto, Sebastiano, Parola, Maurizio

“…Epithelial to mesenchymal transition (EMT) is a fundamental process, paradigmatic of the concept of cell plasticity, that leads epithelial cells to lose their…”
Get more information

The protease activated receptor 2 - CCAAT/enhancer-binding protein beta - SerpinB3 axis inhibition as a novel strategy for the treatment of non-alcoholic steatohepatitis by Villano, Gianmarco, Novo, Erica, Turato, Cristian, Quarta, Santina, Ruvoletto, Mariagrazia, Biasiolo, Alessandra, Protopapa, Francesca, Chinellato, Monica, Martini, Andrea, Trevellin, Elisabetta, Granzotto, Marnie, Cannito, Stefania, Cendron, Laura, De Siervi, Silvia, Guido, Maria, Parola, Maurizio, Vettor, Roberto, Pontisso, Patrizia

“…The serine protease inhibitor SerpinB3 has been described as critical mediator of liver fibrosis and it has been recently proposed as an additional hepatokine…”
Get full text

Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells by Trappoliere, Marco, Caligiuri, Alessandra, Schmid, Monika, Bertolani, Cristiana, Failli, Paola, Vizzutti, Francesco, Novo, Erica, Manzano, Carlo di, Marra, Fabio, Loguercio, Carmela, Pinzani, Massimo

“…Background/Aims Hepatic fibrogenesis, a consequence of chronic liver tissue damage, is characterized by activation of the hepatic stellate cells (HSC). Silybin…”
Get full text

Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells by Cannito, Stefania, Novo, Erica, Compagnone, Alessandra, Valfrè di Bonzo, Lorenzo, Busletta, Chiara, Zamara, Elena, Paternostro, Claudia, Povero, Davide, Bandino, Andrea, Bozzo, Francesca, Cravanzola, Carlo, Bravoco, Vittoria, Colombatto, Sebastiano, Parola, Maurizio

“…Epithelial–mesenchymal transition (EMT) and hypoxia are considered as crucial events favouring invasion and metastasis of many cancer cells. In this study,…”
Get full text

Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis by Cannito, Stefania, Morello, Elisabetta, Bocca, Claudia, Foglia, Beatrice, Benetti, Elisa, Novo, Erica, Chiazza, Fausto, Rogazzo, Mara, Fantozzi, Roberto, Povero, Davide, Sutti, Salvatore, Bugianesi, Elisabetta, Feldstein, Ariel E, Albano, Emanuele, Collino, Massimo, Parola, Maurizio

“…Non-Alcoholic Fatty Liver Disease (NAFLD) is a major form of chronic liver disease in the general population in relation to its high prevalence among…”
Get full text

Histidine-rich glycoprotein in metabolic dysfunction-associated steatohepatitis-related disease progression and liver carcinogenesis by Foglia, Beatrice, Sutti, Salvatore, Cannito, Stefania, Rosso, Chiara, Maggiora, Marina, Casalino, Alice, Bocca, Claudia, Novo, Erica, Protopapa, Francesca, Ramavath, Naresh Naik, Provera, Alessia, Gambella, Alessandro, Bugianesi, Elisabetta, Tacke, Frank, Albano, Emanuele, Parola, Maurizio

“…Metabolic dysfunction-associated steatotic liver disease (MASLD), previously non-alcoholic fatty liver disease (NAFLD), is a leading cause of chronic liver…”
Get full text

Role of Chymase in the Development of Liver Cirrhosis and Its Complications: Experimental and Human Data by Sansoè, Giovanni, Aragno, Manuela, Mastrocola, Raffaella, Mengozzi, Giulio, Novo, Erica, Parola, Maurizio

“…Tissue Angiotensin II (Ang-II), produced through local non ACE-dependent pathways, stimulates liver fibrogenesis, renal vasoconstriction and sodium retention…”
Get full text

Hepatic Myofibroblasts: A Heterogeneous and Redox-Modulated Cell Population in Liver Fibrogenesis by Bocca, Claudia, Protopapa, Francesca, Foglia, Beatrice, Maggiora, Marina, Cannito, Stefania, Parola, Maurizio, Novo, Erica

“…During chronic liver disease (CLD) progression, hepatic myofibroblasts (MFs) represent a unique cellular phenotype that plays a critical role in driving liver…”
Get full text

SerpinB3 as a Pro-Inflammatory Mediator in the Progression of Experimental Non-Alcoholic Fatty Liver Disease by Novo, Erica, Cappon, Andrea, Villano, Gianmarco, Quarta, Santina, Cannito, Stefania, Bocca, Claudia, Turato, Cristian, Guido, Maria, Maggiora, Marina, Protopapa, Francesca, Sutti, Salvatore, Provera, Alessia, Ruvoletto, Mariagrazia, Biasiolo, Alessandra, Foglia, Beatrice, Albano, Emanuele, Pontisso, Patrizia, Parola, Maurizio

“…Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disease worldwide. In 20-30% of patients, NAFLD can progress into…”
Get full text

The biphasic nature of hypoxia-induced directional migration of activated human hepatic stellate cells by Novo, Erica, Povero, Davide, Busletta, Chiara, Paternostro, Claudia, di Bonzo, Lorenzo Valfrè, Cannito, Stefania, Compagnone, Alessandra, Bandino, Andrea, Marra, Fabio, Colombatto, Sebastiano, David, Ezio, Pinzani, Massimo, Parola, Maurizio

“…Liver fibrogenesis is sustained by pro‐fibrogenic myofibroblast‐like cells (MFs), mainly originating from activated hepatic stellate cells (HSC/MFs) or portal…”
Get full text

Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells by ALEFFI, Sara, PETRAI, Ilaria, LATH, Giacomo, PINZNLI, Massimo, MARRA, Fabio, BERTOLALI, Cristiana, PAROLA, Maurizio, COLOMBATTO, Sebastiano, NOVO, Erica, VIZMTTI, Francesco, ANANIA, Frank A, MILANI, Stefano, ROMBOUTS, Krista

“…Leptin upregulates collagen expression in hepatic stellate cells (HSCs), but the possible modulation of other actions has not been elucidated. The aim of this…”
Get full text

SerpinB3 Promotes Pro-fibrogenic Responses in Activated Hepatic Stellate Cells by Novo, Erica, Villano, Gianmarco, Turato, Cristian, Cannito, Stefania, Paternostro, Claudia, Busletta, Chiara, Biasiolo, Alessandra, Quarta, Santina, Morello, Elisabetta, Bocca, Claudia, Miglietta, Antonella, David, Ezio, Sutti, Salvatore, Plebani, Mario, Albano, Emanuele, Parola, Maurizio, Pontisso, Patrizia

“…SerpinB3 is a hypoxia- and hypoxia-inducible factor-2α-dependent cystein protease inhibitor that is up-regulated in hepatocellular carcinoma and in parenchymal…”
Get full text

Curcumin limits the fibrogenic evolution of experimental steatohepatitis by Vizzutti, Francesco, Provenzano, Angela, Galastri, Sara, Milani, Stefano, Delogu, Wanda, Novo, Erica, Caligiuri, Alessandra, Zamara, Elena, Arena, Umberto, Laffi, Giacomo, Parola, Maurizio, Pinzani, Massimo, Marra, Fabio

“…Nonalcoholic steatohepatitis is characterized by the association of steatosis with hepatic cell injury, lobular inflammation and fibrosis. Curcumin is known…”
Get full text

Hypoxia,angiogenesis and liver fibrogenesis in the progression of chronic liver diseases by Paternostro, Claudia, David, Ezio, Novo, Erica, Parola, Maurizio

“…Angiogenesis is a dynamic,hypoxia-stimulated and growth factor-dependent process,and is currently referred to as the formation of new vessels from preexisting…”
Get full text

Hyperdynamic circulatory syndrome in a mouse model transgenic for SerpinB3 by Villano, Gianmarco, Verardo, Alberto, Martini, Andrea, Brocco, Silvia, Pesce, Paola, Novo, Erica, Parola, Maurizio, Sacerdoti, David, Di Pascoli, Marco, Fedrigo, Marny, Castellani, Chiara, Angelini, Annalisa, Pontisso, Patrizia, Bolognesi, Massimo

“…SerpinB3 is a cysteine protease inhibitor involved in several biological activities. It is progressively expressed in chronic liver disease, but not in normal…”
Get full text

n-3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis by Provenzano, Angela, Milani, Stefano, Vizzutti, Francesco, Delogu, Wanda, Navari, Nadia, Novo, Erica, Maggiora, Marina, Maurino, Valter, Laffi, Giacomo, Parola, Maurizio, Marra, Fabio

“…Background & Aims n‐3 polyunsaturated fatty acids (PUFA) ameliorate fatty liver in experimental models, but their effects on inflammation and fibrosis during…”
Get full text

Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis by Marra, Fabio, DeFranco, Raffaella, Robino, Gaia, Novo, Erica, Efsen, Eva, Pastacaldi, Sabrina, Zamara, Elena, Vercelli, Alessandro, Lottini, Benedetta, Spirli, Carlo, Strazzabosco, Mario, Pinzani, Massimo, Parola, Maurizio

“…AIM： To investigate the effects of troglitazone （TGZ）, an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-y （PPAR-y）, for liver…”
Get full text