Search Results - "NORMAN, Gary L"

"Non-criteria" antiphospholipid antibodies add value to antiphospholipid syndrome diagnoses in a large Chinese cohort by Liu, Tingting, Gu, Jieyu, Wan, Liyan, Hu, Qiongyi, Teng, Jialin, Liu, Honglei, Cheng, Xiaobing, Ye, Junna, Su, Yutong, Sun, Yue, Zhou, Jinfeng, Norman, Gary L, Wang, Xuefeng, Yang, Chengde, Shi, Hui

“…Despite expansion in the 2006 Sydney antiphospholipid syndrome (APS) classification criteria to include IgG/IgM anti-β2-glycoprotein (aβ2GPI) antibodies in…”
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AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC by Yamamoto, Kentaroh, Imamura, Hiroshi, Matsuyama, Yutaka, Kume, Yukio, Ikeda, Hitoshi, Norman, Gary L., Shums, Zakera, Aoki, Taku, Hasegawa, Kiyoshi, Beck, Yoshifumi, Sugawara, Yasuhiko, Kokudo, Norihiro

“…Background Alpha-fetoprotein (AFP), lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), des-γ-carboxy prothrombin (DCP), and Golgi protein-73 (GP73)…”
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Clinical Characterization of Antiphospholipid Syndrome by Detection of IgG Antibodies Against β2‐Glycoprotein I Domain 1 and Domain 4/5: Ratio of Anti–Domain 1 to Anti–Domain 4/5 As a Useful New Biomarker for Antiphospholipid Syndrome by Andreoli, Laura, Chighizola, Cecilia B., Nalli, Cecilia, Gerosa, Maria, Borghi, M. Orietta, Pregnolato, Francesca, Grossi, Claudia, Zanola, Alessandra, Allegri, Flavio, Norman, Gary L., Mahler, Michael, Meroni, Pier Luigi, Tincani, Angela

“…Objective It has been suggested that only antibodies against domain 1 (D1) of β2‐glycoprotein I (β2GPI) are pathogenic and diagnostic. The role of antibodies…”
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Autoantibodies to domain 1 of beta 2 glycoprotein 1: A promising candidate biomarker for risk management in antiphospholipid syndrome by Mahler, Michael, Norman, Gary L, Meroni, Pier Luigi, Khamashta, Munther

“…Abstract Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by frequent clotting in arteries and veins and/or miscarriages. Autoantibodies…”
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PR3-ANCA: a promising biomarker in primary sclerosing cholangitis (PSC) by Stinton, Laura M, Bentow, Chelsea, Mahler, Michael, Norman, Gary L, Eksteen, Bertus, Mason, Andrew L, Kaplan, Gilaad G, Lindkvist, Bjorn, Hirschfield, Gideon M, Milkiewicz, Piotr, Cheung, Angela, Janssen, Harry L A, Fritzler, Marvin J

“…The only recognized biomarker for primary sclerosing cholangitis (PSC) is atypical anti-neutrophil cytoplasmic antibodies (aANCA), which, in addition to having…”
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The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex‐biased autoimmunity by Bae, Heekyong R., Hodge, Deborah L., Yang, Guo‐Xiang, Leung, Patrick S.C., Chodisetti, Sathi Babu, Valencia, Julio C., Sanford, Michael, Fenimore, John M., Rahman, Ziaur S.M., Tsuneyama, Koichi, Norman, Gary L., Gershwin, M. Eric, Young, Howard A.

“…We have reported on a murine model of autoimmune cholangitis, generated by altering the AU‐rich element (ARE) by deletion of the interferon gamma (IFN‐γ) 3'…”
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Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk by Egri, Natalia, Bentow, Chelsea, Rubio, Laura, Norman, Gary L, López-Sañudo, Susana, Mahler, Michael, Pérez-Isidro, Albert, Cervera, Ricard, Viñas, Odette, Espinosa, Gerard, Ruiz-Ortiz, Estíbaliz

“…Antibodies to phospholipids (aPL) and associated proteins are a hallmark in the diagnosis of anti-phospholipid syndrome (APS). Those included in the…”
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Evaluation of classical and novel autoantibodies for the diagnosis of Primary Biliary Cholangitis-Autoimmune Hepatitis Overlap Syndrome (PBC-AIH OS) by Nguyen, Henry H, Shaheen, Abdel Aziz, Baeza, Natalia, Lytvyak, Ellina, Urbanski, Stefan J, Mason, Andrew L, Norman, Gary L, Fritzler, Marvin J, Swain, Mark G

“…Up to 20% of Primary Biliary Cholangitis (PBC) patients are estimated to have features that overlap with Autoimmune Hepatitis (AIH). Patients with PBC-AIH…”
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Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis by Joshita, Satoru, Umemura, Takeji, Usami, Yoko, Yamashita, Yuki, Norman, Gary L., Sugiura, Ayumi, Yamazaki, Tomoo, Fujimori, Naoyuki, Kimura, Takefumi, Matsumoto, Akihiro, Igarashi, Koji, Yoshizawa, Kaname, Ota, Masao, Tanaka, Eiji

“…Autotaxin (ATX) is a secreted enzyme metabolized by liver sinusoidal endothelial cells that has been associated with liver fibrosis. We evaluated serum ATX…”
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Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis by Tornai, Tamas, Palyu, Eszter, Vitalis, Zsuzsanna, Tornai, Istvan, Tornai, David, Antal-Szalmas, Peter, Norman, Gary L, Shums, Zakera, Veres, Gabor, Dezsofi, Antal, Par, Gabriella, Par, Alajos, Orosz, Peter, Szalay, Ferenc, Lakatos, Peter Laszlo, Papp, Maria

“…AIM To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing…”
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Significance of serological markers in the disease course of ulcerative colitis in a prospective clinical cohort of patients by Kovacs, Gyorgy, Sipeki, Nora, Suga, Boglarka, Tornai, Tamas, Fechner, Kai, Norman, Gary L, Shums, Zakera, Antal-Szalmas, Peter, Papp, Maria

“…To determine the prognostic potential of classic and novel serologic antibodies regarding unfavorable disease course in a prospective ulcerative colitis (UC)…”
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Validity of the global anti-phospholipid syndrome score to predict thrombosis: a prospective multicentre cohort study by Zuily, Stéphane, de Laat, Bas, Mohamed, Shirine, Kelchtermans, Hilde, Shums, Zakera, Albesa, Roger, Norman, Gary L, Lamboux-Matthieu, Claire, Rat, Anne-Christine, Ninet, Jacques, Magy-Bertrand, Nadine, Pasquali, Jean-Louis, Lambert, Marc, Lorcerie, Bernard, Kaminsky, Pierre, Guillemin, Francis, Regnault, Véronique, Wahl, Denis

“…To investigate the validity of the global APS score (GAPSS) to predict thrombosis in patients with autoimmune diseases. This prospective cohort study included…”
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Prognostic implications of antibodies to Ro/SSA and soluble liver antigen in type 1 autoimmune hepatitis by Montano-Loza, Aldo J., Shums, Zakera, Norman, Gary L., Czaja, Albert J.

“…Background: Antibodies to soluble liver antigen are frequently co‐expressed with antibodies to ribonucleoprotein/Sjögren's syndrome A (Ro/SSA) in autoimmune…”
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Anti‐gp210 and anti‐centromere antibodies are different risk factors for the progression of primary biliary cirrhosis by Nakamura, Minoru, Kondo, Hisayoshi, Mori, Tsuyoshi, Komori, Atsumasa, Matsuyama, Mutsumi, Ito, Masahiro, Takii, Yasushi, Koyabu, Makiko, Yokoyama, Terufumi, Migita, Kiyoshi, Daikoku, Manabu, Abiru, Seigo, Yatsuhashi, Hiroshi, Takezaki, Eiichi, Masaki, Naohiko, Sugi, Kazuhiro, Honda, Koichi, Adachi, Hiroshi, Nishi, Hidehiro, Watanabe, Yukio, Nakamura, Yoko, Shimada, Masaaki, Komatsu, Tatsuji, Saito, Akira, Saoshiro, Takeo, Harada, Hideharu, Sodeyama, Takeshi, Hayashi, Shigeki, Masumoto, Akihide, Sando, Takehiro, Yamamoto, Tetsuo, Sakai, Hironori, Kobayashi, Masakazu, Muro, Toyokichi, Koga, Michiaki, Shums, Zakera, Norman, Gary L., Ishibashi, Hiromi

“…The predictive role of antinuclear antibodies (ANAs) remains elusive in the long‐term outcome of primary biliary cirrhosis (PBC). The progression of PBC was…”
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Utility of Antiphosphatidylserine/Prothrombin and IgA Antiphospholipid Assays in Systemic Lupus Erythematosus by AKHTER, Ehtisham, SHUMS, Zakera, NORMAN, Gary L, BINDER, Walter, HONG FANG, PETRI, Michelle

“…Currently, 3 antiphospholipid assays are widely used clinically [lupus anticoagulant (LAC), anticardiolipin (aCL), and anti-ß2-glycoprotein I (anti-ß2-GPI)]…”
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Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis by Norman, Gary L., Yang, Chen-Yen, Ostendorff, Heather P., Shums, Zakera, Lim, Mark J., Wang, Jinjun, Awad, Amany, Hirschfield, Gideon M., Milkiewicz, Piotr, Bloch, Donald B., Rothschild, Kenneth J., Bowlus, Christopher L., Adamopoulos, Iannis E., Leung, Patrick S.C., Janssen, Harry J., Cheung, Angela C., Coltescu, Catalina, Gershwin, M. Eric

“…Background & Aims Using high‐density human recombinant protein microarrays, we identified two potential biomarkers, kelch‐like 12 (KLHL12) and hexokinase‐1…”
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The IgA Isotype of Anti-β2 Glycoprotein I Antibodies Recognizes Epitopes in Domains 3, 4, and 5 That Are Located in a Lateral Zone of the Molecule (L-Shaped) by Serrano, Manuel, Martinez-Flores, Jose Angel, Norman, Gary L, Naranjo, Laura, Morales, Jose Maria, Serrano, Antonio

“…Antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with presence of anti-phospholipid antibodies (aPL). The APS…”
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The Prevalence of Anti-Hexokinase-1 and Anti-Kelch-Like 12 Peptide Antibodies in Patients With Primary Biliary Cholangitis Is Similar in Europe and North America: A Large International, Multi-Center Study by Norman, Gary L, Reig, Anna, Viñas, Odette, Mahler, Michael, Wunsch, Ewa, Milkiewicz, Piotr, Swain, Mark G, Mason, Andrew, Stinton, Laura M, Aparicio, Maria Belen, Aldegunde, Maria Jose, Fritzler, Marvin J, Parés, Albert

“…Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is present worldwide. Autoantibodies, in particular anti-mitochondrial…”
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Association between serum soluble CD14 and IL‐8 levels and clinical outcome in primary biliary cholangitis by Umemura, Takeji, Sekiguchi, Tomohiro, Joshita, Satoru, Yamazaki, Tomoo, Fujimori, Naoyuki, Shibata, Soichiro, Ichikawa, Yuki, Komatsu, Michiharu, Matsumoto, Akihiro, Shums, Zakera, Norman, Gary L., Tanaka, Eiji, Ota, Masao

“…Background & Aims Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by portal inflammation and immune‐mediated destruction of…”
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Significance of fully automated tests for the diagnosis of antiphospholipid syndrome by Oku, Kenji, Amengual, Olga, Kato, Masaru, Bohgaki, Toshiyuki, Horita, Tetsuya, Yasuda, Shinsuke, Sakamoto, Naoya, Ieko, Masahiro, Norman, Gary L, Atsumi, Tatsuya

“…Abstract Antiphospholipid antibodies (aPLs) can vary both immunologically and functionally, thus it is important to effectively and correctly identify their…”
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