Search Results - "NINOMIYA, HARUAKI"

Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease　― Japanese Guideline on the Management of Asymptomatic Hyperuricemia by Hisatome, Ichiro, Li, Peili, Miake, Junichiro, Taufiq, Fikri, Mahati, Endang, Maharani, Nani, Utami, Sulistiyati Bayu, Kuwabara, Masanari, Bahrudin, Udin, Ninomiya, Haruaki

“…Serum uric acid (UA) is taken up by endothelial cells and reduces the level of nitric oxide (NO) by inhibiting its production and accelerating its degradation…”
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Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia by Sugihara, Shinobu, Hisatome, Ichiro, Kuwabara, Masanari, Niwa, Koichiro, Maharani, Nani, Kato, Masahiko, Ogino, Kazuhide, Hamada, Toshihiro, Ninomiya, Haruaki, Higashi, Yukihito, Ichida, Kimiyoshi, Yamamoto, Kazuhiro

“…Background:Uric acid (UA) serves as an antioxidant in vascular endothelial cells. UA transporter 1 (URAT1) encoded by SLC22A12 is expressed in the kidney and…”
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Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes by Taufiq, Fikri, Maharani, Nani, Li, Peili, Kurata, Yasutaka, Ikeda, Nobuhito, Kuwabara, Masanari, Otani, Naoyuki, Miake, Junichiro, Hasegawa, Akira, Tsuneto, Motokazu, Shirayoshi, Yasuaki, Ninomiya, Haruaki, Saitoh, Tatsuya, Nakai, Akira, Yamamoto, Kazuhiro, Hisatome, Ichiro

“…Background: Intracellular uric acid is known to increase the protein level and channel current of atrial Kv1.5; however, mechanisms of the uric acid-induced…”
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Characterization of Urate Metabolism and Complications of Patients with Renal Hypouricemia by Miyazaki, Satoshi, Hamada, Toshihiro, Isoyama, Tadahiro, Okada, Shinichi, Tomita, Katsuyuki, Endo, Yusuke, Kuwabara, Masanari, Sugihara, Shinobu, Ogino, Kazuhide, Ninomiya, Haruaki, Ichida, Kimiyoshi, Yamamoto, Kazuhiro, Takenaka, Atsushi, Hisatome, Ichiro

“…Objective Both renal hypouricemia (RHU) and gout are associated with renal dysfunction and urolithiasis. The difference in renal complications associated with…”
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Protective Effects of Topiroxostat on an Ischemia-Reperfusion Model of Rat Hearts by Tanno, Shogo, Yamamoto, Kenshiro, Kurata, Yasutaka, Adachi, Maya, Inoue, Yumiko, Otani, Naoyuki, Mishima, Mutsuo, Yamamoto, Yasutaka, Kuwabara, Masanari, Ogino, Kazuhide, Miake, Junichiro, Ninomiya, Haruaki, Shirayoshi, Yasuaki, Okada, Futoshi, Yamamoto, Kazuhiro, Hisatome, Ichiro

“…Background:Ischemia/reperfusion (I/R) injury triggers cardiac dysfunctions via creating reactive oxygen species (ROS). Because xanthine oxidase (XO) is one of…”
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Effects of Conditioned Medium of Adipose-Derived Stem Cells Exposed to Platelet-Rich Plasma on the Expression of Endothelial Nitric Oxide Synthase and Angiogenesis by Endothelial Cells by Morita, Maki, Suyama, Yoshiko, Notsu, Tomomi, Fukuoka, Kohei, Ikuta, Kento, Kanayama, Haruka, Umeda, Ryunosuke, Teraoka, Shogo, Minato, Hiroyuki, Ninomiya, Haruaki, Tsuneto, Motokazu, Shirayoshi, Yasuaki, Hisatome, Ichiro, Yagi, Shunjiro

“…Platelet-rich plasma (PRP) and adipose-derived stem cells (ADSCs) are known to secrete angiogenic factors that contribute to the treatment of intractable…”
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Xanthinuria Type 1 with a Novel Mutation in Xanthine Dehydrogenase and a Normal Endothelial Function by Miyazaki, Satoshi, Hamada, Toshihiro, Sugihara, Shinobu, Mizuta, Einosuke, Endo, Yusuke, Ohtahara, Akira, Komatsu, Koji, Kuwabara, Masanari, Fukuuchi, Tomoko, Kaneko, Kiyoko, Ichida, Kimiyoshi, Ogino, Kazuhide, Ninomiya, Haruaki, Yamamoto, Kazuhiro, Nakamura, Takashi, Hisatome, Ichiro

“…Whether or not extremely low levels of serum uric acid (SUA) in xanthinuria are associated with impairment of the endothelial function and exercise-induced…”
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Pretreatment with cilnidipine attenuates hypoxia/reoxygenation injury in HL-1 cardiomyocytes through enhanced NO production and action potential shortening by Minato, Hiroyuki, Hisatome, Ichiro, Kurata, Yasutaka, Notsu, Tomomi, Nakasone, Naoe, Ninomiya, Haruaki, Hamada, Toshihiro, Tomomori, Takuya, Okamura, Akihiro, Miake, Junichiro, Tsuneto, Motokazu, Shirayoshi, Yasuaki, Endo, Ryo, Otsuki, Akihiro, Okada, Futoshi, Inagaki, Yoshimi

“…Myocardial ischemia/reperfusion injury worsens in the absence of nitric oxide synthase (NOS). Cilnidipine, a Ca channel blocker, has been reported to activate…”
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Prediction for Risk of Hypouricemia in Hospitalized Patients: A Single-center, Retrospective Cohort Study by Hisatome, Ichiro, Tomita, Katsuyuki, Kato, Ryohei, Ikeuchi, Tomoyuki, Touge, Hirokazu, Hamada, Toshihiro, Goto, Tamotsu, Ninomiya, Haruaki, Otani, Naoyuki, Kuwabara, Masanari, Miyazaki, Satoshi, Yamasaki, Akira

“…Background Hypouricemia, defined as a serum uric acid (SUA) level ≤2 mg/dL, could be a risk factor for death in hospitalized patients. However, how explanatory…”
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CORRIGENDUM: β-Adrenergic Blocker, Carvedilol, Abolishes Ameliorating Actions of Adipose-Derived Stem Cell Sheets on Cardiac Dysfunction and Remodeling After Myocardial Infarction by Adachi, Maya, Watanabe, Mai, Kurata, Yasutaka, Inoue, Yumiko, Notsu, Tomomi, Yamamoto, Kenshiro, Horie, Hiromu, Tanno, Shogo, Morita, Maki, Miake, Junichiro, Hamada, Toshihiro, Kuwabara, Masanari, Nakasone, Naoe, Ninomiya, Haruaki, Tsuneto, Motokazu, Shirayoshi, Yasuaki, Yoshida, Akio, Nishimura, Motonobu, Yamamoto, Kazuhiro, Hisatome, Ichiro

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Impact of Hyper- and Hypo-Uricemia on Kidney Function by Miake, Junichiro, Hisatome, Ichiro, Tomita, Katsuyuki, Isoyama, Tadahiro, Sugihara, Shinobu, Kuwabara, Masanari, Ogino, Kazuhide, Ninomiya, Haruaki

“…Uric acid (UA) forms monosodium urate (MSU) crystals to exert proinflammatory actions, thus causing gout arthritis, urolithiasis, kidney disease, and…”
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Azelnidipine protects HL-1 cardiomyocytes from hypoxia/reoxygenation injury by enhancement of NO production independently of effects on gene expression by Minato, Hiroyuki, Endo, Ryo, Kurata, Yasutaka, Notsu, Tomomi, Kinugasa, Yoshiharu, Wakimizu, Takayuki, Tsuneto, Motokazu, Shirayoshi, Yasuaki, Ninomiya, Haruaki, Yamamoto, Kazuhiro, Hisatome, Ichiro, Otsuki, Akihiro

“…It remains to be elucidated whether Ca 2+ antagonists induce pharmacological preconditioning to protect the heart against ischemia/reperfusion injury. The aim…”
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Molecular Mechanisms Underlying Urate-Induced Enhancement of Kv1.5 Channel Expression in HL-1 Atrial Myocytes by Maharani, Nani, Ting, Ya Kuang, Cheng, Jidong, Hasegawa, Akira, Kurata, Yasutaka, Li, Peili, Nakayama, Yuji, Ninomiya, Haruaki, Ikeda, Nobuhito, Morikawa, Kumi, Yamamoto, Kazuhiro, Makita, Naomasa, Yamashita, Takeshi, Shirayoshi, Yasuaki, Hisatome, Ichiro

“…Background:Hyperuricemia induces endothelial dysfunction, oxidative stress and inflammation, increasing cardiovascular morbidities. It also raises the…”
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β-Adrenergic Blocker, Carvedilol, Abolishes Ameliorating Actions of Adipose-Derived Stem Cell Sheets on Cardiac Dysfunction and Remodeling After Myocardial Infarction by Adachi, Maya, Watanabe, Mai, Kurata, Yasutaka, Inoue, Yumiko, Notsu, Tomomi, Yamamoto, Kenshiro, Horie, Hiromu, Tanno, Shogo, Morita, Maki, Miake, Junichiro, Hamada, Toshihiro, Kuwabara, Masanari, Nakasone, Naoe, Ninomiya, Haruaki, Tsuneto, Motokazu, Shirayoshi, Yasuaki, Yoshida, Akio, Nishimura, Motonobu, Yamamoto, Kazuhiro, Hisatome, Ichiro

“…Background:Treatment of myocardial infarction (MI) includes inhibition of the sympathetic nervous system (SNS). Cell-based therapy using adipose-derived stem…”
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Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes by Li, Peili, Kurata, Yasutaka, Taufiq, Fikri, Kuwabara, Masanari, Ninomiya, Haruaki, Higaki, Katsumi, Tsuneto, Motokazu, Shirayoshi, Yasuaki, Lanaspa, Miguel A., Hisatome, Ichiro

“…Background Gout is usually found in patients with atrial fibrillation (AF). K+ efflux is a common trigger of NLRP3 inflammasome activation which is involved in…”
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Enhanced autophagy and mitochondrial aberrations in murine GM1-gangliosidosis by Takamura, Ayumi, Higaki, Katsumi, Kajimaki, Kenya, Otsuka, Susumu, Ninomiya, Haruaki, Matsuda, Junichiro, Ohno, Kousaku, Suzuki, Yoshiyuki, Nanba, Eiji

“…GM1-gangliosidosis is an autosomal recessive lysosomal lipid storage disorder, caused by mutations of the lysosomal β-galactosidase (β-gal) and results in the…”
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Esm1 and Stc1 as Angiogenic Factors Responsible for Protective Actions of Adipose-Derived Stem Cell Sheets on Chronic Heart Failure After Rat Myocardial Infarction by Watanabe, Mai, Horie, Hiromu, Kurata, Yasutaka, Inoue, Yumiko, Notsu, Tomomi, Wakimizu, Takayuki, Adachi, Maya, Yamamoto, Kenshiro, Morikawa, Kumi, Kuwabara, Masanari, Sakaguchi, Takuki, Morisaki, Takayuki, Miake, Junichiro, Nishimura, Motonobu, Tsuneto, Motokazu, Shirayoshi, Yasuaki, Ito, Shin, Kitakaze, Masafumi, Ninomiya, Haruaki, Yamamoto, Kazuhiro, Hisatome, Ichiro

“…Background:Although adipose-derived stem cell (ADSC) sheets improve the cardiac function after myocardial infarction (MI), underlying mechanisms remain to be…”
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A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM1 Gangliosidosis by Takai, Tomoko, Higaki, Katsumi, Aguilar-Moncayo, Matilde, Mena-Barragán, Teresa, Hirano, Yuki, Yura, Kei, Yu, Liang, Ninomiya, Haruaki, García-Moreno, M. Isabel, Sakakibara, Yasubumi, Ohno, Kousaku, Nanba, Eiji, Ortiz Mellet, Carmen, García Fernández, José M., Suzuki, Yoshiyuki

“…Lysosomal β-galactosidase (β-Gal) deficiency causes a group of disorders that include neuronopathic GM1 gangliosidosis and non-neuronopathic Morquio B disease…”
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Analysis of Lujo virus cell entry using pseudotype vesicular stomatitis virus by Tani, Hideki, Iha, Koichiro, Shimojima, Masayuki, Fukushi, Shuetsu, Taniguchi, Satoshi, Yoshikawa, Tomoki, Kawaoka, Yoshihiro, Nakasone, Naoe, Ninomiya, Haruaki, Saijo, Masayuki, Morikawa, Shigeru

“…Several arenaviruses are known to cause viral hemorrhagic fever (VHF) in sub-Saharan Africa and South America, where VHF is a major public health and medical…”
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α1-Adrenergic receptor mediates adipose-derived stem cell sheet-induced protection against chronic heart failure after myocardial infarction in rats by Horie, Hiromu, Hisatome, Ichiro, Kurata, Yasutaka, Yamamoto, Yasutaka, Notsu, Tomomi, Adachi, Maaya, Li, Peili, Kuwabara, Masanari, Sakaguchi, Takuki, Kinugasa, Yoshiharu, Miake, Junichiro, Koba, Satoshi, Tsuneto, Motokazu, Shirayoshi, Yasuaki, Ninomiya, Haruaki, Ito, Shin, Kitakaze, Masafumi, Yamamoto, Kazuhiro, Yoshikawa, Yasushi, Nishimura, Motonobu

“…Cell-based therapy using adipose-derived stem cells (ADSCs) has emerged as a novel therapeutic approach to treat heart failure after myocardial infarction…”
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