Search Results - "NILIUS, Bernd"

The transient receptor potential family of ion channels by Nilius, Bernd, Owsianik, Grzegorz

“…The transient receptor potential (TRP) multigene superfamily encodes integral membrane proteins that function as ion channels. Members of this family are…”
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The puzzle of TRPV4 channelopathies by Nilius, Bernd, Voets, Thomas

“…Hereditary channelopathies, that is, mutations in channel genes that alter channel function and are causal for the pathogenesis of the disease, have been…”
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TRPV4: Molecular Conductor of a Diverse Orchestra by White, John P M, Cibelli, Mario, Urban, Laszlo, Nilius, Bernd, McGeown, J Graham, Nagy, Istvan

“…Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective cation channel, originally described in 2000 by research teams led by…”
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Pharmacology of vanilloid transient receptor potential cation channels by Vriens, Joris, Appendino, Giovanni, Nilius, Bernd

“…Depending on their primary structure, the 28 mammalian transient receptor potential (TRP) cation channels identified so far can be sorted into 6 subfamilies:…”
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Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease by Talavera, Karel, Startek, Justyna B, Alvarez-Collazo, Julio, Boonen, Brett, Alpizar, Yeranddy A, Sanchez, Alicia, Naert, Robbe, Nilius, Bernd

“…The transient receptor potential ankyrin (TRPA) channels are Ca -permeable nonselective cation channels remarkably conserved through the animal kingdom…”
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The transient receptor potential channel TRPA1: from gene to pathophysiology by Nilius, Bernd, Appendino, Giovanni, Owsianik, Grzegorz

“…The Transient Receptor Potential Ankyrin 1 channel (TRPA1), is a member of the large TRP family of ion channels, and functions as a Ca 2+ permeable…”
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Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR) by Pedersen, Stine F., Okada, Yasunobu, Nilius, Bernd

“…The volume-regulated anion channel (VRAC), also known as the volume-sensitive outwardly rectifying (VSOR) anion channel or the volume-sensitive organic…”
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TRPV3: time to decipher a poorly understood family member by Nilius, Bernd, Bíró, Tamás, Owsianik, Grzegorz

“…The vanilloid transient receptor potential channel TRPV3 differs in several aspects from other members of the TRPV subfamily. This Ca2+‐, ATP‐ and…”
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The vanilloid transient receptor potential channel TRPV4: From structure to disease by Everaerts, Wouter, Nilius, Bernd, Owsianik, Grzegorz

“…The Transient Receptor Potential Vanilloid 4 channel, TRPV4, is a Ca 2+ and Mg 2+ permeable non-selective cation channel involved in many different cellular…”
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Development and characterization of a monoclonal antibody blocking human TRPM4 channel by Low, See Wee, Gao, Yahui, Wei, Shunhui, Chen, Bo, Nilius, Bernd, Liao, Ping

“…TRPM4 is a calcium-activated non-selective monovalent cation channel implicated in diseases such as stroke. Lack of potent and selective inhibitors remains a…”
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Spices: the savory and beneficial science of pungency by Nilius, Bernd, Appendino, Giovanni

“…Spicy food does not only provide an important hedonic input in daily life, but has also been anedoctically associated to beneficial effects on our health. In…”
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Bimodal Action of Menthol on the Transient Receptor Potential Channel TRPA1 by Karashima, Yuji, Damann, Nils, Prenen, Jean, Talavera, Karel, Segal, Andrei, Voets, Thomas, Nilius, Bernd

“…TRPA1 is a calcium-permeable nonselective cation transient receptor potential (TRP) channel that functions as an excitatory ionotropic receptor in nociceptive…”
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TRPA1 acts as a cold sensor in vitro and in vivo by Karashima, Yuji, Talavera, Karel, Everaerts, Wouter, Janssens, Annelies, Kwan, Kelvin Y, Vennekens, Rudi, Nilius, Bernd, Voets, Thomas

“…TRPA1 functions as an excitatory ionotropic receptor in sensory neurons. It was originally described as a noxious cold-activated channel, but its cold…”
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Transient Receptor Potential Cation Channels in Disease by Nilius, Bernd, Owsianik, Grzegorz, Voets, Thomas, Peters, John A

“…Department of Physiology, Campus Gasthuisberg, KULeuven, Leuven, Belgium; and Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells…”
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Irritating channels: the case of TRPA1 by Nilius, Bernd, Prenen, Jean, Owsianik, Grzegorz

“…Transient receptor potential (TRP) channels have been extensively studied over the past years. Yet, in most cases, the gating mechanisms of these polymodal…”
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TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat by Vriens, Joris, Owsianik, Grzegorz, Hofmann, Thomas, Philipp, Stephan E., Stab, Julia, Chen, Xiaodi, Benoit, Melissa, Xue, Fenqin, Janssens, Annelies, Kerselaers, Sara, Oberwinkler, Johannes, Vennekens, Rudi, Gudermann, Thomas, Nilius, Bernd, Voets, Thomas

“…Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca 2+-permeable nonselective cation channel. Previous work has demonstrated robust…”
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Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol by Startek, Justyna B, Boonen, Brett, López-Requena, Alejandro, Talavera, Ariel, Alpizar, Yeranddy A, Ghosh, Debapriya, Van Ranst, Nele, Nilius, Bernd, Voets, Thomas, Talavera, Karel

“…The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and…”
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TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism by Materazzi, Serena, Fusi, Camilla, Benemei, Silvia, Pedretti, Pamela, Patacchini, Riccardo, Nilius, Bernd, Prenen, Jean, Creminon, Christophe, Geppetti, Pierangelo, Nassini, Romina

“…Paclitaxel produces a sensory neuropathy, characterized by mechanical and cold hypersensitivity, which are abated by antioxidants. The transient receptor…”
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Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation by Nassini, Romina, Gees, Maarten, Harrison, Selena, De Siena, Gaetano, Materazzi, Serena, Moretto, Nadia, Failli, Paola, Preti, Delia, Marchetti, Nicola, Cavazzini, Alberto, Mancini, Francesca, Pedretti, Pamela, Nilius, Bernd, Patacchini, Riccardo, Geppetti, Pierangelo

“…Platinum-based anticancer drugs cause neurotoxicity. In particular, oxaliplatin produces early-developing, painful, and cold-exacerbated paresthesias. However,…”
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Regulation of transient receptor potential (TRP) channels by phosphoinositides by Rohacs, Tibor, Nilius, Bernd

“…This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal…”
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