Search Results - "NOSEK, THOMAS M"

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation by Haldar, Saptarsi M., Jeyaraj, Darwin, Anand, Priti, Zhu, Han, Lu, Yuan, Prosdocimo, Domenick A., Eapen, Betty, Kawanami, Daiji, Okutsu, Mitsuharu, Brotto, Leticia, Fujioka, Hisashi, Kerner, Janos, Rosca, Mariana G., McGuinness, Owen P., Snow, Rod J., Russell, Aaron P., Gerber, Anthony N., Bai, Xiaodong, Yan, Zhen, Nosek, Thomas M., Brotto, Marco, Hoppel, Charles L., Jain, Mukesh K.

“…The ability of skeletal muscle to enhance lipid utilization during exercise is a form of metabolic plasticity essential for survival. Conversely, metabolic…”
Get full text

Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca2+ homeostasis by Shen, Jinhua, Yu, Wen-Mei, Brotto, Marco, Scherman, Joseph A., Guo, Caiying, Stoddard, Christopher, Nosek, Thomas M., Valdivia, Héctor H., Qu, Cheng-Kui

“…Mutations in the MIP phosphatase MTMR14 are associated with human autosomal centronuclear myopathy. Mice that lack MIP have impaired muscle performance and…”
Get full text

Muscle Fatigue from the Perspective of a Single Crossbridge by DEBOLD, EDWARD P, FITTS, ROBERT H, SUNDBERG, CHRISTOPHER W, NOSEK, THOMAS M

“…ABSTRACTThe repeated intense stimulation of skeletal muscle rapidly decreases its force- and motion-generating capacity. This type of fatigue can be temporally…”
Get full text

Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice by Zhao, Xiaoli, Yoshida, Morikatsu, Brotto, Leticia, Takeshima, Hiroshi, Weisleder, Noah, Hirata, Yutaka, Nosek, Thomas M, Ma, Jianjie, Brotto, Marco

“…1 Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey; 2 Department of Medical Chemistry,…”
Get full text

A pilot test of the GoWoman weight management intervention for women with mobility impairments in the online virtual world of Second Life by Nosek, Margaret A., Robinson-Whelen, Susan, Ledoux, Tracey A., Hughes, Rosemary B., O'Connor, Daniel P., Lee, Rebecca E., Goe, Rebecca, Silveira, Stephanie L., Markley, Rachel, Nosek, Thomas M.

“…Objective: Pilot test GoWoman, a small-group weight management intervention for mobility impaired women that was a disability- and gender-responsive adaptation…”
Get full text

An Internet-Based Virtual Reality Intervention for Enhancing Self-Esteem in Women With Disabilities: Results of a Feasibility Study by Nosek, Margaret A., Robinson-Whelen, Susan, Hughes, Rosemary B., Nosek, Thomas M.

“…Purpose: To examine the feasibility of an online self-esteem enhancement group program for women with disabilities. Method: A sample of 19 racially and…”
Get full text

Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis by Shen, Jinhua, Yu, Wen-Mei, Brotto, Marco, Scherman, Joseph A, Guo, Caiying, Stoddard, Christopher, Nosek, Thomas M, Valdivia, Héctor H, Qu, Cheng-Kui

“…The intracellular Ca(2+) concentration ([Ca(2+)](i)) in skeletal muscles must be rapidly regulated during the excitation-contraction-relaxation process…”
Get full text

Promoting psychological health in women with SCI: Development of an online self-esteem intervention by Robinson-Whelen, Susan, Hughes, Rosemary B., Taylor, Heather B., Markley, Rachel, Vega, José C., Nosek, Thomas M., Nosek, Margaret A.

“…There are no known interventions addressing self-esteem in women following spinal cord injury (SCI). To test the feasibility of an online self-esteem…”
Get full text

Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle by Thornton, Angela M, Zhao, Xiaoli, Weisleder, Noah, Brotto, Leticia S, Bougoin, Sylvain, Nosek, Thomas M, Reid, Michael, Hardin, Brian, Pan, Zui, Ma, Jianjie, Parness, Jerome, Brotto, Marco

“…Muscle atrophy alone is insufficient to explain the significant decline in contractile force of skeletal muscle during normal aging. One contributing factor to…”
Get full text

A Virtual-Reality Weight Loss Program for Women with Mobility Limitations: Results of a Pilot Study by Nosek, Margaret A, Robinson-Whelen, Susan, Hughes, Rosemary B, Ledoux, Tracey, Goe, Rebecca, Silveira, Stephanie, Lee, Rebecca E, O'Connor, Daniel, Nosek, Thomas M

Get full text

Functional and biochemical modifications in skeletal muscles from malarial mice by Brotto, Marco A. P., Marrelli, Mauro T., Brotto, Leticia S., Jacobs‐Lorena, Marcelo, Nosek, Thomas M.

“…Although it is well established that patients suffering from malaria experience skeletal muscle problems (contracture, aches, fatigue, weakness), detailed…”
Get full text

Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis by Romero-Suarez, Sandra, Shen, Jinhua, Brotto, Leticia, Hall, Todd, Mo, Chenglin, Valdivia, Héctor H, Andresen, Jon, Wacker, Michael, Nosek, Thomas M, Qu, Cheng-Kui, Brotto, Marco

“…We have recently reported that a novel muscle-specific inositide phosphatase (MIP/MTMR14) plays a critical role in [Ca2+]i homeostasis through…”
Get full text

Troponin T Core Structure and the Regulatory NH2-Terminal Variable Region by Biesiadecki, Brandon J, Chong, Stephen M, Nosek, Thomas M, Jin, Jian-Ping

“…The conserved central and COOH-terminal regions of troponin T (TnT) interact with troponin C, troponin I, and tropomyosin to regulate striated muscle…”
Get full text

Increased superoxide production during fatigue in the perfused rat diaphragm by KOLBECK, R. C, SHE, Z.-W, CALLAHAN, L. A, NOSEK, T. M

“…This study test the hypothesis that a temporal relationship exists between the production of superoxide anion (O2-) and the contractile activity of perfused…”
Get full text

Truncation by Glu180 Nonsense Mutation Results in Complete Loss of Slow Skeletal Muscle Troponin T in a Lethal Nemaline Myopathy by Jin, Jian-Ping, Brotto, Marco A., Hossain, M.Moazzem, Huang, Qi-Quan, Brotto, Leticia S., Nosek, Thomas M., Morton, D.Holmes, Crawford, Thomas O.

“…A lethal form of nemaline myopathy, named “Amish Nemaline Myopathy” (ANM), is linked to a nonsense mutation at codon Glu180 in the slow skeletal muscle…”
Get full text

Coupled expression of troponin T and troponin I isoforms in single skeletal muscle fibers correlates with contractility by Brotto, Marco A, Biesiadecki, Brandon J, Brotto, Leticia S, Nosek, Thomas M, Jin, Jian-Ping

“…Striated muscle contraction is powered by actin-activated myosin ATPase. This process is regulated by Ca(2+) via the troponin complex. Slow- and fast-twitch…”
Get more information

Temporal Adaptive Changes in Contractility and Fatigability of Diaphragm Muscles from Streptozotocin-Diabetic Rats by Brotto, Marco, Brotto, Leticia, Jin, J.-P., Nosek, Thomas M., Romani, Andrea

“…Diabetes is characterized by ventilatory depression due to decreased diaphragm (DPH) function. This study investigated the changes in contractile properties of…”
Get full text

Troponin T isoforms alter the tolerance of transgenic mouse cardiac muscle to acidosis by Nosek, Thomas M., Brotto, Marco A., Jin, Jian-Ping

“…Troponin T (TnT) is an essential protein in the Ca 2+ regulatory system of striated of muscle. Three fiber type-specific TnT genes have evolved in higher…”
Get full text

Use of a Computerized Audience Response System in Medical Student Teaching: Its Effect on Exam Performance by O'Brien, Timothy E, Wang, Wei, Medvedev, Irene, Wile, Marcia Z, Nosek, Thomas M

“…Use of an audience response system (ARS) during lectures appears to promote active learning but its effect on exam performance has not been well studied. A…”
Get full text

A serious gaming/immersion environment to teach clinical cancer genetics by Nosek, Thomas M, Cohen, Mark, Matthews, Anne, Papp, Klara, Wolf, Nancy, Wrenn, Gregg, Sher, Andrew, Coulter, Kenneth, Martin, Jessica, Wiesner, Georgia L

“…We are creating an interactive, simulated "Cancer Genetics Tower" for the self-paced learning of Clinical Cancer Genetics by medical students (go to:…”
Get more information