Search Results - "NORDFANG, O"

Comparison of the factor VII:C clot analysis and a modified activated factor VII analysis for monitoring factor VII activity in patients treated with recombinant activated factor VII (NovoSeven) by Johannessen, M, Nielsen, G, Nordfang, O

“…Bleeding episodes in haemophilia A and B inhibitor patients are now frequently treated with recombinant activated factor VII (NovoSeven, Novo Nordisk A/S,…”
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Inhibitory properties of full-length and truncated recombinant tissue factor pathway inhibitor (TFPI). Evidence that the third Kunitz-type domain of TFPI is not essential for the inhibition of factor VIIa-tissue factor complexes on cell surfaces by HAMAMOTO, T, YAMAMOTO, M, NORDFANG, O, PETERSEN, J.-G. L, FOSTER, D. C, KISIEL, W

“…Human tissue factor pathway inhibitor (TFPI) is a plasma protease inhibitor that consists of three tandem Kunitz-type inhibitor domains flanked by a negatively…”
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Blocking of tissue factor pathway inhibitor (TFPI) shortens the bleeding time in rabbits with antibody induced haemophilia A by Erhardtsen, E, Ezban, M, Madsen, M T, Diness, V, Glazer, S, Hedner, U, Nordfang, O

“…Tissue factor (TF)/FVIIa initiates coagulation by activating factor IX (FIX) and factor X (FX). Tissue factor pathway inhibitor (TFPI)-FXa complexes form and…”
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Effect of leukocyte proteinases on tissue factor pathway inhibitor by Petersen, L C, Bjørn, S E, Nordfang, O

“…The effect of human neutrophil elastase and cathepsin G on recombinant tissue factor pathway inhibitor (TFPI) was investigated. A weak inhibition by TFPI of…”
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Decline of factor VIII and factor IX inhibitors during long-term treatment with NovoSeven by Johannessen, M, Andreasen, R B, Nordfang, O

“…Recombinant factor VIIa (rFVIIa) (NovoSeveng) is used to treat bleeding episodes in hemophilia A and B patients with inhibitor antibodies against factor VIII…”
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The effect of two-domain tissue factor pathway inhibitor on endotoxin-induced disseminated intravascular coagulation in rabbits by Bregengård, C, Nordfang, O, Wildgoose, P, Svendsen, O, Hedner, U, Diness, V

“…Disseminated intravascular coagulation (DIC) is a common complication in sepsis, and may result from endotoxin-induced exposure of tissue factor on the surface…”
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Recombinant human extrinsic pathway inhibitor. Production, isolation, and characterization of its inhibitory activity on tissue factor-initiated coagulation reactions by Pedersen, A H, Nordfang, O, Norris, F, Wiberg, F C, Christensen, P M, Moeller, K B, Meidahl-Pedersen, J, Beck, T C, Norris, K, Hedner, U

“…Previous studies have shown that extrinsic pathway inhibitor (EPI) is an effective inhibitor of factor Xa alone or factor VIIa-tissue factor complex in the…”
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Evidence that the C-terminus of tissue factor pathway inhibitor (TFPI) is essential for its in vitro and in vivo interaction with lipoproteins by Valentin, S, Nordfang, O, Bregengård, C, Wildgoose, P

“…We have previously shown that the C-terminus of TFPI is essential for its anticoagulant activity. In the present study we have assessed the role of this region…”
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Characterization of human tissue factor pathway inhibitor variants expressed in Saccharomyces cerevisiae by PETERSEN, J. G. L, MEYN, G, RASMUSSEN, J. S, PETERSEN, J, BJØRN, S. E, JONASSEN, I, CHRISTIANSEN, L, NORDFANG, O

“…Human tissue factor pathway inhibitor (TFPI) and three derivatives with deletions of: 1) the complete COOH-terminal third of the polypeptide including the…”
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Generation of active coagulation factor VIII from isolated subunits by Nordfang, O, Ezban, M

“…Factor VIII-light chain (FVIII-LC) and Factor VIII-heavy chain (FVIII-HC) were isolated separately from human plasma and were without coagulation activity…”
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Mechanisms of binding of recombinant extrinsic pathway inhibitor (rEPI) to cultured cell surfaces. Evidence that rEPI can bind to and inhibit factor VIIa-tissue factor complexes in the absence of factor Xa by Callander, N S, Rao, L V, Nordfang, O, Sandset, P M, Warn-Cramer, B, Rapaport, S I

“…Extrinsic pathway inhibitor plays a key role in modulating tissue factor-dependent blood coagulation. We have studied binding of radioiodinated recombinant…”
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Antithrombotic effect of recombinant truncated tissue factor pathway inhibitor (TFPI1-161) in experimental venous thrombosis--a comparison with low molecular weight heparin by Holst, J, Lindblad, B, Bergqvist, D, Nordfang, O, Ostergaard, P B, Petersen, J G, Nielsen, G, Hedner, U

“…The aim was to investigate whether a truncated recombinant Tissue Factor Pathway Inhibitor (TFPI1-161), which lacked the third Kunitz-type domain and the basic…”
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Inhibition of extrinsic pathway inhibitor shortens the coagulation time of normal plasma and of hemophilia plasma by Nordfang, O, Valentin, S, Beck, T C, Hedner, U

“…An increasing amount of evidence suggests that coagulation factors VIII and IX play a role not only in the intrinsic but also in the extrinsic pathway of…”
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Inhibition of factor X activation at extracellular matrix of fibroblasts during flow conditions: a comparison between tissue factor pathway inhibitor and inactive factor VIIa by Valentin, S, Reutlingsperger, C P, Nordfang, O, Lindhout, T

“…Tissue factor pathway inhibitor (TFPI) is a naturally occurring factor Xa-dependent inhibitor of factor VIIa/tissue factor activity. In the present study, we…”
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Synergism between full length TFPI and heparin: evidence for TFPI as an important factor for the antithrombotic activity of heparin by Valentin, S, Ostergaard, P, Kristensen, H, Nordfang, O

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Pharmacokinetics of full length and two-domain tissue factor pathway inhibitor in combination with heparin in rabbits by Bregengaard, C, Nordfang, O, Ostergaard, P, Petersen, J G, Meyn, G, Diness, V, Svendsen, O, Hedner, U

“…Tissue factor pathway inhibitor (TFPI) is a feed back inhibitor of the initial activation of the extrinsic pathway of coagulation. In humans, injection of…”
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The significance of TFPI in clotting assays--comparison and combination with other anticoagulants by Nordfang, O, Kristensen, H I, Valentin, S, Ostergaard, P, Wadt, J

“…The anticoagulant activities of Tissue Factor Pathway Inhibitor (TFPI), heparin and hirudin were compared in intrinsic (APTT) and extrinsic (PT) activated…”
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The functional domains of coagulation factor VIII:C by Burke, R L, Pachl, C, Quiroga, M, Rosenberg, S, Haigwood, N, Nordfang, O, Ezban, M

“…A lack of factor VIII:C, manifested as a bleeding disorder due to the absence of clot formation, is known as hemophilia A, an X chromosome-linked inherited…”
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Effect of tissue factor pathway inhibitor (TFPI) in the HEPTEST assay and in an amidolytic anti factor Xa assay for LMW heparin by Kristensen, H I, Ostergaard, P B, Nordfang, O, Abildgaard, U, Lindahl, A K

“…Both the HEPTEST and amidolytic anti factor Xa assays are currently being used for heparin activity detection in plasma from patients receiving standard…”
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Simultaneous presence of tissue factor pathway inhibitor (TFPI) and low molecular weight heparin has a synergistic effect in different coagulation assays by Valentin, S, Ostergaard, P, Kristensen, H, Nordfang, O

“…Injection of heparin releases tissue factor pathway inhibitor (TFPI) to the blood and, after heparin neutralization, it has been recently demonstrated that the…”
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