Search Results - "NOUT, Remi A"

Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy by León-Castillo, Alicia, de Boer, Stephanie M, Powell, Melanie E, Mileshkin, Linda R, Mackay, Helen J, Leary, Alexandra, Nijman, Hans W, Singh, Naveena, Pollock, Pamela M, Bessette, Paul, Fyles, Anthony, Haie-Meder, Christine, Smit, Vincent T H B M, Edmondson, Richard J, Putter, Hein, Kitchener, Henry C, Crosbie, Emma J, de Bruyn, Marco, Nout, Remi A, Horeweg, Nanda, Creutzberg, Carien L, Bosse, Tjalling

“…The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of…”
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Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer-Combined Analysis of the PORTEC Cohorts by Stelloo, Ellen, Nout, Remi A, Osse, Elisabeth M, Jürgenliemk-Schulz, Ina J, Jobsen, Jan J, Lutgens, Ludy C, van der Steen-Banasik, Elzbieta M, Nijman, Hans W, Putter, Hein, Bosse, Tjalling, Creutzberg, Carien L, Smit, Vincent T H B M

“…Recommendations for adjuvant treatment for women with early-stage endometrial carcinoma are based on clinicopathologic features. Comprehensive genomic…”
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Molecular Classification of Grade 3 Endometrioid Endometrial Cancers Identifies Distinct Prognostic Subgroups by Bosse, Tjalling, Nout, Remi A, McAlpine, Jessica N, McConechy, Melissa K, Britton, Heidi, Hussein, Yaser R, Gonzalez, Carlene, Ganesan, Raji, Steele, Jane C, Harrison, Beth T, Oliva, Esther, Vidal, August, Matias-Guiu, Xavier, Abu-Rustum, Nadeem R, Levine, Douglas A, Gilks, C Blake, Soslow, Robert A

“…Our aim was to investigate whether molecular classification can be used to refine prognosis in grade 3 endometrial endometrioid carcinomas (EECs). Grade 3 EECs…”
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Substantial lymph-vascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer – A pooled analysis of PORTEC 1 and 2 trials by Bosse, Tjalling, Peters, Elke E.M, Creutzberg, Carien L, Jürgenliemk-Schulz, Ina M, Jobsen, Jan J, Mens, Jan Willem M, Lutgens, Ludy C.H.W, van der Steen-Banasik, Elzbieta M, Smit, Vincent T.H.B.M, Nout, Remi A

“…Abstract Background Lymph-vascular space invasion (LVSI) is an important adverse prognostic factor in endometrial cancer (EC). However, its role in relation to…”
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POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer by van Gool, Inge C, Eggink, Florine A, Freeman-Mills, Luke, Stelloo, Ellen, Marchi, Emanuele, de Bruyn, Marco, Palles, Claire, Nout, Remi A, de Kroon, Cor D, Osse, Elisabeth M, Klenerman, Paul, Creutzberg, Carien L, Tomlinson, Ian Pm, Smit, Vincent Thbm, Nijman, Hans W, Bosse, Tjalling, Church, David N

“…Recent studies have shown that 7% to 12% of endometrial cancers are ultramutated due to somatic mutation in the proofreading exonuclease domain of the DNA…”
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Prognostic significance of POLE proofreading mutations in endometrial cancer by Church, David N, Stelloo, Ellen, Nout, Remi A, Valtcheva, Nadejda, Depreeuw, Jeroen, ter Haar, Natalja, Noske, Aurelia, Amant, Frederic, Tomlinson, Ian P M, Wild, Peter J, Lambrechts, Diether, Jürgenliemk-Schulz, Ina M, Jobsen, Jan J, Smit, Vincent T H B M, Creutzberg, Carien L, Bosse, Tjalling

“…Current risk stratification in endometrial cancer (EC) results in frequent over- and underuse of adjuvant therapy, and may be improved by novel biomarkers. We…”
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Manifestation Pattern of Early-Late Vaginal Morbidity After Definitive Radiation (Chemo)Therapy and Image-Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer: An Analysis From the EMBRACE Study by Kirchheiner, Kathrin, MSc, Nout, Remi A., MD, PhD, Tanderup, Kari, PhD, Lindegaard, Jacob C., MD, DMSc, Westerveld, Henrike, MD, PhD, Haie-Meder, Christine, MD, Petrič, Primož, MD, PhD, Mahantshetty, Umesh, DMRT, MD, DNB, Dörr, Wolfgang, DVM, PhD, Pötter, Richard, MD, PhD

“…Background and Purpose Brachytherapy in the treatment of locally advanced cervical cancer has changed substantially because of the introduction of combined…”
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Toxicity and quality of life after adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): an open-label, multicentre, randomised, phase 3 trial by de Boer, Stephanie M, Dr, Powell, Melanie E, MD, Mileshkin, Linda, MD, Katsaros, Dionyssios, Prof, Bessette, Paul, Prof, Haie-Meder, Christine, MD, Ottevanger, Petronella B, MD, Ledermann, Jonathan A, Prof, Khaw, Pearly, MD, Colombo, Alessandro, MD, Fyles, Anthony, Prof, Baron, Marie-Helene, MD, Kitchener, Henry C, Prof, Nijman, Hans W, Prof, Kruitwagen, Roy F, Prof, Nout, Remi A, MD, Verhoeven-Adema, Karen W, PhD, Smit, Vincent T, Prof, Putter, Hein, Prof, Creutzberg, Carien L, Prof

“…Summary Background About 15% of patients with endometrial cancer have high-risk features and are at increased risk of distant metastases and endometrial…”
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The Clinical Approach Toward Giant Cell Tumor of Bone by Heijden, Lizz, Dijkstra, P.D. Sander, Sande, Michiel A.J., Kroep, Judith R., Nout, Remi A., Rijswijk, Carla S.P., Bovée, Judith V.M.G., Hogendoorn, Pancras C.W., Gelderblom, Hans

“…We provide an overview of imaging, histopathology, genetics, and multidisciplinary treatment of giant cell tumor of bone (GCTB), an intermediate, locally…”
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Bowel Function 14 Years After Preoperative Short-Course Radiotherapy and Total Mesorectal Excision for Rectal Cancer: Report of a Multicenter Randomized Trial by Chen, Tina Yen-Ting, Wiltink, Lisette M, Nout, Remi A, Meershoek-Klein Kranenbarg, Elma, Laurberg, Søren, Marijnen, Corrie A.M, van de Velde, Cornelis J.H

“…Micro-Abstract Very long-term bowel function after total mesorectal excision (TME) with or without preoperative short-course radiotherapy (PRT) for rectal…”
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Importance of Technique, Target Selection, Contouring, Dose Prescription, and Dose-Planning in External Beam Radiation Therapy for Cervical Cancer: Evolution of Practice From EMBRACE-I to II by Berger, Thomas, Seppenwoolde, Yvette, Pötter, Richard, Assenholt, Marianne Sanggaard, Lindegaard, Jacob C., Nout, Remi A., de Leeuw, Astrid, Jürgenliemk-Schulz, Ina, Tan, Li Tee, Georg, Dietmar, Kirisits, Christian, Dumas, Isabelle, Nesvacil, Nicole, Swamidas, Jamema, Hudej, Robert, Lowe, Gerry, Hellebust, Taran Paulsen, Menon, Geetha, Fokdal, Lars, Tanderup, Kari

“…To describe the evolution of external beam radiation therapy (EBRT) from EMBRACE-I (general guidelines for EBRT) to the initial phase of the EMBRACE-II study…”
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Stereotactic body radiation therapy on abdominal-pelvic lymph node oligometastases: a systematic review on toxicity by Van Werkhoven, Lucy A, Cammareri, Eugenio, Hoogeman, Mischa S, Nout, Remi A, Milder, Maaike T W, Nuyttens, Joost J M E

“…To review available data on toxicity during and/or after treatment of abdominal-pelvic lymph node oligometastases (A-P LN) with stereotactic body radiation…”
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Fifteen-Year Radiotherapy Outcomes of the Randomized PORTEC-1 Trial for Endometrial Carcinoma by Creutzberg, Carien L., M.D., Ph.D, Nout, Remi A., M.D, Lybeert, Marnix L.M., M.D, Wárlám-Rodenhuis, Carla C., M.D, Jobsen, Jan J., M.D., Ph.D, Mens, Jan-Willem M., M.D, Lutgens, Ludy C.H.W., M.D., Ph.D, Pras, Elisabeth, M.D., Ph.D, van de Poll-Franse, Lonneke V., Ph.D, van Putten, Wim L.J., M.Sc

“…Purpose To evaluate the very long-term results of the randomized Post Operative Radiation Therapy in Endometrial Carcinoma (PORTEC)-1 trial for patients with…”
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Dose-effect relationship between vaginal dose points and vaginal stenosis in cervical cancer: An EMBRACE-I sub-study by Westerveld, Henrike, Kirchheiner, Kathrin, Nout, Remi A., Tanderup, Kari, Lindegaard, Jacob C., Spampinato, Sofia, Sturdza, Alina, Nesvacil, Nicole, Bruheim, Kjersti, Hellebust, Taran P., Pieters, Bradley R., Kirisits, Christian, Jürgenliemk-Schulz, Ina M., Pötter, Richard, de Leeuw, Astrid A.C.

“…•Doses to the vaginal dose points predicts well the risk of vaginal morbidity.•Higher doses to the vaginal PIBS points are associated with vaginal stenosis.•A…”
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Ki-67 in endometrial cancer: scoring optimization and prognostic relevance for window studies by Kitson, Sarah, Sivalingam, Vanitha N, Bolton, James, McVey, Rhona, Nickkho-Amiry, Mashid, Powell, Melanie E, Leary, Alexandra, Nijman, Hans W, Nout, Remi A, Bosse, Tjalling, Renehan, Andrew G, Kitchener, Henry C, Edmondson, Richard J, Crosbie, Emma J

“…Ki-67, a marker of cellular proliferation, is increasingly being used in pre-surgical window studies in endometrial cancer as a primary outcome measure. Unlike…”
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Long-Term Outcome and Quality of Life of Patients With Endometrial Carcinoma Treated With or Without Pelvic Radiotherapy in the Post Operative Radiation Therapy in Endometrial Carcinoma 1 (PORTEC-1) Trial by Nout, Remi A, van de Poll-Franse, Lonneke V, Lybeert, Marnix L M, Wárlám-Rodenhuis, Carla C, Jobsen, Jan J, Mens, Jan Willem M, Lutgens, Ludy C H W, Pras, Betty, van Putten, Wim L J, Creutzberg, Carien L

“…To determine the long-term outcome and health-related quality of life (HRQL) of patients with endometrial carcinoma (EC) treated with or without pelvic…”
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Long-Term Impact of Endometrial Cancer Diagnosis and Treatment on Health-Related Quality of Life and Cancer Survivorship: Results From the Randomized PORTEC-2 Trial by de Boer, Stephanie M., MD, Nout, Remi A., MD, PhD, Jürgenliemk-Schulz, Ina M., MD, PhD, Jobsen, Jan J., MD, PhD, Lutgens, Ludy C.H.W., MD, PhD, van der Steen-Banasik, Elzbieta M., MD, Mens, Jan Willem M., MD, Slot, Annerie, MD, Stenfert Kroese, Marika C., MD, Oerlemans, Simone, PhD, Putter, Hein, MD, PhD, Verhoeven-Adema, Karen W., PhD, Nijman, Hans W., MD, PhD, Creutzberg, Carien L., MD, PhD

“…Purpose To evaluate the long-term health-related quality of life (HRQL) after external beam radiation therapy (EBRT) or vaginal brachytherapy (VBT) among…”
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Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer: Primary Outcomes of the Phase 1 HERBERT Study by Rijkmans, Eva C., MD, Cats, Annemieke, MD, PhD, Nout, Remi A., MD, PhD, van den Bongard, Desiree H.J.G., MD, PhD, Ketelaars, Martijn, PhD, Buijsen, Jeroen, MD, PhD, Rozema, Tom, MD, Franssen, Jan-Huib, MD, Velema, Laura A., MD, van Triest, Baukelien, MD, PhD, Marijnen, Corrie A.M., MD, PhD

“…Purpose To evaluate the toxicity and efficacy of the combination of external beam radiation therapy (EBRT) followed by high-dose-rate endorectal brachytherapy…”
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HYpofractionated, dose-redistributed RAdiotherapy with protons and photons to combat radiation-induced immunosuppression in head and neck squamous cell carcinoma: study protocol of the phase I HYDRA trial by Elbers, Joris B W, Gunsch, Pascal A, Debets, Reno, Keereweer, Stijn, van Meerten, Esther, Zindler, Jaap, van Norden, Yvette, Hoogeman, Mischa S, Verduijn, Gerda M, Kroesen, Michiel, Nout, Remi A

“…Radiotherapy (RT) is the standard of care for most advanced head and neck squamous cell carcinoma (HNSCC) and results in an unfavorable 5-year overall survival…”
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Posttraumatic Stress Disorder After High-Dose-Rate Brachytherapy for Cervical Cancer With 2 Fractions in 1 Application Under Spinal/Epidural Anesthesia: Incidence and Risk Factors by Kirchheiner, Kathrin, MSc, Czajka-Pepl, Agnieszka, MSc, Ponocny-Seliger, Elisabeth, MSc, PhD, Scharbert, Gisela, MD, Wetzel, Léonore, MD, Nout, Remi A., MD, PhD, Sturdza, Alina, MD, Dimopoulos, Johannes C., MD, Dörr, Wolfgang, DVM, PhD, Pötter, Richard, MD, PhD

“…Purpose To investigate the psychological consequences of high-dose-rate brachytherapy with 2 fractions in 1 application under spinal/epidural anesthesia in the…”
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