Search Results - "NIKONENKO, Boris"

Indole triazene compound TU112 demonstrates in vitro activity against dormant Mycobacterium tuberculosis and efficacy against chronic tuberculosis infection in mice by Shleeva, Margarita O., Nikonenko, Boris V., Majorov, Konstantin B., Ivanov, Pavel Yu, Apt, Alexander S., Velezheva, Valeria S.

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Synthesis and antituberculosis activity of indole–pyridine derived hydrazides, hydrazide–hydrazones, and thiosemicarbazones by Velezheva, Valeriya, Brennan, Patrick, Ivanov, Pavel, Kornienko, Albert, Lyubimov, Sergey, Kazarian, Konstantin, Nikonenko, Boris, Majorov, Konstantin, Apt, Alexander

“…[Display omitted] We describe the design, synthesis, and in vitro antimycobacterial activity of a series of novel simple hybrid hydrazides and…”
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Drug Therapy of Experimental Tuberculosis (TB): Improved Outcome by Combining SQ109, a New Diamine Antibiotic, with Existing TB Drugs by NIKONENKO, Boris V, PROTOPOPOVA, Marina, SAMALA, Rowena, EINCK, Leo, NACY, Carol A

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A new model for chronic and reactivation tuberculosis: Infection with genetically attenuated Mycobacterium tuberculosis in mice with polar susceptibility by Kondratieva, Tatiana K., Kapina, Marina A., Rubakova, Elvira I., Kondratieva, Elena V., Nikonenko, Boris V., Majorov, Konstantin B., Dyatlov, Alexander V., Linge, Irina A., Apt, Alexander S.

“…TB infection in mice develops relatively rapidly which interferes with experimental dissection of immune responses and lung pathology features that differ…”
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Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines by Protopopova, Marina, Hanrahan, Colleen, Nikonenko, Boris, Samala, Rowena, Chen, Ping, Gearhart, Jackie, Einck, Leo, Nacy, Carol A.

“…Objectives: The aim of this study was to identify a candidate drug for clinical development from a previously synthesized combinatorial library based on the…”
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In Vitro Activity of 3-Triazeneindoles against Mycobacterium tuberculosis and Mycobacterium avium by Nikonenko, Boris V, Kornienko, Albert, Majorov, Konstantin, Ivanov, Pavel, Kondratieva, Tatiana, Korotetskaya, Maria, Apt, Alexander S, Salina, Elena, Velezheva, Valeriya

“…Among 230 target-synthesized indole-based compounds, seven 3-triazenoindoles showed MICs of 0.2 to 0.5 μg/ml against Mycobacterium tuberculosis strain H37Rv…”
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Activity of SQ641, a Capuramycin Analog, in a Murine Model of Tuberculosis by NIKONENKO, Boris V, REDDY, Venkata M, PROTOPOPOVA, Marina, BOGATCHEVA, Elena, EINCK, Leo, NACY, Carol A

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Latent tuberculosis infection: What we know about its genetic control? by Kondratieva, Tatiana, Azhikina, Tatyana, Nikonenko, Boris, Kaprelyants, Arseny, Apt, Alexander

“…Summary About 90% of all cases of tuberculosis (TB) infection are comprised of latent mycobacterial persistence in the absence of clinical manifestations. In a…”
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Therapeutic Efficacy of SQ641-NE against Mycobacterium tuberculosis by NIKONENKO, Boris, REDDY, Venkata M, BOGATCHEVA, Elena, PROTOPOPOVA, Marina, EINCK, Leo, NACY, Carol A

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Pharmacodynamics and pharmacokinetics of SQ109, a new diamine‐based antitubercular drug by Jia, Lee, Tomaszewski, Joseph E, Hanrahan, Colleen, Coward, Lori, Noker, Patricia, Gorman, Gregory, Nikonenko, Boris, Protopopova, Marina

“…1 SQ109 is a novel [1,2]‐diamine‐based ethambutol (EMB) analog developed from high‐throughput combinatorial screening. The present study aimed at…”
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New 1-hydroxy-2-thiopyridine derivatives active against both replicating and dormant Mycobacterium tuberculosis by Salina, Elena G, Ryabova, Olga, Vocat, Anthony, Nikonenko, Boris, Cole, Stewart T, Makarov, Vadim

“…Abstract Tuberculosis (TB) treatment is confounded by the range of metabolic states displayed by Mycobacterium tuberculosis , by the long duration required and…”
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Drug testing in mouse models of tuberculosis and nontuberculous mycobacterial infections by Nikonenko, Boris V, Apt, Alexander S

“…Summary Mice as a species are susceptible to tuberculosis infection while mouse inbred strains present wide spectrum of susceptibility/resistance to this…”
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Structural Modifications of 3-Triazeneindoles and Their Increased Activity Against Mycobacterium tuberculosis by Majorov, Konstantin B., Nikonenko, Boris V., Ivanov, Pavel Yu, Telegina, Lyudmila N., Apt, Alexander S., Velezheva, Valeria S.

“…We synthesized 100 novel indole-based compounds with polyaza-functionalities, including 3-triazeneindoles, and tested their activity in vitro against…”
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Chronic helminth infection does not exacerbate Mycobacterium tuberculosis infection by Hübner, Marc P, Killoran, Kristin E, Rajnik, Michael, Wilson, Samuel, Yim, Kevin C, Torrero, Marina N, Morris, Christopher P, Nikonenko, Boris, Blanco, Jorge C G, Hemming, Val G, Mitre, Edward

“…Chronic helminth infections induce a Th2 immune shift and establish an immunoregulatory milieu. As both of these responses can suppress Th1 immunity, which is…”
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Rapid, Simple In Vivo Screen for New Drugs Active against Mycobacterium tuberculosis by Nikonenko, Boris V, Samala, Rowena, Einck, Leo, Nacy, Carol A

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Anti-tuberculosis drug therapy in mice of different inbred strains by Nikonenko, Boris V., Einck, Leo, Nacy, Carol A.

“…Standard anti-tuberculosis (TB) drug therapy had distinct effects on the bacilli burden in mice of DBA/2, C3H, SWR/J, and C57BL/6 inbred strains. To…”
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Multigenic Control of Disease Severity after Virulent Mycobacterium tuberculosis Infection in Mice by Sánchez, Fabio, Radaeva, Tatiana V, Nikonenko, Boris V, Persson, Ann-Sophie, Sengul, Selim, Schalling, Martin, Schurr, Erwin, Apt, Alexander S, Lavebratt, Catharina

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In search of new cures for tuberculosis by Protopopova, Marina, Bogatcheva, Elena, Nikonenko, Boris, Hundert, Sam, Einck, Leo, Nacy, Carol A

“…The last 10 years have seen resurgent industry activity in discovery and development of new drugs for the treatment of tuberculosis (TB), a growing widespread…”
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Severity of Tuberculosis in Mice is Linked to Distal Chromosome 3 and Proximal Chromosome 9 by Lavebratt, Catharina, Apt, Alexander S., Nikonenko, Boris V., Schalling, Martin, Schurr, Erwin

“…Genetic factors play a role in host response to infection with Mycobacterium tuberculosis, the number one infectious killer worldwide. Mice of the inbred…”
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Comparative Analysis of T Lymphocytes Recovered from the Lungs of Mice Genetically Susceptible, Resistant, and Hyperresistant to Mycobacterium tuberculosis-Triggered Disease by Lyadova, Irina V, Eruslanov, Evgenyi B, Khaidukov, Sergei V, Yeremeev, Vladimir V, Majorov, Konstantin B, Pichugin, Alexander V, Nikonenko, Boris V, Kondratieva, Tatiana K, Apt, Alexander S

“…Genetic control of susceptibility to tuberculosis (TB) is being intensively studied, and immune responses to mycobacteria are considerably well characterized…”
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