Search Results - "NISHIMURA, Susumu"

Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine by Okada, Norihiro, Oshima, Kenshiro, Iwasaki, Yuki, Maruko, Akiko, Matsumura, Kenya, Iioka, Erica, Vu, Trieu-Duc, Fujitsuka, Naoki, Nishi, Akinori, Sugiyama, Aiko, Nishiyama, Mitsue, Kaneko, Atsushi, Mizoguchi, Kazushige, Yamamoto, Masahiro, Nishimura, Susumu

“…[Display omitted] •Intron retention (IR) is a new pre-symptomatic marker of aging.•The pre-symptomatic state in the liver in terms of gene expression was…”
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Queuosine Formation in Eukaryotic tRNA Occurs via a Mitochondria-localized Heteromeric Transglycosylase by Boland, Coilin, Hayes, Patti, Santa-Maria, Ismael, Nishimura, Susumu, Kelly, Vincent P.

“…tRNA guanine transglycosylase (TGT) enzymes are responsible for the formation of queuosine in the anticodon loop (position 34) of tRNAAsp, tRNAAsn, tRNAHis,…”
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Deletion of the Selenocysteine tRNA Gene in Macrophages and Liver Results in Compensatory Gene Induction of Cytoprotective Enzymes by Nrf2 by Suzuki, Takafumi, Kelly, Vincent P., Motohashi, Hozumi, Nakajima, Osamu, Takahashi, Satoru, Nishimura, Susumu, Yamamoto, Masayuki

“…The selenocysteine tRNA (tRNASec) molecule is the sight of synthesis for the amino acid selenocysteine and the adaptor for its translational insertion into…”
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Alternative Tertiary Structure of tRNA for Recognition by a Posttranscriptional Modification Enzyme by Ishitani, Ryuichiro, Nureki, Osamu, Nameki, Nobukazu, Okada, Norihiro, Nishimura, Susumu, Yokoyama, Shigeyuki

“…Transfer RNA (tRNA) canonically has the clover-leaf secondary structure with the acceptor, D, anticodon, and T arms, which are folded into the L-shaped…”
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Data of RNA-seq transcriptomes of liver, bone, heart, kidney and blood in klotho mice at a pre-symptomatic state and the effect of a traditional Japanese multi-herbal medicine, juzentaihoto by Okada, Norihiro, Oshima, Kenshiro, Iwasaki, Yuki, Maruko, Akiko, Matsumura, Kenya, Iioka, Erica, Vu, Trieu-Duc, Fujitsuka, Naoki, Nishi, Akinori, Sugiyama, Aiko, Nishiyama, Mitsue, Kaneko, Atsushi, Mizoguchi, Kazushige, Yamamoto, Masahiro, Nishimura, Susumu

“…We performed RNA-seq analyses of mRNA isolated from five organs, liver, bone, heart, kidney and blood at the pre-symptomatic state of klotho mice with/without…”
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Sphingosine, a Modulator of Human Translesion DNA Polymerase Activity by Kamath-Loeb, Ashwini S., Balakrishna, Sharath, Whittington, Dale, Shen, Jiang-Cheng, Emond, Mary J., Okabe, Takayoshi, Masutani, Chikahide, Hanaoka, Fumio, Nishimura, Susumu, Loeb, Lawrence A.

“…Translesion (TLS) DNA polymerases are specialized, error-prone enzymes that synthesize DNA across bulky, replication-stalling DNA adducts. In so doing, they…”
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8-Hydroxyguanine: From its discovery in 1983 to the present status by NISHIMURA, Susumu

“…8-Hydroxyguanine (8-OH-G) was discovered in 1983 in our laboratory at the National Cancer Center Research Institute, Tokyo. Since it could be formed in DNA not…”
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Mmh/Ogg1 Gene Inactivation Results in Accumulation of 8-Hydroxyguanine in Mice by Minowa, Osamu, Arai, Tsuyoshi, Hirano, Masanori, Monden, Yoshiaki, Nakai, Shigeyasu, Fukuda, Mayuko, Itoh, Masaki, Takano, Hiroshi, Hippou, Yoshitaka, Aburatani, Hiroyuki, Masumura, Ken-ichi, Nohmi, Takehiko, Nishimura, Susumu, Noda, Tetsuo

“…The major mutagenic base lesion in DNA caused by exposure to reactive oxygen species is 8-hydroxyguanine or 7,8-dihydro-8-oxoguanine (8-OH-G). Products of the…”
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Carcinogenicity of dimethylarsinic acid in Ogg1‐deficient mice by Kinoshita, Anna, Wanibuchi, Hideki, Morimura, Keiichirou, Wei, Min, Nakae, Dai, Arai, Tsuyoshi, Minowa, Osamu, Noda, Tetsuo, Nishimura, Susumu, Fukushima, Shoji

“…Oxidative stress to DNA is recognized as a mechanism underlying carcinogenic effects of some environmental agents. Here, we hypothesized that dimethylarsinic…”
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Structural Snapshots of the KMSKS Loop Rearrangement for Amino Acid Activation by Bacterial Tyrosyl-tRNA Synthetase by Kobayashi, Takatsugu, Takimura, Tetsuo, Sekine, Ryo, Vincent, Kelly, Kamata, Kenji, Sakamoto, Kensaku, Nishimura, Susumu, Yokoyama, Shigeyuki

“…Tyrosyl-tRNA synthetase (TyrRS) has been studied extensively by mutational and structural analyses to elucidate its catalytic mechanism. TyrRS has the HIGH and…”
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Defining logical obstruction with fixpoints in epistemic logic by Nishimura, Susumu

“…The logical method proposed by Goubault, Ledent, and Rajsbaum provides a means of demonstrating the unsolvability of distributed tasks within the epistemic…”
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Role of the Y1 Receptor in the Regulation of Neuropeptide Y-Mediated Feeding: Comparison of Wild-Type, Y1 Receptor-Deficient, and Y5 Receptor-Deficient Mice by Kanatani, Akio, Mashiko, Satoshi, Murai, Naomi, Sugimoto, Nami, Ito, Junko, Fukuroda, Takahiro, Fukami, Takehiro, Morin, Nancy, MacNeil, Douglas J, Van der Ploeg, Lex H. T, Saga, Yumiko, Nishimura, Susumu, Ihara, Masaki

“…Neuropeptide Y (NPY) increases food intake through the action of hypothalamic NPY receptors. At least six subtypes of NPY, peptide YY (PYY), and pancreatic…”
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Studies on crenarchaeal tyrosylation accuracy with mutational analyses of tyrosyl-tRNA synthetase and tyrosine tRNA from Aeropyrum pernix by Iwaki, Jun, Endo, Kanako, Ichikawa, Takayuki, Suzuki, Ryuichiro, Fujimoto, Zui, Momma, Mitsuru, Kuno, Atsushi, Nishimura, Susumu, Hasegawa, Tsunemi

“…Aminoacyl-tRNA synthetases play a key role in the translation of genetic code into correct protein sequences. These enzymes recognize cognate amino acids and…”
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Early Embryonic Lethality Caused by Targeted Disruption of the Mouse Selenocysteine tRNA Gene (Trsp) by Bösl, Michael R., Takaku, Kazuaki, Oshima, Masanobu, Nishimura, Susumu, Taketo, Makoto M.

“…Selenoprotein biosynthesis is mediated by tRNASec, which inserts selenocysteine at UGA codons in a complex, context-specific manner. This opal suppressor…”
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Crystallographic Approach to Identification of Cyclin-dependent Kinase 4 (CDK4)-specific Inhibitors by Using CDK4 Mimic CDK2 Protein by Ikuta, Mari, Kamata, Kenji, Fukasawa, Kazuhiro, Honma, Teruki, Machida, Takumitsu, Hirai, Hiroshi, Suzuki-Takahashi, Ikuko, Hayama, Takashi, Nishimura, Susumu

“…Genetic alteration of one or more components of the p16INK4A-CDK4,6/cyclin D-retinoblastoma pathway is found in more than half of all human cancers. Therefore,…”
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Takashi Sugimura: In Memoriam (1926–2020)–A Personal Perspective by Nishimura, Susumu, Nakagama, Hitoshi

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Annealing kinetics of fission tracks in zircon: an experimental study by Yamada, Ryuji, Tagami, Takahiro, Nishimura, Susumu, Ito, Hisatoshi

“…A series of laboratory annealing experiments on zircon fission tracks has been carried out under heating conditions of 350–750°C for 10 −1–10 3 hr (i.e. 4.5…”
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The discovery of modified nucleosides from the early days to the present: a personal perspective by Nishimura, Susumu, Watanabe, Kimitsuna

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Distinct Repair Activities of Human 7,8-Dihydro-8-oxoguanine DNA Glycosylase and Formamidopyrimidine DNA Glycosylase for Formamidopyrimidine and 7,8-Dihydro-8-oxoguanine by Asagoshi, Kenjiro, Yamada, Takao, Terato, Hiroaki, Ohyama, Yoshihiko, Monden, Yoshiaki, Arai, Tsuyoshi, Nishimura, Susumu, Aburatani, Hiroyuki, Lindahl, Tomas, Ide, Hiroshi

“…7,8-Dihydro-8-oxoguanine (8-oxoG) and 2,6-diamino-4-hydroxyformamidopyrimidine (Fapy) are major DNA lesions formed by reactive oxygen species and are involved…”
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Structural Basis of Nonnatural Amino Acid Recognition by an Engineered Aminoacyl-tRNA Synthetase for Genetic Code Expansion by Kobayashi, Takatsugu, Sakamoto, Kensaku, Takimura, Tetsuo, Sekine, Ryo, Vincent, Kelly, Kamata, Kenji, Nishimura, Susumu, Yokoyama, Shigeyuki, Schimmel, Paul R.

“…The genetic code in a eukaryotic system has been expanded by the engineering of Escherichia coli tyrosyl-tRNA synthetase (TyrRS) with the Y37V and Q195C…”
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