Search Results - "NOORT, Willy A"

Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib by Nijhof, Inger S, Groen, Richard W J, Noort, Willy A, van Kessel, Berris, de Jong-Korlaar, Regina, Bakker, Joost, van Bueren, Jeroen J L, Parren, Paul W H I, Lokhorst, Henk M, van de Donk, Niels W C J, Martens, Anton C M, Mutis, Tuna

“…Novel therapeutic agents have significantly improved the survival of patients with multiple myeloma. Nonetheless, the prognosis of patients with multiple…”
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Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma by Drent, Esther, Groen, Richard W J, Noort, Willy A, Themeli, Maria, Lammerts van Bueren, Jeroen J, Parren, Paul W H I, Kuball, Jürgen, Sebestyen, Zsolt, Yuan, Huipin, de Bruijn, Joost, van de Donk, Niels W C J, Martens, Anton C M, Lokhorst, Henk M, Mutis, Tuna

“…Adoptive transfer of chimeric antigen receptor-transduced T cells is a promising strategy for cancer immunotherapy. The CD38 molecule, with its high expression…”
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Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma by Groen, Richard W.J., Noort, Willy A., Raymakers, Reinier A., Prins, Henk-Jan, Aalders, Linda, Hofhuis, Frans M., Moerer, Petra, van Velzen, Jeroen F., Bloem, Andries C., van Kessel, Berris, Rozemuller, Henk, van Binsbergen, Ellen, Buijs, Arjan, Yuan, Huipin, de Bruijn, Joost D., de Weers, Michel, Parren, Paul W.H.I., Schuringa, Jan Jacob, Lokhorst, Henk M., Mutis, Tuna, Martens, Anton C.M.

“…Interactions within the hematopoietic niche in the BM microenvironment are essential for maintenance of the stem cell pool. In addition, this niche is thought…”
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Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation by in ’t Anker, Pieternella S., Scherjon, Sicco A., Kleijburg-van der Keur, Carin, Noort, Willy A., Claas, FransH.J., Willemze, Roelof, Fibbe, Willem E., Kanhai, HumphreyH.H.

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Sepantronium bromide (YM155) improves daratumumab-mediated cellular lysis of multiple myeloma cells by abrogation of bone marrow stromal cell-induced resistance by de Haart, Sanne J, Holthof, Lisa, Noort, Willy A, Minnema, Monique C, Emmelot, Maarten E, Aarts-Riemens, Tineke, Doshi, Parul, Sasser, Kate, Yuan, Huipin, de Bruijn, Joost, Martens, Anton C M, van de Donk, Niels W C J, Lokhorst, Henk M, Groen, Richard W J, Mutis, Tuna

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Similar repopulating capacity of mitotically active and resting umbilical cord blood CD34+ cells in NOD/SCID mice by Wilpshaar, Jannine, Falkenburg, J. H. Frederik, Tong, Xia, Noort, Willy A., Breese, Robert, Heilman, Doug, Kanhai, Humphrey, Orschell-Traycoff, Christie M., Srour, Edward F.

“…It was hypothesized that during mammalian development, the extensive need for hematopoietic cells requires equal contribution to blood cell production from…”
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Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential by in 't Anker, PS, Noort, WA, Scherjon, SA, Kleijburg-van der Keur, C, Kruisselbrink, AB, van Bezooijen, RL, Beekhuizen, W, Willemze, R, Kanhai, HH, Fibbe, WE

“…Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands. BACKGROUND AND OBJECTIVES: We previously found that human fetal lung is a…”
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Establishing human leukemia xenograft mouse models by implanting human bone marrow–like scaffold-based niches by Antonelli, Antonella, Noort, Willy A., Jaques, Jenny, de Boer, Bauke, de Jong-Korlaar, Regina, Brouwers-Vos, Annet Z., Lubbers-Aalders, Linda, van Velzen, Jeroen F., Bloem, Andries C., Yuan, Huipin, de Bruijn, Joost D., Ossenkoppele, Gert J., Martens, Anton C.M., Vellenga, Edo, Groen, Richard W.J., Schuringa, Jan Jacob

“…To begin to understand the mechanisms that regulate self-renewal, differentiation, and transformation of human hematopoietic stem cells or to evaluate the…”
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Mesenchymal Stem Cells and Hematopoietic Stem Cell Transplantation by FIBBE, WILLEM E., NOORT, WILLY A.

“…: Techniques have recently beome available to isolate and grow mesenchymal progenitors and to manipulate their growth under defined in vitro culture…”
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Nonexpanded primary lung and bone marrow–derived mesenchymal cells promote the engraftment of umbilical cord blood–derived CD34 + cells in NOD/SCID mice by in 't Anker, Pieternella S, Noort, Willy A, Kruisselbrink, Alwine B, Scherjon, Sicco A, Beekhuizen, Willem, Willemze, Roelof, Kanhai, Humphrey H.H, Fibbe, Willem E

“…Previously, we have found that human culture-expanded fetal lung–derived mesenchymal stem cells (MSC) promote the engraftment of umbilical cord blood…”
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Cell cycle and tissue of origin contribute to the migratory behaviour of human fetal and adult mesenchymal stromal cells by Maijenburg, Marijke W., Noort, Willy A., Kleijer, Marion, Kompier, Charlotte J. A., Weijer, Kees, Van Buul, Jaap D., Van Der Schoot, C. Ellen, Voermans, Carlijn

“…Summary Mesenchymal stromal cells (MSC) are potential cells for cellular therapies, in which the recruitment and migration of MSC towards injured tissue is…”
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The Presence of Activated CD4+ T Cells Is Essential for the Formation of Colony-Forming Unit-Endothelial Cells by CD14+ Cells by van Beem, Rachel T, Noort, Willy A, Voermans, Carlijn, Kleijer, Marion, ten Brinke, Anja, van Ham, S. Marieke, van der Schoot, C. Ellen, Zwaginga, Jaap Jan

“…The number of colony forming unit-endothelial cells (CFU-EC) in human peripheral blood was found to be a biological marker for several vascular diseases. In…”
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Mesenchymal stem cells promote engraftment of human umbilical cord blood–derived CD34 + cells in NOD/SCID mice by Noort, Willy A, Kruisselbrink, Alwine B, in't Anker, Pieternella S, Kruger, Marjolein, van Bezooijen, Rutger L, de Paus, Roelf A, Heemskerk, Mirjam H.M, Löwik, Clemens W.G.M, Falkenburg, J.H.Frederik, Willemze, Roel, Fibbe, Willem E

“…Mesenchymal stem cells (MSC) have been implicated as playing an important role in hematopoietic stem cell engraftment. We identified and characterized a new…”
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Stem Cells from In- or Outside of the Heart: Isolation, Characterization, and Potential for Myocardial Tissue Regeneration by Noort, Willy A., Sluijter, Joost P. G., Goumans, Marie-Jose, Chamuleau, Steven A. J., Doevendans, Pieter A.

“…Heart failure emerges with a net loss of viable cardiomyocytes, and there is no current therapy to reverse this process to improve long-term cardiac function…”
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Recovery and functional activity of mononuclear bone marrow and peripheral blood cells after different cell isolation protocols used in clinical trials for cell therapy after acute myocardial infarction by VAN BEEM, Rachel T, HIRSCH, Alexander, LOMMERSE, Ingrid M, JAN ZWAGINGA, Jaap, NOORT, Willy A, BIEMOND, Bart J, PIEK, Jan J, VAN DER SCHOOT, C. Ellen, VOERMANS, Carlijn

“…Clinical trials showed contradictory results in functional recovery after intracoronary infusion of autologous mononuclear (bone marrow) cells in patients with…”
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Enhanced engraftment of umbilical cord blood-derived stem cells in NOD/SCID mice by cotransplantation of a second unrelated cord blood unit by Nauta, Alma J., Kruisselbrink, Alwine B., Lurvink, Ellie, Mulder, Arend, Claas, Frans H., Noort, Willy A., Willemze, Roel, Fibbe, Willem E.

“…Umbilical cord blood (UCB) is considered as an attractive alternative source of hematopoietic stem cells for allogeneic stem cell transplantations in patients…”
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Addition of the Vascular Niche Component to the Human Bone Marrow-like Scaffold Model by Noort, Willy A, de Jong-Korlaar, Regina, Lubbers-Aalders, Linda, Yuan, Huipin, de Bruijn, Joost D, Mitsiades, Constantine S, Martens, Anton CM, Groen, Richard WJ

“…Previously, we have reported that our human bone marrow (BM)-like scaffold xenograft model allows the engraftment and outgrowth of normal and malignant…”
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CD38 Chimeric Antigen Receptor Engineered T Cells As Therapeutic Tools for Multiple Myeloma by Drent, Esther, Groen, Richard, Noort, Willy A., Lammerts van Bueren, Jeroen, Parren, Paul W.H.I., Kuball, Jurgen H, Sebestyen, Zsolt, van de Donk, Niels W.C.J., Martens, Anton C., Lokhorst, Henk M., Mutis, Tuna

“…Chimeric Antigen Receptors (CARs) are engineered constructs consisting of an antibody-derived antigen recognition domain linked to intracellular T cell…”
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Disregulated Osteogenesis By Mesenchymal Stromal Cells (MSC) After In Vivo Exposure To Multiple Myeloma: Studies In a Novel Humanized Mouse Model For Bone Remodelling In Myeloma by Groen, Richard W.J., Noort, Willy A., Sigmans, Jessica, van Stralen, Aniek, Aalders, Linda, Raymakers, Reinier, Yuan, Huipin, Mitsiades, Constantine S., Martens, Anton

“…Multiple myeloma (MM), a B-cell neoplasm characterized by a clonal expansion of malignant plasma cells in the bone marrow (BM), is accompanied by osteolytic…”
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CD38-Targeted Immunochemotherapy Of Multiple Myeloma: Preclinical Evidence For Its Combinatorial Use In Lenalidomide and Bortezomib Refractory/Intolerant MM Patients by Nijhof, Inger S., Noort, Willy A., Lammerts van Bueren, Jeroen, van Kessel, Berris, Bakker, Joost M., Parren, Paul W.H.I., Groen, Richard W.J., van de Donk, Niels W.C.J., Lokhorst, Henk, Mutis, Tuna, Martens, Anton

“…Multiple myeloma (MM) remains an incurable malignancy of clonal plasma cells. Although the new generation of immunomodulatory agents, such as lenalidomide…”
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