Search Results - "NOLL, CHRISTOPHE"
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The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage
Published in Nature communications (11-01-2022)“…The transcription factor hepatocyte nuclear factor 4 A (HNF4A) controls the metabolic features of several endodermal epithelia. Both HNF4A and HNF4G are…”
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Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications
Published in Scientific reports (11-01-2018)“…The epidemic of type 2 diabetes mellitus (T2DM) is fueled by added fructose consumption. Here, we thus combined high-fat/high-fructose diet, with multiple…”
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3
Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men
Published in Nature communications (30-01-2017)“…In rodents, brown adipose tissue (BAT) plays an important role in producing heat to defend against the cold and can metabolize large amounts of dietary fatty…”
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Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans
Published in The journal of clinical endocrinology and metabolism (01-03-2014)“…Context: Recent studies examining brown adipose tissue (BAT) metabolism in adult humans have provided convincing evidence of its thermogenic potential and role…”
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Catechins as a Potential Dietary Supplementation in Prevention of Comorbidities Linked with Down Syndrome
Published in Nutrients (12-05-2022)“…Plant-derived polyphenols flavonoids are increasingly being recognized for their medicinal potential. These bioactive compounds derived from plants are gaining…”
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Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues
Published in PloS one (29-09-2016)“…IL-15 is an inflammatory cytokine secreted by many cell types. IL-15 is also produced during physical exercise by skeletal muscle and has been reported to…”
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7
Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake
Published in Frontiers in pharmacology (27-07-2021)“…Objectives: Arterial hypertension, when exacerbated by excessive dietary salt intake, worsens the morbidity and mortality rates associated with cardiovascular…”
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Adipocyte hypertrophy associates with in vivo postprandial fatty acid metabolism and adipose single-cell transcriptional dynamics
Published in iScience (19-01-2024)“…Adipocyte hypertrophy is associated with metabolic complications independent of obesity. We aimed to determine: 1) the association between adipocyte size and…”
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DeepImageTranslator: A free, user-friendly graphical interface for image translation using deep-learning and its applications in 3D CT image analysis
Published in SLAS technology (01-02-2022)“…The advent of deep-learning has set new standards in an array of image translation applications. At present, the use of these methods often requires computer…”
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Determination of a pharmacokinetic model for [11C]-acetate in brown adipose tissue
Published in EJNMMI research (27-03-2019)“…Background [ 11 C]-acetate positron emission tomography is used to assess oxidative metabolism in various tissues including the heart, tumor, and brown adipose…”
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IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery
Published in Cell reports. Medicine (20-04-2021)“…Insulin-like growth factor-binding protein (IGFBP)-2 is a circulating biomarker of cardiometabolic health. Here, we report that circulating IGFBP-2…”
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Adipose ABHD6 regulates tolerance to cold and thermogenic programs
Published in JCI insight (17-12-2020)“…Enhanced energy expenditure in brown (BAT) and white adipose tissues (WAT) can be therapeutic against metabolic diseases. We examined the thermogenic role of…”
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14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance
Published in Molecular metabolism (Germany) (01-11-2020)“…Adaptive thermogenesis, which is partly mediated by sympathetic input on brown adipose tissue (BAT), is a mechanism of heat production that confers protection…”
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Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat
Published in PloS one (09-09-2009)“…Inflammation followed by fibrosis is a component of islet dysfunction in both rodent and human type 2 diabetes. Because islet inflammation may originate from…”
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Correction: Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues
Published in PloS one (08-11-2016)“…[This corrects the article DOI: 10.1371/journal.pone.0162995.]…”
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DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase
Published in PloS one (21-10-2009)“…Hyperhomocysteinemia, characterized by increased plasma homocysteine level, is associated with an increased risk of atherosclerosis. On the contrary, patients…”
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Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats
Published in Molecular and cellular biochemistry (01-01-2011)“…Hyperhomocysteinemia, characterized by an elevated plasma homocysteine concentration, leads to several clinical manifestations and particularly cardiovascular…”
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Protection and reversal of hepatic fibrosis by red wine polyphenols in hyperhomocysteinemic mice
Published in The Journal of nutritional biochemistry (01-09-2011)“…Hyperhomocysteinemia leads to several clinical manifestations and, particularly, liver disease. Lowering homocysteine through nutrition or other means might…”
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Early reduction of circulating homocysteine levels in Goto–Kakizaki rat, a spontaneous nonobese model of type 2 diabetes
Published in Biochimica et biophysica acta (01-06-2011)“…Diabetes mellitus is associated with increased risk for cardiovascular disorders, which are major causes of mortality in this disease. Hyperhomocysteinemia,…”
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One-carbon cycle alterations induced by Dyrk1a dosage
Published in Molecular genetics and metabolism reports (01-01-2014)“…Hyperhomocysteinemia due to cystathionine beta synthase deficiency confers diverse clinical manifestations. It is characterized by elevated plasma homocysteine…”
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