Search Results - "NISHIMURA, Merry"

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma by Chen, Ruihuan, Nishimura, Merry C., Bumbaca, Stephanie M., Kharbanda, Samir, Forrest, William F., Kasman, Ian M., Greve, Joan M., Soriano, Robert H., Gilmour, Laurie L., Rivers, Celina Sanchez, Modrusan, Zora, Nacu, Serban, Guerrero, Steve, Edgar, Kyle A., Wallin, Jeffrey J., Lamszus, Katrin, Westphal, Manfred, Heim, Susanne, James, C. David, VandenBerg, Scott R., Costello, Joseph F., Moorefield, Scott, Cowdrey, Cynthia J., Prados, Michael, Phillips, Heidi S.

“…The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however,…”
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Trastuzumab uptake and its relation to efficacy in an animal model of HER2-positive breast cancer brain metastasis by Lewis Phillips, Gail D., Nishimura, Merry C., Lacap, Jennifer Arca, Kharbanda, Samir, Mai, Elaine, Tien, Janet, Malesky, Kimberly, Williams, Simon P., Marik, Jan, Phillips, Heidi S.

“…Purpose The extent to which efficacy of the HER2 antibody Trastuzumab in brain metastases is limited by access of antibody to brain lesions remains a question…”
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Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent by Merchant, Mark, Ma, Xiaolei, Maun, Henry R, Zheng, Zhong, Peng, Jing, Romero, Mally, Huang, Arthur, Yang, Nai-ying, Nishimura, Merry, Greve, Joan, Santell, Lydia, Zhang, Yu-Wen, Su, Yanli, Kaufman, Dafna W, Billeci, Karen L, Mai, Elaine, Moffat, Barbara, Lim, Amy, Duenas, Eileen T, Phillips, Heidi S, Xiang, Hong, Young, Judy C, Vande Woude, George F, Dennis, Mark S, Reilly, Dorothea E, Schwall, Ralph H, Starovasnik, Melissa A, Lazarus, Robert A, Yansura, Daniel G

“…Binding of hepatocyte growth factor (HGF) to the receptor tyrosine kinase MET is implicated in the malignant process of multiple cancers, making disruption of…”
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3D micro-CT imaging of the postmortem brain by de Crespigny, Alex, Bou-Reslan, Hani, Nishimura, Merry C., Phillips, Heidi, Carano, Richard A.D., D’Arceuil, Helen E.

“…Magnetic resonance microscopy (μMRI) is becoming an important tool for non-destructive analysis of fixed brain tissue. However, unlike MRI, X-ray computed…”
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Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma by Chen, Ruihuan, Nishimura, Merry C, Kharbanda, Samir, Peale, Frank, Deng, Yuzhong, Daemen, Anneleen, Forrest, William F, Kwong, Mandy, Hedehus, Maj, Hatzivassiliou, Georgia, Friedman, Lori S, Phillips, Heidi S

“…Somatic mutation of isocitrate dehydrogenase 1 (IDH1) is now recognized as the most common initiating event for secondary glioblastoma, a brain tumor type…”
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Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons by Horger, Brian A, Nishimura, Merry C, Armanini, Mark P, Wang, Li-Chong, Poulsen, Kris T, Rosenblad, Carl, Kirik, Deniz, Moffat, Barbara, Simmons, Laura, Johnson, Eugene, Jr, Milbrandt, Jeff, Rosenthal, Arnon, Bjorklund, Anders, Vandlen, Richard A, Hynes, Mary A, Phillips, Heidi S

“…Glial cell line-derived neurotrophic factor (GDNF) exhibits potent effects on survival and function of midbrain dopaminergic (DA) neurons in a variety of…”
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Disruption of a Single Allele of the Nerve Growth Factor Gene Results in Atrophy of Basal Forebrain Cholinergic Neurons and Memory Deficits by Chen, Karen S, Nishimura, Merry C, Armanini, Mark P, Crowley, Craig, Spencer, Susan D, Phillips, Heidi S

“…Administration of nerve growth factor (NGF) to aged or lesioned animals has been shown to reverse the atrophy of basal forebrain cholinergic neurons and…”
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PET of Glial Metabolism Using 2-18F-Fluoroacetate by Marik, Jan, Ogasawara, Annie, Martin-McNulty, Baby, Ross, Jed, Flores, Judith E, Gill, Herman S, Tinianow, Jeff N, Vanderbilt, Alexander N, Nishimura, Merry, Peale, Franklin, Pastuskovas, Cinthia, Greve, Joan M, van Bruggen, Nicholas, Williams, Simon P

“…Imaging of the glial activation that occurs in response to central nervous system trauma and inflammation could become a powerful technique for the assessment…”
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Synchronous Onset of NGF and TrkA Survival Dependence in Developing Dorsal Root Ganglia by White, Fletcher A, Silos-Santiago, Inmaculada, Molliver, Derek C, Nishimura, Merry, Phillips, Heidi, Barbacid, Mariano, Snider, William D

“…Determinations of dorsal root ganglion (DRG) neuron loss in nerve growth factor (NGF) and neurotrophin-3 (NT-3) null mutant mice have supported the concept…”
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Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons by Crowley, C, Spencer, S D, Nishimura, M C, Chen, K S, Pitts-Meek, S, Armanini, M P, Ling, L H, McMahon, S B, Shelton, D L, Levinson, A D

“…Homologous recombination was utilized to generate mice with a deletion in the coding sequence of the nerve growth factor (NGF) gene. Animals homozygous for NGF…”
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Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma by Salphati, Laurent, Alicke, Bruno, Heffron, Timothy P, Shahidi-Latham, Sheerin, Nishimura, Merry, Cao, Tim, Carano, Richard A, Cheong, Jonathan, Greve, Joan, Koeppen, Hartmut, Lau, Shari, Lee, Leslie B, Nannini-Pepe, Michelle, Pang, Jodie, Plise, Emile G, Quiason, Cristine, Rangell, Linda, Zhang, Xiaolin, Gould, Stephen E, Phillips, Heidi S, Olivero, Alan G

“…Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Limited treatment options have only marginally impacted patient survival over…”
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Distribution of the phosphatidylinositol 3-kinase inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models-assessment by matrix-assisted laser desorption ionization imaging by Salphati, Laurent, Shahidi-Latham, Sheerin, Quiason, Cristine, Barck, Kai, Nishimura, Merry, Alicke, Bruno, Pang, Jodie, Carano, Richard A, Olivero, Alan G, Phillips, Heidi S

“…Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, and the limited available treatment options have not meaningfully impacted…”
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NGF Receptor Expression in Sensory Neurons Develops Normally in Embryos Lacking NGF by Davies, Alun M., Wyatt, Sean, Nishimura, Merry, Phillips, Heidi

“…Numerous in vivo and in vitro studies have shown that NGF increases the expression of its receptors, p75 and TrkA, in NGF-responsive cell lines and in…”
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Targeting the PI3K Pathway in the Brain-Efficacy of a PI3K Inhibitor Optimized to Cross the Blood―Brain Barrier by SALPHATI, Laurent, HEFFRON, Timothy P, KOEPPEN, Hartmut, LAU, Shari, LEE, Leslie B, PANG, Jodie, PLISE, Emile G, POKORNY, Jenny L, BOU RESLAN, Hani, SARKARIA, Jann N, WALLIN, Jeffrey J, XIAOLIN ZHANG, ALICKE, Bruno, GOULD, Stephen E, OLIVERO, Alan G, PHILLIPS, Heidi S, NISHIMURA, Merry, BARCK, Kai, CARANO, Richard A, CHEONG, Jonathan, EDGAR, Kyle A, GREVE, Joan, KHARBANDA, Samir

“…Glioblastoma (GBM), the most common primary brain tumor in adults, presents a high frequency of alteration in the PI3K pathway. Our objectives were to identify…”
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Hominoid-specific enzyme GLUD2 promotes growth of IDH1 R132H glioma by Chen, Ruihuan, Nishimura, Merry C., Kharbanda, Samir, Peale, Frank, Deng, Yuzhong, Daemen, Anneleen, Forrest, William F., Kwong, Mandy, Hedehus, Maj, Hatzivassiliou, Georgia, Friedman, Lori S., Phillips, Heidi S.

“…Significance Mutation of isocitrate dehydrogenase 1 ( IDH1 ) is believed to be the initiating event for the majority of secondary glioblastomas and lower-grade…”
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Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132Hglioma by Chen, Ruihuan, Nishimura, Merry C., Kharbanda, Samir, Peale, Frank, Deng, Yuzhong, Daemen, Anneleen, Forrest, William F., Kwong, Mandy, Hedehus, Maj, Hatzivassiliou, Georgia, Friedman, Lori S., Phillips, Heidi S.

“…Somatic mutation of isocitrate dehydrogenase 1 (IDH1) is now recognized as the most common initiating event for secondary glioblastoma, a brain tumor type…”
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Hominoid-specific enzyme GLUD2 promotes growth of IDH1^sup R132H^ glioma by Chen, Ruihuan, Nishimura, Merry C, Kharbanda, Samir, Peale, Frank, Deng, Yuzhong, Daemen, Anneleen, rest, William F, Kwong, Mandy, Hedehus, Maj, Hatzivassiliou, Georgia, Friedman, Lori S, Phillips, Heidi S

“…Somatic mutation of isocitrate dehydrogenase 1 (IDH1) is now recognized as the most common initiating event for secondary glioblastoma, a brain tumor type…”
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Hominoid-specific enzyme GLUD2 promotes growth of IDH1 super( R132H) glioma by Chen, Ruihuan, Nishimura, Merry C, Kharbanda, Samir, Peale, Frank, Deng, Yuzhong, Daemen, Anneleen, rest, William F, Kwong, Mandy, Hedehus, Maj, Hatzivassiliou, Georgia, Friedman, Lori S, Phillips, Heidi S

“…Somatic mutation of isocitrate dehydrogenase 1 (IDH1) is now recognized as the most common initiating event for secondary glioblastoma, a brain tumor type…”
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Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent by Merchant, Mark, Ma, Xiaolei, Maun, Henry R., Zheng, Zhong, Peng, Jing, Romero, Mally, Huang, Arthur, Yang, Nai-ying, Nishimura, Merry, Greve, Joan, Santell, Lydia, Zhang, Yu-Wen, Su, Yanli, Kaufman, Dafna W., Billeci, Karen L., Mai, Elaine, Moffat, Barbara, Lim, Amy, Duenas, Eileen T., Phillips, Heidi S., Xiang, Hong, Young, Judy C., Woude, George F. Vande, Dennis, Mark S., Reilly, Dorothea E., Schwall, Ralph H., Starovasnik, Melissa A., Lazarus, Robert A., Yansura, Daniel G.

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Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin by Milbrandt, Jeffrey, de Sauvage, Frederic J, Fahrner, Timothy J, Baloh, Robert H, Leitner, Melanie L, Tansey, Malú G, Lampe, Patricia A, Heuckeroth, Robert O, Kotzbauer, Paul T, Simburger, Kelli S, Golden, Judith P, Davies, Jamie A, Vejsada, Richard, Kato, Ann C, Hynes, Mary, Sherman, Daniel, Nishimura, Merry, Wang, Li-Chong, Vandlen, Richard, Moffat, Barbara, Klein, Robert D, Poulsen, Kris, Gray, Christa, Garces, Alain, Henderson, Christopher E, Phillips, Heidi S, Johnson, Eugene M

“…A novel neurotrophic factor named Persephin that is ∼40% identical to glial cell line–derived neurotrophic factor (GDNF) and neurturin (NTN) has been…”
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