Search Results - "NOVICK, Richard"

Early insight into spontaneous mutations by Novick, Richard P.

“…Letter to the Editor…”
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Quorum sensing in staphylococci by Novick, Richard P, Geisinger, Edward

“…The staphylococcal agr locus encodes a quorum sensing (QS) system that controls the expression of virulence and other accessory genes by a classical…”
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Activation and Inhibition of the Receptor Histidine Kinase AgrC Occurs through Opposite Helical Transduction Motions by Wang, Boyuan, Zhao, Aishan, Novick, Richard P., Muir, Tom W.

“…Staphylococcus aureus virulence is regulated when secreted autoinducing peptides (AIPs) are recognized by a membrane-bound receptor histidine kinase (RHK),…”
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Staphylococcal pathogenicity islands—movers and shakers in the genomic firmament by Novick, Richard P, Ram, Geeta

“…•SaPIs are helper phage inducible, highly mobile elements that carry toxin genes.•SaPIs have a distinctive life style that is highly beneficial to their host…”
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Bacteriophage-mediated spread of bacterial virulence genes by Penadés, José R, Chen, John, Quiles-Puchalt, Nuria, Carpena, Nuria, Novick, Richard P

“…Highlights • Phage-mediated transduction drives bacterial evolution. • pac -phages can package any bacterial DNA. • Both pac and cos phages can transfer mobile…”
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Phage-Mediated Intergeneric Transfer of Toxin Genes by Chen, John, Novick, Richard P

“…Because bacteriophages generally parasitize only closely related bacteria, it is assumed that phage-mediated genetic exchange occurs primarily within species…”
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The Floating (Pathogenicity) Island: A Genomic Dessert by Novick, Richard P, Ram, Geeta

“…Among the prokaryotic genomic islands (GIs) involved in horizontal gene transfer (HGT) are the classical pathogenicity islands, including the integrative and…”
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Autoinduction and signal transduction in the regulation of staphylococcal virulence by Novick, Richard P.

“…Summary The accessory genes of Staphylococcus aureus, in‐cluding those involved in pathogenesis, are controlled by a complex regulatory network that includes…”
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Conversion of staphylococcal pathogenicity islands to CRISPR-carrying antibacterial agents that cure infections in mice by Ram, Geeta, Ross, Hope F, Novick, Richard P, Rodriguez-Pagan, Ivelisse, Jiang, Dunrong

“…Engineered staphylococcal pathogenicity islands offer a potentially superior alternative to phages for antibacterial therapy Staphylococcus aureus and other…”
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The phage-related chromosomal islands of Gram-positive bacteria by Novick, Richard P, Christie, Gail E, Penadés, Jose R

“…Key Points Staphylococcus aureus pathogenicity islands (SaPIs) are highly mobile phage-related mobile genetic elements in staphylococci. Elements similar to…”
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Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils by Nielsen, Anita, Månsson, Maria, Bojer, Martin S, Gram, Lone, Larsen, Thomas O, Novick, Richard P, Frees, Dorte, Frøkiær, Hanne, Ingmer, Hanne

“…Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a serious human pathogen, and particularly the spread of community associated (CA)-MRSA…”
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Antibacterial particles and predatory bacteria as alternatives to antibacterial chemicals in the era of antibiotic resistance by Novick, Richard P

“…•One solution to the antibiotic resistance crisis: unitary antibacterial agents that act on individual bacteria.•Four of these are reviewed: three use phage…”
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Reconstitution of the S. aureus agr quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis by Zhao, Aishan, Bodine, Steven P, Xie, Qian, Wang, Boyuan, Ram, Geeta, Novick, Richard P, Muir, Tom W

“…In virulence is under the control of a quorum sensing (QS) circuit encoded in the accessory gene regulator ( ) genomic locus. Key to this pathogenic behavior…”
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Off-Pump or On-Pump Coronary-Artery Bypass Grafting at 30 Days by Lamy, André, Devereaux, P.J, Prabhakaran, Dorairaj, Taggart, David P, Hu, Shengshou, Paolasso, Ernesto, Straka, Zbynek, Piegas, Leopoldo S, Akar, Ahmet Ruchan, Jain, Anil R, Noiseux, Nicolas, Padmanabhan, Chandrasekar, Bahamondes, Juan-Carlos, Novick, Richard J, Vaijyanath, Prashant, Reddy, Sukesh, Tao, Liang, Olavegogeascoechea, Pablo A, Airan, Balram, Sulling, Toomas-Andres, Whitlock, Richard P, Ou, Yongning, Ng, Jennifer, Chrolavicius, Susan, Yusuf, Salim

“…A total of 4752 patients for whom CABG was planned were randomly assigned to undergo the procedure on-pump or off-pump. At 30 days, the rates of death,…”
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Pathogenicity Island-Directed Transfer of Unlinked Chromosomal Virulence Genes by Chen, John, Ram, Geeta, Penadés, José R., Brown, Stuart, Novick, Richard P.

“…In recent decades, the notorious pathogen Staphylococcus aureus has become progressively more contagious, more virulent, and more resistant to antibiotics…”
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Effects of Off-Pump and On-Pump Coronary-Artery Bypass Grafting at 1 Year by Lamy, André, Devereaux, P.J, Prabhakaran, Dorairaj, Taggart, David P, Hu, Shengshou, Paolasso, Ernesto, Straka, Zbynek, Piegas, Leopoldo S, Akar, Ahmet Ruchan, Jain, Anil R, Noiseux, Nicolas, Padmanabhan, Chandrasekar, Bahamondes, Juan-Carlos, Novick, Richard J, Vaijyanath, Prashant, Reddy, Sukesh Kumar, Tao, Liang, Olavegogeascoechea, Pablo A, Airan, Balram, Sulling, Toomas-Andres, Whitlock, Richard P, Ou, Yongning, Pogue, Janice, Chrolavicius, Susan, Yusuf, Salim

“…A total of 4752 patients were randomly assigned to CABG with (on-pump) or without (off-pump) cardiopulmonary bypass. At 1 year, there was no significant…”
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Five-Year Outcomes after Off-Pump or On-Pump Coronary-Artery Bypass Grafting by Lamy, André, Devereaux, P.J, Prabhakaran, Dorairaj, Taggart, David P, Hu, Shengshou, Straka, Zbynek, Piegas, Leopoldo S, Avezum, Alvaro, Akar, Ahmet R, Lanas Zanetti, Fernando, Jain, Anil R, Noiseux, Nicolas, Padmanabhan, Chandrasekar, Bahamondes, Juan-Carlos, Novick, Richard J, Tao, Liang, Olavegogeascoechea, Pablo A, Airan, Balram, Sulling, Toomas-Andres, Whitlock, Richard P, Ou, Yongning, Gao, Peggy, Pettit, Shirley, Yusuf, Salim

“…After 5 years of follow-up in this trial, the rates of the composite outcome of death, stroke, myocardial infarction, renal failure, or repeat…”
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Failure-to-Rescue Rate as a Measure of Quality of Care in a Cardiac Surgery Recovery Unit: A Five-Year Study by Ahmed, Elnazeer O., MD, FRCSI, Butler, Ron, MD, MSc, Novick, Richard J., MD, MSc

“…Background Failure to rescue, which is defined as the probability of death after a complication that was not present on admission, was introduced as a quality…”
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Phage-inducible islands in the Gram-positive cocci by Martínez-Rubio, Roser, Quiles-Puchalt, Nuria, Martí, Miguel, Humphrey, Suzanne, Ram, Geeta, Smyth, Davida, Chen, John, Novick, Richard P, Penadés, José R

“…The SaPIs are a cohesive subfamily of extremely common phage-inducible chromosomal islands (PICIs) that reside quiescently at specific att sites in the…”
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agr function in clinical Staphylococcus aureus isolates by Traber, Katrina E, Lee, Elsie, Benson, Sarah, Corrigan, Rebecca, Cantera, Mariela, Shopsin, Bo, Novick, Richard P

“…1 Molecular Pathogenesis Program and Department of Microbiology and Medicine, Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball…”
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