Search Results - "NOE, Adele"

Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi) by Gu, Jessie, Noe, Adele, Chandra, Priya, Al-Fayoumi, Suliman, Ligueros-Saylan, Monica, Sarangapani, Ramesh, Maahs, Suzanne, Ksander, Gary, Rigel, Dean F., Jeng, Arco Y., Lin, Tsu-Han, Zheng, Weiyi, Dole, William P.

“…Angiotensin receptor blockade and neprilysin (NEP) inhibition together offer potential benefits for the treatment of hypertension and heart failure. LCZ696 is…”
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Rationale and design of TRANSITION: a randomized trial of pre‐discharge vs. post‐discharge initiation of sacubitril/valsartan by Pascual‐Figal, Domingo, Wachter, Rolf, Senni, Michele, Belohlavek, Jan, Noè, Adele, Carr, David, Butylin, Dmytro

“…Aims The prognosis after hospitalization for acute decompensated heart failure (ADHF) remains poor, especially <30 days post‐discharge. Evidence‐based…”
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Pharmacokinetic and Pharmacodynamic Characteristics of Single-dose Canakinumab in Patients With Type 2 Diabetes Mellitus by Noe, Adele, PhD, Howard, Campbell, MD, Thuren, Tom, MD, PhD, Taylor, Ann, MD, Skerjanec, Andrej, PhD

“…Abstract Purpose Interleukin (IL)-1β, an inflammatory molecule, contributes to the development of atherothrombosis and worsening of islet β-cell function…”
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Influence of diabetes on sacubitril/valsartan titration and clinical outcomes in patients hospitalized for heart failure by Witte, Klaus K., Wachter, Rolf, Senni, Michele, Belohlavek, Jan, Straburzynska‐Migaj, Ewa, Fonseca, Candida, Lonn, Eva, Noè, Adele, Schwende, Heike, Butylin, Dmytro, Chiang, YannTong, Pascual‐Figal, Domingo

“…Aims Diabetes mellitus is associated with worse outcomes and lower attainment of disease‐modifying therapies in patients with heart failure with reduced…”
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Initiation of sacubitril/valsartan shortly after hospitalisation for acutely decompensated heart failure in patients with newly diagnosed (de novo) heart failure: a subgroup analysis of the TRANSITION study by Senni, Michele, Wachter, Rolf, Witte, Klaus K., Straburzynska‐Migaj, Ewa, Belohlavek, Jan, Fonseca, Candida, Mueller, Christian, Lonn, Eva, Chakrabarti, Arhit, Bao, Weibin, Noe, Adele, Schwende, Heike, Butylin, Dmytro, Pascual‐Figal, Domingo

“…Aims Sacubitril/valsartan has shown efficacy and tolerability in patients with heart failure (HF) and reduced ejection fraction (HFrEF) in the ambulatory…”
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Sacubitril/Valsartan Initiated in Hospitalized Patients with Heart Failure with Reduced Ejection Fraction after Hemodynamic Stabilization: Primary Results of the TRANSITION Study by Wachter, Rolf, Senni, Michele, Belohlavek, Jan, Butylin, Dmytro, Noe, Adele, Pascual-Figal, Domingo

“…Sacubitril/valsartan (S/V) is indicated for the treatment of chronic heart failure with reduced ejection fraction (HFrEF). The TRANSITION study aims to provide…”
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Safety and tolerability of canakinumab, an IL-1β inhibitor, in type 2 diabetes mellitus patients: a pooled analysis of three randomised double-blind studies by Howard, Campbell, Noe, Adele, Skerjanec, Andrej, Holzhauer, Björn, Wernsing, Margaret, Ligueros-Saylan, Monica, Thuren, Tom

“…We aimed to assess the safety and tolerability of different doses of canakinumab versus placebo in patients with type 2 diabetes mellitus (T2DM). Data were…”
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International REgistry to assess medical Practice with lOngitudinal obseRvation for Treatment of Heart Failure (REPORT-HF): rationale for and design of a global registry by Filippatos, Gerasimos, Khan, Sadiya Sana, Ambrosy, Andrew P., Cleland, John G.F., Collins, Sean P., Lam, Carolyn S.P., Angermann, Christiane E., Ertl, Georg, Dahlström, Ulf, Hu, Dayi, Dickstein, Kenneth, Perrone, Sergio V., Ghadanfar, Mathieu, Bermann, Georgina, Noe, Adele, Schweizer, Anja, Maier, Thomas, Gheorghiade, Mihai

“…Aims The clinical characteristics, initial presentation, management, and outcomes of patients hospitalized with new‐onset (first diagnosis) heart failure (HF)…”
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The DGAT1 inhibitor pradigastat does not induce photosensitivity in healthy human subjects: a randomized controlled trial using three defined sunlight exposure conditions by Bauer, Daniel, Soon, Rachel L, Kulmatycki, Kenneth, Chen, Yuming, Noe, Adele, Chen, Jin, Dosik, Jonathan S, Meyers, Dan

“…The DGAT1 inhibitor, pradigastat, demonstrated a mild phototoxicity signal in preclinical studies. Therefore, this clinical trial was conducted to assess the…”
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Stromelysin-1 Activation Correlates with Invasiveness in Squamous Cell Carcinoma by DE ANGELIS, Tiziana, NOE, Adele, CHATTERJEE, Mitali, MULHOLLAND, Joy

“…The expression of selected metalloproteinases and tissue inhibitors of metalloproteinases (TIMP) was examined in three squamous cell carcinoma (SCC) cell lines…”
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Effect of Pradigastat, a Diacylglycerol Acyltransferase 1 Inhibitor, on the QTcF Interval in Humans by Meyers, Charles D., Noe, Adele, Salunke, Atish, Movva, Aishwarya, Kulmatycki, Kenneth, Neelakantham, Srikanth, Crissey, Anne, Majumdar, Tapan, Chen, Jin

“…Pradigastat, a novel diacylglycerol acyltransferase 1 inhibitor, has been studied in familial chylomicronemia syndrome. To evaluate the effects of…”
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Abstract 15567: Short-Term Effect on Cardiac Biomarkers of Initiation of Sacubitril/Valsartan in Hospitalized Patients With Heart Failure and Reduced Ejection Fraction: Results of the Transition Study by Pascual-Figal, Domingo, Senni, Michele, Belohlavek, Jan, Butylin, Dmytro, Noe, Adele, Bao, Weibin, Wachter, Rolf

“…IntroductionThe benefit of sacubitril/valsartan (S/V) in patients with chronic heart failure and reduced ejection fraction (HFrEF) is associated with a…”
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Safety and tolerability of canakinumab, an IL-1[beta] inhibitor, in type 2 diabetes mellitus patients: a pooled analysis of three randomised double-blind studies by Howard, Campbell, Noe, Adele, Skerjanec, Andrej, Holzhauer, Björn, Wernsing, Margaret, Ligueros-Saylan, Monica, Thuren, Tom

“…Doc number: 94 Abstract Background: We aimed to assess the safety and tolerability of different doses of canakinumab versus placebo in patients with type 2…”
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Differentiation of innovator versus generic cyclosporine via a drug interaction on sirolimus by KOVARIK, John M, NOE, Adele, YIBIN WANG, MUELLER, Irene, DENUCCI, Gilberto, SCHMOUDER, Robert L

“…Both sirolimus and cyclosporine are immunosuppressants used in a combined regimen after organ transplantation. When coadministered with the innovator…”
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NT-proBNP Response to Sacubitril/Valsartan in Hospitalized Heart Failure Patients With Reduced Ejection Fraction: TRANSITION Study by Pascual-Figal, Domingo, Wachter, Rolf, Senni, Michele, Bao, Weibin, Noè, Adele, Schwende, Heike, Butylin, Dmytro, Prescott, Margaret F

“…This study examined the effects of sacubitril/valsartan on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels and determined patient characteristics…”
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Clinical Development of an Everolimus Pediatric Formulation: Relative Bioavailability, Food Effect, and Steady-State Pharmacokinetics by Kovarik, John M., Noe, Adele, Berthier, Stephane, McMahon, Louis, Langholff, Wayne K., Marion, Alan S., Hoyer, Peter Friedrich, Ettenger, Robert, Rordorf, Christiane

“…The immunosuppressant everolimus used in organ transplantation is formulated as a conventional tablet for adults and a dispersible tablet that can be…”
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Stromelysin-1 Activation Correlates with Invasiveness in Squamous Cell Carcinoma11The authors have declared not to have a conflict of interest by De Angelis, Tiziana, Noè, Adele, Chatterjee, Mitali, Mulholland, Joy

“…The expression of selected metalloproteinases and tissue inhibitors of metalloproteinases (TIMP) was examined in three squamous cell carcinoma (SCC) cell lines…”
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Stromelysin-1 Activation Correlates with Invasiveness in Squamous Cell Carcinoma1 by De Angelis, Tiziana, Noè, Adele, Chatterjee, Mitali, Mulholland, Joy

“…The expression of selected metalloproteinases and tissue inhibitors of metalloproteinases (TIMP) was examined in three squamous cell carcinoma (SCC) cell lines…”
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Prostacyclin-sensitive adenylate cyclase in cultured myocytes: differences between rabbit aorta and mesenteric artery by Oliva, D, Noè, A, Nicosia, S, Bernini, F, Fumagalli, R, Whittle, B J, Moncada, S, Vane, J R

“…Prostacyclin relaxes isolated strips of rabbit mesenteric artery and stimulates cholesteryl ester hydrolysis in rabbit aortic smooth muscle cells. Both effects…”
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Recombinational repair of genetic mutations by Cole-Strauss, A, Nöe, A, Kmiec, E B

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