Search Results - "NONN, Larisa"

Harnessing the Utility of Ex Vivo Patient Prostate Tissue Slice Cultures by Perez, Lillian M, Nonn, Larisa

“…Patient-derived prostate tissue explant cultures are powerful research tools that offer the potential for personalized medicine. These cultures preserve the…”
Get full text

Elevated serum microRNA levels associate with absence of high-grade prostate cancer in a retrospective cohort by Mihelich, Brittany L, Maranville, Joseph C, Nolley, Rosalie, Peehl, Donna M, Nonn, Larisa

“…To reduce treatment of indolent prostate cancer (PCa), biomarkers are needed to improve identification of patients with a low-risk of having aggressive…”
Get full text

High levels of PIWI‐interacting RNAs are present in the small RNA landscape of prostate epithelium from vitamin D clinical trial specimens by Baumann, Bethany, Lugli, Giovanni, Gao, Shang, Zenner, Morgan, Nonn, Larisa

“…Background Vitamin D, a hormone that acts through the nuclear vitamin D receptor (VDR), upregulates antitumorigenic microRNA in prostate epithelium. This may…”
Get full text

MICRORNAS: FROM BIOLOGY TO CLINICAL IMPLEMENTATION by Nonn, Larisa

Get full text

Evidence for field cancerization of the prostate by Nonn, Larisa, Ananthanarayanan, Vijayalakshmi, Gann, Peter H.

“…BACKGROUND Field cancerization, which is not yet well‐characterized in the prostate, occurs when large areas of an organ or tissue surface are affected by a…”
Get full text

Cell-type specific expression of oncogenic and tumor suppressive microRNAs in the human prostate and prostate cancer by Kumar, Binod, Rosenberg, Avi Z., Choi, Su Mi, Fox-Talbot, Karen, De Marzo, Angelo M., Nonn, Larisa, Brennen, W. Nathaniel, Marchionni, Luigi, Halushka, Marc K., Lupold, Shawn E.

“…MiR-1 and miR-143 are frequently reduced in human prostate cancer (PCa), while miR-141 and miR-21 are frequently elevated. Consequently, these miRNAs have been…”
Get full text

Tumor Suppressor microRNAs, miR-100 and -125b, are Regulated by 1,25-dihydroxyvitamin D in Primary Prostate Cells and in Patient Tissue by GIANGRECO, Angeline A, VAISHNAV, Avani, WAGNER, Dennis, FINELLI, Antonio, FLESHNER, Neil, VAN DER KWAST, Theodorus, VIETH, Reinhold, NONN, Larisa

“…MiR-100 and miR-125b are lost in many cancers and have potential function as tumor suppressors. Using both primary prostatic epithelial cultures and laser…”
Get full text

Randomized Clinical Trial of Vitamin D3 Doses on Prostatic Vitamin D Metabolite Levels and Ki67 Labeling in Prostate Cancer Patients by Wagner, Dennis, Trudel, Dominique, Van der Kwast, Theodorus, Nonn, Larisa, Giangreco, Angeline Antonio, Li, Doris, Dias, Andre, Cardoza, Monique, Laszlo, Sanda, Hersey, Karen, Klotz, Laurence, Finelli, Antonio, Fleshner, Neil, Vieth, Reinhold

“…Context: Vitamin D3 might benefit prostate cancer (PCa) patients because prostate cells can locally synthesize the active hormone calcitriol. Objective: Our…”
Get full text

Keratin Profiling by Single-Cell RNA-Sequencing Identifies Human Prostate Stem Cell Lineage Hierarchy and Cancer Stem-Like Cells by Hu, Wen-Yang, Hu, Dan-Ping, Xie, Lishi, Nonn, Larisa, Lu, Ranli, Abern, Michael, Shioda, Toshihiro, Prins, Gail S.

“…Single prostate stem cells can generate stem and progenitor cells to form prostaspheres in 3D culture. Using a prostasphere-based label retention assay, we…”
Get full text

Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth by Petiwala, Sakina M, Berhe, Saba, Li, Gongbo, Puthenveetil, Angela G, Rahman, Ozair, Nonn, Larisa, Johnson, Jeremy J

“…The Mediterranean diet has long been attributed to preventing or delaying the onset of cardiovascular disease, diabetes and various solid organ cancers. In…”
Get full text

The miR-183 family cluster alters zinc homeostasis in benign prostate cells, organoids and prostate cancer xenografts by Dambal, Shweta, Baumann, Bethany, McCray, Tara, Williams, LaTanya, Richards, Zachary, Deaton, Ryan, Prins, Gail S., Nonn, Larisa

“…The miR-183 cluster, which is comprised of paralogous miRs-183, -96 and -182, is overexpressed in many cancers, including prostate adenocarcinoma (PCa). Prior…”
Get full text

Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5 : Implications for prostate cancer prevention by vitamin D by NONN, Larisa, LIHONG PENG, FELDMAN, David, PEEHL, Donna M

“…Although numerous studies have implicated vitamin D in preventing prostate cancer, the underlying mechanism(s) remains unclear. Using normal human prostatic…”
Get full text

Circulating Plasma microRNA to Differentiate Cushing's Disease From Ectopic ACTH Syndrome by Belaya, Zhanna, Khandaeva, Patimat, Nonn, Larisa, Nikitin, Alexey, Solodovnikov, Alexander, Sitkin, Ivan, Grigoriev, Andrey, Pikunov, Mikhail, Lapshina, Anastasia, Rozhinskaya, Liudmila, Melnichenko, Galina, Dedov, Ivan

“…Corticotropinomas and adrenocorticotropic hormone (ACTH)-secreting neuroendocrine tumors exhibit differential levels of some microRNAs (miRs) compared to…”
Get full text

Isolation and functional interrogation of adult human prostate epithelial stem cells at single cell resolution by Hu, Wen-Yang, Hu, Dan-Ping, Xie, Lishi, Li, Ye, Majumdar, Shyama, Nonn, Larisa, Hu, Hong, Shioda, Toshi, Prins, Gail S.

“…Using primary cultures of normal human prostate epithelial cells, we developed a novel prostasphere-based, label-retention assay that permits identification…”
Get full text

Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells by MORENO, Jacqueline, KRISHNAN, Aruna V, SWAMI, Srilatha, NONN, Larisa, PEEHL, Donna M, FELDMAN, David

“…Calcitriol exhibits antiproliferative and pro-differentiation effects in prostate cancer. Our goal is to further define the mechanisms underlying these…”
Get full text

Prostate Stroma Increases the Viability and Maintains the Branching Phenotype of Human Prostate Organoids by Richards, Zachary, McCray, Tara, Marsili, Joseph, Zenner, Morgan L, Manlucu, Jacob T, Garcia, Jason, Kajdacsy-Balla, Andre, Murray, Marcus, Voisine, Cindy, Murphy, Adam B, Abdulkadir, Sarki A, Prins, Gail S, Nonn, Larisa

“…The fibromuscular stroma of the prostate regulates normal epithelial differentiation and contributes to carcinogenesis in vivo. We developed and characterized…”
Get full text

The Absence of Mitochondrial Thioredoxin 2 Causes Massive Apoptosis, Exencephaly, and Early Embryonic Lethality in Homozygous Mice by Nonn, Larisa, Williams, Ryan R., Erickson, Robert P., Powis, Garth

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Selective modulation of endoplasmic reticulum stress markers in prostate cancer cells by a standardized mangosteen fruit extract by Li, Gongbo, Petiwala, Sakina M, Pierce, Dana R, Nonn, Larisa, Johnson, Jeremy J

“…The increased proliferation of cancer cells is directly dependent on the increased activity of the endoplasmic reticulum (ER) machinery which is responsible…”
Get full text

Gene expression patterns in the human breast after pregnancy by Asztalos, Szilard, Gann, Peter H, Hayes, Meghan K, Nonn, Larisa, Beam, Craig A, Dai, Yang, Wiley, Elizabeth L, Tonetti, Debra A

“…Epidemiologic studies have established that pregnancy has a bidirectional, time-dependent effect on breast cancer risk; a period of elevated risk is followed…”
Get full text

Vitamin D sufficiency enhances differentiation of patient-derived prostate epithelial organoids by McCray, Tara, Pacheco, Julian V., Loitz, Candice C., Garcia, Jason, Baumann, Bethany, Schlicht, Michael J., Valyi-Nagy, Klara, Abern, Michael R., Nonn, Larisa

“…Vitamin D is an essential steroid hormone that regulates systemic calcium homeostasis and cell fate decisions. The prostate gland is hormonally regulated,…”
Get full text