Search Results - "NOONAN, P"
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Frontal Cortex and Reward-Guided Learning and Decision-Making
Published in Neuron (Cambridge, Mass.) (23-06-2011)“…Reward-guided decision-making and learning depends on distributed neural circuits with many components. Here we focus on recent evidence that suggests four…”
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Stents for Idiopathic Intracranial Hypertension: Meta-Analyzed, Hypo-Analyzed, and In Need of a Trial
Published in American journal of neuroradiology : AJNR (01-02-2016)Get full text
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Local and global reward learning in the lateral frontal cortex show differential development during human adolescence
Published in PLoS biology (02-03-2023)“…Reward-guided choice is fundamental for adaptive behaviour and depends on several component processes supported by prefrontal cortex. Here, across three…”
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The Evolution of Lineage-Specific Regulatory Activities in the Human Embryonic Limb
Published in Cell (03-07-2013)“…The evolution of human anatomical features likely involved changes in gene regulation during development. However, the nature and extent of human-specific…”
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High-Resolution Epigenomic Atlas of Human Embryonic Craniofacial Development
Published in Cell reports (Cambridge) (01-05-2018)“…Defects in patterning during human embryonic development frequently result in craniofacial abnormalities. The gene regulatory programs that build the…”
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Contrasting Roles for Orbitofrontal Cortex and Amygdala in Credit Assignment and Learning in Macaques
Published in Neuron (Cambridge, Mass.) (02-09-2015)“…Recent studies have challenged the view that orbitofrontal cortex (OFC) and amygdala mediate flexible reward-guided behavior. We trained macaques to perform an…”
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On the relationship between the "default mode network" and the "social brain"
Published in Frontiers in human neuroscience (21-06-2012)“…The default mode network (DMN) of the brain consists of areas that are typically more active during rest than during active task performance. Recently however,…”
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The organization of dorsal frontal cortex in humans and macaques
Published in The Journal of neuroscience (24-07-2013)“…The human dorsal frontal cortex has been associated with the most sophisticated aspects of cognition, including those that are thought to be especially refined…”
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Distinct Mechanisms for Distractor Suppression and Target Facilitation
Published in The Journal of neuroscience (10-02-2016)“…It is well established that preparatory attention improves processing of task-relevant stimuli. Although it is often more important to ignore task-irrelevant…”
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Evolutionary changes in promoter and enhancer activity during human corticogenesis
Published in Science (American Association for the Advancement of Science) (06-03-2015)“…Human higher cognition is attributed to the evolutionary expansion and elaboration of the human cerebral cortex. However, the genetic mechanisms contributing…”
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Social Network Size Affects Neural Circuits in Macaques
Published in Science (American Association for the Advancement of Science) (04-11-2011)“…It has been suggested that variation in brain structure correlates with the sizes of individuals' social networks. Whether variation in social network size…”
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Contrasting Effects of Medial and Lateral Orbitofrontal Cortex Lesions on Credit Assignment and Decision-Making in Humans
Published in The Journal of neuroscience (19-07-2017)“…The orbitofrontal cortex is critical for goal-directed behavior. Recent work in macaques has suggested the lateral orbitofrontal cortex (lOFC) is relatively…”
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Integrated analyses resolve conflicts over squamate reptile phylogeny and reveal unexpected placements for fossil taxa
Published in PloS one (24-03-2015)“…Squamate reptiles (lizards and snakes) are a pivotal group whose relationships have become increasingly controversial. Squamates include >9000 species, making…”
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Phylogenomics Reveals Ancient Gene Tree Discordance in the Amphibian Tree of Life
Published in Systematic biology (01-01-2021)“…Abstract Molecular phylogenies have yielded strong support for many parts of the amphibian Tree of Life, but poor support for the resolution of deeper nodes,…”
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The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment
Published in Nature communications (10-03-2015)“…Recent studies implicate chromatin modifiers in autism spectrum disorder (ASD) through the identification of recurrent de novo loss of function mutations in…”
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A neural circuit covarying with social hierarchy in macaques
Published in PLoS biology (01-09-2014)“…Despite widespread interest in social dominance, little is known of its neural correlates in primates. We hypothesized that social status in primates might be…”
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Evolution of Gene Regulation in Humans
Published in Annual review of genomics and human genetics (31-08-2016)“…As a species, we possess unique biological features that distinguish us from other primates. Here, we review recent efforts to identify changes in gene…”
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Human-Specific Gain of Function in a Developmental Enhancer
Published in Science (American Association for the Advancement of Science) (05-09-2008)“…Changes in gene regulation are thought to have contributed to the evolution of human development. However, in vivo evidence for uniquely human developmental…”
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Selective inhibition of distracting input
Published in Behavioural brain research (14-12-2018)“…We review a series of studies exploring distractor suppression. It is often assumed that preparatory distractor suppression is controlled via top-down…”
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The genomic landscape of cohesin-associated chromatin interactions
Published in Genome research (01-08-2013)“…Cohesin is implicated in establishing tissue-specific DNA loops that target enhancers to promoters, and also localizes to sites bound by the insulator protein…”
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