Search Results - "NOVICK, STEVEN J."

A comparison of statistical methods for animal oncology studies by Zhang, Tianhui, Novick, Steven J.

“…In pre‐clinical oncology studies, tumor‐bearing animals are treated and observed over a period of time in order to measure and compare the efficacy of one or…”
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A simple test for synergy for a small number of combinations by Novick, Steven J.

“…A method for detecting deviations from the Loewe additive drug combination reference model for in vitro drug combination experimentation is described. It is…”
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Pharmacovirological Impact of an Integrase Inhibitor on Human Immunodeficiency Virus Type 1 cDNA Species In Vivo by GOFFINET, Christine, ALLESPACH, Ina, KEPPLER, Oliver T, OBERBREMER, Lena, GOLDEN, Pamela L, FOSTER, Scott A, JOHNS, Brian A, WEATHERHEAD, Jason G, NOVICK, Steven J, CHISWELL, Karen E, GARVEY, Edward P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Setting Alert and Action Limits in the Presence of Significant Amount of Censoring in Data by Novick, Steven J, Zhao, Wei, Yang, Harry

“…In manufacturing settings, control limits are often set using a three-sigma rule (i.e., three estimated standard deviations above and below the estimated…”
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Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infection by Hoover, Jennifer, Lewandowski, Thomas, Straub, Robert J, Novick, Steven J, DeMarsh, Peter, Aubart, Kelly, Rittenhouse, Stephen, Zalacain, Magdalena

“…GSK1322322 is a novel inhibitor of peptide deformylase (PDF) with good in vitro activity against bacteria associated with community-acquired pneumonia and skin…”
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A new PK equivalence test for a bridging study by Novick, Steven J., Zhang, Xiang, Yang, Harry

“…In a bridging study, the plasma drug concentration-time curve is generally used to assess bioequivalence between the two formulations. Selected pharmacokinetic…”
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Directly testing the linearity assumption for assay validation by Novick, Steven J., Yang, Harry

“…The ICH Q2(R1) (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use) guideline for testing…”
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Development of a high-throughput electrophysiological assay for the human ether-à-go-go related potassium channel hERG by Gillie, Daniel J., Novick, Steven J., Donovan, Brian T., Payne, Lisa A., Townsend, Claire

“…Drug-induced prolongation of the QT interval via block of the hERG potassium channel is a major cause of attrition in drug development. The advent of automated…”
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Testing Assay Linearity Over a Pre-Specified Range by Yang, Harry, Novick, Steven J., LeBlond, David

“…Validation of linearity is a regulatory requirement. Although many methods are proposed, they suffer from several deficiencies including difficulties of…”
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The acute extracellular flux (XF) assay to assess compound effects on mitochondrial function by Wang, Ruolan, Novick, Steven J, Mangum, James B, Queen, Kennedy, Ferrick, David A, Rogers, George W, Stimmel, Julie B

“…Numerous investigations have linked mitochondrial dysfunction to adverse health outcomes and drug-induced toxicity. The pharmaceutical industry is challenged…”
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Testing drug additivity based on monotherapies by Yang, Harry, Novick, Steven J., Zhao, Wei

“…Under the Loewe additivity, constant relative potency between two drugs is a sufficient condition for the two drugs to be additive. Implicit in this condition…”
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Nonlinear Blending: A Useful General Concept for the Assessment of Combination Drug Synergy by PETERSON, JOHN J., NOVICK, STEVEN J.

“…Human diseases may involve cellular signaling networks that contain redundant pathways, so that blocking a single pathway in the system cannot achieve the…”
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Corrected Score Estimation via Complex Variable Simulation Extrapolation by Novick, Steven J, Stefanski, Leonard A

“…A Monte Carlo method of computing unbiased estimating equations for the analysis of data measured with error is described. Asymptotic distribution results are…”
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Estimating a nonlinear function of a normal mean by Stefanski, Leonard A., Novick, Steven J., Devanarayan, Viswanath

“…We derive a Monte-Carlo-amenable, minimum variance unbiased estimator of a nonlinear function of a normal mean and the variance of the estimator. Applications…”
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Development and Validation of a high-throughput Structure-Activity Relationship Assay for the hERG Potassium Channel by Gillie, Daniel J., Novick, Steven J., Donovan, Brian T., Payne, Lisa A., Townsend, Claire

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