Search Results - "NIZET, Victor"

The Ontogeny of a Neutrophil: Mechanisms of Granulopoiesis and Homeostasis by Lawrence, Shelley M, Corriden, Ross, Nizet, Victor

“…Comprising the majority of leukocytes in humans, neutrophils are the first immune cells to respond to inflammatory or infectious etiologies and are crucial…”
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The Accidental Orthodoxy of Drs. Mueller and Hinton by Nizet, Victor

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Understanding how leading bacterial pathogens subvert innate immunity to reveal novel therapeutic targets by Nizet, Victor, MD

“…Staphylococcus aureus (SA) and group A Streptococcus (GAS) are prominent Gram-positive bacterial pathogens, each associated with a variety of mucosal and…”
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Staphylococcus aureus modulation of innate immune responses through Toll-like (TLR), (NOD)-like (NLR) and C-type lectin (CLR) receptors by Askarian, Fatemeh, Wagner, Theresa, Johannessen, Mona, Nizet, Victor

“…Early recognition of pathogens by the innate immune system is crucial for bacterial clearance. Many pattern recognition receptors (PRRs) such as Toll-like…”
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Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management by Thamphiwatana, Soracha, Angsantikul, Pavimol, Escajadillo, Tamara, Zhang, Qiangzhe, Olson, Joshua, Luk, Brian T., Zhang, Sophia, Fang, Ronnie H., Gao, Weiwei, Nizet, Victor, Zhang, Liangfang

“…Sepsis, resulting from uncontrolled inflammatory responses to bacterial infections, continues to cause high morbidity and mortality worldwide. Currently,…”
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Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens by LaRock, Christopher N., Nizet, Victor

“…Cationic antimicrobial peptides (CAMPs) are critical front line contributors to host defense against invasive bacterial infection. These immune factors have…”
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The intricate pathogenicity of group a Streptococcus : A comprehensive update by Bergsten, Helena, Nizet, Victor

“…Group A (GAS) is a versatile pathogen that targets human lymphoid, decidual, skin, and soft tissues. Recent advancements have shed light on its airborne…”
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HIF Transcription Factors, Inflammation, and Immunity by Palazon, Asis, Goldrath, Ananda W., Nizet, Victor, Johnson, Randall S.

“…The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible factor (HIF) transcription factors; these play an integral role in the…”
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Pharmacological Targeting of Pore-Forming Toxins as Adjunctive Therapy for Invasive Bacterial Infection by Escajadillo, Tamara, Nizet, Victor

“…For many of the most important human bacterial infections, invasive disease severity is fueled by the cell damaging and pro-inflammatory effects of secreted…”
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Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus by WALKER, Mark J, BARNETT, Timothy C, MCARTHUR, Jason D, COLE, Jason N, GILLEN, Christine M, HENNINGHAM, Anna, SRIPRAKASH, K. S, SANDERSON-SMITH, Martina L, NIZET, Victor

“…Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human infections such as pharyngitis and impetigo and serious infections such as…”
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Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A by Yamanaka, Kazuya, Reynolds, Kirk A., Kersten, Roland D., Ryan, Katherine S., Gonzalez, David J., Nizet, Victor, Dorrestein, Pieter C., Moore, Bradley S.

“…Recent developments in next-generation sequencing technologies have brought recognition of microbial genomes as a rich resource for novel natural product…”
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Color me bad: microbial pigments as virulence factors by Liu, George Y, Nizet, Victor

“…A hallmark feature of several pathogenic microbes is the distinctive color of their colonies when propagated in the clinical laboratory. Such pigmentation…”
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Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq by Liu, Xue, Kimmey, Jacqueline M., Matarazzo, Laura, de Bakker, Vincent, Van Maele, Laurye, Sirard, Jean-Claude, Nizet, Victor, Veening, Jan-Willem

“…Streptococcus pneumoniae is an opportunistic human pathogen that causes invasive diseases, including pneumonia, with greater health risks upon influenza A…”
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Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches by Patras, Kathryn A, Nizet, Victor

“…Group B (GBS) colonizes the gastrointestinal and vaginal epithelium of a significant percentage of healthy women, with potential for ascending intrauterine…”
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Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance by Kavvas, Erol S., Catoiu, Edward, Mih, Nathan, Yurkovich, James T., Seif, Yara, Dillon, Nicholas, Heckmann, David, Anand, Amitesh, Yang, Laurence, Nizet, Victor, Monk, Jonathan M., Palsson, Bernhard O.

“…Mycobacterium tuberculosis is a serious human pathogen threat exhibiting complex evolution of antimicrobial resistance (AMR). Accordingly, the many publicly…”
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Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis by Harbut, Michael B., Vilchèze, Catherine, Luo, Xiaozhou, Hensler, Mary E., Guo, Hui, Yang, Baiyuan, Chatterjee, Arnab K., Nizet, Victor, Jacobs, William R., Schultz, Peter G., Wang, Feng

“…Infections caused by antibiotic-resistant bacteria are a rising public health threat and make the identification of new antibiotics a priority. From a…”
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A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus by Valderrama, J. Andrés, Kulkarni, Surashree S., Nizet, Victor, Bier, Ethan

“…Gene-drive systems in diploid organisms bias the inheritance of one allele over another. CRISPR-based gene-drive expresses a guide RNA (gRNA) into the genome…”
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Collective Resistance in Microbial Communities by Intracellular Antibiotic Deactivation by Sorg, Robin A, Lin, Leo, van Doorn, G Sander, Sorg, Moritz, Olson, Joshua, Nizet, Victor, Veening, Jan-Willem

“…The structure and composition of bacterial communities can compromise antibiotic efficacy. For example, the secretion of β-lactamase by individual bacteria…”
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Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis by Tagliabracci, Vincent S, Engel, James L, Wiley, Sandra E, Xiao, Junyu, Gonzalez, David J, Nidumanda Appaiah, Hitesh, Koller, Antonius, Nizet, Victor, White, Kenneth E, Dixon, Jack E

“…The family with sequence similarity 20, member C (Fam20C) has recently been identified as the Golgi casein kinase. Fam20C phosphorylates secreted proteins on…”
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Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation by Lizcano, Anel, Secundino, Ismael, Döhrmann, Simon, Corriden, Ross, Rohena, Cristina, Diaz, Sandra, Ghosh, Pradipta, Deng, Lingquan, Nizet, Victor, Varki, Ajit

“…Healthy blood neutrophils are functionally quiescent in the bloodstream, have a short lifespan, and exit the circulation to carry out innate immune functions,…”
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