Search Results - "NOHMI, T"

Radiation induced COX-2 expression and mutagenesis at non-targeted lung tissues of gpt delta transgenic mice by Chai, Y, Calaf, G M, Zhou, H, Ghandhi, S A, Elliston, C D, Wen, G, Nohmi, T, Amundson, S A, Hei, T K

“…Background: Although radiation-induced bystander effects have been confirmed using a variety of endpoints, the mechanism(s) underlying these effects are not…”
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Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme by Eastmond, David A., Hartwig, Andrea, Anderson, Diana, Anwar, Wagida A., Cimino, Michael C., Dobrev, Ivan, Douglas, George R., Nohmi, Takehiko, Phillips, David H., Vickers, Carolyn

“…Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of…”
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Comprehensive toxicity study of safrole using a medium-term animal model with gpt delta rats by Jin, M, Kijima, A, Suzuki, Y, Hibi, D, Inoue, T, Ishii, Y, Nohmi, T, Nishikawa, A, Ogawa, K, Umemura, T

“…Graphical abstract . The overall data suggested that the present model might be a promising candidate for investigating comprehensive toxicities of the agents…”
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Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards by TWEATS, D. J, BLAKEY, D, TICE, R, HEFLICH, R. H, JACOBS, A, JACOBSEN, S. D, MORITA, T, NOHMI, T, O'DONOVAN, M. R, SASAKI, Y. F, SOFUNI, T

“…In vivo genotoxicity tests play a pivotal role in genotoxicity testing batteries. They are used both to determine if potential genotoxicity observed in vitro…”
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Roles of chromosomal and episomal dinB genes encoding DNA pol IV in targeted and untargeted mutagenesis in Escherichia coli by Kim, S R, Matsui, K, Yamada, M, Gruz, P, Nohmi, T

“…DNA polymerase IV (pol IV) in Escherichia coli is a member of a novel family of DNA polymerases (the DinB/UmuC/Rad30/Rev1 super-family or the DNA polymerase Y…”
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Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test by TWEATS, D. J, BLAKEY, D, TICE, R, HEFLICH, R. H, JACOBS, A, JACOBSEN, S. D, MORITA, T, NOHMI, T, O'DONOVAN, M. R, SASAKI, Y. F, SOFUNI, T

“…A survey conducted as part of an International Workshop on Genotoxicity Testing (IWGT) has identified a number of compounds that appear to be more readily…”
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Molecular nature of ultraviolet B light-induced deletions in the murine epidermis by HORIGUCHI, Mieko, MASUMURA, Ken-Ichi, IKEHATA, Hironobu, ONO, Tetsuya, KANKE, Yusuke, NOHMI, Takehiko

“…Depletion of the stratospheric ozone layer leads to an increase in ambient UV loads, which are expected to raise skin cancer incidences. Tumor development in…”
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Acrylamide genotoxicity in young versus adult gpt delta male rats by KOYAMA, Naoki, YASUI, Manabu, IMAI, Toshio, HONMA, Masamitsu, KIMURA, Aoi, TAKAMI, Shigeaki, SUZUKI, Takuya, MASUMURA, Kenichi, NOHMI, Takehiko, MASUDA, Shuichi, KINAE, Naohide, MATSUDA, Tomonari

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RecA-Mediated Cleavage Activates UmuD for Mutagenesis: Mechanistic Relationship between Transcriptional Derepression and Posttranslational Activation by Nohmi, Takehiko, Battista, John R., Dodson, Lori A., Walker, Graham C.

“…The products of the SOS-regulated umuDC operon are required for most UV and chemical mutagenesis in Escherichia coli. It has been shown that the UmuD protein…”
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Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests by Tweats, D.J., Blakey, D., Heflich, R.H., Jacobs, A., Jacobsen, S.D., Morita, T., Nohmi, T., O’Donovan, M.R., Sasaki, Y.F., Sofuni, T., Tice, R.

“…In vivo genotoxicity tests play a pivotal role in genotoxicity testing batteries. They are used both to determine if potential genotoxicity observed in vitro…”
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Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests by Tweats, D.J., Blakey, D., Heflich, R.H., Jacobs, A., Jacobsen, S.D., Morita, T., Nohmi, T., O’Donovan, M.R., Sasaki, Y.F., Sofuni, T., Tice, R.

“…A survey conducted as part of an International Workshop on Genotoxicity Testing (IWGT) has identified a number of compounds that appear to be more readily…”
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In vivo transgenic mutation assays by Heddle, John A., Dean, Stephen, Nohmi, Takehiko, Boerrigter, Michaël, Casciano, Daniel, Douglas, George R., Glickman, Barry W., Gorelick, Nancy J., Mirsalis, Jon C., Martus, Hans-Jörg, Skopek, Thomas R., Thybaud, Veronique, Tindall, Kenneth R., Yajima, Nobuhiro

“…Transgenic rodent gene mutation models provide quick and statistically reliable assays for mutations in the DNA from any tissue. For regulatory applications,…”
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Evaluation of the genotoxicity of stevioside and steviol using six in vitro and one in vivo mutagenicity assays by Matsui, M., Matsui, K., Kawasaki, Y., Oda, Y., Noguchi, T., Kitagawa, Y., Sawada, M., Hayashi, M., Nohmi, T., Yoshihira, K., Ishidate, M., Sofuni, T.

“…Stevioside, a constituent of Stevia rebaudiana, is commonly used as a non-caloric sugar substitute in Japan. The genetic toxicities of stevioside and its…”
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Environmental stress and lesion-bypass DNA polymerases by NOHMI, Takehiko

“…In nature, microbes live under a variety of harsh conditions, such as excess DNA damage, starvation, pH shift, or high temperatures. Microbial cells respond to…”
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Spi− selection: An efficient method to detect γ-ray-induced deletions in transgenic mice by Nohmi, T., Suzuki, M., Masumura, K., Yamada, M., Matsui, K., Ueda, O., Suzuki, H., Katoh, M., Ikeda, H., Sofuni, T.

“…Despite the importance of genome rearrangement in the etiology of cancer and human genetic disease, deletion mutations are poorly detectable by transgenic…”
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Spectra of gpt mutations in ethylnitrosourea-treated and untreated transgenic mice by Masumura, K., Matsui, M., Katoh, M., Horiya, N., Ueda, O., Tanabe, H., Yamada, M., Suzuki, H., Sofuni, T., Nohmi, T.

“…We have established a new transgenic mouse mutagenicity assay for the efficient detection of point mutations and deletions in vivo (Nohmi et al. [1996] Env…”
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Development of novel genotoxicity assays by genetic engineering methods by Nohmi, T

“…Novel genotoxicity assays have been developed to efficiently detect the genotoxicity of various environmental chemicals, and to evaluate the potential hazards…”
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Primary mutagenicity screening of food additives currently used in Japan by Ishidate, Jr, M, Sofuni, T, Yoshikawa, K, Hayashi, M, Nohmi, T, Sawada, M, Matsuoka, A

“…Salmonella/microsome tests (Ames tests) and chromosomal aberration tests in vitro using a Chinese hamster fibroblast cell line were carried out on 190…”
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Improvement of the Spi- assay for mutations in gpt delta mice by including magnesium ions during plaque formation by Shibata, A., Masutani, M., Nozaki, T., Kamada, N., Fujihara, H., Masumura, K., Nakagama, H., Sugimura, T., Kobayashi, S., Suzuki, H., Nohmi, T.

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Regionally-targeted mutagenesis by metabolically-activated steviol: DNA sequence analysis of steviol-induced mutants of guanine phosphoribosyltransferase (gpt) gene of Salmonella typhimurium TM677 by Matsui, M., Sofuni, T., Nohmi, T.

“…Steviol is the aglycone of stevioside, a non–caloric sugar substitute commonly used in Japan. Steviol strongly induces mutations at the guanine…”
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