Search Results - "NOHMI Takehiko"

Thresholds of Genotoxic and Non-Genotoxic Carcinogens by Nohmi, Takehiko

“…Exposure to chemical agents is an inevitable consequence of modern society; some of these agents are hazardous to human health. The effects of chemical…”
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Mutagenicity of carcinogenic heterocyclic amines in Salmonella typhimurium YG strains and transgenic rodents including gpt delta by Nohmi, Takehiko, Watanabe, Masahiko

“…Chemical carcinogens to humans have been usually identified by epidemiological studies on the relationships between occupational or environmental exposure to…”
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Environmental stress and lesion-bypass DNA polymerases by NOHMI, Takehiko

“…In nature, microbes live under a variety of harsh conditions, such as excess DNA damage, starvation, pH shift, or high temperatures. Microbial cells respond to…”
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Chemically-Induced DNA Damage, Mutagenesis, and Cancer by Basu, Ashis K, Nohmi, Takehiko

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Thresholds of Genotoxic and Non-Genotoxic Carcinogens by Nohmi, Takehiko

“…Exposure to chemical agents is an inevitable consequence of modern society; some of these agents are hazardous to human health. The effects of chemical…”
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Chromosome aberrations induced by the non-mutagenic carcinogen acetamide involve in rat hepatocarcinogenesis through micronucleus formation in hepatocytes by Nakamura, Kenji, Ishii, Yuji, Takasu, Shinji, Nohmi, Takehiko, Shibutani, Makoto, Ogawa, Kumiko

“…Chromosome aberrations (CAs), i.e. changes in chromosome number or structure, are known to cause chromosome rearrangements and subsequently tumorigenesis…”
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In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats by Gi, Min, Fujioka, Masaki, Kakehashi, Anna, Okuno, Takahiro, Masumura, Kenichi, Nohmi, Takehiko, Matsumoto, Michiharu, Omori, Masako, Wanibuchi, Hideki, Fukushima, Shoji

“…1,4-Dioxane is a widely used synthetic industrial chemical and its contamination of drinking water and food is a potential health concern. It induces liver…”
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DNA polymerase kappa counteracts inflammation‐induced mutagenesis in multiple organs of mice by Hakura, Atsushi, Sui, Hajime, Sonoda, Jiro, Matsuda, Tomonari, Nohmi, Takehiko

“…In vitro studies indicate that DNA polymerase kappa (Polκ) is able to accurately and efficiently perform DNA synthesis using templates containing various types…”
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Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells by Suzuki, Tetsuya, Sassa, Akira, Grúz, Petr, Gupta, Ramesh C., Johnson, Francis, Adachi, Noritaka, Nohmi, Takehiko

“…•A plasmid with benzo[a]pyrene adduct was introduced into human Pol ζ L2618M cells.•The benzo[a]pyrene adduct primarily induced G to T mutations at the lesion…”
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Comparison of the frequencies of ENU-induced point mutations in male germ cells and inherited germline mutations in their offspring by Masumura, Kenichi, Ando, Tomoko, Toyoda-Hokaiwado, Naomi, Ukai, Akiko, Nohmi, Takehiko, Honma, Masamitsu

“…Gene mutations induced in germ cells may be transmitted to the next generation and cause adverse effects such as genetic diseases. Certain mutations may result…”
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Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells by Xu, An, Chai, Yunfei, Nohmi, Takehiko, Hei, Tom K

“…Titanium dioxide (TiO2) nanoparticles and fullerene (C60) are two attractive manufactured nanoparticles with great promise in industrial and medical…”
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Background data of 2-year-old male and female F344 gpt delta rats by Matsushita, Kohei, Ishii, Yuji, Kijima, Aki, Takasu, Shinji, Kuroda, Ken, Takagi, Hisayoshi, Nohmi, Takehiko, Ogawa, Kumiko, Umemura, Takashi

“…Although gpt delta rats, as reporter gene-transgenic rats, were originally developed for in vivo mutation assays, they have also been used to evaluate chemical…”
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DNA polymerase κ suppresses inflammation and inflammation-induced mutagenesis and carcinogenic potential in the colon of mice by Hakura, Atsushi, Sui, Hajime, Seki, Yuki, Sonoda, Jiro, Yoshida, Yusaku, Takagi, Hisayoshi, Yokose, Shigeo, Matsuda, Tomonari, Asakura, Shoji, Nohmi, Takehiko

“…Chronic inflammation induces DNA damage and promotes cell proliferation, thereby increasing the risk of cancer. DNA polymerase κ (Pol κ), involved in…”
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Validation study of the combined repeated‐dose toxicity and genotoxicity assay using gpt delta rats by Akagi, Jun‐ichi, Toyoda, Takeshi, Cho, Young‐Man, Mizuta, Yasuko, Nohmi, Takehiko, Nishikawa, Akiyoshi, Ogawa, Kumiko

“…Transgenic rodents carrying reporter genes to detect organ‐specific in vivo genetic alterations are useful for risk assessment of genotoxicity that causes…”
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Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine by Sassa, Akira, Çağlayan, Melike, Rodriguez, Yesenia, Beard, William A., Wilson, Samuel H., Nohmi, Takehiko, Honma, Masamitsu, Yasui, Manabu

“…Numerous ribonucleotides are incorporated into the genome during DNA replication. Oxidized ribonucleotides can also be erroneously incorporated into DNA…”
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New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay by Masumura, Kenichi, Ando, Tomoko, Ukai, Akiko, Fujiwara, Sho, Yokose, Shigeo, You, Xinyue, Suzuki, Takayoshi, Hayashi, Hiroyuki, Nohmi, Takehiko, Takagi, Hisayoshi, Honma, Masamitsu

“…Gene mutation assays in transgenic rodents are useful tools to investigate in vivo mutagenicity in a target tissue. Using a lambda EG10 transgene containing…”
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Lack of genotoxic mechanisms in early‐stage furan‐induced hepatocellular tumorigenesis in gpt delta rats by Hibi, Daisuke, Yokoo, Yu, Suzuki, Yuta, Ishii, Yuji, Jin, Meilan, Kijima, Aki, Nohmi, Takehiko, Nishikawa, Akiyoshi, Umemura, Takashi

“…Furan has been used as an intermediate in the chemical‐manufacturing industry and has been shown to contaminate various foods. Although furan induces…”
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Site-specific in vivo mutagenicity in the kidney of gpt delta rats given a carcinogenic dose of ochratoxin A by Hibi, Daisuke, Suzuki, Yuta, Ishii, Yuji, Jin, Meilan, Watanabe, Maiko, Sugita-Konishi, Yoshiko, Yanai, Tokuma, Nohmi, Takehiko, Nishikawa, Akiyoshi, Umemura, Takashi

“…Ochratoxin A (OTA) can induce renal tumors that originate from the S3 segment of the proximal tubules in rodents, but the results of conventional mutagenicity…”
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Effects of the scid mutation on X-ray-induced deletions in the brain and spleen of gpt delta mice by Masumura, Kenichi, Yatagai, Fumio, Ochiai, Masako, Nakagama, Hitoshi, Nohmi, Takehiko

“…DNA-dependent protein kinase (DNA-PK), consisting of a Ku heterodimer (Ku70/80) and a large catalytic subunit (DNA-PKcs), plays an important role in the repair…”
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Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice by Aoki, Yasunobu, Ohno, Mizuki, Matsumoto, Michiyo, Matsumoto, Michi, Masumura, Kenichi, Nohmi, Takehiko, Tsuzuki, Teruhisa

“…Base pair mismatches in genomic DNA can result in mutagenesis, and consequently in tumorigenesis. To investigate how mismatch repair deficiency increases…”
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