Search Results - "NOVAK, Rodger"

Are pleuromutilin antibiotics finally fit for human use? by Novak, Rodger

“…In 1951, the first reference to the antibacterial substance pleuromutilin was made in a paper published in the Proceedings of the National Academy of Sciences…”
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Synthesis of group A streptococcal virulence factors is controlled by a regulatory RNA molecule by Mangold, Monika, Siller, Maria, Roppenser, Bernhard, Vlaminckx, Bart J. M., Penfound, Tom A., Klein, Reinhard, Novak, Rodger, Novick, Richard P., Charpentier, Emmanuelle

“…Summary The capacity of pathogens to cause disease depends strictly on the regulated expression of their virulence factors. In this study, we demonstrate that…”
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Mechanistic Basis for the Action of New Cephalosporin Antibiotics Effective against Methicillin- and Vancomycin-resistant Staphylococcus aureus by Fuda, Cosimo, Hesek, Dusan, Lee, Mijoon, Heilmayer, Werner, Novak, Rodger, Vakulenko, Sergei B., Mobashery, Shahriar

“…Emergence of methicillin-resistant Staphylococcus aureus (MRSA) has created challenges in treatment of nosocomial infections. The recent clinical emergence of…”
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Site-Specific Manifestations of Invasive Group A Streptococcal Disease: Type Distribution and Corresponding Patterns of Virulence Determinants by VLAMINCKX, Bart J. M, MASCINI, Ellen M, SCHELLEKENS, Joop, SCHOULS, Leo M, PAAUW, Armand, FLUIT, Ad C, NOVAK, Rodger, VERHOEF, Jan, SCHMITZ, Franz Josef

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Clinical Isolates of Streptococcus pneumoniae That Exhibit Tolerance of Vancomycin by Normark, Birgitta Henriques, Novak, Rodger, Örtqvist, Åke, Källenius, Gunilla, Tuomanen, Elaine, Normark, Staffan

“…The ability of Streptococcus pneumoniae to escape lysis and killing by vancomycin, a property termed “tolerance,” has recently been noted in a laboratory…”
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Pneumolysin, a Protein Toxin of Streptococcus pneumoniae, Induces Nitric Oxide Production from Macrophages by BRAUN, J. S, NOVAK, R, GAO, G, MURRAY, P. J, SHENEP, J. L

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Regulation of growth inhibition at high temperature, autolysis, transformation and adherence in Streptococcus pneumoniae by ClpC by Charpentier, Emmanuelle, Novak, Rodger, Tuomanen, Elaine

“…The ClpC ATPase is a subfamily of HSP100/Clp molecular chaperones–regulators of proteolysis. By screening a library of loss of function mutants for the ability…”
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Identification of a Streptococcus pneumoniae Gene Locus Encoding Proteins of an ABC Phosphate Transporter and a Two-Component Regulatory System by Novak, R, Cauwels, A, Charpentier, E, Tuomanen, E

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The pleuromutilin antibiotics: a new class for human use by Novak, Rodger, Shlaes, David M

“…Pleuromutilins were discovered as natural-product antibiotics in 1950. Tiamulin was the first pleuromutilin compound to be approved for veterinary use in 1979,…”
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CRISPR-Cas Gene Editing to Cure Serious Diseases: Treat the Patient, Not the Germ Line by Lundberg, Ante S., Novak, Rodger

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Intracerebral hemorrhages, fibrinolysis, and prostate carcinoma by Braun, Johann S, Novak, Rodger, Torzewski, Michael, Soehngen, Dietmar

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Crispr/Cas9- Mediated Genome Editing of Human CD34+ Cells Upregulate Fetal Hemoglobin to Clinically Relevant Levels in Single Cell-Derived Erythroid Colonies by Mishra, Bibhu, Chou, Song, Lin, Michelle I, Paik, Elizabeth J, Zhang, Ying, Liang, Ruibin, Tomkinson, Kaleigh, Pettiglio, Michael, Sanginario, Andrew, Allen, Melanie, Cradick, Thomas, John, Matthias, Chakraborty, Tirtha, Cowan, Chad A, Novak, Rodger, Lundberg, Ante S

“…Fetal hemoglobin (HbF) is abundant in the late stage fetus and newborns, but is progressively lost over the first 6 months of life as the genes encoding the…”
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CRISPR/Cas9 Genome Editing to Treat Sickle Cell Disease and B-Thalassemia: Re-Creating Genetic Variants to Upregulate Fetal Hemoglobin Appear Well-Tolerated, Effective and Durable by Lin, Michelle I., Paik, Elizabeth, Mishra, Bibhu, Burkhardt, David, Kernytsky, Andrew, Pettiglio, Michael, Chen, Yi-Shan, Tomkinson, Kaleigh, Woo, Amanda, Cortes, Mauricio, Tan, Siyuan, Borland, Todd D, Klein, Lawrence, Yen, Angela, Mahajan, Sudipta, Chan, Eric, Eustace, Brenda, Porteus, Matthew, Chakraborty, Tirtha, Cowan, Chad, Novak, Rodger, Lundberg, Ante

“…Persistent expression of fetal hemoglobin (HbF) beyond the neonatal period is a rare, naturally-occurring condition, referred to as the Hereditary Persistence…”
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Re-Creating Hereditary Persistence of Fetal Hemoglobin (HPFH) to Treat Sickle Cell Disease (SCD) and β-Thalassemia by Lin, Michelle I, Paik, Elizabeth J, Mishra, Bibhu P, Chou, Song, Zhang, Ying, Tomkinson, Kaleigh, Pettiglio, Michael A, Sanginario, Andrew, Woo, Amanda, Lee, Min Jin, Allen, Melanie, Cradick, Thomas J, Chakraborty, Tirtha, Porteus, Matthew, Lee, Ciaran M, Bao, Gang, Miccio, Annarita, Lattanzi, Annalisa, Mavilio, Fulvio, Cowan, Chad A, Novak, Rodger, Lundberg, Ante S

“…Hereditary persistence of fetal hemoglobin, a naturally occurring condition that substantially ameliorates disease in SCD and β-thalassemia, is associated with…”
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Capsular Expression in Streptococcus pneumoniae Negatively Affects Spontaneous and Antibiotic-Induced Lysis and Contributes to Antibiotic Tolerance by Fernebro, Jenny, Andersson, Ingrid, Sublett, Jack, Morfeldt, Eva, Novak, Rodger, Tuomanen, Elaine, Normark, Staffan, Normark, Birgitta Henriques

“…Penicillin and vancomycin induce a lytic response in Streptococcus pneumoniae that requires the N-acetylmuramyl-l-alanine amidase LytA. We show that clinical…”
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Isolation and Characterization of Vancomycin-Tolerant Streptococcus pneumoniae from the Cerebrospinal Fluid of a Patient Who Developed Recrudescent Meningitis by McCullers, Jonathan A., Keith English, B., Novak, Rodger

“…The emergence of tolerance to vancomycin has recently been reported in Streptococcus pneumoniae, the most common cause of bacterial meningitis. A vancomycin-…”
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Apoptosis-Inducing Factor Mediates Microglial and Neuronal Apoptosis Caused by Pneumococcus by Braun, Johann S., Novak, Rodger, Murray, Peter J., Eischen, Christine M., Susin, Santos A., Kroemer, Guido, Halle, Annett, Weber, Joerg R., Tuomanen, Elaine I., Cleveland, John L.

“…Streptococcus pneumoniae is the major cause of bacterial meningitis and it damages the hippocampus by inducing neuronal apoptosis. The blocking of caspases…”
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Penicillin tolerance genes of Streptococcus pneumoniae: the ABC‐type manganese permease complex Psa by Novak, Rodger, Braun, Johann S., Charpentier, Emmanuelle, Tuomanen, Elaine

“…Downregulation of the major autolysin in Streptococcus pneumoniae leads to penicillin tolerance, a feature that is characterized by the ability to survive but…”
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Signal Transduction by a Death Signal Peptide: Uncovering the Mechanism of Bacterial Killing by Penicillin by Novak, Rodger, Charpentier, Emmanuelle, Braun, Johann S., Tuomanen, Elaine

“…The binding of bactericidal antibiotics like penicillins, cephalosporins, and glycopeptides to their bacterial targets stops bacterial growth but does not…”
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Toxin-Gene Profile Heterogeneity among Endemic Invasive European Group A Streptococcal Isolates by Schmitz, Franz-Josef, Beyer, Andreas, Charpentier, Emmanuelle, Normark, Birgitta Henriques, Schade, Marc, Fluit, Ad C., Hafner, Dieter, Novak, Rodger

“…We determined the toxin-gene profiles of 239 endemic, invasive group A streptococcal (GAS) isolates that circulated, within a 5-year period, in European…”
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