Search Results - "NORPPA, Hannu"

Safety Aspects of Bio-Based Nanomaterials by Catalán, Julia, Norppa, Hannu

“…Moving towards a bio-based and circular economy implies a major focus on the responsible and sustainable utilization of bio-resources. The emergence of…”
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Genotoxic and immunotoxic effects of cellulose nanocrystals in vitro by Catalán, Julia, Ilves, Marit, Järventaus, Hilkka, Hannukainen, Kati-Susanna, Kontturi, Eero, Vanhala, Esa, Alenius, Harri, Savolainen, Kai M, Norppa, Hannu

“…Nanocellulosics are among the most promising innovations for a wide‐variety of applications in materials science. Although nanocellulose is presently produced…”
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Surface functionalization and size modulate the formation of reactive oxygen species and genotoxic effects of cellulose nanofibrils by Aimonen, Kukka, Imani, Monireh, Hartikainen, Mira, Suhonen, Satu, Vanhala, Esa, Moreno, Carlos, Rojas, Orlando J, Norppa, Hannu, Catalán, Julia

“…Cellulose nanofibrils (CNFs) have emerged as a sustainable and environmentally friendly option for a broad range of applications. The fibrous nature and high…”
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Genotoxicity of nanomaterials: DNA damage and micronuclei induced by carbon nanotubes and graphite nanofibres in human bronchial epithelial cells in vitro by Lindberg, Hanna K., Falck, Ghita C.-M., Suhonen, Satu, Vippola, Minnamari, Vanhala, Esa, Catalán, Julia, Savolainen, Kai, Norppa, Hannu

“…Despite the increasing industrial use of different nanomaterials, data on their genotoxicity are scant. In the present study, we examined the potential…”
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Biomarkers of nanomaterials hazard from multi-layer data by Fortino, Vittorio, Kinaret, Pia Anneli Sofia, Fratello, Michele, Serra, Angela, Saarimäki, Laura Aliisa, Gallud, Audrey, Gupta, Govind, Vales, Gerard, Correia, Manuel, Rasool, Omid, Ytterberg, Jimmy, Monopoli, Marco, Skoog, Tiina, Ritchie, Peter, Moya, Sergio, Vázquez-Campos, Socorro, Handy, Richard, Grafström, Roland, Tran, Lang, Zubarev, Roman, Lahesmaa, Riitta, Dawson, Kenneth, Loeschner, Katrin, Larsen, Erik Husfeldt, Krombach, Fritz, Norppa, Hannu, Kere, Juha, Savolainen, Kai, Alenius, Harri, Fadeel, Bengt, Greco, Dario

“…There is an urgent need to apply effective, data-driven approaches to reliably predict engineered nanomaterial (ENM) toxicity. Here we introduce a predictive…”
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Genotoxicity and Cytotoxicity of Gold Nanoparticles In Vitro: Role of Surface Functionalization and Particle Size by Vales, Gerard, Suhonen, Satu, Siivola, Kirsi M., Savolainen, Kai M., Catalán, Julia, Norppa, Hannu

“…Several studies suggested that gold nanoparticles (NPs) could be genotoxic in vitro and in vivo. However, gold NPs have currently produced present a wide range…”
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Genotoxicity evaluation of nanosized titanium dioxide, synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes by Tavares, Ana M., Louro, Henriqueta, Antunes, Susana, Quarré, Stephanie, Simar, Sophie, De Temmerman, Pieter-Jan, Verleysen, Eveline, Mast, Jan, Jensen, Keld A., Norppa, Hannu, Nesslany, Fabrice, Silva, Maria João

“…•Genotoxicity of nano-titanium dioxide, silica and carbon nanotubes was assessed.•A standardized procedure was used for satisfactory dispersion of all…”
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Genotoxicity of short single-wall and multi-wall carbon nanotubes in human bronchial epithelial and mesothelial cells in vitro by Lindberg, Hanna K, Falck, Ghita C.-M, Singh, Rajinder, Suhonen, Satu, Järventaus, Hilkka, Vanhala, Esa, Catalán, Julia, Farmer, Peter B, Savolainen, Kai M, Norppa, Hannu

“…Abstract Although some types of carbon nanotubes (CNTs) have been described to induce mesothelioma in rodents and genotoxic effects in various cell systems,…”
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Genotoxic and inflammatory effects of nanofibrillated cellulose in murine lungs by Catalán, Julia, Rydman, Elina, Aimonen, Kukka, Hannukainen, Kati-Susanna, Suhonen, Satu, Vanhala, Esa, Moreno, Carlos, Meyer, Valérie, Perez, Denilson da Silva, Sneck, Asko, Forsström, Ulla, Højgaard, Casper, Willemoes, Martin, Winther, Jacob R, Vogel, Ulla, Wolff, Henrik, Alenius, Harri, Savolainen, Kai M, Norppa, Hannu

“…Nanofibrillated cellulose (NFC) is a sustainable and renewable nanomaterial, with diverse potential applications in the paper and medical industries. As NFC…”
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Role of Surface Chemistry in the In Vitro Lung Response to Nanofibrillated Cellulose by Aimonen, Kukka, Suhonen, Satu, Hartikainen, Mira, Lopes, Viviana R, Norppa, Hannu, Ferraz, Natalia, Catalán, Julia

“…Wood-derived nanofibrillated cellulose (NFC) has emerged as a sustainable material with a wide range of applications and increasing presence in the market…”
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Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways by Kinaret, Pia A. S., Ndika, Joseph, Ilves, Marit, Wolff, Henrik, Vales, Gerard, Norppa, Hannu, Savolainen, Kai, Skoog, Tiina, Kere, Juha, Moya, Sergio, Handy, Richard D., Karisola, Piia, Fadeel, Bengt, Greco, Dario, Alenius, Harri

“…Toxicogenomics opens novel opportunities for hazard assessment by utilizing computational methods to map molecular events and biological processes. In this…”
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Genotoxicity of inhaled nanosized TiO2 in mice by Lindberg, Hanna K., Falck, Ghita C.-M., Catalán, Julia, Koivisto, Antti J., Suhonen, Satu, Järventaus, Hilkka, Rossi, Elina M., Nykäsenoja, Heli, Peltonen, Yrjö, Moreno, Carlos, Alenius, Harri, Tuomi, Timo, Savolainen, Kai M., Norppa, Hannu

“…► Mice inhaled nanosized TiO2 anatase–brookite (0.8, 7.2, or 28.5mg/m3) for 5 days. ► A dose-dependent deposition of Ti in lung tissue was seen. ► No increase…”
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Report from the in vitro micronucleus assay working group by Kirsch-Volders, Micheline, Sofuni, Toshio, Aardema, Marilyn, Albertini, Silvio, Eastmond, David, Fenech, Michael, Ishidate, Motoi, Kirchner, Stephan, Lorge, Elisabeth, Morita, Takeshi, Norppa, Hannu, Surrallés, Jordi, Vanhauwaert, Annelies, Wakata, Akihiro

“…At the Washington “2nd International Workshop on Genotoxicity Testing” (25–26 March 1999) current methodologies and data for the in vitro micronucleus test…”
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HBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium by Tavares, Ana, Aimonen, Kukka, Ndaw, Sophie, Fučić, Aleksandra, Catalán, Julia, Duca, Radu Corneliu, Godderis, Lode, Gomes, Bruno C, Janasik, Beata, Ladeira, Carina, Louro, Henriqueta, Namorado, Sónia, Nieuwenhuyse, An Van, Norppa, Hannu, Scheepers, Paul T J, Ventura, Célia, Verdonck, Jelle, Viegas, Susana, Wasowicz, Wojciech, Santonen, Tiina, Silva, Maria João, On Behalf Of The Hbm Eu Chromates Study Team

“…A study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the…”
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IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans by Albertini, Richard J, Anderson, Diana, Douglas, George R, Hagmar, Lars, Hemminki, Kari, Merlo, Franco, Natarajan, A.T, Norppa, Hannu, Shuker, David E.G, Tice, Raymond, Waters, Michael D, Aitio, Antero

“…The purpose of these guidelines is to provide concise guidance on the planning, performing and interpretation of studies to monitor groups or individuals…”
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Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity by Tuimala, Jarno, Szekely, Gabor, Gundy, Sarolta, Hirvonen, Ari, Norppa, Hannu

“…Mutagen sensitivity, measuring the extent of chromosome damage induced by an in vitro treatment of peripheral lymphocytes with bleomycin, has been associated…”
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The Effects of GSTM1 and GSTT1 Polymorphisms on Micronucleus Frequencies in Human Lymphocytes In vivo by KIRSCH-VOLDERS, Micheline, MATEUCA, Raluca Antonina, GODDERIS, Lode, HAUFROID, Vincent, ISHIKAWA, Hitoshi, LAFFON, Blanca, MARCOS, Ricardo, MIGLIORE, Lucia, NORPPA, Hannu, TEIXEIRA, Joao Paulo, ZIJNO, Andrea, FENECH, Michael, ROELANTS, Mathieu, TREMP, Annie, ZEIGER, Errol, BONASSI, Stefano, HOLLAND, Nina, CHANG, Wushou Peter, AKA, Peter Vande, DEBOECK, Marlies

“…The influence of genetic polymorphisms in GSTM1 and GSTT1 genes on micronucleus frequencies in human peripheral blood lymphocytes was assessed through a pooled…”
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Micronuclei, hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4′-methylenediphenyl diisocyanate (MDI) by Lindberg, Hanna K., Korpi, Anne, Santonen, Tiina, Säkkinen, Kirsi, Järvelä, Merja, Tornaeus, Jarkko, Ahonen, Niina, Järventaus, Hilkka, Pasanen, Anna-Liisa, Rosenberg, Christina, Norppa, Hannu

“…Toluene diisocyanate (TDI) and 4,4′-methylenediphenyl diisocyanate (MDI), used in the production of polyurethane foam, are well known for their irritating and…”
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Report from the In Vitro Micronucleus Assay Working Group by Kirsch-Volders, Micheline, Sofuni, Toshio, Aardema, Marilyn, Albertini, Silvio, Eastmond, David, Fenech, Michael, Ishidate Jr, Motoi, Lorge, Elisabeth, Norppa, Hannu, Surrallés, Jordi, von der Hude, Wilhelm, Wakata, Akihiro

“…At the Washington International Workshop on Genotoxicity Test Procedures (March 25–26, 1999), the current methodologies and data for the in vitro micronucleus…”
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Micronucleus assay for mouse alveolar Type II and Clara cells by Lindberg, Hanna K, Falck, Ghita C.-M, Catalán, Julia, Santonen, Tiina, Norppa, Hannu

“…The objective of our study was to develop a micronucleus (MN) assay for detecting genotoxic damage after inhalation exposure in mouse alveolar Type II and…”
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