Search Results - "NISSLEY, S. P"

The nature and regulation of the receptors for insulin-like growth factors by RECHLER, M. M, NISSLEY, S. P

“…Two subtypes of IGF receptors have been identified. Type I IGF receptors have a Mr greater than 300,000 and are composed of disulfide-linked 130,000-dalton…”
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Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10 by Dey, B R, Frick, K, Lopaczynski, W, Nissley, S P, Furlanetto, R W

“…We have used the yeast two-hybrid system to study the interaction between the IGF-I receptor and two putative substrates, IRS-1 and Shc. In addition, we have…”
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An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts by Kiess, W, Haskell, J F, Lee, L, Greenstein, L A, Miller, B E, Aarons, A L, Rechler, M M, Nissley, S P

“…To better define the biologic function of the type II insulin-like growth factor (IGF) receptor, we raised a blocking antiserum in a rabbit by immunizing with…”
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Developmental regulation of insulin-like growth factor II mRNA in different rat tissues by Brown, A L, Graham, D E, Nissley, S P, Hill, D J, Strain, A J, Rechler, M M

“…Insulin-like growth factor II (IGF-II) is present at high levels in fetal and early neonatal rat plasma, and decreases profoundly following birth. In the…”
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Biochemical evidence that the type II insulin-like growth factor receptor is identical to the cation-independent mannose 6-phosphate receptor by Kiess, W, Blickenstaff, G D, Sklar, M M, Thomas, C L, Nissley, S P, Sahagian, G G

“…Cloning and sequencing of the human type II insulin-like growth factor (IGF) receptor cDNA revealed an 80% deduced amino acid sequence homology with the bovine…”
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Developmental expression of the tissue insulin-like growth factor II/mannose 6-phosphate receptor in the rat. Measurement by quantitative immunoblotting by SKLAR, M. M, KIESS, W, THOMAS, C. L, NISSLEY, S. P

“…We used quantitative immunoblotting to measure the total tissue insulin-like growth factor II/mannose 6-phosphate (IGF-II/Man-6-P) receptor in the rat. Whole…”
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Insulin-like growth factor-II (IGF-II) inhibits both the cellular uptake of β-galactosidase and the binding of β-galactosidase to purified IGF-II/mannose 6-phosphate receptor by Kiess, W, Thomas, C L, Greenstein, L A, Lee, L, Sklar, M M, Rechler, M M, Sahagian, G G, Nissley, S P

“…The insulin-like growth factor-II/mannose 6-phosphate receptor which targets acid hydrolases to lysosomes, has two different binding sites, one for the mannose…”
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Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants by Luyten, F P, Hascall, V C, Nissley, S P, Morales, T I, Reddi, A H

“…The influences of insulin-like growth factor I (IGF-I) and insulin-like growth factor II (IGF-II) on biosynthesis and catabolism of proteoglycans (PG) in…”
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Type II Insulin-Like Growth Factor Receptor is Present in Rat Serum by Kiess, Wieland, Greenstein, Lawrence A., White, Robert M., Lee, Lilly, Rechler, Matthew M., Nissley, S. Peter

“…We previously identified in fetal rat serum a component capable of specifically binding radiolabeled insulin-like growth factor type II (IGF-II) that is…”
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Characterization of insulin-like growth factor I-stimulated tyrosine kinase activity associated with the beta-subunit of type I insulin-like growth factor receptors of rat liver cells by Sasaki, N, Rees-Jones, R W, Zick, Y, Nissley, S P, Rechler, M M

“…We previously reported that insulin-like growth factor I (IGF-I) stimulates the phosphorylation of a Mr 98,000 protein thought to be the beta-subunit of the…”
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Developmental patterns of insulin-like growth factor-I and -II synthesis and regulation in rat fibroblasts by Adams, S. O, Nissley, S. P, Handwerger, S, Rechler, M. M

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Increased Levels of Multiplication-Stimulating Activity, an Insulin-Like Growth Factor, in Fetal Rat Serum by Moses, Alan C., Nissley, S. Peter, Short, Patricia A., Rechler, Matthew M., White, Robert M., Knight, Alfred B., Higa, Olga Z.

“…Multiplication-stimulating activity (MSA), purified from medium conditioned by the BRL-3A rat liver cell line, previously has been shown to be closely related…”
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Modulation of insulinlike growth factor I binding to human fibroblast monolayer cultures by insulinlike. Growth factor carrier proteins released to the incubation media by DE VROEDE, M. A, TSENG, L. Y.-H, KATSOYANNIS, P. G, NISSLEY, S. P, RECHLER, M. M

“…The relative contributions of type I and type II insulinlike growth factor (IGF) receptors and IGF carrier proteins to the binding of IGF-I tracer to cultured…”
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Pertussis toxin sensitive G-proteins are not involved in the mitogenic signaling pathway of insulin-like growth factor-I in normal rat kidney epithelial (NRKE) cells by Siebler, T., Kiess, W., Linder, B., Kessler, U., Schwarz, H.P., Nissley, S.P.

“…There is controversy as to whether or not a pertussis toxin sensitive G-protein is involved in the signaling pathway of insulin-like growth factor-I. We have…”
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Structure, specificity, and regulation of the insulin-like growth factor-binding proteins in adult rat serum by Yang, Y W, Wang, J F, Orlowski, C C, Nissley, S P, Rechler, M M

“…Insulin-like growth factor-I (IGF-I), the principal IGF in adult rat serum, occurs complexed to specific binding proteins. After fractionation of serum on…”
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Rat C6 glial cells synthesize insulin-like growth factor I (IGF-I) and express IGF-I receptors and IGF-II/mannose 6-phosphate receptors by Kiess, W, Lee, L, Graham, D E, Greenstein, L, Tseng, L Y, Rechler, M M, Nissley, S P

“…We have used the rat C6 glial cell line as a model system to study the role of insulin-like growth factors (IGF) in neuroglial cells of the central nervous…”
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Purification of an insulin-like growth factor II receptor from rat chondrosarcoma cells by August, G P, Nissley, S P, Kasuga, M, Lee, L, Greenstein, L, Rechler, M M

“…An insulin-like growth factor II (IGF-II) receptor was purified from rat chondrosarcoma cells by Triton X-100 solubilization of a 100,000 X g membrane…”
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Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor by King, G L, Kahn, C R, Rechler, M M, Nissley, S P

“…Insulin and such insulinlike growth factors as multiplication stimulating activity (MSA) are related polypeptides that have common biological activities. Both…”
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Coordinate Developmental Regulation of High and Low Molecular Weight mRNAs for Rat Insulin-Like Growth Factor II by Graham, Dale E., Rechler, Matthew M., Brown, Alexandra L., Frunzio, Rodolfo, Romanus, Joyce A., Bruni, C. Bruno, Whitfield, Harvey J., Nissley, S. Peter, Seelig, Steven, Berry, Susan

“…Insulin-like growth factor II (IGF-II) is a mitogenic polypeptide that is thought to play a role in fetal growth and development. To study the hormonal and…”
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The chick embryo fibroblast cation-independent mannose 6-phosphate receptor is functional and immunologically related to the mammalian insulin-like growth factor-II (IGF-II)/man 6-P receptor but does not bind IGF-II by Yang, Y W, Robbins, A R, Nissley, S P, Rechler, M M

“…The insulin-like growth factor-II (IGF-II)/Mannose 6-P receptor (Man 6-P) is a multifunctional receptor that binds two unrelated ligands, IGF-II and lysosomal…”
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