Search Results - "NIXON, F"

Sphingolipids in inflammation: pathological implications and potential therapeutic targets by Nixon, Graeme F.

“…Sphingolipids are formed via the metabolism of sphingomyelin, a constituent of the plasma membrane, or by de novo synthesis. Enzymatic pathways result in the…”
Get full text

Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development by Leeansyah, Edwin, Loh, Liyen, Nixon, Douglas F., Sandberg, Johan K.

“…Innate-like, evolutionarily conserved MR1-restricted mucosa-associated invariant T (MAIT) cells represent a large antimicrobial T-cell subset in humans. Here,…”
Get full text

The CD4⁻CD8⁻ MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8⁺ MAIT cell pool by Dias, Joana, Boulouis, Caroline, Gorin, Jean-Baptiste, van den Biggelaar, Robin H. G. A., Lal, Kerri G., Gibbs, Anna, Loh, Liyen, Gulam, Muhammad Yaaseen, Sia, Wan Rong, Bari, Sudipto, Hwang, William Y. K., Nixon, Douglas F., Nguyen, Son, Betts, Michael R., Buggert, Marcus, Eller, Michael A., Broliden, Kristina, Tjernlund, Annelie, Sandberg, Johan K., Leeansyah, Edwin

“…Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the MHC class…”
Get full text

Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection by Lopez-Vergès, Sandra, Milush, Jeffrey M, Schwartz, Brian S, Pando, Marcelo J, Jarjoura, Jessica, York, Vanessa A, Houchins, Jeffrey P, Miller, Steve, Kang, Sang-Mo, Norris, Phillip J, Nixon, Douglas F, Lanier, Lewis L

“…During human CMV infection, there is a preferential expansion of natural killer (NK) cells expressing the activating CD94–NKG2C receptor complex, implicating…”
Get full text

Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity by Ndhlovu, Lishomwa C., Lopez-Vergès, Sandra, Barbour, Jason D., Jones, R. Brad, Jha, Aashish R., Long, Brian R., Schoeffler, Eric C., Fujita, Tsuyoshi, Nixon, Douglas F., Lanier, Lewis L.

“…Natural killer (NK) cells are innate lymphocytes that play an important role against viral infections and cancer. This effect is achieved through a complex…”
Get full text

Heterologous vaccine interventions: boosting immunity against future pandemics by Marín-Hernández, Daniela, Nixon, Douglas F., Hupert, Nathaniel

“…While vaccines traditionally have been designed and used for protection against infection or disease caused by one specific pathogen, there are known…”
Get full text

Telescope: Characterization of the retrotranscriptome by accurate estimation of transposable element expression by Bendall, Matthew L, de Mulder, Miguel, Iñiguez, Luis Pedro, Lecanda-Sánchez, Aarón, Pérez-Losada, Marcos, Ostrowski, Mario A, Jones, R Brad, Mulder, Lubbertus C F, Reyes-Terán, Gustavo, Crandall, Keith A, Ormsby, Christopher E, Nixon, Douglas F

“…Characterization of Human Endogenous Retrovirus (HERV) expression within the transcriptomic landscape using RNA-seq is complicated by uncertainty in fragment…”
Get full text

Allatostatin C modulates nociception and immunity in Drosophila by Bachtel, Nathaniel D., Hovsepian, Gary A., Nixon, Douglas F., Eleftherianos, Ioannis

“…Bacterial induced inflammatory responses cause pain through direct activation of nociceptive neurons, and the ablation of these neurons leads to increased…”
Get full text

T Cell Immunity in Acute HIV-1 Infection by Streeck, Hendrik, Nixon, Douglas F.

“…Exceedingly high viral loads and rapid loss of CD4+ T cells in all tissue compartments are a hallmark of acute human immunodeficiency virus type 1 (HIV-1)…”
Get full text

Ribosomal profiling of human endogenous retroviruses in healthy tissues by Dopkins, Nicholas, Singh, Bhavya, Michael, Stephanie, Zhang, Panpan, Marston, Jez L, Fei, Tongyi, Singh, Manvendra, Feschotte, Cedric, Collins, Nicholas, Bendall, Matthew L, Nixon, Douglas F

“…Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the human…”
Get full text

Human Endogenous Retrovirus K in Cancer: A Potential Biomarker and Immunotherapeutic Target by Curty, Gislaine, Marston, Jez L, de Mulder Rougvie, Miguel, Leal, Fabio E, Nixon, Douglas F, Soares, Marcelo A

“…In diseases where epigenetic mechanisms are changed, such as cancer, many genes show altered gene expression and inhibited genes become activated. Human…”
Get full text

Extreme immunotherapy: emergency immunology to defeat pandemics by Nixon, Douglas F, Marín-Hernández, Daniela, Hupert, Nathaniel

“…The ongoing global COVID-19 pandemic has thrown into sharp relief the gap between modern biology's ability to investigate and respond to a novel pathogen and…”
Get full text

MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection by Paquin-Proulx, Dominic, Avelino-Silva, Vivian I, Santos, Bianca A N, Silveira Barsotti, Nathália, Siroma, Fabiana, Fernandes Ramos, Jessica, Coracini Tonacio, Adriana, Song, Alice, Maestri, Alvino, Barros Cerqueira, Natalia, Felix, Alvina Clara, Levi, José Eduardo, Greenspun, Benjamin C, de Mulder Rougvie, Miguel, Rosenberg, Michael G, Nixon, Douglas F, Kallas, Esper G

“…Dengue virus (DENV) and Zika virus (ZIKV) are members of the Flaviviridae and are predominantly transmitted via mosquito bites. Both viruses are responsible…”
Get full text

Anticipated reduction in COVID-19 mortality due to population-wide BCG vaccination: evidence from Germany by Marín-Hernández, Daniela, Nixon, Douglas F., Hupert, Nathaniel

“…Bacillus Calmette-Guérin (BCG) vaccine is known to have "bystander benefits" in protecting against heterologous infections; interim analysis of the "ACTIVATE"…”
Get full text

Integrating human endogenous retroviruses into transcriptome-wide association studies highlights novel risk factors for major psychiatric conditions by Duarte, Rodrigo R. R., Pain, Oliver, Bendall, Matthew L., de Mulder Rougvie, Miguel, Marston, Jez L., Selvackadunco, Sashika, Troakes, Claire, Leung, Szi Kay, Bamford, Rosemary A., Mill, Jonathan, O’Reilly, Paul F., Srivastava, Deepak P., Nixon, Douglas F., Powell, Timothy R.

“…Human endogenous retroviruses (HERVs) are repetitive elements previously implicated in major psychiatric conditions, but their role in aetiology remains…”
Get full text

HIV-1 replication and latency are balanced by mTOR-driven cell metabolism by Crater, Jacqueline M, Nixon, Douglas F, Furler O'Brien, Robert L

“…Human Immunodeficiency virus type 1 (HIV-1) relies on host cell metabolism for all aspects of viral replication. Efficient HIV-1 entry, reverse transcription,…”
Get full text

Human CD4+ CD25+ Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens by AANDAHL, Einar M, MICHAËLSSON, Jakob, MORETTO, Walter J, HECHT, Frederick M, NIXON, Douglas F

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Enriched environment and stress exposure influence splenic B lymphocyte composition by Gurfein, Blake T, Hasdemir, Burcu, Milush, Jeffrey M, Touma, Chadi, Palme, Rupert, Nixon, Douglas F, Darcel, Nicholas, Hecht, Frederick M, Bhargava, Aditi

“…Prolonged chronic stress has deleterious effects on immune function and is associated with numerous negative health outcomes. The spleen harbors one-fourth of…”
Get full text

Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry by Duarte, Rodrigo R. R., Copertino, Dennis C., Iñiguez, Luis P., Marston, Jez L., Bram, Yaron, Han, Yuling, Schwartz, Robert E., Chen, Shuibing, Nixon, Douglas F., Powell, Timothy R.

“…Abstract Background Vaccination programs have been launched worldwide to halt the spread of COVID-19. However, the identification of existing, safe compounds…”
Get full text

Off-Target Effect of Activation of NF-κB by HIV Latency Reversal Agents on Transposable Elements Expression by Curty, Gislaine, Iniguez, Luis P, Soares, Marcelo A, Nixon, Douglas F, de Mulder Rougvie, Miguel

“…Many drugs have been evaluated to reactivate HIV-1 from cellular reservoirs, but the off-target effects of these latency reversal agents (LRA) remain poorly…”
Get full text