Search Results - "NISHIMURA, Tomohiro"

L-type Amino Acid Transporter 1 (SLC7A5)-Mediated Transport of Pregabalin at the Rat Blood-Spinal Cord Barrier and its Sensitivity to Plasma Branched-Chain Amino Acids by Akashi, Tomoya, Noguchi, Saki, Takahashi, Yu, Nishimura, Tomohiro, Tomi, Masatoshi

“…Pregabalin is an anti-neuropathic pain drug inhibiting the α2δ subunit of the voltage-dependent calcium channel in the spinal cord. The aim of this study is to…”
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Development of a Pharmacokinetic Model of Transplacental Transfer of Metformin to Predict In Vivo Fetal Exposure by Kurosawa, Ken, Chiba, Koji, Noguchi, Saki, Nishimura, Tomohiro, Tomi, Masatoshi

“…Two types of systems are used in ex vivo human placental perfusion studies to predict fetal drug exposures, that is, closed systems with recirculation of the…”
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Dendrite fragmentation induced by massive-like δ–γ transformation in Fe–C alloys by Yasuda, Hideyuki, Morishita, Kohei, Nakatsuka, Noriaki, Nishimura, Tomohiro, Yoshiya, Masato, Sugiyama, Akira, Uesugi, Kentaro, Takeuchi, Akihisa

“…Dendrite arm fragmentation is considered in solidification structure tailoring. Time-resolved and in situ imaging using synchrotron radiation X-rays allows the…”
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Transplacental Pharmacokinetic Model of Digoxin Based on Ex Vivo Human Placental Perfusion Study by Kurosawa, Ken, Noguchi, Saki, Nishimura, Tomohiro, Tomi, Masatoshi, Chiba, Koji

“…Digoxin is used as first-line therapy to treat fetal supraventricular tachycardia; however, because of the narrow therapeutic window, it is essential to…”
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Assessment of individual radionuclide distributions from the Fukushima nuclear accident covering central-east Japan by Kinoshita, Norikazu, Sueki, Keisuke, Sasa, Kimikazu, Kitagawa, Jun-ichi, Ikarashi, Satoshi, Nishimura, Tomohiro, Wong, Ying-Shee, Satou, Yukihiko, Handa, Koji, Takahashi, Tsutomu, Sato, Masanori, Yamagata, Takeyasu

“…A tremendous amount of radioactivity was discharged because of the damage to cooling systems of nuclear reactors in the Fukushima No. 1 nuclear power plant in…”
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Time-resolved and In-situ Observation of Solidification in TiAl Alloys by Nishimura, Tomohiro, Ishida, Hitoshi, Yasuda, Hideyuki

“…Time-resolved and in-situ observation of solidification by X-ray imaging is a powerful method to empirically understand the solidification process of metallic…”
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Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line by Takahashi, Yu, Nishimura, Tomohiro, Higuchi, Kei, Noguchi, Saki, Tega, Yuma, Kurosawa, Toshiki, Deguchi, Yoshiharu, Tomi, Masatoshi

“…Purpose The anti-epileptic drug pregabalin crosses the blood-brain barrier (BBB) in spite of its low lipophilicity. This study was performed to determine…”
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LAT1-Targeting Thermoresponsive Fluorescent Polymer Probes for Cancer Cell Imaging by Matsuura, Minami, Ohshima, Mariko, Hiruta, Yuki, Nishimura, Tomohiro, Nagase, Kenichi, Kanazawa, Hideko

“…L-type amino acid transporter 1 (LAT1) is more highly expressed in cancer cells compared with normal cells. LAT1 targeting probes would therefore be a…”
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Toxicity screening of 13 Gambierdiscus strains using neuro-2a and erythrocyte lysis bioassays by Pisapia, Francesco, Holland, William C., Hardison, D. Ransom, Litaker, R. Wayne, Fraga, Santiago, Nishimura, Tomohiro, Adachi, Masao, Nguyen-Ngoc, Lam, Séchet, Véronique, Amzil, Zouher, Herrenknecht, Christine, Hess, Philipp

“…•13 strains of Gambierdiscus have been screened for CTX- and MTX-toxicity.•G. excentricus is the most toxic species found so far in the Atlantic.•Highest…”
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The double edge to parasite escape: invasive host is less infected but more infectable by Keogh, Carolyn L., Miura, Osamu, Nishimura, Tomohiro, Byers, James E.

“…Nonnative species that escape their native-range parasites may benefit not only from reduced infection pathology, but also from relaxed selection on costly…”
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Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers by Fujita, Arimi, Noguchi, Saki, Hamada, Rika, Inoue, Satoko, Shimada, Tsutomu, Katakura, Satomi, Maruyama, Tetsuo, Sai, Yoshimichi, Nishimura, Tomohiro, Tomi, Masatoshi

“…Purpose Multidrug resistance protein 1 (MDR1) is located at the interface between two syncytiotrophoblast layers in rodent placenta, and may influence fetal…”
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Morphology of Gambierdiscus scabrosus sp. nov. (Gonyaulacales): a new epiphytic toxic dinoflagellate from coastal areas of Japan by Nishimura, Tomohiro, Sato, Shinya, Tawong, Wittaya, Sakanari, Hiroshi, Yamaguchi, Haruo, Adachi, Masao, Vaulot, D

“…A new epiphytic dinoflagellate is described, G ambierdiscus scabrosus sp. nov., from tidal pools and rocky shores along the coastal areas of Japan. Cells are…”
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A New Hadrosaurine (Dinosauria: Hadrosauridae) from the Marine Deposits of the Late Cretaceous Hakobuchi Formation, Yezo Group, Japan by Kobayashi, Yoshitsugu, Nishimura, Tomohiro, Takasaki, Ryuji, Chiba, Kentaro, Fiorillo, Anthony R., Tanaka, Kohei, Chinzorig, Tsogtbaatar, Sato, Tamaki, Sakurai, Kazuhiko

“…A nearly complete skeleton of a new hadrosaurid, Kamuysaurus japonicus gen. et sp. nov., was discovered from the outer shelf deposits of the Upper Cretaceous…”
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Associations between locomotive and non-locomotive physical activity and physical performance in older community-dwelling females with and without locomotive syndrome: a cross-sectional study by Nishimura, Tomohiro, Hagio, Atsushi, Hamaguchi, Kanako, Kurihara, Toshiyuki, Iemitsu, Motoyuki, Sanada, Kiyoshi

“…Locomotive syndrome (LS) is a condition of reduced mobility due to a disorder of the locomotive system. Increasing moderate to vigorous physical activity…”
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Genetic diversity and distribution of the ciguatera-causing dinoflagellate Gambierdiscus spp. (Dinophyceae) in coastal areas of Japan by Nishimura, Tomohiro, Sato, Shinya, Tawong, Wittaya, Sakanari, Hiroshi, Uehara, Keita, Shah, Md Mahfuzur Rahman, Suda, Shoichiro, Yasumoto, Takeshi, Taira, Yohsuke, Yamaguchi, Haruo, Adachi, Masao

“…The marine epiphytic dinoflagellate genus Gambierdiscus produce toxins that cause ciguatera fish poisoning (CFP): one of the most significant seafood-borne…”
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Abundance of the benthic dinoflagellate Prorocentrum and the diversity, distribution, and diarrhetic shellfish toxin production of Prorocentrum lima complex and P. caipirignum in Japan by Nishimura, Tomohiro, Uchida, Hajime, Noguchi, Ryoko, Oikawa, Hiroshi, Suzuki, Toshiyuki, Funaki, Hiroshi, Ihara, Chiho, Hagino, Kyoko, Arimitsu, Shingo, Tanii, Yuta, Abe, Shota, Hashimoto, Kana, Mimura, Katsuya, Tanaka, Kouki, Yanagida, Ippei, Adachi, Masao

“…•Prorocentrum cell density in subtropical was higher than that in temperate Japan.•Japanese P. lima complex was separated into two clades.•The two clades and…”
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Effect of an Introduced Phytoene Synthase Gene Expression on Carotenoid Biosynthesis in the Marine Diatom Phaeodactylum tricornutum by Kadono, Takashi, Kira, Nozomu, Suzuki, Kengo, Iwata, Osamu, Ohama, Takeshi, Okada, Shigeru, Nishimura, Tomohiro, Akakabe, Mai, Tsuda, Masashi, Adachi, Masao

“…Carotenoids exert beneficial effects on human health through their excellent antioxidant activity. To increase carotenoid productivity in the marine Pennales…”
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Time-resolved and In-situ Observation of δ–γ Transformation during Unidirectional Solidification in Fe–C Alloys by Nishimura, Tomohiro, Morishita, Kohei, Yoshiya, Masato, Nagira, Tomoya, Yasuda, Hideyuki

“…Time-resolved and in-situ observations using synchrotron radiation X-rays successfully proved that a massive-like transformation, in which the γ phase was…”
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Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6 by Nishimura, Tomohiro, Higuchi, Kei, Yoshida, Yuko, Sugita-Fujisawa, Yuki, Kojima, Kazuaki, Sugimoto, Maiko, Santo, Marie, Tomi, Masatoshi, Nakashima, Emi

“…Hypotaurine is a precursor of taurine and a physiological antioxidant that circulates in adult and fetal plasma. The purpose of the present study was to…”
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Erratum to “Selection of the Massive-like δ-γ Transformation due to Nucleation of Metastable δ Phase in Fe-18 Mass%Cr-Ni Alloys with Ni Contents of 8, 11, 14 and 20 Mass%” [ISIJ International, Vol. 59 (2019), No. 3, pp. 459-465] by Nishimura, Tomohiro, Matsubayashi, Ryota, Morishita, Kohei, Yoshiya, Masato, Nagira, Tomoya, Yasuda, Hideyuki

“…Temperatures indicated in panels of Fig. 5 were calculated using an incorrect cooling rate. Temperatures in Figs. 7 and 8 were correctly calculated. While the…”
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