Search Results - "NIKLASON, LAURA E."

Understanding the Extracellular Matrix to Enhance Stem Cell-Based Tissue Regeneration by Niklason, Laura E.

“…The extracellular matrix is a biologically critical entity that has historically been poorly understood. Here we discuss how new tools for characterizing…”
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Bioengineered human blood vessels by Niklason, Laura E., Lawson, Jeffrey H.

“…Biotechnology approaches to repair and replace arteries have been under development for more than a century. Early synthetic approaches used rubber-based…”
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Decellularized tissue-engineered blood vessel as an arterial conduit by Quint, Clay, Kondo, Yuka, Manson, Roberto J, Lawson, Jeffrey H, Dardik, Alan, Niklason, Laura E

“…Arterial tissue-engineering techniques that have been reported previously typically involve long waiting times of several months while cells from the recipient…”
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The History of Engineered Tracheal Replacements: Interpreting the Past and Guiding the Future by Greaney, Allison M, Niklason, Laura E

“…The development of a tracheal graft to replace long-segment defects has thwarted clinicians and engineers alike for over 100 years. To better understand the…”
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Quantification of Extracellular Matrix Proteins from a Rat Lung Scaffold to Provide a Molecular Readout for Tissue Engineering[S] by Hill, Ryan C., Calle, Elizabeth A., Dzieciatkowska, Monika, Niklason, Laura E., Hansen, Kirk C.

“…The use of extracellular matrix (ECM)11The abbreviations used are:ECMextracellular matrixCHAPS3-[(3-cholamidopropyl)…”
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Tissue-Engineered Lungs for in Vivo Implantation by Petersen, Thomas H, Calle, Elizabeth A, Zhao, Liping, Lee, Eun Jung, Gui, Liqiong, Raredon, MichaSam B, Gavrilov, Kseniya, Yi, Tai, Zhuang, Zhen W, Breuer, Christopher, Herzog, Erica, Niklason, Laura E

“…Because adult lung tissue has limited regeneration capacity, lung transplantation is the primary therapy for severely damaged lungs. To explore whether lung…”
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Acellular Normal and Fibrotic Human Lung Matrices as a Culture System for In Vitro Investigation by BOOTH, Adam J, HADLEY, Ryan, MOORE, Bethany B, MARTINEZ, Fernando J, NIKLASON, Laura E, WHITE, Eric S, CORNETT, Ashley M, DREFFS, Alyssa A, MATTHES, Stephanie A, TSUI, Jessica L, WEISS, Kevin, HOROWITZ, Jeffrey C, FIORE, Vincent F, BARKER, Thomas H

“…Extracellular matrix (ECM) is a dynamic tissue that contributes to organ integrity and function, and its regulation of cell phenotype is a major aspect of cell…”
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Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials by Lawson, Jeffrey H, MD PhD, Glickman, Marc H, MD, Ilzecki, Marek, MD PhD, Jakimowicz, Tomasz, MD PhD, Jaroszynski, Andrzej, MD PhD, Peden, Eric K, MD, Pilgrim, Alison J, MD PhD, Prichard, Heather L, PhD, Guziewicz, Malgorzata, MD PhD, Przywara, Stanisław, MD PhD, Szmidt, Jacek, MD PhD, Turek, Jakub, MD, Witkiewicz, Wojciech, MD PhD, Zapotoczny, Norbert, MD, Zubilewicz, Tomasz, MD PhD, Niklason, Laura E, Dr

“…Summary Background For patients with end-stage renal disease who are not candidates for fistula, dialysis access grafts are the best option for chronic…”
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Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids by Cakir, Bilal, Tanaka, Yoshiaki, Kiral, Ferdi Ridvan, Xiang, Yangfei, Dagliyan, Onur, Wang, Juan, Lee, Maria, Greaney, Allison M., Yang, Woo Sub, duBoulay, Catherine, Kural, Mehmet Hamdi, Patterson, Benjamin, Zhong, Mei, Kim, Jonghun, Bai, Yalai, Min, Wang, Niklason, Laura E., Patra, Prabir, Park, In-Hyun

“…Microglia play a role in the emergence and preservation of a healthy brain microenvironment. Dysfunction of microglia has been associated with…”
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A short discourse on vascular tissue engineering by Chang, William G., Niklason, Laura E.

“…Vascular tissue engineering has significant potential to make a major impact on a wide array of clinical problems. Continued progress in understanding basic…”
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Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor by Sivarapatna, Amogh, Ghaedi, Mahboobe, Le, Andrew V, Mendez, Julio J, Qyang, Yibing, Niklason, Laura E

“…Abstract Endothelial cells (ECs) exist in different microenvironments in vivo , including under different levels of shear stress in arteries versus veins…”
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Computation and visualization of cell–cell signaling topologies in single-cell systems data using Connectome by Raredon, Micha Sam Brickman, Yang, Junchen, Garritano, James, Wang, Meng, Kushnir, Dan, Schupp, Jonas Christian, Adams, Taylor S., Greaney, Allison M., Leiby, Katherine L., Kaminski, Naftali, Kluger, Yuval, Levchenko, Andre, Niklason, Laura E.

“…Single-cell RNA-sequencing data has revolutionized our ability to understand of the patterns of cell–cell and ligand–receptor connectivity that influence the…”
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Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices by Calle, Elizabeth A., Hill, Ryan C., Leiby, Katherine L., Le, Andrew V., Gard, Ashley L., Madri, Joseph A., Hansen, Kirk C., Niklason, Laura E.

“…[Display omitted] Extracellular matrix is a key component of many products in regenerative medicine. Multiple regenerative medicine products currently in the…”
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Matrix composition and mechanics of decellularized lung scaffolds by Petersen, Thomas H, Calle, Elizabeth A, Colehour, Maegen B, Niklason, Laura E

“…The utility of decellularized native tissues for tissue engineering has been widely demonstrated. Here, we examine the production of decellularized lung…”
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Readily available tissue-engineered vascular grafts by Dahl, Shannon L M, Kypson, Alan P, Lawson, Jeffrey H, Blum, Juliana L, Strader, Justin T, Li, Yuling, Manson, Roberto J, Tente, William E, DiBernardo, Louis, Hensley, M Taylor, Carter, Riley, Williams, Tiare P, Prichard, Heather L, Dey, Margaret S, Begelman, Keith G, Niklason, Laura E

“…Autologous or synthetic vascular grafts are used routinely for providing access in hemodialysis or for arterial bypass in patients with cardiovascular disease…”
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Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds by Mendez, Julio J, Ghaedi, Mahboobe, Steinbacher, Derek, Niklason, Laura E

“…Identification of appropriate donor cell types is important for lung cell therapy and for lung regeneration. Previous studies have indicated that mesenchymal…”
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Single-cell connectomic analysis of adult mammalian lungs by Raredon, Micha Sam Brickman, Adams, Taylor Sterling, Suhail, Yasir, Schupp, Jonas Christian, Poli, Sergio, Neumark, Nir, Leiby, Katherine L, Greaney, Allison Marie, Yuan, Yifan, Horien, Corey, Linderman, George, Engler, Alexander J, Boffa, Daniel J, Kluger, Yuval, Rosas, Ivan O, Levchenko, Andre, Kaminski, Naftali, Niklason, Laura E

“…Efforts to decipher chronic lung disease and to reconstitute functional lung tissue through regenerative medicine have been hampered by an incomplete…”
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Alveolar epithelial differentiation of human induced pluripotent stem cells in a rotating bioreactor by Ghaedi, Mahboobe, Mendez, Julio J, Bove, Peter F, Sivarapatna, Amogh, Raredon, Micha Sam B, Niklason, Laura E

“…Abstract Traditional stem cell differentiation protocols make use of a variety of cytokines including growth factors (GFs) and inhibitors in an effort to…”
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Vascularization of Natural and Synthetic Bone Scaffolds by Liu, Xi, Jakus, Adam E., Kural, Mehmet, Qian, Hong, Engler, Alexander, Ghaedi, Mahboobe, Shah, Ramille, Steinbacher, Derek M., Niklason, Laura E.

“…Vascularization of engineered bone tissue is critical for ensuring its survival after implantation. In vitro pre-vascularization of bone grafts with…”
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Transplantation of bioengineered rat lungs recellularized with endothelial and adipose-derived stromal cells by Doi, Ryoichiro, Tsuchiya, Tomoshi, Mitsutake, Norisato, Nishimura, Satoshi, Matsuu-Matsuyama, Mutsumi, Nakazawa, Yuka, Ogi, Tomoo, Akita, Sadanori, Yukawa, Hiroshi, Baba, Yoshinobu, Yamasaki, Naoya, Matsumoto, Keitaro, Miyazaki, Takuro, Kamohara, Ryotaro, Hatachi, Go, Sengyoku, Hideyori, Watanabe, Hironosuke, Obata, Tomohiro, Niklason, Laura E., Nagayasu, Takeshi

“…Bioengineered lungs consisting of a decellularized lung scaffold that is repopulated with a patient’s own cells could provide desperately needed donor organs…”
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