Search Results - "NONYANE, Molati"

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies by Doria-Rose, Nicole A., Schramm, Chaim A., Gorman, Jason, Moore, Penny L., Bhiman, Jinal N., DeKosky, Brandon J., Ernandes, Michael J., Georgiev, Ivelin S., Kim, Helen J., Pancera, Marie, Staupe, Ryan P., Altae-Tran, Han R., Bailer, Robert T., Crooks, Ema T., Cupo, Albert, Druz, Aliaksandr, Garrett, Nigel J., Hoi, Kam H., Kong, Rui, Louder, Mark K., Longo, Nancy S., McKee, Krisha, Nonyane, Molati, O’Dell, Sijy, Roark, Ryan S., Rudicell, Rebecca S., Schmidt, Stephen D., Sheward, Daniel J., Soto, Cinque, Wibmer, Constantinos Kurt, Yang, Yongping, Zhang, Zhenhai, Mullikin, James C., Binley, James M., Sanders, Rogier W., Wilson, Ian A., Moore, John P., Ward, Andrew B., Georgiou, George, Williamson, Carolyn, Abdool Karim, Salim S., Morris, Lynn, Kwong, Peter D., Shapiro, Lawrence, Mascola, John R.

“…Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the HIV-1 envelope, but the mechanism of their elicitation has been…”
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Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape by Moore, Penny L, Gray, Elin S, Wibmer, C Kurt, Bhiman, Jinal N, Nonyane, Molati, Sheward, Daniel J, Hermanus, Tandile, Bajimaya, Shringkhala, Tumba, Nancy L, Abrahams, Melissa-Rose, Lambson, Bronwen E, Ranchobe, Nthabeleng, Ping, Lihua, Ngandu, Nobubelo, Karim, Quarraisha Abdool, Karim, Salim S Abdool, Swanstrom, Ronald I, Seaman, Michael S, Williamson, Carolyn, Morris, Lynn

“…A minority of HIV-1–infected individuals develop broadly neutralizing antibodies, which are considered an important goal of many HIV vaccine strategies. Moore…”
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Potent and Broad Neutralization of HIV-1 Subtype C by Plasma Antibodies Targeting a Quaternary Epitope Including Residues in the V2 Loop by MOORE, Penny L, GRAY, Elin S, SIBEKO, Sengeziwe, MLISANA, Koleka, ABDOOL KARIM, Salim S, WILLIAMSON, Carolyn, PINTER, Abraham, MORRIS, Lynn, SHEWARD, Daniel, MADIGA, Maphuti, RANCHOBE, Nthabeleng, ZHONG LAI, HONNEN, William J, NONYANE, Molati, TUMBA, Nancy, HERMANUS, Tandile

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Multiple Pathways of Escape from HIV Broadly Cross-Neutralizing V2-Dependent Antibodies by Moore, Penny L, Sheward, Daniel, Nonyane, Molati, Ranchobe, Nthabeleng, Hermanus, Tandile, Gray, Elin S, Abdool Karim, Salim S, Williamson, Carolyn, Morris, Lynn

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V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity by van Eeden, Charmaine, Wibmer, Constantinos Kurt, Scheepers, Cathrine, Richardson, Simone I., Nonyane, Molati, Lambson, Bronwen, Mkhize, Nonhlanhla N., Vijayakumar, Balakrishnan, Sheng, Zizhang, Stanfield-Oakley, Sherry, Bhiman, Jinal N., Bekker, Valerie, Hermanus, Tandile, Mabvakure, Batsirai, Ismail, Arshad, Moody, M. Anthony, Wiehe, Kevin, Garrett, Nigel, Karim, Salim Abdool, Dirr, Heini, Fernandes, Manuel A., Sayed, Yasien, Shapiro, Lawrence, Ferrari, Guido, Haynes, Barton F., Moore, Penny L., Morris, Lynn

“…Antibodies that bind residue K169 in the V2 region of the HIV-1 envelope correlated with reduced risk of infection in the RV144 vaccine trial but were…”
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Rapid Induction of Multifunctional Antibodies in Rabbits and Macaques by Clade C HIV-1 CAP257 Envelopes Circulating During Epitope-Specific Neutralization Breadth Development by Malherbe, Delphine C, Wibmer, Constantinos Kurt, Nonyane, Molati, Reed, Jason, Sather, D Noah, Spencer, David A, Schuman, Jason T, Guo, Biwei, Pandey, Shilpi, Robins, Harlan, Park, Byung, Fuller, Deborah H, Sacha, Jonah B, Moore, Penny L, Hessell, Ann J, Haigwood, Nancy L

“…We report here on HIV-1 immunization results in rabbits and macaques co-immunized with clade C gp160 DNA and gp140 trimeric envelope vaccines, a strategy…”
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Longitudinal analysis of subtype C envelope tropism for memory CD4+ T cell subsets over the first 3 years of untreated HIV-1 infection by Gartner, Matthew J, Gorry, Paul R, Tumpach, Carolin, Zhou, Jingling, Dantanarayana, Ashanti, Chang, J. Judy, Angelovich, Thomas A, Ellenberg, Paula, Laumaea, Annemarie E, Nonyane, Molati, Moore, Penny L, Lewin, Sharon R, Churchill, Melissa J, Flynn, Jacqueline K, Roche, Michael

“…Abstract Background HIV-1 infects a wide range of CD4 + T cells with different phenotypic properties and differing expression levels of entry coreceptors. We…”
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Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan by Umotoy, Jeffrey, Bagaya, Bernard S., Joyce, Collin, Schiffner, Torben, Menis, Sergey, Saye-Francisco, Karen L., Biddle, Trevor, Mohan, Sanjay, Vollbrecht, Thomas, Kalyuzhniy, Oleksander, Madzorera, Sharon, Kitchin, Dale, Lambson, Bronwen, Nonyane, Molati, Kilembe, William, Poignard, Pascal, Schief, William R., Burton, Dennis R., Murrell, Ben, Moore, Penny L., Briney, Bryan, Sok, Devin, Landais, Elise

“…The VH1-2 restricted VRC01-class of antibodies targeting the HIV envelope CD4 binding site are a major focus of HIV vaccine strategies. However, a detailed…”
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HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth by Sheward, Daniel J., Marais, Jinny, Bekker, Valerie, Murrell, Ben, Eren, Kemal, Bhiman, Jinal N., Nonyane, Molati, Garrett, Nigel, Woodman, Zenda L., Abdool Karim, Quarraisha, Abdool Karim, Salim S., Morris, Lynn, Moore, Penny L., Williamson, Carolyn

“…Eliciting antibodies that neutralize a broad range of circulating HIV strains (broadly neutralizing antibodies [bnAbs]) represents a key priority for vaccine…”
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Antibody Isotype Switching as a Mechanism to Counter HIV Neutralization Escape by Scheepers, Cathrine, Bekker, Valerie, Anthony, Colin, Richardson, Simone I., Oosthuysen, Brent, Moyo, Thandeka, Kgagudi, Prudence, Kitchin, Dale, Nonyane, Molati, York, Talita, Mielke, Dieter, Mabvakure, Batsirai M., Sheng, Zizhang, Lambson, Bronwen E., Ismail, Arshad, Garrett, Nigel J., Abdool Karim, Salim S., Shapiro, Lawrence, Williamson, Carolyn, Morris, Lynn, Moore, Penny L.

“…Neutralizing antibodies (nAbs) to highly variable viral pathogens show remarkable diversification during infection, resulting in an “arms race” between virus…”
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Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN by Alexandre, Kabamba B, Moore, Penny L, Nonyane, Molati, Gray, Elin S, Ranchobe, Nthabeleng, Chakauya, Ereck, McMahon, James B, O’Keefe, Barry R, Chikwamba, Rachel, Morris, Lynn

“…Abstract We examined the ability of HIV-1 subtype C to develop resistance to the inhibitory lectins, griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin…”
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Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models by Lacerda, Miguel, Moore, Penny L, Ngandu, Nobubelo K, Seaman, Michael, Gray, Elin S, Murrell, Ben, Krishnamoorthy, Mohan, Nonyane, Molati, Madiga, Maphuti, Wibmer, Constantinos Kurt, Sheward, Daniel, Bailer, Robert T, Gao, Hongmei, Greene, Kelli M, Karim, Salim S Abdool, Mascola, John R, Korber, Bette TM, Montefiori, David C, Morris, Lynn, Williamson, Carolyn, Seoighe, Cathal

“…BACKGROUND: Identification of the epitopes targeted by antibodies that can neutralize diverse HIV-1 strains can provide important clues for the design of a…”
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