Search Results - "NIXON, ALAN J."

Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor by Rivas, Felipe, Zahid, Osama K., Reesink, Heidi L., Peal, Bridgette T., Nixon, Alan J., DeAngelis, Paul L., Skardal, Aleksander, Rahbar, Elaheh, Hall, Adam R.

“…Hyaluronan (or hyaluronic acid, HA) is a ubiquitous molecule that plays critical roles in numerous physiological functions in vivo, including tissue hydration,…”
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Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine model by Wilke, Markus M., Nydam, Daryl V., Nixon, Alan J.

“…Mesenchymal stem cells (MSCs) provide an important source of pluripotent cells for musculoskeletal tissue repair. This study examined the impact of MSC…”
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Cell- and gene-based approaches to tendon regeneration by Nixon, Alan J., BVSc, MS, Watts, Ashlee E., DVM, Schnabel, Lauren V., DVM

“…Repair of rotator cuff tears in experimental models has been significantly improved by the use of enhanced biologic approaches, including platelet-rich plasma,…”
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Mechanical characterization of matrix-induced autologous chondrocyte implantation (MACI®) grafts in an equine model at 53 weeks by Griffin, Darvin J, Bonnevie, Edward D, Lachowsky, Devin J, Hart, James C.A, Sparks, Holly D, Moran, Nance, Matthews, Gloria, Nixon, Alan J, Cohen, Itai, Bonassar, Lawrence J

“…Abstract There has been much interest in using autologous chondrocytes in combination with scaffold materials to aid in cartilage repair. In the present study,…”
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AAV-mediated Overexpression of IL-10 Mitigates the Inflammatory Cascade in Stimulated Equine Chondrocyte Pellets by Ortved, Kyla F, Begum, Laila, Stefanovski, Darko, Nixon, Alan J

“…Following joint trauma, a posttraumatic inflammatory cascade drives degeneration of the joint. We aimed to assess whether transduction of chondrocytes with…”
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Galectin-1 and galectin-3 expression in equine mesenchymal stromal cells (MSCs), synovial fibroblasts and chondrocytes, and the effect of inflammation on MSC motility by Reesink, Heidi L, Sutton, Ryan M, Shurer, Carolyn R, Peterson, Ryan P, Tan, Julie S, Su, Jin, Paszek, Matthew J, Nixon, Alan J

“…Mesenchymal stromal cells (MSCs) can be used intra-articularly to quell inflammation and promote cartilage healing; however, mechanisms by which MSCs mitigate…”
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Temporal expression of growth factors and matrix molecules in healing tendon lesions by Dahlgren, Linda A., Mohammed, Hussni O., Nixon, Alan J.

“…Overuse tendon injuries are common among elite and recreational athletes. Tendon healing may be enhanced at the cellular level through the use of exogenous…”
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Arthroscopic removal of discrete palmar carpal osteochondral fragments in horses: 25 cases (1999-2013) by Lang, Hayley M, Nixon, Alan J

“…To characterize discrete palmar carpal osteochondral fragmentation in horses and to document the effect of osteoarthritis and surgical removal of these…”
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Return to racing after surgical management of third carpal bone slab fractures in thoroughbred and standardbred racehorses by Doering, Alyssa K., Reesink, Heidi L., Luedke, Lauren K., Moore, Christina, Nixon, Alan J., Fortier, Lisa A., Ducharme, Norm G., Ross, Michael W., Levine, David G., Richardson, Dean W., Stefanovski, Darko, Ortved, Kyla F.

“…Objective To determine the prognosis for racing of horses surgically treated for slab fractures of the third carpal bone (C3). Study design Retrospective case…”
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Autologous chondrocyte implantation drives early chondrogenesis and organized repair in extensive full- and partial-thickness cartilage defects in an equine model by Nixon, Alan J., Begum, Laila, Mohammed, Hussni O., Huibregtse, Barbara, O'Callaghan, Michael M., Matthews, Gloria L.

“…Autologous chondrocyte implantation (ACI) has been used clinically for over 15 years and yet definitive evidence of chondrocyte persistence and direct impact…”
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Gene Therapy in Musculoskeletal Repair by NIXON, ALAN J., GOODRICH, LAURIE R., SCIMECA, MICHAEL S., WITTE, THOMAS H., SCHNABEL, LAUREN V., WATTS, ASHLEE E., ROBBINS, PAUL D.

“…:  Local and regional gene therapy has improved healing in preclinical trials of articular and other muculoskeletal conditions. Combinations of cell…”
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Biochemical and Biomechanical Properties of Lesion and Adjacent Articular Cartilage After Chondral Defect Repair in an Equine Model by Strauss, Eric J., Goodrich, Laurie R., Chen, Chih-Tung, Hidaka, Chisa, Nixon, Alan J.

“…Background: Chondral defects may lead to degradative changes in the surrounding cartilage, predisposing patients to developing osteoarthritis. Purpose: To…”
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Chondrocytic differentiation of mesenchymal stem cells sequentially exposed to transforming growth factor-β1 in monolayer and insulin-like growth factor-I in a three-dimensional matrix by Worster, Allison A, Brower-Toland, Brent D, Fortier, Lisa A, Bent, Stephen J, Williams, Janice, Nixon, Alan J

“…This study evaluated chondrogenesis of mesenchymal progenitor stem cells (MSCs) cultured initially under pre-confluent monolayer conditions exposed to…”
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Galectins-1 and-3 Increase in Equine Post-traumatic Osteoarthritis by Reesink, Heidi L, Nixon, Alan J, Su, Jin, Liu, Sherry, Sutton, Ryan M, Mann, Sabine, Watts, Ashlee E, Peterson, Ryan P

“…Galectins are potent regulators of cell adhesion, growth and apoptosis in diverse cell types, including chondrocytes and synovial fibroblasts. Elevations in…”
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Insulin-like growth factor-I improves cellular and molecular aspects of healing in a collagenase-induced model of flexor tendinitis by Dahlgren, Linda A, van der Meulen, Marjolein C.H, Bertram, John E.A, Starrak, Greg S, Nixon, Alan J

“…Flexor tendinitis is a common and debilitating injury of elite and recreational athletes. Healing may be improved through intratendinous injection of…”
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Enhanced repair of extensive articular defects by insulin-like growth factor-I-laden fibrin composites by Nixon, A J, Fortier, L A, Williams, J, Mohammed, H

“…Stem cells indigenous to the cancellous spaces of the bone bed in an acute injury provide an important source of pluripotent cells for cartilage repair…”
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RNA Interference Mediated Interleukin-1β Silencing in Inflamed Chondrocytes Decreases Target and Downstream Catabolic Responses by Ortved, Kyla F., Austin, Bethany S., Scimeca, Michael S., Nixon, Alan J.

“…Posttraumatic activation of the catabolic cascade plays a major role in degradation of cartilage. Interleukin-1β (IL-1β), a primary instigator in the catabolic…”
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Expression of insulin-like growth factor binding proteins in healing tendon lesions by Dahlgren, Linda A., Mohammed, Hussni O., Nixon, Alan J.

“…The treatment of overuse tendon injuries with exogenous growth factors such as insulin‐like growth factor‐I (IGF‐I) may facilitate an improved return to…”
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Implantation of rAAV5-IGF-I Transduced Autologous Chondrocytes Improves Cartilage Repair in Full-thickness Defects in the Equine Model by Ortved, Kyla F, Begum, Laila, Mohammed, Hussni O, Nixon, Alan J

“…Cartilage injury often precipitates osteoarthritis which has driven research to bolster repair in cartilage impact damage. Autologous chondrocytes transduced…”
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Concentrated Bone Marrow Aspirate Improves Full-Thickness Cartilage Repair Compared with Microfracture in the Equine Model by Fortier, Lisa A., Potter, Hollis G., Rickey, Ellen J., Schnabel, Lauren V., Foo, Li Foong, Chong, Leroy R., Stokol, Tracy, Cheetham, Jon, Nixon, Alan J.

“…The purpose of this study was to compare the outcomes of treatment with bone marrow aspirate concentrate, a simple, one-step, autogenous, and arthroscopically…”
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