Search Results - "NOBUHARA, Youichi"

Cytoprotective Effects of 4, 6-Bis(1H-pyrazol-1-yl)pyrimidine and Related Compounds on HCl·Ethanol-Induced Gastric Lesions in Rats by IKEDA, Masazumi, MARUYAMA, Kazumi, NOBUHARA, Youichi, YAMADA, Toshihiro, OKABE, Susumu

“…Bis(1H-pyrazol-1-yl)- and bis(1H-imidazol-1-yl)pyrimidines were synthesized and evaluated for cytoprotective effects. Among them, 4,…”
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Synthesis and Cytoprotective Antiulcer Activity of 2- or 4-(1H-Pyrazol-1-yl)pyrimidine Derivatives Related to Mepirizole and Dulcerozine by IKEDA, Masazumi, MARUYAMA, Kazumi, NOBUHARA, Youichi, YAMADA, Toshihiro, OKABE, Susumu

“…(1H-Pyrazol-1-yl)-, (1H-imidazol-1-yl)-, and (1H-1, 2, 4-triazol-1-yl)phrimidines were prepared and evaluated for cytoprotective antiulcer activity. Among…”
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Cytoprotective effects of 4,6-bis(1H-pyrazol-1-yl)pyrimidine and related compounds on HCl.ethanol-induced gastric lesions in rats by IKEDA, M, MARUYAMA, K, NOBUHARA, Y, YAMADA, T, OKABE, S

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Role of luminal Ca2+ on normal and damaged gastric mucosa in the rat by TAKEUCHI, K, NOBUHARA, Y, OKABE, S

“…Influence of luminal Ca2+ on the integrity of normal mucosa and recovery of damaged mucosa in anesthetized rat stomachs was studied using a perfusion system…”
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Pyridazinones. 1. Synthesis, antisecretory, and antiulcer activities of thio amide derivatives by Yamada, Toshihiro, Nobuhara, Youichi, Yamaguchi, Azuma, Ohki, Masahiko

“…In an effort to develop new types of antiulcer agents, a series of novel 3(2H)-pyridazinone derivatives and related analogues was synthesized. Substituted…”
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Possible role of endogenous prostaglandins in alkaline response in rat gastric mucosa damaged by hypertonic NaCl by NOBUHARA, Y, TAKEUCHI, K

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Pyridazinones. 2. Synthesis and antisecretory and antiulcer activities of thiourea and 2-cyanoguanidine derivatives by Yamada, Toshihiro, Nobuhara, Youichi, Shimamura, Hiroshi, Tsukamoto, Yoshitsugu, Yoshihara, Kazuo, Yamaguchi, Azuma, Ohki, Masahiko

“…In an effort to develop new types of antiulcer agents, we synthesized a series of novel 2-[omega-(thioureido)alkyl]- and…”
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Vinegar is a Dietary Mild Irritant to the Rat Gastric Mucosa by NOBUHARA, Youichi, TAKEUCHI, Koji, OKABE, Susumu

“…Exposure of the rat stomach to acetic acid (0.3—3%) caused a concentration-dependent reduction of transmucosal potential difference (PD) and increase of…”
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Studies on New Antiulcer Agents. I. Synthesis and Antisecretory Activity of Pyridazine Derivatives by YAMADA, TOSHIHIRO, NOBUHARA, YOUICHI, SHIMAMURA, HIROSHI, YOSHIHARA, KAZUO, YAMAGUCHI, AZUMA, OHKI, MASAHIKO

“…The pyridine ring of 2-phenyl-2-(2-pyridyl) thioacetamide (Ia), the lead compound for the present study, was replaced by a pyridazine ring in the hope of…”
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Functional and Morphological Alterations in the Rat Stomach Following Exposure to Hypertonic NaCl Solution by TAKEUCHI, Koji, YAMAKUNI, Hisashi, NOBUHARA, Youichi, OKABE, Susumu

“…We examined the effects of 1 M NaCl as a mild irritant on gastric potential difference (PD), acid secretion, mucosai blood flow (MBF), and DNA synthetic…”
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CHANGES IN TRANSMUCOSAL POTENTIAL DIFFERENCE AND LUMINAL PH IN ANESTHETIZED RAT STOMACH AFTER EXPOSURE TO ETHANOL by TAKEUCHI, Koji, NOBUHARA, Youichi, OKABE, Susumu

“…Mucosa-damaging agents such as aspirin, bile salts or ethanol have been shown to produce a reduction of gastric potential difference (PD), associated with…”
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Effects of Various Agents on Prednisolone-Induced Gastric Lesions in Rats by NOBUHARA, Youichi, TAKEUCHI, Koji, OKABE, Susumu

“…We studied the effects of various agents on prednisolone-induced gastric lesions in rats. Gastric lesions were produced by subcutaneous administration of 50…”
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Effects of Various Agents on Prednisolone-Induced Gastric Lesions in Rats by NOBUHARA, Youichi, TAKEUCHI, Koji, OKABE, Susumu

“…We studied the effects of various agents on prednisolone-induced gastric lesions in rats. Gastric lesions were produced by subcutaneous administration of 50…”
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Inhibition of gastric motor activity by 16,16-dimethyl prostaglandin E2. A possible explanation of cytoprotection by TAKEUCHI, K, NOBUHARA, Y

“…Effects of 16-dimethyl prostaglandin E2 (16-dmPGE2) and necrotizing agents on gastric motility and gastric mucosa were studied in conscious rats. Gastric…”
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Influence of prednisolone on gastric alkaline response in rat stomach. A possible explanation for steroid-induced gastric lesion by NOBUHARA, Y, UEKI, S, TAKEUCHI, K

“…Exposure of the rat stomach for 10 min to 1 M NaCl produced an increase of luminal pH (alkaline response) with a concomitant reduction of the transmucosal…”
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Effects of hemorrhagic shock on alkaline secretion and mucosal tolerance to acid in rat duodenum: a comparative study with indomethacin by TAKEUCHI, K, NOBUHARA, Y, TANAKA, H, NISHIWAKI, H, OKABE, S

“…The effects of hemorrhagic shock (HE) on duodenal HCO3- secretion and mucosal tolerance to acid were investigated in anesthetized rats and compared with those…”
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CHANGES IN TRANSMUCOSAL POTENTIAL DIFFERENCE AND LUMINAL PH IN ANESTHETIZED RAT STOMACH AFTER EXPOSURE TO ETHANOL by TAKEUCHI, Koji, NOBUHARA, Youichi, OKABE, Susumu

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Effects of MAR-99, a new must cell stabilizer, on gastric secretion and various acute gastric lesions in rats by Nobuhara, Youichi, Tagami, Mitsuko, Ishizuka, Yasuhiro, Kataoka, Mikiko, Yaginuma, Hideya, Sato, Makoto

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