Search Results - "NOEL, Alan R"

Pharmacodynamics of Ceftaroline against Staphylococcus aureus Studied in an In Vitro Pharmacokinetic Model of Infection by MACGOWAN, Alasdair P, NOEL, Alan R, TOMASELLI, Sharon, BOWKER, Karen E

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Pharmacodynamics of the Antibacterial Effect of and Emergence of Resistance to Doripenem in Pseudomonas aeruginosa and Acinetobacter baumannii in an In Vitro Pharmacokinetic Model by BOWKER, Karen E, NOEL, Alan R, TOMASELLI, Sharon G, ELLIOTT, Heather, MACGOWAN, Alasdair P

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Pharmacodynamics of Telavancin Studied in an In Vitro Pharmacokinetic Model of Infection by MACGOWAN, Alasdair P, NOEL, Alan R, TOMASELLI, Sharon, ELLIOTT, Heather C, BOWKER, Karen E

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Pharmacodynamics of Minocycline against Staphylococcus aureus in an In Vitro Pharmacokinetic Model by BOWKER, Karen E, NOEL, Alan R, MACGOWAN, Alasdair P

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Pharmacodynamics of the Antibacterial Effect and Emergence of Resistance to Tomopenem, Formerly RO4908463/CS-023, in an In Vitro Pharmacokinetic Model of Staphylococcus aureus Infection by MACGOWAN, Alasdair P, BOWKER, Karen E, NOEL, Alan R

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Antibacterial effect of seven days exposure to ceftolozane-tazobactam as monotherapy and in combination with fosfomycin or tobramycin against Pseudomonas aeruginosa with ceftolozane-tazobactam MICs at or above 4 mg/l in an in vitro pharmacokinetic model by Attwood, Marie, Griffin, Pippa, Noel, Alan R, Albur, Maha, Macgowan, Alasdair P

“…Abstract Objectives To use a pre-clinical pharmacokinetic infection model to assess the antibacterial effect of ceftolozane/tazobactam alone or in combination…”
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Bacterial Strain-to-Strain Variation in Pharmacodynamic Index Magnitude, a Hitherto Unconsidered Factor in Establishing Antibiotic Clinical Breakpoints by MACGOWAN, Alasdair P, REYNOLDS, Rosy, NOEL, Alan R, BOWKER, Karen E

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Comparative bactericidal activity of representative β-lactams against Enterobacterales, Acinetobacter baumannii and Pseudomonas aeruginosa by Noel, Alan R, Attwood, Marie, Bowker, Karen E, MacGowan, Alasdair P, Albur, Maha

“…There is surprisingly little comparative published data on the bactericidal action of different sub-classes of β-lactams against aerobic Gram-negative rods,…”
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Antibacterial effect of ceftolozane/tazobactam in combination with amikacin against aerobic Gram-negative bacilli studied in an in vitro pharmacokinetic model of infection by Noel, Alan R, Bowker, Karen E, Attwood, Marie, MacGowan, Alasdair P

“…To use a pre-clinical infection model to assess the antibacterial effect of human simulations of dosing with ceftolozane/tazobactam (with or without amikacin)…”
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Antibacterial effect of imipenem/relebactam on aerobic Gram-negative bacilli: in vitro simulations of 7 or 14 day human exposures by Noel, Alan R, Bowker, Karen E, Attwood, Marie, MacGowan, Alasdair P

“…Abstract Objectives We assessed the antibacterial effect of human simulations of dosing with imipenem/relebactam (with or without amikacin) on…”
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Exposure of Escherichia coli to antibiotic-efflux pump inhibitor combinations in a pharmacokinetic model: impact on bacterial clearance and drug resistance by MacGowan, Alasdair P, Attwood, M L G, Noel, Alan R, Barber, R, Aron, Zachary, Opperman, Timothy J, Grimsey, Elizabeth, Stone, Jack, Ricci, Vito, Piddock, L J V

“…Efflux pump inhibitors (EPIs) offer an attractive therapeutic option when combined with existing classes. However, their optimal dosing strategies are unknown…”
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Population pharmacokinetics/pharmacodynamics of minocycline plus rifampicin in patients with complicated skin and skin structure infections caused by MRSA by Pardos, Sonia Luque, Hope, William, Kotsaki, Antigone, Das, Shampa, Giamarellos-Bourboulis, Evangelos J, Kontopoulouk, Theano, Akinosoglou, Karolina, O'Hare, Miriam, Attwood, Marie L G, Bowker, Karen E, Noel, Alan R, Lovering, Andrew M, Bayliss, Mark A J, Evans, Rebecca N, MacGowan, Alasdair P

“…The population pharmacokinetics/pharmacodynamics (PK/PD) of minocycline, rifampicin and linezolid in patients with complicated skin and soft tissue infections…”
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Lessons from isavuconazole therapeutic drug monitoring at a United Kingdom Reference Center by Borman, Andrew M, Hughes, Jessica M, Oliver, Debra, Fraser, Mark, Sunderland, Julie, Noel, Alan R, Johnson, Elizabeth M

“…Abstract We determined isavuconazole serum concentrations for 150 UK patients receiving standard isavuconazole dosing regimens, including serial therapeutic…”
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Pharmacodynamics of plazomicin and a comparator aminoglycoside, amikacin, studied in an in vitro pharmacokinetic model of infection by Noel, Alan R., Attwood, Marie, Bowker, Karen E., Kim, Aryun, Krause, Kevin M., MacGowan, Alasdair P.

“…•The pharmacodynamics of plazomicin were studied in a pre-clinical model of infection.•Plazomicin AUC/MIC ratios for 24-h static and bactericidal effects were…”
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A pilot observational study of CSF vancomycin therapeutic drug monitoring during the treatment of nosocomial ventriculitis by Arkell, Paul, Wilson, Richard, Antcliffe, David B, Gilchrist, Mark, Noel, Alan R, Wilson, Mark, Barnes, Sophie C, Watkins, Killian, Holmes, Alison, Rawson, Timothy M

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Pharmacodynamics of Ceftolozane plus Tazobactam Studied in an In Vitro Pharmacokinetic Model of Infection by MacGowan, Alasdair P, Noel, Alan R, Tomaselli, Sharon G, Nicholls, Donna, Bowker, Karen E

“…Ceftolozane plus tazobactam is an antipseudomonal cephalosporin combined with tazobactam, an established beta-lactamase inhibitor, and has in vitro potency…”
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Pharmacodynamics of inhaled amikacin (BAY 41-6551) studied in an in vitro pharmacokinetic model of infection by Bowker, Karen E, Noel, Alan R, Tomaselli, Sharon, Attwood, Marie, MacGowan, Alasdair P

“…The pharmacodynamics of inhaled antimicrobials are poorly studied. Amikacin is being developed for inhalational therapy as BAY 41-6551. We employed an in vitro…”
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Pharmacodynamics of Moxifloxacin against Anaerobes Studied in an In Vitro Pharmacokinetic Model by NOEL, Alan R, BOWKER, Karen E, MACGOWAN, Alasdair P

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Pharmacodynamics of piperacillin/tazobactam against Pseudomonas aeruginosa: antibacterial effect and risk of emergence of resistance by Carson, Amy A, Bowker, Karen E, Attwood, Marie, Noel, Alan R, MacGowan, Alasdair P

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Differences in the pharmacodynamics of ceftaroline against different species of Enterobacteriaceae studied in an in vitro pharmacokinetic model of infection by Bowker, Karen E, Noel, Alan R, Tomaselli, Sharon, MacGowan, Alasdair P

“…Dose-ranging experiments were performed to study the pharmacodynamics of ceftaroline against Enterobacteriaceae. A range of fT>MIC values (0%-100%) were…”
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