Search Results - "NIMMERJAHN, Falk"

Keeping T-he Killers at Bay via FcγRIIb by Nimmerjahn, Falk

“…Understanding how cytotoxic T cells are regulated is key for enhancing or suppressing their activity in tumor or transplantation settings. A study by Morris…”
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Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity? by Seeling, Michaela, Brückner, Christin, Nimmerjahn, Falk

“…Key Points Serum and/or autoantibody glycosylation is altered in many autoantibody-dependent and autoantibody-independent autoimmune diseases IgG glycosylation…”
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Anti-inflammatory actions of intravenous immunoglobulin by Nimmerjahn, Falk, Ravetch, Jeffrey V

“…The remarkable success story of the therapeutic application of pooled immunoglobulin G (IgG) preparations from thousands of donors, the so-called intravenous…”
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Antibody-mediated modulation of immune responses by Nimmerjahn, Falk, Ravetch, Jeffrey V

“…Activation of the humoral immune system by microbial infections or self-antigens results in the initiation of strong pro-inflammatory reactions. Antibodies of…”
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There Is (Scientific) Strength in Numbers: A Comprehensive Quantitation of Fc Gamma Receptor Numbers on Human and Murine Peripheral Blood Leukocytes by Kerntke, Christina, Nimmerjahn, Falk, Biburger, Markus

“…Antibodies are essential mediators of immunological defense mechanisms, are clinically used as therapeutic agents, but are also functionally involved in…”
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Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation by Kaneko, Yoshikatsu, Nimmerjahn, Falk, Ravetch, Jeffrey V

“…Immunoglobulin G (IgG) mediates pro- and anti-inflammatory activities through the engagement of its Fc fragment (Fc) with distinct Fcg receptors (FcgRs). One…”
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Divergent Immunoglobulin G Subclass Activity Through Selective Fc Receptor Binding by Nimmerjahn, Falk, Ravetch, Jeffrey V

“…Subclasses of immunoglobulin G (IgG) display substantial differences in their ability to mediate effector responses, contributing to variable activity of…”
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Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis by Azizov, Vugar, Dietel, Katharina, Steffen, Franziska, Dürholz, Kerstin, Meidenbauer, Julia, Lucas, Sébastien, Frech, Michael, Omata, Yasunori, Tajik, Narges, Knipfer, Lisa, Kolenbrander, Anne, Seubert, Silvia, Lapuente, Dennis, Sokolova, Maria V., Hofmann, Jörg, Tenbusch, Matthias, Ramming, Andreas, Steffen, Ulrike, Nimmerjahn, Falk, Linker, Ralf, Wirtz, Stefan, Herrmann, Martin, Temchura, Vladimir, Sarter, Kerstin, Schett, Georg, Zaiss, Mario M.

“…Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism…”
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Functional Fc receptors are crucial in antibody‐mediated protection against cytomegalovirus by Bootz, Anna, Reuter, Nina, Nimmerjahn, Falk, Britt, William J., Mach, Michael, Winkler, Thomas H.

“…Human cytomegalovirus is a medically important pathogen. Previously, using murine CMV (MCMV), we provided evidence that both neutralizing and nonneutralizing…”
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Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc by Anthony, Robert M, Nimmerjahn, Falk, Ashline, David J, Reinhold, Vernon N, Paulson, James C, Ravetch, Jeffrey V

“…It is well established that high doses of monomeric immunoglobulin G (IgG) purified from pooled human plasma [intravenous immunoglobulin (IVIG)] confer…”
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There Is Strength in Numbers: Quantitation of Fc Gamma Receptors on Murine Tissue-Resident Macrophages by Vorsatz, Christof, Friedrich, Niklas, Nimmerjahn, Falk, Biburger, Markus

“…Many of the effector functions of antibodies rely on the binding of antibodies/immune complexes to cellular Fcγ receptors (FcγRs). Since the majority of innate…”
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Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages by Stamatiades, Efstathios G., Tremblay, Marie-Eve, Bohm, Mathieu, Crozet, Lucile, Bisht, Kanchan, Kao, Daniela, Coelho, Carolina, Fan, Xiying, Yewdell, William T., Davidson, Anne, Heeger, Peter S., Diebold, Sandra, Nimmerjahn, Falk, Geissmann, Frederic

“…Small immune complexes cause type III hypersensitivity reactions that frequently result in tissue injury. The responsible mechanisms, however, remain unclear…”
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Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice by Seeling, Michaela, Hillenhoff, Ulrike, David, Jean Pierre, Schett, Georg, Tuckermann, Jan, Lux, Anja, Nimmerjahn, Falk

“…Destruction of bone tissue by osteoclasts represents a severe pathological phenotype during inflammatory arthritis and results in joint pain and bone…”
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Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity by Quast, Isaak, Keller, Christian W, Maurer, Michael A, Giddens, John P, Tackenberg, Björn, Wang, Lai-Xi, Münz, Christian, Nimmerjahn, Falk, Dalakas, Marinos C, Lünemann, Jan D

“…IgG molecules exert both pro- and antiinflammatory effector functions based on the composition of the fragment crystallizable (Fc) domain glycan. Sialylated…”
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Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion by Schwartz, Christian, Turqueti-Neves, Adriana, Hartmann, Susanne, Yu, Philipp, Nimmerjahn, Falk, Voehringer, David

“…Significance Gastrointestinal worms (helminths) infect more than 2 billion people, and vaccines are not yet available. Helminths elicit a type 2 immune…”
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Mechanisms of Autoantibody-Induced Pathology by Ludwig, Ralf J, Vanhoorelbeke, Karen, Leypoldt, Frank, Kaya, Ziya, Bieber, Katja, McLachlan, Sandra M, Komorowski, Lars, Luo, Jie, Cabral-Marques, Otavio, Hammers, Christoph M, Lindstrom, Jon M, Lamprecht, Peter, Fischer, Andrea, Riemekasten, Gabriela, Tersteeg, Claudia, Sondermann, Peter, Rapoport, Basil, Wandinger, Klaus-Peter, Probst, Christian, El Beidaq, Asmaa, Schmidt, Enno, Verkman, Alan, Manz, Rudolf A, Nimmerjahn, Falk

“…Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as…”
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Editorial: Effector functions of therapeutic antibodies by Boross, Peter, Peipp, Matthias, Nimmerjahn, Falk

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Of Mice and Men: The Need for Humanized Mouse Models to Study Human IgG Activity in Vivo by Lux, Anja, Nimmerjahn, Falk

“…Antibodies of the IgG isotype have a variety of pro- and anti-inflammatory effector functions, making them attractive platforms for the development of novel…”
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Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin by Harre, Ulrike, Georgess, Dan, Bang, Holger, Bozec, Aline, Axmann, Roland, Ossipova, Elena, Jakobsson, Per-Johan, Baum, Wolfgang, Nimmerjahn, Falk, Szarka, Eszter, Sarmay, Gabriella, Krumbholz, Grit, Neumann, Elena, Toes, Rene, Scherer, Hans-Ulrich, Catrina, Anca Irinel, Klareskog, Lars, Jurdic, Pierre, Schett, Georg

“…Autoimmunity is complicated by bone loss. In human rheumatoid arthritis (RA), the most severe inflammatory joint disease, autoantibodies against citrullinated…”
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Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate by Schoenen, Hanne, Bodendorfer, Barbara, Hitchens, Kelly, Manzanero, Silvia, Werninghaus, Kerstin, Nimmerjahn, Falk, Agger, Else Marie, Stenger, Steffen, Andersen, Peter, Ruland, Jurgen, Brown, Gordon D, Wells, Christine, Lang, Roland

“…The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-dibehenate (TDB) are potent adjuvants for Th1/Th17…”
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